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Search results 1601 to 1700 out of 1795 for Nkx2-5

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Type Details Score
Publication
First Author: Patzak D
Year: 1999
Journal: Hum Genet
Title: Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein.
Volume: 105
Issue: 5
Pages: 506-12
Publication
First Author: Palmer S
Year: 2001
Journal: J Cell Biol
Title: The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner.
Volume: 153
Issue: 5
Pages: 985-98
Protein
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: false
Publication
First Author: Wang DZ
Year: 1999
Journal: Development
Title: Requirement of a novel gene, Xin, in cardiac morphogenesis.
Volume: 126
Issue: 6
Pages: 1281-94
Protein
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 320  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
Publication
First Author: Divine JK
Year: 2006
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Cooperative interactions among intestinal GATA factors in activating the rat liver fatty acid binding protein gene.
Volume: 291
Issue: 2
Pages: G297-306
Publication
First Author: Divine JK
Year: 2004
Journal: Am J Physiol Gastrointest Liver Physiol
Title: GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha.
Volume: 287
Issue: 5
Pages: G1086-99
Publication
First Author: Guo M
Year: 2006
Journal: Int J Cancer
Title: Hypermethylation of the GATA gene family in esophageal cancer.
Volume: 119
Issue: 9
Pages: 2078-83
Publication
First Author: Bélanger A
Year: 1986
Journal: J Steroid Biochem
Title: Plasma levels of steroid glucuronides in prepubertal, adult and elderly men.
Volume: 24
Issue: 5
Pages: 1069-72
Publication
First Author: Zhu W
Year: 2000
Journal: J Biol Chem
Title: Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease.
Volume: 275
Issue: 45
Pages: 35291-6
Publication
First Author: Li H
Year: 2015
Journal: J Cell Biol
Title: Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.
Volume: 211
Issue: 3
Pages: 605-17
Publication
First Author: Schindeler A
Year: 2005
Journal: Exp Cell Res
Title: Muscle costameric protein, Chisel/Smpx, associates with focal adhesion complexes and modulates cell spreading in vitro via a Rac1/p38 pathway.
Volume: 307
Issue: 2
Pages: 367-80
Publication
First Author: Schott JJ
Year: 1998
Journal: Science
Title: Congenital heart disease caused by mutations in the transcription factor NKX2-5.
Volume: 281
Issue: 5373
Pages: 108-11
Publication
First Author: Masaki H
Year: 2010
Journal: Genes Cells
Title: DPPA4 modulates chromatin structure via association with DNA and core histone H3 in mouse embryonic stem cells.
Volume: 15
Issue: 4
Pages: 327-37
Protein Domain
Type: Family
Description: This entry represents the GATA family of transcription factors, such as GATA-4, GATA-5 and GATA-6. These transcription factors regulate critical steps of cellular differentiation during vertebrate development. GATA-4, 5 and 6 each contain two GATA-type zinc fingers, and are known to activate numerous enterocytic genes [, ]. Loss of GATA-4 and GATA-5 has been reported in human gastric and colon cancer []. GATA-4 binds to the consensus sequence 5'-AGATAG-3', and acts as a transcriptional activator of Anf in cooperation with Nkx2-5 []. It interacts with the homeobox domain of Nkx2-5 through its C-terminal zinc finger. It also interacts with Jarid2 which represses its ability to activate transcription of Anf. Defects in GATA-4 are the cause of atrial septal defect type 2 (ASD2) (OMIM:607941)[]. ASD2 is a congenital heart malformation characterised by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.GATA-5 binds to the functionally important Cef-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer []. It may play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity.
Protein Domain
Type: Family
Description: Chisel protein plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The X-linked gene Chisel (Csl/Smpx) was first found expressed selectively in human cardiac and skeletal muscle cells []. It is expressed in embryos in sub-regions of the developing heart corresponding to the future chamber myocardium and in developing skeletal muscles []. It is a potential target of the cardiac homeodomain transcription factor Nkx2-5 []. It localises to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway [].
Protein Domain
Type: Family
Description: Developmental pluripotency-associated protein 2 (Dppa2, also known as ECAT15-2) and Dppa4 (also known as ECAT15-1) have a common DNA binding domain known as the SAP motif. Dppa2 has been found to bind to the regulatory region of Nkx2-5 in embryonic stem (ES) cells []. Dppa4 has been found to bind to both DNA and histone H3 necessary for the chromatin structure resistance to MNase and for the proper localization of Dppa4 in ES cell nuclei [].
Protein Domain
Type: Family
Description: Developmental pluripotency-associated protein 2 (Dppa2, also known as ECAT15-2) has a DNA binding domain known as the SAP motif. Dppa2 has been found to bind to the regulatory region of Nkx2-5 in embryonic stem (ES) cells [].
Protein Domain
Type: Family
Description: Homeobox genes play fundamental roles in specifying cell fate and positional identity in embryos. Homeobox gene Csx/Nkx2.5, one of the vertebrate homologues of Drosophila tinman, is expressed in the precardiac mesoderm and in the myocardium of the embryonic and adult heart [, ]and is one of the master regulators of cardiac development, homeostasis and disease [, ]. Csx associates with the transcription factor GATA4 and this interaction may regulate a subset of cardiac muscle-specific genes []. Nkx2-5 regulates the gene encoding the Kcnh2 channel [].Mutations of the human Nkx2.5 gene cause congenital heart disease ASD7, characterised by incomplete closure of the wall between the atria [, , ].
Publication
First Author: Han L
Year: 2023
Journal: Nat Cell Biol
Title: Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism.
Volume: 25
Issue: 7
Pages: 1033-1046
Publication
First Author: Hughes J
Year: 2019
Journal: Sci Rep
Title: Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression.
Volume: 9
Issue: 1
Pages: 11388
Publication
First Author: Howell GR
Year: 2004
Journal: Genet Res
Title: Identification of a cryptic lethal mutation in the mouse t(w73) haplotype.
Volume: 84
Issue: 3
Pages: 153-9
Publication
First Author: Tsuchihashi T
Year: 2011
Journal: Dev Biol
Title: Hand2 function in second heart field progenitors is essential for cardiogenesis.
Volume: 351
Issue: 1
Pages: 62-9
Publication      
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
Publication
First Author: Yin Z
Year: 2006
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression.
Volume: 291
Issue: 2
Pages: L191-9
Publication
First Author: Kwon C
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.
Volume: 104
Issue: 26
Pages: 10894-9
Publication
First Author: Iyer LM
Year: 2018
Journal: Nucleic Acids Res
Title: A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
Volume: 46
Issue: 6
Pages: 2850-2867
Publication
First Author: McFadden DG
Year: 2005
Journal: Development
Title: The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.
Volume: 132
Issue: 1
Pages: 189-201
Publication
First Author: Zhu Y
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Tbx5-dependent pathway regulating diastolic function in congenital heart disease.
Volume: 105
Issue: 14
Pages: 5519-24
Publication
First Author: Banerjee I
Year: 2014
Journal: PLoS Genet
Title: Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.
Volume: 10
Issue: 2
Pages: e1004114
Publication
First Author: Banerjee I
Year: 2012
Journal: Circ Res
Title: Thymosin beta 4 is dispensable for murine cardiac development and function.
Volume: 110
Issue: 3
Pages: 456-64
Publication
First Author: Saadane N
Year: 2000
Journal: Am J Physiol Heart Circ Physiol
Title: Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice.
Volume: 278
Issue: 3
Pages: H796-805
Publication
First Author: Mysliwiec MR
Year: 2011
Journal: J Biol Chem
Title: Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression.
Volume: 286
Issue: 19
Pages: 17193-204
Publication
First Author: Gaborit N
Year: 2012
Journal: Development
Title: Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.
Volume: 139
Issue: 21
Pages: 4007-19
Publication
First Author: Puskaric S
Year: 2010
Journal: Hum Mol Genet
Title: Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart.
Volume: 19
Issue: 23
Pages: 4625-33
Publication
First Author: Ismat FA
Year: 2005
Journal: Circ Res
Title: Homeobox protein Hop functions in the adult cardiac conduction system.
Volume: 96
Issue: 8
Pages: 898-903
Publication
First Author: Xin M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.
Volume: 104
Issue: 19
Pages: 7975-80
Publication  
First Author: Zheng X
Year: 2021
Journal: Front Cell Dev Biol
Title: PDGFRα-Signaling Is Dispensable for the Development of the Sinoatrial Node After Its Fate Commitment.
Volume: 9
Pages: 647165
Publication
First Author: Delgado-Olguín P
Year: 2012
Journal: Nat Genet
Title: Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Volume: 44
Issue: 3
Pages: 343-7
Publication
First Author: Qiao Y
Year: 2017
Journal: Circ Res
Title: Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice.
Volume: 121
Issue: 5
Pages: 549-563
Publication
First Author: Bergstrom DE
Year: 2003
Journal: Mamm Genome
Title: Overlapping deletions spanning the proximal two-thirds of the mouse t complex.
Volume: 14
Issue: 12
Pages: 817-29
Publication
First Author: Ho YS
Year: 2016
Journal: Stem Cells
Title: Cardioprotective Actions of TGFβRI Inhibition Through Stimulating Autocrine/Paracrine of Survivin and Inhibiting Wnt in Cardiac Progenitors.
Volume: 34
Issue: 2
Pages: 445-55
Publication
First Author: Harris LG
Year: 2016
Journal: Nucleic Acids Res
Title: Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes.
Volume: 44
Issue: 8
Pages: 3610-7
Publication
First Author: Jung-Ching Lin J
Year: 2005
Journal: J Med Sci
Title: Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin.
Volume: 25
Issue: 5
Pages: 215-222
Allele
Name: transgene insertion 9, Eric N Olson
Allele Type: Transgenic
Attribute String: Recombinase
Publication
First Author: Cardona M
Year: 2015
Journal: PLoS One
Title: Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart.
Volume: 10
Issue: 6
Pages: e0131411
Publication
First Author: Jones BT
Year: 2023
Journal: Genes Dev
Title: Target-directed microRNA degradation regulates developmental microRNA expression and embryonic growth in mammals.
Volume: 37
Issue: 13-14
Pages: 661-674
Publication
First Author: Ye J
Year: 2013
Journal: J Cell Sci
Title: A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart.
Volume: 126
Issue: Pt 7
Pages: 1682-91
Strain
Attribute String: targeted mutation, mutant stock
Publication
First Author: Kong Y
Year: 2001
Journal: Circulation
Title: Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation.
Volume: 103
Issue: 22
Pages: 2731-8
Publication
First Author: Flachs P
Year: 2012
Journal: PLoS Genet
Title: Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.
Volume: 8
Issue: 11
Pages: e1003044
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Li Q
Year: 2012
Journal: J Biol Chem
Title: Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene.
Volume: 287
Issue: 34
Pages: 29088-100
Publication
First Author: Zhu L
Year: 2007
Journal: Hum Mol Genet
Title: Identification of a novel role of ZIC3 in regulating cardiac development.
Volume: 16
Issue: 14
Pages: 1649-60
Publication  
First Author: Samokhin AO
Year: 2018
Journal: Sci Transl Med
Title: NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
Volume: 10
Issue: 445
Publication
First Author: Jesty SA
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart.
Volume: 109
Issue: 33
Pages: 13380-5
Transgene
Type: transgene
Organism: mouse, laboratory
Allele
Name: transgene insertion 2, Bruce Conklin
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: transgenic, mutant stock
Publication
First Author: Teerawanichpan P
Year: 2007
Journal: Biochim Biophys Acta
Title: Investigations of combinations of mutations in the jellyfish green fluorescent protein (GFP) that afford brighter fluorescence, and use of a version (VisGreen) in plant, bacterial, and animal cells.
Volume: 1770
Issue: 9
Pages: 1360-8
Publication
First Author: van Laake LW
Year: 2010
Journal: Circ Res
Title: Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance.
Volume: 107
Issue: 3
Pages: 340-7
Allele
Name: deletion, Chr 17, John C Schimenti 7
Allele Type: Radiation induced
Attribute String: Null/knockout
Allele
Name: deletion, Chr 17, John C Schimenti 8
Allele Type: Radiation induced
Attribute String: Null/knockout
Allele
Name: NK2 homeobox 5; targeted mutation 1.1, Mohammad Pashmforoush
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Strain
Attribute String: targeted mutation, mutant strain, congenic
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele
Name: NK2 homeobox 5; targeted mutation 1.1, William T Pu
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Allele
Name: regulatory region 431; endonuclease-mediated mutation 1, David S Park
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Regulatory Region
Type: enhancer
Organism: mouse, laboratory
Allele
Name: transgene insertion 1, Sean Wu
Allele Type: Transgenic
Attribute String: Inducible, Recombinase, Reporter
Publication  
First Author: Hoelscher SC
Year: 2020
Journal: Int J Mol Sci
Title: miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations.
Volume: 21
Issue: 3
Allele
Name: NK2 homeobox 5; targeted mutation 2.1, Mauro W Costa
Allele Type: Targeted
Attribute String: Not Specified
Allele
Name: NK2 homeobox 5; targeted mutation 3.1, Mauro W Costa
Allele Type: Targeted
Attribute String: Not Specified
Allele
Name: regulatory region 125; endonuclease-mediated mutation 1, Tim Mohun
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Allele
Name: NK2 homeobox 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: regulatory region 125; endonuclease-mediated mutation 2, Tim Mohun
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Allele
Name: transgene insertion, Tim Mohun
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
Allele
Name: transgene insertion, Kyu-Ho Lee
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion 12, Yumiko Saga
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Strain
Attribute String: transgenic, mutant stock
Allele
Name: transgene insertion 13, Yumiko Saga
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Strain
Attribute String: transgenic, mutant stock
Allele
Name: sweetheart long non-coding RNA; targeted mutation 1.1, Phillip Grote
Allele Type: Targeted
Attribute String: Null/knockout
Genotype
Symbol: Hand1/Hand1 Tg(Nkx2-5-cre)9Eno/?
Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hand1/Hand1 Rr133/Rr133<+> Tg(Nkx2-5-cre)9Eno/?
Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hand1/Hand1 Rr133/Rr133 Tg(Nkx2-5-cre)9Eno/?
Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hey2/Hey2 Tg(Nkx2-5-cre)9Eno/?
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hand2/Hand2 Tg(Nkx2-5-cre)9Eno/?
Background: involves: 129 * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gata4/Gata4 Tg(Nkx2-5-cre)9Eno/?
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true