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Search results 1701 to 1800 out of 2972 for Ca2

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Type Details Score
Publication
17360695 | -
First Author: Nakagawa Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Arabidopsis plasma membrane protein crucial for Ca2+ influx and touch sensing in roots.
Volume: 104
Issue: 9
Pages: 3639-44
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Protein Domain
IPR039010 | Synaptotagmin_SMP
Type: Domain
Description: SMP is a proposed lipid-binding module, ie a synaptotagmin-like mitochondrial-lipid-binding domain found in eukaryotes. The SMP domain has a β-barrel structure like protein modules in the tubular-lipid-binding (TULIP) superfamily. It dimerises to form an approximately 90-Angstrom-long cylinder traversed by a channel lined entirely with hydrophobic residues. The following two C2 domains then form arched structures flexibly linked to the SMP domain. The SMP domain is a lipid-binding domain that links the ER with other lipid bilayer-membranes within the cell [].This entry represents the SMP domain found in plant synaptotagmins []and extended synaptotagmins from metazoa. The extended synaptotagmins transport glycerolipids between the two bilayers via their lipid-harboring SMP domains and Ca2 + regulates their membrane tethering and lipid transport function [].
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Protein Domain
IPR037881 | RGS14_RGS
Type: Domain
Description: RGS14 is a regulator of G protein signaling (RGS) protein. It regulates G protein nucleotide exchange and hydrolysis by acting as a GTPase-activating protein (GAP) through its RGS domain, and as a guanine nucleotide dissociation inhibitor (GDI) through its GoLoco motif [, ]. Both domains of RGS14 target members of the Gialpha subclass []. It is a microtubule-associated protein that may modulate microtubule dynamics and spindle formation []and play an essential role during mammalian cell division []. RGS14 regulates the activation of alphaMbeta2 integrin during phagocytosis []. It is a key regulator of signalling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory [].This entry represents the RGS domain of RGS14.
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Protein Domain
IPR039683 | Lsm12-like
Type: Family
Description: This entry represents Lsm12 and its homologues. Lsm12 is a putative RNA-binding and regulation protein that might be involved in mRNA degradation or tRNA splicing []. Recently, it was demonstrated that it binds nicotinic acid adenine dinucleotide phosphate (NAADP) that confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca2 release []. Therefore, further studies of the potential crosstalk between NAADP signaling and RNA regulation are required.Sm and Sm-like proteins of the Lsm (like Sm) domain family are generally involved in essential RNA-processing tasks []. All the LSM proteins are evolutionarily conserved in eukaryotes with an N-terminal Lsm domain to bind nucleic acids followed by a C-terminal region, some of which have a C-terminal methyltransferase domain.
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Protein Domain
IPR028798 | TPC2
Type: Family
Description: This entry represents TPC2. It modulates neural differentiation of mouse embryonic stem cells []. It may also be involved in smooth muscle contraction []. Two-pore segment channels (TPCs or TPCNs) are located in membranes of acidic intracellular organelles (such as endo-lysosomes and plant vacuoles) and contain two putative pore-forming repeats. Each of these repeats contains six transmembrane segments and an intervening pore-loop, an architecture featured in voltage-gated channels []. Functional TPC channels are assembled from two TPC protein subunits forming a pore that conducts mainly Ca2 and Na. TPCs exist as three isoforms (TPC1-3): TPC1 and TPC2 are the most universal isoforms since TPC3 is absent from the genomes of many animals including those of human, mice, rats and flies [].
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Protein Domain
IPR002048 | EF_hand_dom
Type: Domain
Description: Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both sides by a twelve residue α-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). Ca2 binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers [, , , , ].
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Protein Domain
IPR028801 | TPC1_animal
Type: Family
Description: Two-pore segment channels (TPCs or TPCNs) are located in membranes of acidic intracellular organelles (such as endo-lysosomes and plant vacuoles) and contain two putative pore-forming repeats. Each of these repeats contains six transmembrane segments and an intervening pore-loop, an architecture featured in voltage-gated channels []. Functional TPC channels are assembled from two TPC protein subunits forming a pore that conducts mainly Ca2 and Na. TPCs exist as three isoforms (TPC1-3): TPC1 and TPC2 are the most universal isoforms since TPC3 is absent from the genomes of many animals including those of human, mice, rats and flies []. This entry represents TPC1 from animals [, ]. TPC1 was first identified as an NAADP (nicotinic acid adenine dinucleotide phosphate)-regulated Ca2+ channel. Later it was shown to serve as a voltage-gated highly-selective Na+ channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles [, , , , ].
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Protein Domain
IPR045766 | MCAfunc
Type: Domain
Description: MCAfunc domain (MCAfunc) is located in the N-terminal region of a mechanosensitive channel protein MID1-COMPLEMENTING ACTIVITY (MCA). MCAfunc represents the provisionally advocated ARPK domain (Amino-terminal domain of Rice putative Protein Kinases), overlapping with the EF hand-like region at the N terminus []. In MCA proteins, MCAfunc has Ca2 influx activity and is proposed to be a functional domain of MCAs []. MCAfunc is exclusively observed in streptophytes and exists not only in MCA but also in E3 ubiquitin ligase-like proteins, ARO3-like proteins and and protein kinases. In the most basal plant lineage, charophytes, MCAfunc is only found in E3 ubiquitin ligase-like proteins and protein of presently unknown function, while MCA proteins are exclusively found in land plants, from bryophytes to angiosperms.
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Protein
Q9DAM2
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Publication
12445456 | -
First Author: Michalak M
Year: 2002
Journal: Biochim Biophys Acta
Title: Calreticulin in cardiac development and pathology.
Volume: 1600
Issue: 1-2
Pages: 32-7
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Publication
9038332 | -
First Author: Kopito RR
Year: 1997
Journal: Cell
Title: ER quality control: the cytoplasmic connection.
Volume: 88
Issue: 4
Pages: 427-30
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Publication
10085286 | J:53466
First Author: Mesaeli N
Year: 1999
Journal: J Cell Biol
Title: Calreticulin is essential for cardiac development.
Volume: 144
Issue: 5
Pages: 857-68
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Publication
11375414 | J:69596
First Author: Nakamura K
Year: 2001
Journal: J Clin Invest
Title: Complete heart block and sudden death in mice overexpressing calreticulin.
Volume: 107
Issue: 10
Pages: 1245-53
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Publication
9693955 | -
First Author: Coppolino MG
Year: 1998
Journal: Int J Biochem Cell Biol
Title: Calreticulin.
Volume: 30
Issue: 5
Pages: 553-8
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Publication
20018950 | -
First Author: Zhu MX
Year: 2010
Journal: Am J Physiol Cell Physiol
Title: Calcium signaling via two-pore channels: local or global, that is the question.
Volume: 298
Issue: 3
Pages: C430-41
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Publication
21712437 | -
First Author: Limbach C
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
Volume: 108
Issue: 31
Pages: E392-401
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Protein Domain
IPR009169 | Calreticulin
Type: Family
Description: Calreticulin is a ubiquitous protein found in a wide range of species and in all nucleated cell types. It is an ancient and highly conserved protein with an exceptionally wide scope and variety of functions. Initially known as the high-affinity calcium-binding endoplasmic reticulum (ER) and sarcoplamic reticulum (SR) protein "calregulin", calreticulin is now known to associate with proteins in the cytoplasm, nucleus and extracellular compartment. Calreticulin is a major Ca2 -binding/storage chaperone residing in the ER lumen []. Molecular chaperones residing in the ER facilitate the folding and prevent the aggregation of newly synthesized proteins. Interaction between the molecular chaperone and the misfolded protein leads to the retention, retranslocation and eventual degradation of the misfolded protein by the proteasome after ubiquitination []. Calreticulin binds (buffers) Ca2 with high capacity and participates in folding newly synthesized proteins and glycoproteins. It is an important component of the calreticulin/calnexin cycle and quality control pathways in the ER []. Studies on calreticulin-deficient and calreticulin-transgenic mice revealed that calreticulin is a new cardiac embryonic gene and is essential during cardiac development [, ]. Calreticulin has also been characterised as an extracellular lectin, an intracellular mediator of integrin-mediated cell adhesion, an inhibitor of steroid hormone-regulated gene expression and a C1q-binding protein []. A proposed model of calreticulin domains includes a globular N-domain, a central proline-rich P-domain and an acidic C-domain. A detailed structure of the central P-domain was revealed by NMR studies, while a model of the globular N-domain of calreticulin is based on crystallographic data reported for the highly similar calnexin [].Calreticulin is also known as calregulin, Erp60, CRP55, CAB-63 and CaBP3 [].
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Protein Coding Gene
MGI:2178323 | Clstn3
Type: protein_coding_gene
Organism: mouse, laboratory
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Chromosome Structure Variation
MGI:5555957 | Del(5Gtf2i-Fkbp6)1Vcam
Type: chromosomal_deletion
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Del(5Gtf2i-Fkbp6)1Vcam/+
Background: B6.129-Del(5Gtf2i-Fkbp6)1Vcam(J:204278)
Zygosity: ht
Has Mutant Allele: true
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Publication
11967539 | J:76211
First Author: Mantamadiotis T
Year: 2002
Journal: Nat Genet
Title: Disruption of CREB function in brain leads to neurodegeneration.
Volume: 31
Issue: 1
Pages: 47-54
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Publication
34093132 | J:314525
 
First Author: Pak A
Year: 2021
Journal: Front Cell Neurosci
Title: Impaired Adaptation and Laminar Processing of the Oddball Paradigm in the Primary Visual Cortex of Fmr1 KO Mouse.
Volume: 15
Pages: 668230
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Publication
32268079 | J:299959
First Author: Kissinger ST
Year: 2020
Journal: Cell Rep
Title: Visual Experience-Dependent Oscillations and Underlying Circuit Connectivity Changes Are Impaired in Fmr1 KO Mice.
Volume: 31
Issue: 1
Pages: 107486
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Publication
22179110 | J:181567
First Author: Zhang J
Year: 2011
Journal: Nat Neurosci
Title: Visual map development depends on the temporal pattern of binocular activity in mice.
Volume: 15
Issue: 2
Pages: 298-307
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Publication
22529300 | J:188744
First Author: Filbert EL
Year: 2012
Journal: J Immunol
Title: Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells.
Volume: 188
Issue: 11
Pages: 5421-7
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Publication
29444426 | J:271143
First Author: Garden DLF
Year: 2018
Journal: Cell Rep
Title: Inferior Olive HCN1 Channels Coordinate Synaptic Integration and Complex Spike Timing.
Volume: 22
Issue: 7
Pages: 1722-1733
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Publication
23785152 | J:352204
First Author: Jasnow AM
Year: 2013
Journal: J Neurosci
Title: Thy1-expressing neurons in the basolateral amygdala may mediate fear inhibition.
Volume: 33
Issue: 25
Pages: 10396-404
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Publication
37656620 | J:340612
First Author: Laricchiuta D
Year: 2023
Journal: Cell Rep
Title: Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.
Volume: 42
Issue: 9
Pages: 113066
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Publication
31122677 | J:278128
First Author: Geraghty AC
Year: 2019
Journal: Neuron
Title: Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Volume: 103
Issue: 2
Pages: 250-265.e8
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Publication
9125370 | J:123610
First Author: Caroni P
Year: 1997
Journal: J Neurosci Methods
Title: Overexpression of growth-associated proteins in the neurons of adult transgenic mice.
Volume: 71
Issue: 1
Pages: 3-9
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Publication
33850125 | J:333602
First Author: Tamim I
Year: 2021
Journal: Nat Commun
Title: Spreading depression as an innate antiseizure mechanism.
Volume: 12
Issue: 1
Pages: 2206
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Publication
33563727 | J:354004
First Author: Gao M
Year: 2021
Journal: J Neurosci
Title: Visual Familiarity Induced 5-Hz Oscillations and Improved Orientation and Direction Selectivities in V1.
Volume: 41
Issue: 12
Pages: 2656-2667
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Publication
24849626 | J:213205
 
First Author: Brown J
Year: 2014
Journal: Elife
Title: The inhibitory microcircuit of the substantia nigra provides feedback gain control of the basal ganglia output.
Volume: 3
Pages: e02397
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Publication
24185427 | J:207781
First Author: Apostolides PF
Year: 2013
Journal: Nat Neurosci
Title: Regulation of interneuron excitability by gap junction coupling with principal cells.
Volume: 16
Issue: 12
Pages: 1764-72
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Strain
MGI:5800673 | B6;CBA-Tg(CAG-GFPuv/AEQ*)30Alns/Cnbc
Attribute String: mutant stock, transgenic
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Protein Coding Gene
MGI:99516 | Tnr
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Ywhae<tm1Awb> | MGI:2667341
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; targeted mutation 1, Anthony Wynshaw-Boris
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tg(Thy1-APP<SL>)28Lpr | MGI:3510606
Name: transgene insertion 28, Laurent Pradier
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Abi2<tm1Pen> | MGI:3526871
Name: abl interactor 2; targeted mutation 1, Ann Marie Pendergast
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tuba1a<Jna> | MGI:3617352
 
Name: tubulin, alpha 1A; jenna
Allele Type: Chemically induced (ENU)
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Allele
Zbtb18<tm1Haok> | MGI:3851929
Name: zinc finger and BTB domain containing 18; targeted mutation 1, Haruo Okado
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Ywhaz<Gt(OST432062)Lex> | MGI:4315078
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; gene trap OST432062, Lexicon Genetics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Allele
Arid1b<em1Iha> | MGI:6286071
Name: AT-rich interaction domain 1B; endonuclease-mediated mutation 1, Izuho Hatada
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Bex3<em1Jjcar> | MGI:7430934
Name: brain expressed X-linked 3; endonuclease-mediated mutation 1, Jaime J Carvajal Garcia-Valdecasas
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Nr4a3/Nr4a3
Background: involves: 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fyn/Fyn
Background: either: 129S7/SvEvBrd-Fyn or (involves: 129S7/SvEvBrd * C57BL/6J)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pou1f1/Pou1f1
Background: C3H/HeJ-Pou1f1/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Zbtb18/Zbtb18
Background: involves: 129/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APP)28Lpr/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bicd2/Bicd2 Tg(GFAP-cre)25Mes/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kif3b/Kif3b<+>
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Publication
11084361 | -
First Author: Anantharaman V
Year: 2000
Journal: Trends Biochem Sci
Title: Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors.
Volume: 25
Issue: 11
Pages: 535-7
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Publication
27049771 | -
First Author: Upadhyay AA
Year: 2016
Journal: PLoS Comput Biol
Title: Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes.
Volume: 12
Issue: 4
Pages: e1004862
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Protein Coding Gene
MGI:88145 | Bdnf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99918 | Mecp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q80X60
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
Q8BHW6
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
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Protein
B1ASN7
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: true
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Protein
A2AB62
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: false
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Protein
A0A087WPM6
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
Q497J8
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Publication
7553064 | -
First Author: Kawasaki H
Year: 1995
Journal: Protein Profile
Title: Calcium-binding proteins 1: EF-hands.
Volume: 2
Issue: 4
Pages: 297-490
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Publication
9228939 | -
First Author: Kretsinger RH
Year: 1997
Journal: Nat Struct Biol
Title: EF-hands embrace.
Volume: 4
Issue: 7
Pages: 514-6
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Publication
8848832 | -
First Author: Ikura M
Year: 1996
Journal: Trends Biochem Sci
Title: Calcium binding and conformational response in EF-hand proteins.
Volume: 21
Issue: 1
Pages: 14-7
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Publication
7656053 | -
First Author: Skelton NJ
Year: 1994
Journal: Nat Struct Biol
Title: Signal transduction versus buffering activity in Ca(2+)-binding proteins.
Volume: 1
Issue: 4
Pages: 239-45
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Publication
10591109 | -
First Author: Yap KL
Year: 1999
Journal: Proteins
Title: Diversity of conformational states and changes within the EF-hand protein superfamily.
Volume: 37
Issue: 3
Pages: 499-507
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Publication
20150244 | J:159253
First Author: Simpson JE
Year: 2010
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium.
Volume: 298
Issue: 5
Pages: G683-91
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Publication
14600151 | J:127436
First Author: Lehtonen J
Year: 2004
Journal: J Biol Chem
Title: Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family.
Volume: 279
Issue: 4
Pages: 2719-27
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Publication
15218065 | J:326271
First Author: Pushkin A
Year: 2004
Journal: J Physiol
Title: Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells.
Volume: 559
Issue: Pt 1
Pages: 55-65
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Publication
3408670 | J:9300
First Author: Novak EK
Year: 1988
Journal: Br J Haematol
Title: Cocoa: a new mouse model for platelet storage pool deficiency.
Volume: 69
Issue: 3
Pages: 371-8
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Publication
8207439 | J:18790
First Author: Brion LP
Year: 1994
Journal: J Neurochem
Title: Up-regulation of carbonic anhydrase isozyme IV in CNS myelin of mice genetically deficient in carbonic anhydrase II.
Volume: 63
Issue: 1
Pages: 360-6
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Publication
9277584 | J:42494
First Author: Brion LP
Year: 1997
Journal: Am J Physiol
Title: Expression of carbonic anhydrase IV in carbonic anhydrase II-deficient mice.
Volume: 273
Issue: 2 Pt 2
Pages: F234-45
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Publication
23881097 | J:200079
First Author: Ruusuvuori E
Year: 2013
Journal: EMBO J
Title: Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
Volume: 32
Issue: 16
Pages: 2275-86
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Publication
1686722 | J:804
 
First Author: Cornwell MM
Year: 1991
Journal: Cancer Treat Res
Title: Molecular biology of P-glycoprotein.
Volume: 57
Pages: 37-56
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Publication
28254758 | J:246181
First Author: Chatel B
Year: 2017
Journal: FASEB J
Title: Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice.
Volume: 31
Issue: 6
Pages: 2562-2575
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Publication
6529441 | J:7772
First Author: von Deimling OH
Year: 1984
Journal: Biochem Genet
Title: Esterase-26 (ES-26): characterization and genetic location on chromosome 3 of an eserine-sensitive esterase of the house mouse (Mus musculus).
Volume: 22
Issue: 11-12
Pages: 1119-26
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Publication
26510953 | J:329765
First Author: Fitz NF
Year: 2015
Journal: Brain
Title: Opposing effects of Apoe/Apoa1 double deletion on amyloid-β pathology and cognitive performance in APP mice.
Volume: 138
Issue: Pt 12
Pages: 3699-715
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Publication
35856618 | J:328001
First Author: Ursin RL
Year: 2022
Journal: mBio
Title: Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells.
Volume: 13
Issue: 4
Pages: e0183922
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Publication
37117012 | J:358966
First Author: Li M
Year: 2023
Journal: J Neurosci
Title: Hypothalamic Supramammillary Nucleus Selectively Excites Hippocampal CA3 Interneurons to Suppress CA3 Pyramidal Neuron Activity.
Volume: 43
Issue: 25
Pages: 4612-4624
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Publication
37075948 | J:335199
 
First Author: Harbin NH
Year: 2023
Journal: Neurobiol Dis
Title: RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus.
Volume: 181
Pages: 106128
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Publication
35907861 | J:327086
First Author: Mueller FS
Year: 2022
Journal: BMC Biol
Title: Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice.
Volume: 20
Issue: 1
Pages: 170
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Protein Coding Gene
MGI:1346052 | Apc2
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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