|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1701 to 1800 out of 2731 for Akt1

<< First    < Previous  |  Next >    Last >>
0.017s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
25449280 | J:220284
First Author: Yang L
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Stem cell factor (SCF) protects osteoblasts from oxidative stress through activating c-Kit-Akt signaling.
Volume: 455
Issue: 3-4
Pages: 256-61
•
•
•
•
•
Publication
27450812 | J:238873
First Author: Pei B
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway.
Volume: 478
Issue: 1
Pages: 199-205
•
•
•
•
•
Publication
27076519 | J:246198
First Author: Xu Y
Year: 2016
Journal: J Cell Sci
Title: Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.
Volume: 129
Issue: 10
Pages: 2085-95
•
•
•
•
•
Publication
29269414 | J:258439
First Author: Sun S
Year: 2018
Journal: J Biol Chem
Title: Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes.
Volume: 293
Issue: 7
Pages: 2383-2394
•
•
•
•
•
Publication
28481866 | J:247825
First Author: Xin B
Year: 2017
Journal: Oncogene
Title: Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways.
Volume: 36
Issue: 36
Pages: 5087-5097
•
•
•
•
•
Publication
30499878 | J:295616
First Author: Hong J
Year: 2019
Journal: Shock
Title: Pharmacological Inhibition of PTEN Restores Remote Ischemic Postconditioning Cardioprotection in Hypercholesterolemic Mice: Potential Role of PTEN/AKT/GSK3β SIGNALS.
Volume: 52
Issue: 5
Pages: 522-531
•
•
•
•
•
Publication
24296537 | J:315326
First Author: Tan SH
Year: 2014
Journal: Autophagy
Title: Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.
Volume: 10
Issue: 2
Pages: 226-42
•
•
•
•
•
Publication
25612735 | J:318304
First Author: Nurminskaya M
Year: 2014
Journal: J Vasc Res
Title: Transglutaminase 2 promotes PDGF-mediated activation of PDGFR/Akt1 and β-catenin signaling in vascular smooth muscle cells and supports neointima formation.
Volume: 51
Issue: 6
Pages: 418-28
•
•
•
•
•
Publication
27919004 | J:331004
 
First Author: Zhong J
Year: 2017
Journal: Int Immunopharmacol
Title: Irbesartan ameliorates hyperlipidemia and liver steatosis in type 2 diabetic db/db mice via stimulating PPAR-γ, AMPK/Akt/mTOR signaling and autophagy.
Volume: 42
Pages: 176-184
•
•
•
•
•
Publication
27910071 | J:320634
 
First Author: Joshi A
Year: 2017
Journal: Adv Exp Med Biol
Title: PI3K/PTEN/AKT Genetic Mouse Models of Endometrial Carcinoma.
Volume: 943
Pages: 261-273
•
•
•
•
•
Publication
37429524 | J:344659
 
First Author: Mukherjee S
Year: 2023
Journal: Mol Metab
Title: Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo.
Volume: 75
Pages: 101767
•
•
•
•
•
Publication
37611643 | J:340592
 
First Author: Zhu H
Year: 2023
Journal: Biochem Pharmacol
Title: CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis.
Volume: 215
Pages: 115753
•
•
•
•
•
Publication
12783884 | J:85181
First Author: Yang ZZ
Year: 2003
Journal: J Biol Chem
Title: Protein kinase B alpha/Akt1 regulates placental development and fetal growth.
Volume: 278
Issue: 34
Pages: 32124-31
•
•
•
•
•
Publication
16792529 | J:225409
First Author: Fritzius T
Year: 2006
Journal: Biochem J
Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
Volume: 399
Issue: 1
Pages: 9-20
•
•
•
•
•
Publication
18160256 | J:213903
First Author: Nawa M
Year: 2008
Journal: Cell Signal
Title: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.
Volume: 20
Issue: 3
Pages: 493-505
•
•
•
•
•
Publication
19778506 | J:154919
First Author: Kim JY
Year: 2009
Journal: Neuron
Title: DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
Volume: 63
Issue: 6
Pages: 761-73
•
•
•
•
•
Publication
24156551 | J:213891
 
First Author: Nawa M
Year: 2013
Journal: BMC Biochem
Title: KCTD20, a relative of BTBD10, is a positive regulator of Akt.
Volume: 14
Pages: 27
•
•
•
•
•
Publication
19122674 | J:145752
First Author: Luan B
Year: 2009
Journal: Nature
Title: Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
Volume: 457
Issue: 7233
Pages: 1146-9
•
•
•
•
•
Publication
22959435 | J:261829
First Author: Yang T
Year: 2012
Journal: Cell Rep
Title: POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.
Volume: 2
Issue: 3
Pages: 640-51
•
•
•
•
•
Publication
17141160 | J:137592
First Author: Guertin DA
Year: 2006
Journal: Dev Cell
Title: Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Volume: 11
Issue: 6
Pages: 859-71
•
•
•
•
•
Publication
17640867 | J:124931
First Author: Chew V
Year: 2007
Journal: J Biol Chem
Title: Leupaxin negatively regulates B cell receptor signaling.
Volume: 282
Issue: 37
Pages: 27181-91
•
•
•
•
•
Publication
22187460 | J:180126
First Author: Troutman TD
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt.
Volume: 109
Issue: 1
Pages: 273-8
•
•
•
•
•
Publication
31442424 | J:281991
First Author: Jung SM
Year: 2019
Journal: Mol Cell
Title: Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
Volume: 75
Issue: 4
Pages: 807-822.e8
•
•
•
•
•
Publication
19744960 | J:153971
First Author: Giovannone B
Year: 2009
Journal: Hum Mol Genet
Title: GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.
Volume: 18
Issue: 23
Pages: 4629-39
•
•
•
•
•
Publication
23839944 | J:203449
First Author: Berry DC
Year: 2013
Journal: J Biol Chem
Title: The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.
Volume: 288
Issue: 34
Pages: 24528-39
•
•
•
•
•
Publication
17043309 | J:113443
First Author: Yang Q
Year: 2006
Journal: Genes Dev
Title: Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
Volume: 20
Issue: 20
Pages: 2820-32
•
•
•
•
•
Publication
22734004 | J:185346
First Author: Marshall JL
Year: 2012
Journal: J Cell Biol
Title: Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration.
Volume: 197
Issue: 7
Pages: 1009-27
•
•
•
•
•
Publication
23695157 | J:201107
First Author: Al-Qusairi L
Year: 2013
Journal: FASEB J
Title: Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways.
Volume: 27
Issue: 8
Pages: 3384-94
•
•
•
•
•
Publication
18227156 | J:134206
First Author: Qiao G
Year: 2008
Journal: Mol Cell Biol
Title: T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
Volume: 28
Issue: 7
Pages: 2470-80
•
•
•
•
•
Publication
19543271 | J:154956
First Author: Kato M
Year: 2009
Journal: Nat Cell Biol
Title: TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN.
Volume: 11
Issue: 7
Pages: 881-9
•
•
•
•
•
Publication
29301787 | J:277053
First Author: Sudhahar V
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.
Volume: 38
Issue: 3
Pages: 529-541
•
•
•
•
•
Publication
27649495 | J:251510
First Author: Bruder-Nascimento T
Year: 2016
Journal: PLoS One
Title: Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3.
Volume: 11
Issue: 9
Pages: e0162731
•
•
•
•
•
Publication
22975078 | J:193789
First Author: Li Q
Year: 2013
Journal: Mol Cell Endocrinol
Title: Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes.
Volume: 365
Issue: 1
Pages: 25-35
•
•
•
•
•
Publication
16513828 | J:129482
First Author: Luque RM
Year: 2006
Journal: Endocrinology
Title: Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function.
Volume: 147
Issue: 6
Pages: 2754-63
•
•
•
•
•
Publication
23832089 | J:199992
First Author: Pajvani UB
Year: 2013
Journal: Nat Med
Title: Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.
Volume: 19
Issue: 8
Pages: 1054-60
•
•
•
•
•
Publication
25730471 | J:220886
First Author: Jeffery E
Year: 2015
Journal: Nat Cell Biol
Title: Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
Volume: 17
Issue: 4
Pages: 376-85
•
•
•
•
•
Publication
22581458 | J:189042
First Author: Taguchi K
Year: 2012
Journal: Endocrinology
Title: Inhibitor of G protein-coupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving β-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction.
Volume: 153
Issue: 7
Pages: 2985-96
•
•
•
•
•
Publication
28322786 | J:251423
First Author: Zhao J
Year: 2017
Journal: Biochem Biophys Res Commun
Title: ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.
Volume: 486
Issue: 4
Pages: 865-871
•
•
•
•
•
Publication
25576887 | J:234539
First Author: Mohammed Abdul KS
Year: 2015
Journal: Biochim Biophys Acta
Title: Mild hypoxia in vivo regulates cardioprotective SUR2A: A role for Akt and LDH.
Volume: 1852
Issue: 5
Pages: 709-19
•
•
•
•
•
Publication
26107252 | J:228671
First Author: Wilson JE
Year: 2015
Journal: Nat Med
Title: Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Volume: 21
Issue: 8
Pages: 906-13
•
•
•
•
•
Publication
24789910 | J:212927
First Author: Alexander MS
Year: 2014
Journal: J Clin Invest
Title: MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms.
Volume: 124
Issue: 6
Pages: 2651-67
•
•
•
•
•
Publication
24667640 | J:212771
First Author: Koga T
Year: 2014
Journal: J Clin Invest
Title: CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.
Volume: 124
Issue: 5
Pages: 2234-45
•
•
•
•
•
Publication
35581352 | J:326260
First Author: Di Pietro C
Year: 2022
Journal: Exp Mol Med
Title: Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis.
Volume: 54
Issue: 5
Pages: 639-652
•
•
•
•
•
Publication
19483717 | J:150139
First Author: Liu G
Year: 2009
Journal: Nat Immunol
Title: The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
Volume: 10
Issue: 7
Pages: 769-77
•
•
•
•
•
Publication
22383528 | J:184361
First Author: Qin J
Year: 2012
Journal: J Biol Chem
Title: Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt.
Volume: 287
Issue: 17
Pages: 13620-32
•
•
•
•
•
Publication
23410496 | J:251024
First Author: Salles MJ
Year: 2013
Journal: J Neurochem
Title: Transient and rapid activation of Akt/GSK-3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens.
Volume: 125
Issue: 4
Pages: 532-44
•
•
•
•
•
Publication
32580946 | J:299143
First Author: Baine S
Year: 2020
Journal: J Biol Chem
Title: Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling.
Volume: 295
Issue: 33
Pages: 11720-11728
•
•
•
•
•
Publication
16886062 | J:113106
First Author: Cauwels A
Year: 2006
Journal: J Clin Invest
Title: Anaphylactic shock depends on PI3K and eNOS-derived NO.
Volume: 116
Issue: 8
Pages: 2244-51
•
•
•
•
•
Publication
23749633 | J:204828
First Author: Qiao G
Year: 2013
Journal: J Immunol
Title: T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells.
Volume: 191
Issue: 2
Pages: 632-9
•
•
•
•
•
Publication
25482987 | J:218850
First Author: Bisson JA
Year: 2015
Journal: Dev Biol
Title: Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.
Volume: 398
Issue: 1
Pages: 80-96
•
•
•
•
•
Publication
14561707 | J:162300
First Author: Zhang H
Year: 2003
Journal: J Clin Invest
Title: Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.
Volume: 112
Issue: 8
Pages: 1223-33
•
•
•
•
•
Publication
25168244 | J:230207
First Author: Salazar M
Year: 2015
Journal: Cell Death Differ
Title: Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.
Volume: 22
Issue: 1
Pages: 131-44
•
•
•
•
•
Publication
14691534 | J:86212
First Author: Trotman LC
Year: 2003
Journal: PLoS Biol
Title: Pten dose dictates cancer progression in the prostate.
Volume: 1
Issue: 3
Pages: E59
•
•
•
•
•
Publication
15967113 | J:100163
First Author: Hu X
Year: 2005
Journal: Neoplasia
Title: mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.
Volume: 7
Issue: 4
Pages: 356-68
•
•
•
•
•
Publication
16204028 | J:101604
First Author: Li Q
Year: 2005
Journal: Cancer Res
Title: The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.
Volume: 65
Issue: 19
Pages: 8622-7
•
•
•
•
•
Publication
20708588 | J:163669
First Author: Ashton GH
Year: 2010
Journal: Dev Cell
Title: Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
Volume: 19
Issue: 2
Pages: 259-69
•
•
•
•
•
Publication
19250983 | J:148189
First Author: Yan F
Year: 2009
Journal: Gastroenterology
Title: Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.
Volume: 136
Issue: 4
Pages: 1297-1307, e1-3
•
•
•
•
•
Publication
26453307 | J:228576
First Author: Singh BK
Year: 2016
Journal: J Biol Chem
Title: Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
Volume: 291
Issue: 1
Pages: 198-214
•
•
•
•
•
Publication
23142783 | J:190868
First Author: Gulen MF
Year: 2012
Journal: Immunity
Title: Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.
Volume: 37
Issue: 5
Pages: 800-12
•
•
•
•
•
Publication
14730361 | J:87871
First Author: Song J
Year: 2004
Journal: Nat Immunol
Title: The costimulation-regulated duration of PKB activation controls T cell longevity.
Volume: 5
Issue: 2
Pages: 150-8
•
•
•
•
•
Publication
15280422 | J:93924
First Author: Vivarelli MS
Year: 2004
Journal: J Exp Med
Title: RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation.
Volume: 200
Issue: 3
Pages: 399-404
•
•
•
•
•
Publication
22131333 | J:180812
First Author: Moon JB
Year: 2012
Journal: J Immunol
Title: Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade.
Volume: 188
Issue: 1
Pages: 163-9
•
•
•
•
•
Publication
26974342 | J:231148
 
First Author: Guo X
Year: 2016
Journal: Elife
Title: GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway.
Volume: 5
Pages: e11903
•
•
•
•
•
Publication
21239436 | J:173881
First Author: Hughes E
Year: 2011
Journal: Endocrinology
Title: Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferation.
Volume: 152
Issue: 3
Pages: 847-55
•
•
•
•
•
Publication
24213576 | J:216271
First Author: Zhu B
Year: 2014
Journal: Oncogene
Title: PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling.
Volume: 33
Issue: 46
Pages: 5348-59
•
•
•
•
•
Publication
23538858 | J:205462
First Author: Jin F
Year: 2013
Journal: Mol Cancer Res
Title: ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity.
Volume: 11
Issue: 7
Pages: 736-47
•
•
•
•
•
Publication
22553040 | J:267936
First Author: Duan B
Year: 2012
Journal: J Neurosci
Title: PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity.
Volume: 32
Issue: 18
Pages: 6351-63
•
•
•
•
•
Publication
24642468 | J:209590
First Author: Li J
Year: 2014
Journal: J Clin Invest
Title: Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation.
Volume: 124
Issue: 4
Pages: 1483-96
•
•
•
•
•
Publication
35878016 | J:336519
 
First Author: Simoes DCM
Year: 2022
Journal: J Cell Biol
Title: An integrin axis induces IFN-β production in plasmacytoid dendritic cells.
Volume: 221
Issue: 9
•
•
•
•
•
Publication
17181553 | J:119645
First Author: Thomson RE
Year: 2007
Journal: J Neurochem
Title: Fibroblast growth factor receptor 3 kinase domain mutation increases cortical progenitor proliferation via mitogen-activated protein kinase activation.
Volume: 100
Issue: 6
Pages: 1565-78
•
•
•
•
•
Publication
16286931 | J:103933
First Author: Tavazoie SF
Year: 2005
Journal: Nat Neurosci
Title: Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2.
Volume: 8
Issue: 12
Pages: 1727-34
•
•
•
•
•
Publication
24857423 | J:244250
First Author: Iyer S
Year: 2014
Journal: Stem Cells Dev
Title: SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis.
Volume: 23
Issue: 19
Pages: 2336-51
•
•
•
•
•
Publication
29046360 | J:270161
First Author: Wang L
Year: 2018
Journal: FASEB J
Title: A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.
Volume: 32
Issue: 2
Pages: 875-887
•
•
•
•
•
Publication
26302789 | J:226418
First Author: Caserta E
Year: 2015
Journal: Genes Dev
Title: Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.
Volume: 29
Issue: 16
Pages: 1707-20
•
•
•
•
•
Publication
26487685 | J:227271
First Author: Gao YQ
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance.
Volume: 112
Issue: 44
Pages: 13627-32
•
•
•
•
•
Publication
27697523 | J:240558
First Author: Kurebayashi Y
Year: 2016
Journal: Biochem Biophys Res Commun
Title: TGF-β-induced phosphorylation of Akt and Foxo transcription factors negatively regulates induced regulatory T cell differentiation.
Volume: 480
Issue: 1
Pages: 114-119
•
•
•
•
•
Publication
23673657 | J:199655
First Author: Rajala A
Year: 2013
Journal: J Biol Chem
Title: Insulin receptor signaling in cones.
Volume: 288
Issue: 27
Pages: 19503-15
•
•
•
•
•
Publication
28350865 | J:246983
First Author: Le B
Year: 2017
Journal: PLoS One
Title: Multi-drug loaded micelles delivering chemotherapy and targeted therapies directed against HSP90 and the PI3K/AKT/mTOR pathway in prostate cancer.
Volume: 12
Issue: 3
Pages: e0174658
•
•
•
•
•
Publication
23520049 | J:196198
First Author: Yeh ES
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten.
Volume: 110
Issue: 15
Pages: 6103-8
•
•
•
•
•
Publication
25646773 | J:229053
First Author: Kenerson HL
Year: 2015
Journal: PLoS One
Title: Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt.
Volume: 10
Issue: 2
Pages: e0117000
•
•
•
•
•
Publication
24481416 | J:206951
First Author: Sun C
Year: 2014
Journal: Neuroreport
Title: PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice.
Volume: 25
Issue: 3
Pages: 177-83
•
•
•
•
•
Publication
23376645 | J:311794
First Author: Kenerson HL
Year: 2013
Journal: Gastroenterology
Title: Akt and mTORC1 have different roles during liver tumorigenesis in mice.
Volume: 144
Issue: 5
Pages: 1055-65
•
•
•
•
•
Publication
26442967 | J:227645
 
First Author: Yuzugullu H
Year: 2015
Journal: Nat Commun
Title: A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis.
Volume: 6
Pages: 8501
•
•
•
•
•
Publication
24466179 | J:212559
First Author: Moriishi T
Year: 2014
Journal: PLoS One
Title: Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation.
Volume: 9
Issue: 1
Pages: e86629
•
•
•
•
•
Publication
34385359 | J:326435
First Author: Wang H
Year: 2021
Journal: J Neurosci
Title: Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
Volume: 41
Issue: 39
Pages: 8163-8180
•
•
•
•
•
Publication
27746098 | J:240762
First Author: Rivera-Gonzalez GC
Year: 2016
Journal: Cell Stem Cell
Title: Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis.
Volume: 19
Issue: 6
Pages: 738-751
•
•
•
•
•
Publication
17942753 | J:130058
First Author: Woodland RT
Year: 2008
Journal: Blood
Title: Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.
Volume: 111
Issue: 2
Pages: 750-60
•
•
•
•
•
Publication
24670654 | J:210466
First Author: Liu P
Year: 2014
Journal: Nature
Title: Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Volume: 508
Issue: 7497
Pages: 541-5
•
•
•
•
•
Publication
27170189 | J:233892
First Author: Itoh Y
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex.
Volume: 113
Issue: 21
Pages: E2955-64
•
•
•
•
•
Publication
27568561 | J:239020
First Author: Forand A
Year: 2016
Journal: Cell Rep
Title: Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction.
Volume: 16
Issue: 10
Pages: 2736-2748
•
•
•
•
•
Publication
22521878 | J:184605
First Author: Hagiwara A
Year: 2012
Journal: Cell Metab
Title: Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Volume: 15
Issue: 5
Pages: 725-38
•
•
•
•
•
Publication
18845810 | J:155283
First Author: Piantadosi CA
Year: 2008
Journal: Circ Res
Title: Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1.
Volume: 103
Issue: 11
Pages: 1232-40
•
•
•
•
•
Publication
17989209 | J:130507
First Author: Albinsson S
Year: 2008
Journal: Am J Physiol Cell Physiol
Title: Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall.
Volume: 294
Issue: 1
Pages: C271-9
•
•
•
•
•
Publication
18832587 | J:143429
First Author: Nagaike K
Year: 2008
Journal: Am J Pathol
Title: Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.
Volume: 173
Issue: 5
Pages: 1464-75
•
•
•
•
•
Publication
22814751 | J:201481
First Author: O'Brien KA
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.
Volume: 32
Issue: 9
Pages: 2232-40
•
•
•
•
•
Publication
36982451 | J:334510
 
First Author: Ramezanidoraki N
Year: 2023
Journal: Int J Mol Sci
Title: Activation of the PI3K/AKT/mTOR Pathway in Cajal-Retzius Cells Leads to Their Survival and Increases Susceptibility to Kainate-Induced Seizures.
Volume: 24
Issue: 6
•
•
•
•
•
Publication
19470613 | J:149829
First Author: Ljungberg MC
Year: 2009
Journal: Dis Model Mech
Title: Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.
Volume: 2
Issue: 7-8
Pages: 389-98
•
•
•
•
•
Publication
23995785 | J:256658
First Author: Bjerke GA
Year: 2014
Journal: Oncogene
Title: Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis.
Volume: 33
Issue: 28
Pages: 3660-7
•
•
•
•
•
Publication
21135130 | J:170424
First Author: Long YC
Year: 2011
Journal: Mol Cell Biol
Title: Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.
Volume: 31
Issue: 3
Pages: 430-41
•
•
•
•
•
Publication
20083607 | J:161077
First Author: Trazzi S
Year: 2010
Journal: J Biol Chem
Title: CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling.
Volume: 285
Issue: 13
Pages: 10098-109
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom