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Search results 1601 to 1700 out of 3140 for Sod1

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Type Details Score
Interaction Experiment
Gal J (2009)
Description: Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.
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Publication
11796754 | J:78835
First Author: Yoshihara T
Year: 2002
Journal: J Neurochem
Title: Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
Volume: 80
Issue: 1
Pages: 158-67
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Publication
19686706 | J:157418
 
First Author: Ohnishi S
Year: 2009
Journal: Brain Res
Title: Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis.
Volume: 1296
Pages: 216-24
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Publication
14741400 | J:88033
First Author: Li PA
Year: 2004
Journal: Brain Res Mol Brain Res
Title: Up-regulation and altered distribution of lysyl oxidase in the central nervous system of mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis.
Volume: 120
Issue: 2
Pages: 115-22
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Publication
17715356 | J:356375
First Author: Ferraiuolo L
Year: 2007
Journal: J Neurosci
Title: Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS.
Volume: 27
Issue: 34
Pages: 9201-19
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Publication
24899723 | J:270069
First Author: Roberts BR
Year: 2014
Journal: J Neurosci
Title: Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.
Volume: 34
Issue: 23
Pages: 8021-31
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Publication
21310237 | J:172765
First Author: Nguyen KT
Year: 2011
Journal: Neurobiol Dis
Title: Repetitive nerve stimulation transiently opens the mitochondrial permeability transition pore in motor nerve terminals of symptomatic mutant SOD1 mice.
Volume: 42
Issue: 3
Pages: 381-90
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Publication
38292023 | J:348768
 
First Author: Ratano P
Year: 2023
Journal: Front Mol Neurosci
Title: Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3.
Volume: 16
Pages: 1333745
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Publication
26297318 | J:227669
 
First Author: Fujisawa T
Year: 2015
Journal: Neurobiol Dis
Title: A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.
Volume: 82
Pages: 478-486
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Publication
30123078 | J:319587
First Author: Zhang J
Year: 2018
Journal: Int J Biol Sci
Title: Preliminary Observation about Alteration of Proteins and Their Potential Functions in Spinal Cord of SOD1 G93A Transgenic Mice.
Volume: 14
Issue: 10
Pages: 1306-1320
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Publication
27716798 | J:254881
First Author: Glajch KE
Year: 2016
Journal: PLoS One
Title: MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.
Volume: 11
Issue: 10
Pages: e0164103
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Publication
25841320 | J:224501
 
First Author: Li Y
Year: 2015
Journal: Neuroscience
Title: Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model.
Volume: 298
Pages: 12-25
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Publication
27570488 | J:287958
First Author: Lu Y
Year: 2016
Journal: Int J Biol Sci
Title: The Overexpression of TDP-43 Protein in the Neuron and Oligodendrocyte Cells Causes the Progressive Motor Neuron Degeneration in the SOD1 G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis.
Volume: 12
Issue: 9
Pages: 1140-9
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Publication
24699224 | J:215408
 
First Author: Jiang HQ
Year: 2014
Journal: Neuroscience
Title: Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis.
Volume: 277
Pages: 132-8
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Publication
20071543 | J:157705
First Author: Duplan L
Year: 2010
Journal: J Neurosci
Title: Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death.
Volume: 30
Issue: 2
Pages: 785-96
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Publication
26778957 | J:244841
 
First Author: Gajowiak A
Year: 2015
Journal: Front Mol Neurosci
Title: Mice Overexpressing Both Non-Mutated Human SOD1 and Mutated SOD1(G93A) Genes: A Competent Experimental Model for Studying Iron Metabolism in Amyotrophic Lateral Sclerosis.
Volume: 8
Pages: 82
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Publication
16036435 | J:100363
First Author: Achilli F
Year: 2005
Journal: Amyotroph Lateral Scler Other Motor Neuron Disord
Title: The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12.
Volume: 6
Issue: 2
Pages: 111-4
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Publication
25452714 | J:313647
 
First Author: Mühling T
Year: 2014
Journal: Front Cell Neurosci
Title: Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca(2+) transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic mice.
Volume: 8
Pages: 353
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Publication
22249462 | J:357679
First Author: Gertz B
Year: 2012
Journal: J Neuropathol Exp Neurol
Title: Nuclear localization of human SOD1 and mutant SOD1-specific disruption of survival motor neuron protein complex in transgenic amyotrophic lateral sclerosis mice.
Volume: 71
Issue: 2
Pages: 162-77
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Publication
39201793 | J:357635
 
First Author: Martin LJ
Year: 2024
Journal: Int J Mol Sci
Title: Nuclear Localization of Human SOD1 in Motor Neurons in Mouse Model and Patient Amyotrophic Lateral Sclerosis: Possible Links to Cholinergic Phenotype, NADPH Oxidase, Oxidative Stress, and DNA Damage.
Volume: 25
Issue: 16
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Allele
Tg(SOD1*)125Dbo | MGI:3695897
Name: transgene insertion 125, David Borschelt
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
25557022 | J:226527
First Author: Xu G
Year: 2015
Journal: J Neurochem
Title: Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.
Volume: 133
Issue: 3
Pages: 452-64
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Allele
Tg(SOD1*G37R)1Dwc | MGI:3629226
Name: transgene insertion 1, Don W Cleveland
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Publication
15294873 | J:93621
First Author: Tateno M
Year: 2004
Journal: Hum Mol Genet
Title: Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model.
Volume: 13
Issue: 19
Pages: 2183-96
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Publication
23509252 | J:194235
First Author: Song Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.
Volume: 110
Issue: 14
Pages: 5428-33
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Publication
27999308 | J:318381
 
First Author: Jiang HZ
Year: 2016
Journal: Int J Mol Sci
Title: Downregulation of Homer1b/c in SOD1 G93A Models of ALS: A Novel Mechanism of Neuroprotective Effect of Lithium and Valproic Acid.
Volume: 17
Issue: 12
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Allele
Tg(SOD1*G85R)74Dwc | MGI:2182172
Name: transgene insertion 74, Don W Cleveland
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*H46R*H48Q)139Dbo | MGI:3695885
Name: transgene insertion 139, David Borschelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo | MGI:4849838
Name: transgene insertion 110, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
25940956 | J:225540
First Author: Tortarolo M
Year: 2015
Journal: J Neurochem
Title: Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression.
Volume: 135
Issue: 1
Pages: 109-24
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Publication
25274775 | J:218098
First Author: Carroll J
Year: 2015
Journal: Hum Mol Genet
Title: Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.
Volume: 24
Issue: 3
Pages: 828-40
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Publication
30635270 | J:272996
 
First Author: Chaplot K
Year: 2019
Journal: Dis Model Mech
Title: SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis.
Volume: 12
Issue: 2
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Publication
29440992 | J:313132
 
First Author: Duval N
Year: 2018
Journal: Front Cell Neurosci
Title: The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord.
Volume: 12
Pages: 15
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Allele
Tg(SOD1*G37R)106Dpr | MGI:2182087
Name: transgene insertion 106, Donald L Price
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*G93A)2Gur | MGI:2183718
Name: transgene insertion 2, Mark E Gurney
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*G37R)9Dpr | MGI:3574015
Name: transgene insertion 9, Donald L Price
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*G127X)716Mrkl | MGI:5286585
Name: transgene insertion 716, Stefan L Marklund
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*G85R)#Roos | MGI:5448547
Name: transgene insertion, Raymond Roos
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Myl1-SOD1*G93A)#Amu | MGI:5499110
Name: transgene insertion, Antonio Musaro
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*H46R)IAra | MGI:5699320
Name: transgene insertion I, Toshiyuki Araki
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*H46R)LAra | MGI:5699326
Name: transgene insertion L, Toshiyuki Araki
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
24141020 | J:260941
 
First Author: Peviani M
Year: 2014
Journal: Neurobiol Dis
Title: Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.
Volume: 62
Pages: 218-32
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Publication
9382875 | J:106420
First Author: Zhang B
Year: 1997
Journal: J Cell Biol
Title: Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation.
Volume: 139
Issue: 5
Pages: 1307-15
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Publication
34823547 | J:315161
First Author: Malada Edelstein YF
Year: 2021
Journal: J Neuroinflammation
Title: Early upregulation of cytosolic phospholipase A2α in motor neurons is induced by misfolded SOD1 in a mouse model of amyotrophic lateral sclerosis.
Volume: 18
Issue: 1
Pages: 274
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Transgene
MGI:2671093 | Tg(SOD1)2Gur
Type: transgene
Organism: mouse, laboratory
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Allele
Tg(SOD1*H46R*H48Q)58Dbo | MGI:3695884
Name: transgene insertion 58, David Borschelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*)DF7Yaw | MGI:5449420
Name: transgene insertion DF7, Yasuhiro Watanabe
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*L126Z)#Deng | MGI:5449894
Name: transgene insertion, Han-Xiang Deng
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*)D-14Dbo | MGI:5621172
Name: transgene insertion D-14, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*G85R/EYFP)641Alho | MGI:5621057
Name: transgene insertion 641, Arthur L Horwich
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(Sod1*G86R)M1Jwg | MGI:2183736
Name: transgene insertion M1, Jon W Gordon
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Prnp-Immt/SOD1*G93A)7Gmnf | MGI:5575878
Name: transgene insertion 7, Giovanni Manfredi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*L126Z)45Dbo | MGI:5621061
Name: transgene insertion 45, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence
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Gene
5630 | PRPH
Type: gene
Organism: human
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Genotype
Genotype
Symbol: Tg(SOD1*H46R)#Maw/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Publication
26528138 | J:313119
 
First Author: Baker DJ
Year: 2015
Journal: Front Cell Neurosci
Title: Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis.
Volume: 9
Pages: 410
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Genotype
Genotype
Symbol: Isl1/Isl1<+> Tg(SOD1*G37R)1Dwc/?
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(ITGAM-cre)2781Gkl/? Tg(SOD1*G37R)1Dwc/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
15649651 | J:95541
First Author: Endo T
Year: 2005
Journal: Free Radic Biol Med
Title: Elevation of superoxide dismutase increases acoustic trauma from noise exposure.
Volume: 38
Issue: 4
Pages: 492-8
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Allele
Tg(SOD1)10Cje | MGI:3053950
Name: transgene insertion 10, Charles J Epstein
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
15472100 | J:134752
First Author: Saito A
Year: 2004
Journal: Stroke
Title: Oxidative stress affects the integrin-linked kinase signaling pathway after transient focal cerebral ischemia.
Volume: 35
Issue: 11
Pages: 2560-5
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Publication
15306124 | J:134596
First Author: Saito A
Year: 2004
Journal: Brain Res Mol Brain Res
Title: Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1.
Volume: 127
Issue: 1-2
Pages: 89-95
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Publication
11239196 | J:127965
First Author: Huang CY
Year: 2001
Journal: Stroke
Title: Overexpression of copper-zinc superoxide dismutase attenuates acute activation of activator protein-1 after transient focal cerebral ischemia in mice.
Volume: 32
Issue: 3
Pages: 741-7
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Genotype
Genotype
Symbol: Tg(SOD1*G85R)148Dwc/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G85R)74Dwc/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo/Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo
Background: involves: C3H * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*)125Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*H46R*H48Q)139Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Publication
18624915 | J:138853
First Author: Krishnan J
Year: 2008
Journal: J Neurochem
Title: Over-expression of Hsp27 does not influence disease in the mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Volume: 106
Issue: 5
Pages: 2170-83
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Genotype
Genotype
Symbol: Tg(SOD1*G93A)2Gur/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G37R)106Dpr/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G37R)29Dpr/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G37R)42Dpr/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G37R)9Dpr/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G127X)716Mrkl/Tg(SOD1*G127X)716Mrkl
Background: B6JBom.Cg-Tg(SOD1*G127X)716Mrkl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G85R)#Roos/?
Background: involves: C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*L126Z)#Deng/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myl1-SOD1*G93A)#Amu/?
Background: FVB/NJ-Tg(Myl1-SOD1*G93A)#Amu
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*H46R)IAra/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*H46R)LAra/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*H46R*H48Q)58Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1)2Gur/? Tg(SOD1*G85R)#Roos/?
Background: involves: C57BL/6 * C57BL/6J * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*)DF7Yaw/?
Background: C57BL/6-Tg(SOD1*)DF7Yaw
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*)DF7Yaw/Tg(SOD1*)DF7Yaw
Background: C57BL/6-Tg(SOD1*)DF7Yaw
Zygosity: hm
Has Mutant Allele: true
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Allele
Vegfa<tm2Pec> | MGI:2136623
Name: vascular endothelial growth factor A; targeted mutation 2, Peter Carmeliet
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tg(NFH)120Jpj | MGI:2182067
Name: transgene insertion 120, Jean-Pierre Julien
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(NEFH)200Jpj | MGI:2182068
Name: transgene insertion 200, Jean-Pierre Julien
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Thy1-SOD1*G93A)T3Hgrd | MGI:3785090
Name: transgene insertion T3, Casper Hoogenraad
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Thy1-Sncg)HvP36Putt | MGI:4440514
Name: transgene insertion HvP36, Herman van der Putten
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Thy1-DCTN1*G59S)M2Pcw | MGI:5308396
Name: transgene insertion M2, Philip C Won
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Sod1<m1H> | MGI:5575771
 
Name: superoxide dismutase 1, soluble; mutation 1, Harwell
Allele Type: Chemically induced (ENU)
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Allele
Tg(SOD1*G85R/EYFP)737Alho | MGI:5630056
Name: transgene insertion 737, Arthur L Horwich
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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DO Term
DOID:0060199 | amyotrophic lateral sclerosis type 7
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Transgene
MGI:2388196 | Tg(SOD1)3Cje
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(Sod1*G86R)M1Jwg/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G93A)1Gur/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G93A)1Gur/?
Background: B6.Cg-Tg(SOD1*G93A)1Gur/J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G93A)1Gur/?
Background: B6SJL-Tg(SOD1*G93A)1Gur/J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G93A)1Gur/?
Background: B6SJL-Tg(SOD1*G93A)1Gur
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1*G93A)1Gur/?
Background: B6.Cg-Tg(SOD1*G93A)1Gur
Zygosity: ot
Has Mutant Allele: true
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