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Search results 1601 to 1661 out of 1661 for Rb1

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Type Details Score
Publication
38191672 | J:345581
First Author: Oser MG
Year: 2024
Journal: Oncogene
Title: Genetically-engineered mouse models of small cell lung cancer: the next generation.
Volume: 43
Issue: 7
Pages: 457-469
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Publication
26168399 | J:345783
First Author: George J
Year: 2015
Journal: Nature
Title: Comprehensive genomic profiles of small cell lung cancer.
Volume: 524
Issue: 7563
Pages: 47-53
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Publication
34593608 | J:345784
First Author: Voigt E
Year: 2021
Journal: Mol Cancer Res
Title: Sox2 Is an Oncogenic Driver of Small-Cell Lung Cancer and Promotes the Classic Neuroendocrine Subtype.
Volume: 19
Issue: 12
Pages: 2015-2025
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Publication
38355807 | J:346650
First Author: Wang J
Year: 2024
Journal: Oncogene
Title: Targeted inhibition of SCF(SKP2) confers anti-tumor activities resulting in a survival benefit in osteosarcoma.
Volume: 43
Issue: 13
Pages: 962-975
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Publication
20016601 | J:155800
First Author: Chen D
Year: 2009
Journal: Nature
Title: Division and apoptosis of E2f-deficient retinal progenitors.
Volume: 462
Issue: 7275
Pages: 925-9
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Publication
35840016 | J:329209
 
First Author: Nguyen BT
Year: 2022
Journal: Free Radic Biol Med
Title: Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene.
Volume: 189
Pages: 2-19
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Publication
16403804 | J:106760
First Author: Melcon G
Year: 2006
Journal: Hum Mol Genet
Title: Loss of emerin at the nuclear envelope disrupts the Rb1/E2F and MyoD pathways during muscle regeneration.
Volume: 15
Issue: 4
Pages: 637-51
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Publication
15659706 | J:105467
First Author: Tan KA
Year: 2005
Journal: Biol Reprod
Title: Androgen regulation of stage-dependent cyclin D2 expression in Sertoli cells suggests a role in modulating androgen action on spermatogenesis.
Volume: 72
Issue: 5
Pages: 1151-60
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Publication
2630183 | J:10376
First Author: Valentine M
Year: 1989
Journal: Cytogenet Cell Genet
Title: Closely linked loci on the long arm of chromosome 13 flank a specific 2;13 translocation breakpoint in childhood rhabdomyosarcoma.
Volume: 52
Issue: 3-4
Pages: 128-32
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Publication
15313589 | J:92008
First Author: Rice JM
Year: 2004
Journal: Toxicol Appl Pharmacol
Title: Causation of nervous system tumors in children: insights from traditional and genetically engineered animal models.
Volume: 199
Issue: 2
Pages: 175-91
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Publication
33481853 | J:300806
First Author: Quaglia F
Year: 2021
Journal: PLoS One
Title: Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression.
Volume: 16
Issue: 1
Pages: e0244985
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Publication
21239885 | J:356419
First Author: Huang M
Year: 2011
Journal: Cell Cycle
Title: Overlapping and distinct pRb pathways in the mammalian auditory and vestibular organs.
Volume: 10
Issue: 2
Pages: 337-51
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Genotype
Genotype
Symbol: Rb1/Rb1 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129/Sv * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129 * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hells/Hells Rb1/Rb1 Rbl1/Rbl1 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129 * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
33218272 | J:313636
First Author: Choong CJ
Year: 2021
Journal: Autophagy
Title: Alternative mitochondrial quality control mediated by extracellular release.
Volume: 17
Issue: 10
Pages: 2962-2974
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Publication
32876528 | J:310981
First Author: González-Rodríguez P
Year: 2021
Journal: Autophagy
Title: The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.
Volume: 17
Issue: 5
Pages: 1259-1277
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Publication
10202156 | J:54310
First Author: Aagaard L
Year: 1999
Journal: EMBO J
Title: Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.
Volume: 18
Issue: 7
Pages: 1923-38
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Publication
18004385 | J:127714
First Author: Vaquero A
Year: 2007
Journal: Nature
Title: SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Volume: 450
Issue: 7168
Pages: 440-4
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Publication
11701123 | J:72503
First Author: Peters AH
Year: 2001
Journal: Cell
Title: Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Volume: 107
Issue: 3
Pages: 323-37
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Publication
14690609 | -
First Author: Peters AH
Year: 2003
Journal: Mol Cell
Title: Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.
Volume: 12
Issue: 6
Pages: 1577-89
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Publication
14690610 | -
First Author: Rice JC
Year: 2003
Journal: Mol Cell
Title: Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.
Volume: 12
Issue: 6
Pages: 1591-8
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Publication
14702045 | J:88268
First Author: García-Cao M
Year: 2004
Journal: Nat Genet
Title: Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.
Volume: 36
Issue: 1
Pages: 94-9
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Protein
A2AEB6
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Publication
12039029 | -
First Author: Alvarez-Venegas R
Year: 2002
Journal: Gene
Title: SET-domain proteins of the Su(var)3-9, E(z) and trithorax families.
Volume: 285
Issue: 1-2
Pages: 25-37
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Publication
10848615 | -
First Author: Firestein R
Year: 2000
Journal: Mol Cell Biol
Title: Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9.
Volume: 20
Issue: 13
Pages: 4900-9
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Publication
14765126 | J:88283
First Author: Ait-Si-Ali S
Year: 2004
Journal: EMBO J
Title: A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.
Volume: 23
Issue: 3
Pages: 605-15
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Publication
16858404 | J:200435
First Author: Mal AK
Year: 2006
Journal: EMBO J
Title: Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.
Volume: 25
Issue: 14
Pages: 3323-34
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Publication
16449642 | -
First Author: Carbone R
Year: 2006
Journal: Mol Cell Biol
Title: Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein.
Volume: 26
Issue: 4
Pages: 1288-96
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Publication
16818776 | J:134992
First Author: Bradley SP
Year: 2006
Journal: J Immunol
Title: The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.
Volume: 177
Issue: 2
Pages: 1179-88
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Protein Domain
IPR011381 | Histone_H3-K9_MeTrfase
Type: Family
Description: Members of this family trimethylate 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. It also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. This enzyme mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats [, , ]. SUV39H1 (the human ortholog) is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation[], regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein [], BMP-induced repression, repression of switch recombination to IgA []and regulation of telomere length [, ]. SUV39H1 is a component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus []. The activity of this enzyme has been mapped to the SET domain and the adjacent cysteine-rich regions []. The SET domain was originally identified in Su(var)3-9, E(z) and Trithorax genes in Drosophila melanogaster (Fruit fly) []. The sequence conservation pattern and structure analysis of the SET domain provides clues regarding the possible active site residues of the domain. There are three conserved sequence motifs in most of the SET domains. The N-terminal motif (I) has characteristic glycines. The central motif (II) has a distinct pattern of polar and charged residues (Asn, His). The C-terminal conserved motif (III) has a characteristic dyad of polar residues. It has been shown that deregulated SUV39H1 interferes at multiple levels with mammalian higher-order chromatin organisation []and these properties depend primarily on the SET domain [, ]. Methyltransferases (EC [intenz:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.
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Publication
17493263 | J:160877
First Author: Herschkowitz JI
Year: 2007
Journal: Genome Biol
Title: Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors.
Volume: 8
Issue: 5
Pages: R76
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Publication
8139568 | J:72121
First Author: Sáenz Robles MT
Year: 1994
Journal: Mol Cell Biol
Title: Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.
Volume: 14
Issue: 4
Pages: 2686-98
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Protein
Q9R0Q4
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
A2AEB3
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: true
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Protein
Q3TME1
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
Q3TXN7
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Protein
A2AEB5
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Protein
Q3U6G8
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
A2AEB4
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
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Publication
18485871 | -
First Author: Murayama A
Year: 2008
Journal: Cell
Title: Epigenetic control of rDNA loci in response to intracellular energy status.
Volume: 133
Issue: 4
Pages: 627-39
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Publication
12963728 | -
First Author: Cai Y
Year: 2003
Journal: J Biol Chem
Title: Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.
Volume: 278
Issue: 44
Pages: 42733-6
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Publication
25125178 | -
First Author: Du SJ
Year: 2014
Journal: Anat Rec (Hoboken)
Title: SMYD proteins: key regulators in skeletal and cardiac muscle development and function.
Volume: 297
Issue: 9
Pages: 1650-62
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Publication
26985287 | -
First Author: Mitchell LH
Year: 2016
Journal: ACS Med Chem Lett
Title: Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
Volume: 7
Issue: 2
Pages: 134-8
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Publication
26101576 | -
First Author: Sweis RF
Year: 2015
Journal: ACS Med Chem Lett
Title: Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.
Volume: 6
Issue: 6
Pages: 695-700
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Publication
32408548 | -
 
First Author: Jarrell DK
Year: 2020
Journal: Vet Sci
Title: Characterizing the Role of SMYD2 in Mammalian Embryogenesis-Future Directions.
Volume: 7
Issue: 2
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Publication
10949293 | J:75203
First Author: Rea S
Year: 2000
Journal: Nature
Title: Regulation of chromatin structure by site-specific histone H3 methyltransferases.
Volume: 406
Issue: 6796
Pages: 593-9
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Protein
Q8R5A0
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
Q8K085
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
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Publication
15045029 | -
First Author: Kobor MS
Year: 2004
Journal: PLoS Biol
Title: A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.
Volume: 2
Issue: 5
Pages: E131
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Publication
15196461 | -
First Author: Doyon Y
Year: 2004
Journal: Curr Opin Genet Dev
Title: The highly conserved and multifunctional NuA4 HAT complex.
Volume: 14
Issue: 2
Pages: 147-54
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Protein
Q9EQQ0
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: false
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Protein
O54864
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Protein
Q3TNH3
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: true
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Protein
A0A0R4J074
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: false
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Protein
A2AC19
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
F6WB49
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: true
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Publication
7897657 | -
First Author: Schluckebier G
Year: 1995
Journal: J Mol Biol
Title: Universal catalytic domain structure of AdoMet-dependent methyltransferases.
Volume: 247
Issue: 1
Pages: 16-20
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Publication
16225687 | -
 
First Author: Kozbial PZ
Year: 2005
Journal: BMC Struct Biol
Title: Natural history of S-adenosylmethionine-binding proteins.
Volume: 5
Pages: 19
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Publication
21858014 | -
First Author: Wlodarski T
Year: 2011
Journal: PLoS One
Title: Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome.
Volume: 6
Issue: 8
Pages: e23168
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Publication
12826405 | -
First Author: Schubert HL
Year: 2003
Journal: Trends Biochem Sci
Title: Many paths to methyltransfer: a chronicle of convergence.
Volume: 28
Issue: 6
Pages: 329-35
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom