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Search results 1601 to 1700 out of 1777 for Spp1

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Type Details Score
Publication
2738922 | -
First Author: Semerjian AV
Year: 1989
Journal: J Mol Biol
Title: Genetic structure of the bacteriophage P22 PL operon.
Volume: 207
Issue: 1
Pages: 1-13
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Publication
9180375 | -
First Author: Becker B
Year: 1997
Journal: J Mol Biol
Title: Head morphogenesis genes of the Bacillus subtilis bacteriophage SPP1.
Volume: 268
Issue: 5
Pages: 822-39
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Publication
1385991 | -
First Author: Baxa CA
Year: 1992
Journal: DNA Seq
Title: DNA sequence characterization of the G gene region of bacteriophage Mu.
Volume: 2
Issue: 5
Pages: 329-33
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Protein Domain
IPR006528 | Phage_head_morphogenesis_dom
Type: Domain
Description: This domain is found in proteins found in the tailed bacteriophages Caudovirales and in bacterial prophages, internally or toward the C terminus.Minor head protein GP7 from Bacillus phage SPP1 is required for viral head morphogenesis []. Gp7 binds the viral DNA inside the capsid and the portal protein and may control the DNA exit from the virion []. Some other have also been identified as being involved in phage head morphogenesis [].
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Publication
10930407 | -
First Author: Gual A
Year: 2000
Journal: J Biol Chem
Title: Functional analysis of the terminase large subunit, G2P, of Bacillus subtilis bacteriophage SPP1.
Volume: 275
Issue: 45
Pages: 35311-9
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Publication
25991862 | -
First Author: Chaban Y
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Structural rearrangements in the phage head-to-tail interface during assembly and infection.
Volume: 112
Issue: 22
Pages: 7009-14
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HT Experiment
E-GEOD-77126 | The mdx mutation in the 129/Sv background results in a milder phenotype: Transcriptome comparative analysis searching for the protective factors
Series Id: GSE77126
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:3028490 | B6.129S6(Cg)-Spp1<tm1Blh>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:4365382 | 129S/SvEv-Spp1<tm1Blh>
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6392149 | 129S6(Cg)-Spp1<tm1Blh>/PlcgJ
Attribute String: mutant strain, targeted mutation
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Strain
MGI:3758637 | B6.129S6-Spp1<tm1Blh>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:4365379 | 129S6/SvEvTac-Spp1<tm1Blh>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:4365377 | BKSW.129S6-Spp1<tm1Blh>
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Spp1<tm1Rit> | MGI:1932084
Name: secreted phosphoprotein 1; targeted mutation 1, Susan R Rittling
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:5495284 | STOCK Tg(Spp1-EGFP)PD43Gsat/Mmucd
Attribute String: transgenic, mutant stock
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Allele
Tg(Spp1-icre/ERT2)#Lecl | MGI:6514326
Name: transgene insertion, Isabelle A Leclercq
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Strain
MGI:6771192 | C57BL/6JSmoc-Spp1<em1 Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7718278 | C57BL/6JSmoc-Spp1<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: involves: 129S6/SvEvTac * Black Swiss
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: B6.129S6(Cg)-Spp1/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: B6.129S6-Spp1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1<+>
Background: BKSW.129S6-Spp1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: BKSW.129S6-Spp1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1<+>
Background: involves: 129S6/SvEvTac * Black Swiss
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: 129S6/SvEvTac-Spp1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: 129S/SvEv-Spp1
Zygosity: hm
Has Mutant Allele: true
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Publication
15775977 | -
First Author: Schlichter A
Year: 2005
Journal: EMBO J
Title: Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains.
Volume: 24
Issue: 6
Pages: 1222-31
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Publication
16921172 | -
First Author: Dehé PM
Year: 2006
Journal: J Biol Chem
Title: Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation.
Volume: 281
Issue: 46
Pages: 35404-12
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Protein Domain
IPR006437 | Phage_terminase_lsu
Type: Family
Description: This group of sequences represent a highly divergent family of the large subunit of phage terminase. All members are encoded by phage genomes or within prophage regions of bacterial genomes. This is a distinct family from the phage terminase family represented by .Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase are usually hetero-oligomers composed of a small and a large subunit [, ]. This entry includes the large subunit, including GP2 from Bacillus phage SPP1 [, ].
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Protein Domain
IPR024657 | COMPASS_Set1_N-SET
Type: Domain
Description: The COMPASS complex (complex proteins associated with Set1p) is conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes []. Five domains are conserved in Saccharomyces cerevisiae Set1 and other eukaryotic Set1-related proteins: an amino-terminal RNA-recognition motif (RRM), a semi-conserved central domain, an N-SET domain, the catalytic SET domain, and the C-terminal post-SET domain. This entry represents the N-SET domain, which promotes trimethylation in conjunction with the RRM domain []and is necessary for binding of the Spp1 component of COMPASS into the complex [].
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Protein Domain
IPR011855 | Phgtail_TP901_1
Type: Family
Description: This entry describes the major tail protein (MTP) of the Siphoviridae and MTP genes in prophage regions of bacterial genomes. Homologues are also found in Gene Transfer Agents (GTA) [], including ORFg9 (RCAP_rcc01691) of the GTA of Rhodobacter capsulatus (Rhodopseudomonas capsulata) [see Fig.1, in ]. The tail tube protein gp17.1* from bacteriophage SPP1 forms a sixfold helical, rigid tail tube which ejects of the phage DNA into the host when it binds to the entry receptor on the host cell surface, triggering structural rearrangements of the tail tube [].
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Protein Domain
IPR035412 | Terminase_L_N
Type: Domain
Description: This entry represents the N-terminal domain of the large subunit of the terminase protein.Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit. This region possess an endonuclease and ATPase activity that require Mg2+ and a neutral or slightly basic reaction. This region is also found in bacterial sequences [, ].Proteins containing this domain include gp2 from Bacillus phage SPP1 [, ].
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Protein Domain
IPR023838 | T7SS_EsaA
Type: Domain
Description: Members of this family are associated with type VII secretion systems. EsaA from Staphylococcus aureus is encoded within a cluster comprised of eight predicted ORFs (esxA, esaA, essA, esaB, essB, essC, esxY, and esxB) []. Its function is unknown, though it is probably involved, with EsxA and EsxB, in the establishment of infection in the host. It is not necessary for the production and secretion of EsxA or EsxB []. Some members of this family, such as YueB from Bacillus subtilis, seem to act as membrane receptors for bacteriophage SPP1 [].In some proteins this entry represents the conserved N-terminal domain.
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Strain
MGI:3850425 | B6Rcc.129S7-Spp1<tm1Rit>/Cnrm
Attribute String: targeted mutation, congenic
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Strain
MGI:4839230 | B6.129S7-Spp1<tm1Rit>
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1
Background: B6.129S7-Spp1
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE49562 | Exploring the gene expression associated with Pten deficiency in the developing inner ear
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
37418531 | J:337957
First Author: Coulis G
Year: 2023
Journal: Sci Adv
Title: Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis.
Volume: 9
Issue: 27
Pages: eadd9984
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Publication
17467979 | J:121824
First Author: De Bortoli M
Year: 2007
Journal: Eur J Cancer
Title: Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases.
Volume: 43
Issue: 8
Pages: 1308-17
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Publication
35440090 | J:324178
First Author: Wu Y
Year: 2022
Journal: Cell Death Dis
Title: UHRF1 establishes crosstalk between somatic and germ cells in male reproduction.
Volume: 13
Issue: 4
Pages: 377
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Publication
8586437 | J:29921
First Author: Aplin HM
Year: 1995
Journal: Genomics
Title: Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21.
Volume: 30
Issue: 2
Pages: 347-9
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Publication
24069507 | J:202465
First Author: Hubbard NE
Year: 2013
Journal: Genes Cancer
Title: Transgenic mammary epithelial osteopontin (spp1) expression induces proliferation and alveologenesis.
Volume: 4
Issue: 5-6
Pages: 201-12
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Publication
38704393 | J:349444
First Author: Huang T
Year: 2024
Journal: Nat Commun
Title: Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow.
Volume: 15
Issue: 1
Pages: 3769
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Publication
21407193 | -
 
First Author: Xu C
Year: 2011
Journal: Nat Commun
Title: The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.
Volume: 2
Pages: 227
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Publication
23246437 | -
First Author: Sommermeyer V
Year: 2013
Journal: Mol Cell
Title: Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes.
Volume: 49
Issue: 1
Pages: 43-54
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Protein Domain
IPR044269 | Terminase_large_su_SPP1-like
Type: Family
Description: Many DNA viruses package their genomes in a reaction catalysed by a powerful DNA-packaging motor, a complex that consists of a dodecameric portal protein and a terminase that converts ATP hydrolysis into linear translation of DNA. The terminase is formed by a small subunit, which binds to packaging initiation sites to prepare for genome packaging, and a large subunit which has ATPase activity and binds directly to the portal protein. The small subunit is essential for binding to DNA and also activates the large subunit ATPase activity [, , ].This entry represents the terminase large subunit, an ATPase necessary for viral DNA translocation into empty capsids and it also acts as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction. Included in this family is the terminase large subunit from Bacillus phage SPP1 []and related sequences.
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Protein Domain
IPR038666 | SSP1_head-tail_sf
Type: Homologous_superfamily
Description: This entry describes the head-tail adaptor protein of bacteriophage SPP1and related proteins in other bacteriophage and prophage regions of bacterial genomes. Homologues are also found in Gene Transfer Agents (GTA) [], including ORFg7 (RCAP_rcc01689) of the GTA of Rhodobacter capsulatus (Rhodopseudomonas capsulata) [].In bacteriophage SPP1, the gp16 protein functions as a stopper, locking the viral DNA into the capsid. When the tail attachment binds to the entry receptor, gp16 opens by a diaphragm-like motion, allowing the genome to exit the capsid through the tail tube to the host cell. During virion assembly, gp16 functions as a docking platform to which the preassembled tail binds [].The SPP1 head-to-tail connector is composed of cyclical dodecamers of the portal protein gp6 and of the 2 head completion proteins gp15 and gp16 [].
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Protein Domain
IPR005335 | Terminase_ssu
Type: Family
Description: Packaging of double-stranded viral DNA concatemers requires interaction of the prohead with virus DNA. This process is mediated by a phage-encoded DNA recognition and terminase protein. The terminase enzymes described so far, which are hetero-oligomers composed of a small and a large subunit, do not have a significant level of sequence homology. The small terminase subunit is thought to form a nucleoprotein structure that helps to position the terminase large subunit at the packaging initiation site []. The small terminase protein is essential for the initial recognition of viral DNA and regulates the motor's ATPase and nuclease activities during DNA translocation []and for switching between viral DNA replication and packaging. DNA packaging in tailed bacteriophages and in evolutionarily related herpesviruses is controlled by a viral-encoded terminase. The terminase complex characterised in Bacillus subtilis bacteriophages SF6 and SPP1 consists of two proteins: G1P and G2P [, ].
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Protein Domain
IPR037869 | Spp1/CFP1
Type: Family
Description: Spp1 is a component of the COMPASS (Set1C) complex []. It promotes meiotic DNA double-strand break formation in promoters by tethering histone H3K4 methylation sites to chromosome axes []. This entry also includes CXXC-type zinc finger protein 1 (also known as CFP1) from animals [].CXXC-type zinc finger protein 1 (CXXC1 or CFP1) is a component of the SETD1 histone H3K4 methyltransferase complex. CXXC1 directs the complex to a chromatin region via its CXXC zinc finger with a specificity for a CpG unmethylated motif, particularly CpGG [, ].The COMPASS (Complex Proteins Associated with Set1 or Set1C) is the yeast homologue of the human MLL complex, which is required for mono-, di-, and trimethylation of lysine 4 of histone H3 []. It is required in telomeric transcriptional silencing []. The complex consists of Set1, Bre2, Spp1, Sdc1, Shg1, Swd1, Swd2, and Swd3 [, ].
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Protein Domain
IPR008767 | Phage_SPP1_head-tail_adaptor
Type: Family
Description: This entry describes the head-tail adaptor protein of bacteriophage SPP1and related proteins in other bacteriophage and prophage regions of bacterial genomes. Homologues are also found in Gene Transfer Agents (GTA) [], including ORFg7 (RCAP_rcc01689) of the GTA of Rhodobacter capsulatus (Rhodopseudomonas capsulata) [].In bacteriophage SPP1, the gp16 protein functions as a stopper, locking the viral DNA into the capsid. When the tail attachment binds to the entry receptor, gp16 opens by a diaphragm-like motion, allowing the genome to exit the capsid through the tail tube to the host cell. During virion assembly, gp16 functions as a docking platform to which the preassembled tail binds [].The SPP1 head-to-tail connector is composed of cyclical dodecamers of the portal protein gp6 and of the 2 head completion proteins gp15 and gp16 [].
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Strain
MGI:5491925 | B6Rcc.Cg-Spp1<tm1Rit> Apc<Min>/Cnrm
Attribute String: congenic, mutant strain, spontaneous mutation, targeted mutation
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Strain
MGI:4365384 | 129S/SvEv-Spp1<tm1Blh> Umod<tm1Xrw>
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:4835172 | B6Rcc.129-Cd44<tm1.1Ugu> Spp1<tm1Rit>/Cnrm
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5002495 | B6Rcc.129-Spp1<tm1Rit> Cd44<tm2.1Ugu>/Cnrm
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Mgp/Mgp Spp1/Spp1
Background: involves: Black Swiss * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mgp/Mgp Spp1/Spp1<+>
Background: involves: Black Swiss * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mgp/Mgp<+> Spp1/Spp1
Background: involves: Black Swiss * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alpl/Alpl Spp1/Spp1
Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dmd/? Spp1/Spp1
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dmd/Dmd Spp1/Spp1
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Spp1/Spp1
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Spp1/Spp1<+>
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Spp1/Spp1 Umod/Umod
Background: 129S/SvEv-Spp1 Umod
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Spp1/Spp1<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Spp1/Spp1
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alpl/Alpl Spp1/Spp1
Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
22207627 | -
First Author: Büttner CR
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for DNA recognition and loading into a viral packaging motor.
Volume: 109
Issue: 3
Pages: 811-6
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Publication
22858866 | -
First Author: Zhao H
Year: 2012
Journal: J Mol Biol
Title: Structural and functional studies of the phage Sf6 terminase small subunit reveal a DNA-spooling device facilitated by structural plasticity.
Volume: 423
Issue: 3
Pages: 413-26
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Publication
23545641 | -
First Author: Benini S
Year: 2013
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun
Title: The 1.58 Å resolution structure of the DNA-binding domain of bacteriophage SF6 small terminase provides new hints on DNA binding.
Volume: 69
Issue: Pt 4
Pages: 376-81
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Publication
11805083 | -
First Author: Krogan NJ
Year: 2002
Journal: J Biol Chem
Title: COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.
Volume: 277
Issue: 13
Pages: 10753-5
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Publication
30365547 | J:267768
First Author: Tian H
Year: 2018
Journal: PLoS Genet
Title: CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse.
Volume: 14
Issue: 10
Pages: e1007657
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Publication
16306063 | J:104560
First Author: Turk R
Year: 2006
Journal: FASEB J
Title: Common pathological mechanisms in mouse models for muscular dystrophies.
Volume: 20
Issue: 1
Pages: 127-9
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Publication
19805226 | J:153245
First Author: Shimatani K
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia.
Volume: 106
Issue: 37
Pages: 15807-12
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Publication
21289624 | J:262076
First Author: Ding Z
Year: 2011
Journal: Nature
Title: SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.
Volume: 470
Issue: 7333
Pages: 269-73
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Publication
31619583 | J:309000
 
First Author: Katholnig K
Year: 2019
Journal: JCI Insight
Title: Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
Volume: 4
Issue: 20
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Publication
17636175 | J:123303
First Author: Herington JL
Year: 2007
Journal: Reproduction
Title: The conceptus increases secreted phosphoprotein 1 gene expression in the mouse uterus during the progression of decidualization mainly due to its effects on uterine natural killer cells.
Volume: 133
Issue: 6
Pages: 1213-21
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Publication
39730092 | J:361248
 
First Author: Rajput M
Year: 2024
Journal: Brain Behav Immun
Title: Cognitive decline and neuroinflammation in a mouse model of obesity: An accelerating role of ageing.
Volume: 125
Pages: 226-239
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Publication
35799541 | J:348653
First Author: Fu XX
Year: 2023
Journal: Neural Regen Res
Title: Lamotrigine protects against cognitive deficits, synapse and nerve cell damage, and hallmark neuropathologies in a mouse model of Alzheimer's disease.
Volume: 18
Issue: 1
Pages: 189-193
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Publication
28527011 | J:320904
First Author: Imai Y
Year: 2017
Journal: Chromosoma
Title: The PRDM9 KRAB domain is required for meiosis and involved in protein interactions.
Volume: 126
Issue: 6
Pages: 681-695
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Publication
36076283 | J:330823
First Author: Shi H
Year: 2022
Journal: Acta Neuropathol Commun
Title: Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3(+) neurodegenerative microglia.
Volume: 10
Issue: 1
Pages: 136
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Publication
29945938 | J:326555
First Author: Xiao P
Year: 2018
Journal: Blood Adv
Title: Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice.
Volume: 2
Issue: 12
Pages: 1480-1494
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Publication
23886891 | J:200076
First Author: Tsukui T
Year: 2013
Journal: Am J Pathol
Title: Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis.
Volume: 183
Issue: 3
Pages: 758-73
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Publication
34412701 | J:311303
First Author: Hunter M
Year: 2021
Journal: Acta Neuropathol Commun
Title: Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery.
Volume: 9
Issue: 1
Pages: 140
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Publication
9823334 | J:50948
First Author: Crawford HC
Year: 1998
Journal: Cancer Res
Title: Distinct roles of osteopontin in host defense activity and tumor survival during squamous cell carcinoma progression in vivo.
Volume: 58
Issue: 22
Pages: 5206-15
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Publication
17183687 | J:129394
 
First Author: Graefe SE
Year: 2006
Journal: PLoS One
Title: Genes from Chagas susceptibility loci that are differentially expressed in T. cruzi-resistant mice are candidates accounting for impaired immunity.
Volume: 1
Pages: e57
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Publication
20798685 | J:186981
First Author: Lépine S
Year: 2011
Journal: Cell Death Differ
Title: Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.
Volume: 18
Issue: 2
Pages: 350-61
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Publication
34336839 | J:308303
 
First Author: Shao C
Year: 2021
Journal: Front Cell Dev Biol
Title: Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland.
Volume: 9
Pages: 691050
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Publication
37957201 | J:342628
First Author: Mori K
Year: 2023
Journal: Sci Rep
Title: Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice.
Volume: 13
Issue: 1
Pages: 19768
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Strain
MGI:4835175 | B6Rcc.129-Cd44<tm1Ugu> Spp1<tm1Rit>/Cnrm
Attribute String: targeted mutation, mutant strain, congenic
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Publication
22922013 | J:303295
First Author: Español-Suñer R
Year: 2012
Journal: Gastroenterology
Title: Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice.
Volume: 143
Issue: 6
Pages: 1564-1575.e7
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Publication
31027317 | J:303280
 
First Author: Lesaffer B
Year: 2019
Journal: Cells
Title: Comparison of the Opn-CreER and Ck19-CreER Drivers in Bile Ducts of Normal and Injured Mouse Livers.
Volume: 8
Issue: 4
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Genotype
Genotype
Symbol: Aprt/Aprt Spp1/Spp1
Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Spp1-icre/ERT2)#Lecl/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
10688657 | -
First Author: Voo KS
Year: 2000
Journal: Mol Cell Biol
Title: Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.
Volume: 20
Issue: 6
Pages: 2108-21
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Publication
16168379 | -
First Author: Schneider J
Year: 2005
Journal: Mol Cell
Title: Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression.
Volume: 19
Issue: 6
Pages: 849-56
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Protein Domain
IPR038713 | Terminase_Gp1_N_sf
Type: Homologous_superfamily
Description: Packaging of double-stranded viral DNA concatemers requires interaction of the prohead with virus DNA. This process is mediated by a phage-encoded DNA recognition and terminase protein. The terminase enzymes described so far, which are hetero-oligomers composed of a small and a large subunit, do not have a significant level of sequence homology. The small terminase subunit is thought to form a nucleoprotein structure that helps to position the terminase large subunit at the packaging initiation site []. The small terminase protein is essential for the initial recognition of viral DNA and regulates the motor's ATPase and nuclease activities during DNA translocation []and for switching between viral DNA replication and packaging. DNA packaging in tailed bacteriophages and in evolutionarily related herpesviruses is controlled by a viral-encoded terminase. The terminase complex characterised in Bacillus subtilis bacteriophages SF6 and SPP1 consists of two proteins: G1P and G2P [, ].This entry represents the N-terminal domain of the terminase small subunit, which contains a HTH DNA-binding motif []. The first three helices of G1P form the typical helix-turn-helix DNA-binding motif, which is followed by a fourth helix. The fourth helix acts as a linker between the DNA-binding domain and the oligomerization domain [].
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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