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Search results 1701 to 1800 out of 4306 for C3

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Type Details Score
Publication
20974804 | J:169711
First Author: Wallace SW
Year: 2011
Journal: Mol Cell Biol
Title: The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.
Volume: 31
Issue: 1
Pages: 81-91
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Publication
22959435 | J:261829
First Author: Yang T
Year: 2012
Journal: Cell Rep
Title: POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.
Volume: 2
Issue: 3
Pages: 640-51
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HT Experiment
GSE255296 | Single Cell Transcriptomic Profiling of MYBPC3-associated Hypertrophic Cardiomyopathy Across Species Reveals Conservation of Biological Process but Not Gene Expression
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
2256941 | -
First Author: Sugai M
Year: 1990
Journal: Biochem Biophys Res Commun
Title: A novel epidermal cell differentiation inhibitor (EDIN): purification and characterization from Staphylococcus aureus.
Volume: 173
Issue: 1
Pages: 92-8
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Publication
2108433 | -
First Author: Popoff M
Year: 1990
Journal: Nucleic Acids Res
Title: DNA sequence of exoenzyme C3, an ADP-ribosyltransferase encoded by Clostridium botulinum C and D phages.
Volume: 18
Issue: 5
Pages: 1291
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Protein Domain
IPR016678 | Mono-ADP_RibTrfase_C3/Edin
Type: Family
Description: This group represents a group of mono-ADP-ribosyltransferases, including Edin (epidermal cell differentiation inhibitor) from Staphylococcus aureus and C3 from phage. Edin inhibits terminal differentiation of cultured mouse keratinocytes []. C3 is an ADP-ribosyltransferase [, ].
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QTL
MGI:96981 | Micrl
Type: QTL
Organism: mouse, laboratory
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Protein
P06684
Organism: Mus musculus/domesticus
Length: 1680  
Fragment?: false
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Protein
P01029
Organism: Mus musculus/domesticus
Length: 1738  
Fragment?: false
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Publication
8760305 | J:34966
First Author: Pelicci G
Year: 1996
Journal: Oncogene
Title: A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.
Volume: 13
Issue: 3
Pages: 633-41
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Publication
23345394 | J:198061
First Author: Savino MT
Year: 2013
Journal: J Leukoc Biol
Title: The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development.
Volume: 93
Issue: 4
Pages: 549-59
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Publication
25795214 | J:253115
First Author: Han J
Year: 2015
Journal: Diabetes
Title: Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis.
Volume: 64
Issue: 8
Pages: 2892-904
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Publication
27707963 | J:235937
First Author: Beauvais G
Year: 2016
Journal: J Neurosci
Title: Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.
Volume: 36
Issue: 40
Pages: 10245-10256
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Publication
24275136 | J:211890
First Author: Gomez JA
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Synthetic embryonic lethality upon deletion of the ER cochaperone p58(IPK) and the ER stress sensor ATF6α.
Volume: 443
Issue: 1
Pages: 115-9
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Publication
18923430 | J:156044
First Author: Petrova K
Year: 2008
Journal: EMBO J
Title: Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3.
Volume: 27
Issue: 21
Pages: 2862-72
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Allele
Pcdhg<em3Rwb> | MGI:5644502
Name: protocadherin gamma cluster; endonuclease-mediated mutation 3, Robert W Burgess
Allele Type: Endonuclease-mediated
Attribute String: Modified isoform(s)
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Strain
MGI:6428276 | C57BL/6JSmoc-C3<em1(C3)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6428277 | C57BL/6JSmoc-C3<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7577277 | C57BL/6JGpt-Tg(C3)123Gpt/Gpt
Attribute String: coisogenic, mutant strain, transgenic
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Ontology Term
- | Flavonoid biosynthesis
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Allele
Micrl<R> | MGI:5014255
 
Name: microwave induced increase in complement receptor B cells; responder
Allele Type: QTL
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Allele
Micrl<n> | MGI:5014256
 
Name: microwave induced increase in complement receptor B cells; non-responder
Allele Type: QTL
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HT Experiment
E-MEXP-1544 | Transcription profiling by array of mice with thyroid hormone receptor alpha or beta knock-out
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
P17981
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: false
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Publication
17116687 | J:118168
First Author: Cho YJ
Year: 2007
Journal: Mol Cell Biol
Title: Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.
Volume: 27
Issue: 3
Pages: 899-911
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Publication
14634666 | -
First Author: Uhlik MT
Year: 2003
Journal: Nat Cell Biol
Title: Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.
Volume: 5
Issue: 12
Pages: 1104-10
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Publication
26969129 | J:238439
 
First Author: Sarowar T
Year: 2016
Journal: Mol Brain
Title: Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.
Volume: 9
Pages: 28
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Publication
10679324 | -
First Author: Tolias KF
Year: 2000
Journal: Curr Biol
Title: Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.
Volume: 10
Issue: 3
Pages: 153-6
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Publication
16831446 | -
First Author: Fredslund F
Year: 2006
Journal: J Mol Biol
Title: The structure of bovine complement component 3 reveals the basis for thioester function.
Volume: 361
Issue: 1
Pages: 115-27
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Publication
19368894 | -
First Author: Krishnan V
Year: 2009
Journal: Structure
Title: The crystal structure of cobra venom factor, a cofactor for C3- and C5-convertase CVFBb.
Volume: 17
Issue: 4
Pages: 611-9
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Protein Domain
IPR035815 | NTR_complement_C3
Type: Domain
Description: The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement systems, as all pathways (classical, alternative, and lectin) result in the processing of C3 by C3 convertase. The larger fragment, activated C3b, contains the NTR/C345C domain and binds covalently, via a reactive thioester, to cell surface carbohydrates including components of bacterial cell walls and immune aggregates. The smaller cleavage product, C3a, acts independently as a diffusible signal to mediate local inflammatory processes. The structure of C3 shows that the NTR/C345C domain is located in an exposed position relative to the rest of the molecule. The function of the domain in complement C3 is poorly understood [, ].This domain is also found in cobra venom factor, a functional analogue of human complement component C3b [].
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Protein Coding Gene
MGI:88228 | C4b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96031 | Hc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR040839 | MG4
Type: Domain
Description: This domain is MG4 found in thioester-containing proteins (TEPs) such as Alpha-2-macroglobulin, complement C3 and C5 and complement-like proteins [, ].
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Publication
17350798 | J:121808
First Author: Tamura M
Year: 2007
Journal: Genomics
Title: Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.
Volume: 89
Issue: 5
Pages: 618-29
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Publication
1623525 | J:17164
First Author: Pelicci G
Year: 1992
Journal: Cell
Title: A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Volume: 70
Issue: 1
Pages: 93-104
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Publication
16923392 | J:115988
First Author: Oyadomari S
Year: 2006
Journal: Cell
Title: Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload.
Volume: 126
Issue: 4
Pages: 727-39
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Publication
19801575 | J:154993
First Author: Zhao L
Year: 2010
Journal: Hum Mol Genet
Title: Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome.
Volume: 19
Issue: 1
Pages: 25-35
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Publication
37988464 | J:349394
First Author: Fattinger SA
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.
Volume: 120
Issue: 48
Pages: e2315503120
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HT Experiment
E-GEOD-18393 | Gene expression of colon from control or VilCre;Ihhflox/flox mice
Series Id: GSE18393
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Igl<tm2Bgmn> | MGI:3701068
Name: immunoglobulin lambda chain complex; targeted mutation 2, Marianne Bruggemann
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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QTL
MGI:88509 | Crl1
Type: QTL
Organism: mouse, laboratory
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Publication
4545163 | J:5442
First Author: Gelfand MC
Year: 1974
Journal: J Exp Med
Title: Ontogeny of B lymphocytes. 3. H-2 linkage of a gene controlling the rate of appearance of complement receptor lymphocytes.
Volume: 139
Issue: 5
Pages: 1142-53
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Ontology Term
- | Calvin cycle
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GO Term
GO:0009854 | oxidative photosynthetic carbon pathway
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GO Term
GO:0080093 | regulation of photorespiration
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Publication
11368914 | -
First Author: Masumoto N
Year: 2001
Journal: Gene
Title: Additional organizational features of the murine gamma-glutamyl hydrolase gene. Two remotely situated exons within the complement C3 gene locus encode an alternate 5' end and proximal ORF under the control of a bidirectional promoter.
Volume: 268
Issue: 1-2
Pages: 183-94
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Publication
11219490 | J:67442
First Author: Shibata MA
Year: 2001
Journal: Cancer Gene Ther
Title: Suppression of mammary carcinoma growth in vitro and in vivo by inducible expression of the Cdk inhibitor p21.
Volume: 8
Issue: 1
Pages: 23-35
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Strain
MGI:2163576 | JGBF/LeTyJ
Attribute String: inbred strain, spontaneous mutation
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Strain
MGI:2161978 | BXH19/TyJ
Attribute String: recombinant inbred (RI)
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Strain
MGI:2163304 | BXH9/TyJ
Attribute String: recombinant inbred (RI)
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Strain
MGI:2162567 | BXH3/TyJ
Attribute String: recombinant inbred (RI)
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Strain
MGI:2162570 | BXH8/TyJ
Attribute String: recombinant inbred (RI)
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Strain
MGI:2162905 | BXH4/TyJ
Attribute String: recombinant inbred (RI)
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Strain
MGI:2161970 | BXH10/TyJ
Attribute String: recombinant inbred (RI)
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Strain
MGI:2162442 | BXH7/TyJ
Attribute String: recombinant inbred (RI)
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Strain
MGI:5049869 | C3HeB/FeN
Attribute String: inbred strain
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Strain
MGI:2163096 | BXH14/TyJ
Attribute String: recombinant inbred (RI)
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Strain
MGI:2162040 | BXH6/TyJ
Attribute String: recombinant inbred (RI)
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Publication
25329545 | J:218404
First Author: Roobol A
Year: 2015
Journal: Biochem J
Title: p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Volume: 465
Issue: 2
Pages: 213-25
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Publication
27239042 | J:238165
First Author: Ozcan L
Year: 2016
Journal: Cell Rep
Title: Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance.
Volume: 15
Issue: 10
Pages: 2214-2225
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Publication
27076121 | J:234800
First Author: Triaca V
Year: 2016
Journal: Aging Cell
Title: NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.
Volume: 15
Issue: 4
Pages: 661-72
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Publication
15705776 | J:98292
First Author: Garlow SJ
Year: 2005
Journal: Endocrinology
Title: Genetic analysis of the hypothalamic corticotropin-releasing factor system.
Volume: 146
Issue: 5
Pages: 2362-8
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Publication
11877420 | J:76516
First Author: Tarr PE
Year: 2002
Journal: J Biol Chem
Title: Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
Volume: 277
Issue: 19
Pages: 16798-804
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Publication
11088019 | J:66125
First Author: Luzi L
Year: 2000
Journal: Curr Opin Genet Dev
Title: Evolution of Shc functions from nematode to human.
Volume: 10
Issue: 6
Pages: 668-74
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Publication
10226653 | J:54708
First Author: Sakaguchi AY
Year: 1998
Journal: Somat Cell Mol Genet
Title: Chromosomal sublocalization of the transcribed human telomere repeat binding factor 2 gene and comparative mapping in the mouse.
Volume: 24
Issue: 3
Pages: 157-63
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Protein Domain
IPR006455 | Homeodomain_ZF_HD
Type: Domain
Description: This entry represents a class of homeobox domain that differs substantially from the typical homeobox domain described in . It is found in both C4 and C3 plants [].
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Allele
Gt(ROSA)26Sor<tm1(RAC1*)Jkis> | MGI:5307896
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Joseph L Kissil
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Strain
MGI:7514868 | B6(CBA)-Pcdhg<em3Rwb>/JaweJ
Attribute String: endonuclease-mediated mutation, mutant strain
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Allele
Cfi<em2Jiwe> | MGI:7507066
Name: complement component factor i; endonuclease-mediated mutation 2, Jiqiu Wen
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Publication
10934475 | J:63704
First Author: Lin D
Year: 2000
Journal: Nat Cell Biol
Title: A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity.
Volume: 2
Issue: 8
Pages: 540-7
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Publication
17403031 | -
First Author: Bourguignon LY
Year: 2007
Journal: J Neurochem
Title: Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes.
Volume: 101
Issue: 4
Pages: 1002-17
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Publication
18676768 | J:142161
First Author: Mustafa A
Year: 2008
Journal: Clin Cancer Res
Title: Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer.
Volume: 14
Issue: 15
Pages: 4935-42
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Publication
37146973 | J:354034
First Author: Li S
Year: 2023
Journal: J Nutr
Title: Paternal Combined Botanicals Contribute to the Prevention of Estrogen Receptor-Negative Mammary Cancer in Transgenic Mice.
Volume: 153
Issue: 7
Pages: 1959-1973
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Strain
MGI:2163891 | JGBF/LeJ
Attribute String: inbred strain, spontaneous mutation
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Pseudogene
MGI:1330351 | Sprr2c-ps
Type: pseudogene
Organism: mouse, laboratory
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GO Term
GO:0032355 | response to estradiol
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GO Term
GO:0071392 | cellular response to estradiol stimulus
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GO Term
GO:0005601 | classical-complement-pathway C3/C5 convertase complex
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GO Term
GO:0051550 | aurone metabolic process
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Publication
12080059 | -
First Author: Leys D
Year: 2002
Journal: J Biol Chem
Title: Crystal structures at atomic resolution reveal the novel concept of "electron-harvesting" as a role for the small tetraheme cytochrome c.
Volume: 277
Issue: 38
Pages: 35703-11
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Protein Domain
IPR012286 | Tetrahaem_cytochrome
Type: Domain
Description: Flavocytochrome C3 (Fcc3) enzymes from a number of Shewanella species, including Shewanella frigidimarina (strain NCIMB 400), have respiratory fumarate reductase activity, which enables the bacteria to respire anaerobically with fumarate as a terminal electron acceptor. Flavocytochrome C3 in S. frigidimarina is a soluble, single chain tetrahaem enzyme found in the periplasm, making it distinct from other bacterial fumarate reductases (), which are membrane-bound, multi-subunit enzymes, even though their function is analogous.Shewanella Fcc3 is composed of three domains: an N-terminal tetrahaem cytochrome domain, a flavin domain and a clamp domain. The cytochrome domain can also occur on its own in some tetrahaem cytochromes implicated in iron oxidation. This entry represents the cytochrome domain, which has a different arrangement of the polypeptide chain in comparison to classical tetra-haem cytochrome C3 [, ].
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Publication
10934474 | J:69174
First Author: Joberty G
Year: 2000
Journal: Nat Cell Biol
Title: The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.
Volume: 2
Issue: 8
Pages: 531-9
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Publication
9875846 | J:51606
First Author: Krautwurst D
Year: 1998
Journal: Cell
Title: Identification of ligands for olfactory receptors by functional expression of a receptor library.
Volume: 95
Issue: 7
Pages: 917-26
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Publication
12922167 | -
First Author: Smith SA
Year: 2003
Journal: Biochim Biophys Acta
Title: Mapping of regions within the vaccinia virus complement control protein involved in dose-dependent binding to key complement components and heparin using surface plasmon resonance.
Volume: 1650
Issue: 1-2
Pages: 30-9
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Publication
20218853 | -
First Author: Paran N
Year: 2010
Journal: Expert Rev Vaccines
Title: Complement-bound human antibodies to vaccinia virus B5 antigen protect mice from virus challenge.
Volume: 9
Issue: 3
Pages: 255-9
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Protein Domain
IPR038597 | GGGP/HepGP_synthase_sf
Type: Homologous_superfamily
Description: This entry represents geranylgeranylglyceryl phosphate (GGGP) synthase and Heptaprenylglyceryl phosphate (HepGP) synthase.GGGP synthase is a prenyltransferase that catalyses the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. This entry also matches putative glycerol-1-phosphate prenyltransferases that may catalyse the transfer of a prenyl moiety to sn-glycerol-1-phosphate (G1P) []. HepGP synthase is a prenyltransferase that catalyses in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP) [].
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Protein Domain
IPR008205 | GGGP_HepGP_synthase
Type: Family
Description: This entry represents geranylgeranylglyceryl phosphate (GGGP) synthase and Heptaprenylglyceryl phosphate (HepGP) synthase.GGGP synthase is a prenyltransferase that catalyses the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. This entry also matches putative glycerol-1-phosphate prenyltransferases that may catalyse the transfer of a prenyl moiety to sn-glycerol-1-phosphate (G1P) []. HepGP synthase is a prenyltransferase that catalyses in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP) [].
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Protein Domain
IPR011176 | CCP_VACV_C3/B5
Type: Family
Description: This group represents complement control proteins, vaccinia virus C3-type. The vaccinia virus complement control protein C3 is involved in modulating the host inflammatory response by blocking both classical and alternative pathways of complement activity through its ability to bind host complement components C3b and C4b (complement 3b and 4b, respectively) []. Protein B5, another member of this group, binds complement components C3 and C1q []. By blocking complement activation at multiple sites, the complement control proteins can down-regulate pro-inflammatory chemotactic factors (C3a, C4a, and C5a), resulting in reduced cellular influx and inflammation..
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Publication
8610109 | J:32205
First Author: O'Bryan JP
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.
Volume: 93
Issue: 7
Pages: 2729-34
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Publication
11167010 | J:67347
First Author: Yoder JA
Year: 2000
Journal: Gene
Title: The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13.
Volume: 261
Issue: 2
Pages: 235-42
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Publication
21117147 | J:166965
First Author: Hawley SP
Year: 2011
Journal: Dev Dyn
Title: Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development.
Volume: 240
Issue: 1
Pages: 221-31
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HT Experiment
E-GEOD-11659 | Comparative analysis of gene expression in 9 BXH RI strains and progenitors (B6 and C3) and BXHF1
Series Id: GSE11659
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Allele
Tcra<tm1Cgn> | MGI:2388328
Name: T cell receptor alpha chain; targeted mutation 1,University of Cologne
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tg(C3-1-TAg)cJeg | MGI:3039067
Name: transgene insertion c, Jeffrey E Green
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Sphk1<tm1Rlp> | MGI:3526071
Name: sphingosine kinase 1; targeted mutation 1, Richard L Proia
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tg(C3-HA)142Dmp | MGI:3717261
Name: transgene insertion 142, Drew M Pardoll
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(C3-HA)137Dmp | MGI:3717263
Name: transgene insertion 137, Drew M Pardoll
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5437478 | B6;129-Gt(ROSA)26Sor<tm1(RAC1*)Jkis>/J
Attribute String: mutant stock, targeted mutation
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Allele
Pcdhg<em31Rwb> | MGI:6285824
Name: protocadherin gamma cluster; endonuclease-mediated mutation 31, Robert W Burgess
Allele Type: Endonuclease-mediated
Attribute String: Modified isoform(s)
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