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Search results 1701 to 1800 out of 1899 for Cdk5

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Type Details Score
Publication
First Author: Qu D
Year: 2007
Journal: Neuron
Title: Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.
Volume: 55
Issue: 1
Pages: 37-52
Publication
First Author: Kumar A
Year: 2005
Journal: Neuron
Title: Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum.
Volume: 48
Issue: 2
Pages: 303-14
Publication
First Author: Carter AM
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Phosphoprotein-based biomarkers as predictors for cancer therapy.
Volume: 117
Issue: 31
Pages: 18401-18411
Publication
First Author: Ko SY
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors.
Volume: 116
Issue: 5
Pages: 1770-1775
Publication
First Author: Stromsdorfer KL
Year: 2016
Journal: Cell Rep
Title: NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice.
Volume: 16
Issue: 7
Pages: 1851-60
Publication
First Author: Lindqvist J
Year: 2017
Journal: J Cell Sci
Title: Nestin contributes to skeletal muscle homeostasis and regeneration.
Volume: 130
Issue: 17
Pages: 2833-2842
Publication
First Author: Rei D
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway.
Volume: 112
Issue: 23
Pages: 7291-6
Publication  
First Author: Pujol CN
Year: 2020
Journal: Sci Signal
Title: Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis.
Volume: 13
Issue: 618
Publication
First Author: Humbert S
Year: 2000
Journal: Neuroreport
Title: Synaptic localization of p39, a neuronal activator of cdk5.
Volume: 11
Issue: 10
Pages: 2213-6
Publication
First Author: Sakurai T
Year: 2008
Journal: J Cell Biol
Title: Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.
Volume: 183
Issue: 2
Pages: 339-52
Publication
First Author: Taniguchi M
Year: 2012
Journal: Neuron
Title: Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.
Volume: 73
Issue: 1
Pages: 108-20
Publication
First Author: Choi JH
Year: 2014
Journal: Genes Dev
Title: Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming.
Volume: 28
Issue: 21
Pages: 2361-9
Publication
First Author: Gupta P
Year: 2022
Journal: Cell Rep
Title: Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer.
Volume: 40
Issue: 7
Pages: 111218
Publication
First Author: Zou J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Neddylation mediates ventricular chamber maturation through repression of Hippo signaling.
Volume: 115
Issue: 17
Pages: E4101-E4110
Publication
First Author: Xie L
Year: 2012
Journal: Dev Cell
Title: Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Volume: 23
Issue: 2
Pages: 280-91
Publication  
First Author: Eom T
Year: 2013
Journal: Elife
Title: NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.
Volume: 2
Pages: e00178
Publication
First Author: Ho UY
Year: 2021
Journal: Commun Biol
Title: WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.
Volume: 4
Issue: 1
Pages: 645
Protein
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
Publication
First Author: Arragain S
Year: 2010
Journal: J Biol Chem
Title: Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA.
Volume: 285
Issue: 37
Pages: 28425-33
Publication
First Author: Antoine JC
Year: 1999
Journal: Arch Neurol
Title: Antiamphiphysin antibodies are associated with various paraneoplastic neurological syndromes and tumors.
Volume: 56
Issue: 2
Pages: 172-7
Publication
First Author: Anton BP
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli.
Volume: 105
Issue: 6
Pages: 1826-31
Publication
First Author: Nicolet Y
Year: 2004
Journal: Nucleic Acids Res
Title: AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation.
Volume: 32
Issue: 13
Pages: 4015-25
Protein Domain
Type: Family
Description: The methylthiotransferase (MTTase) or miaB-like family is named after the (dimethylallyl)adenosine tRNA MTTase miaB protein, which catalyses a C-H to C-S bond conversion in the methylthiolation of tRNA. A related bacterial enzyme RimO performs a similar methylthiolation, but on a protein substrate. RimO acts on the ribosomal protein S12 and forms a separate MTTase subfamily. The miaB-subfamily includes mammalian CDK5 regulatory subunit-associated proteins and similar proteins in other eukaryotes. Two other subfamilies, yqeV and CDKAL1, are named after a Bacillus subtilis and a human protein, respectively. While yqeV-like proteins are found in bacteria, CDKAL1 subfamily members occur in eukaryotes and in archaebacteria [].The likely MTTases from these 4 subfamilies contain an N-terminal MTTase domain, a central radical generating fold and a C-terminal TRAM domain (see ). The core forms a radical SAM fold (or AdoMet radical), containing a cysteine motif CxxxCxxC that binds a [4Fe-4S]cluster [, , ]. A reducing equivalent from the [4Fe-4S]+ cluster is used to cleave S-adenosylmethionine (SAM) to generate methionine and a 5'-deoxyadenosyl radical. The latter is thought to produce a reactive substrate radical that is amenable to sulphur insertion [, ]. The N-terminal MTTase domain contains 3 cysteines that bind a second [4Fe-4S]cluster, in addition to the radical-generating [4Fe-4S]cluster, which could be involved in the thiolation reaction. The C-terminal TRAM domain is not shared with other radical SAM proteins outside the MTTase family. The TRAM domain can bind to RNA substrate and seems to be important for substrate recognition. The tertiary structure of the central radical SAM fold has six beta/alpha motifs resembling a three-quarter TIM barrel core []. The N-terminal MTTase domain might form an additional [beta/alpha]2 TIM barrel unit [].
Protein Domain
Type: Homologous_superfamily
Description: The methylthiotransferase (MTTase) or miaB-like family is named after the (dimethylallyl)adenosine tRNA MTTase miaB protein, which catalyses a C-H to C-S bond conversion in the methylthiolation of tRNA. A related bacterial enzyme rimO performs a similar methylthiolation, but on a protein substrate. RimO acts on the ribosomal protein S12 and forms a separate MTTase subfamily. The miaB-subfamily includes mammalian CDK5 regulatory subunit-associated proteins and similar proteins in other eukaryotes. Two other subfamilies, yqeV and CDKAL1, are named after a Bacillus subtilis and a human protein, respectively. While yqeV-like proteins are found in bacteria, CDKAL1 subfamily members occur in eukaryotes and in archaebacteria. The likely MTTases from these 4 subfamilies contain an N-terminal MTTase domain, a central radical generating fold and a C-terminal TRAM domain (see ). The core forms a radical SAM fold (or AdoMet radical), containing a cysteine motif CxxxCxxC that binds a [4Fe-4S]cluster [, , ]. A reducing equivalent from the [4Fe-4S]+ cluster is used to cleave S-adenosylmethionine (SAM) to generate methionine and a 5'-deoxyadenosyl radical. The latter is thought to produce a reactive substrate radical that is amenable to sulphur insertion [, ]. The N-terminal MTTase domain contains 3 cysteines that bind a second [4Fe-4S]cluster, in addition to the radical-generating [4Fe-4S]cluster, which could be involved in the thiolation reaction. The C-terminal TRAM domain is not shared with other radical SAM proteins outside the MTTase family. The TRAM domain can bind to RNA substrate and seems to be important for substrate recognition. The tertiary structure of the central radical SAM fold has six beta/alpha motifs resembling a three-quarter TIM barrel core (see ) []. The N-terminal MTTase domain might form an additional [beta/alpha]2 TIM barrel unit [].
Protein Domain
Type: Conserved_site
Description: The methylthiotransferase (MTTase) or miaB-like family is named after the (dimethylallyl)adenosine tRNA MTTase miaB protein, which catalyses a C-H to C-S bond conversion in the methylthiolation of tRNA. A related bacterial enzyme rimO performs a similar methylthiolation, but on a protein substrate. RimO acts on the ribosomal protein S12 andforms a separate MTTase subfamily. The miaB-subfamily includes mammalian CDK5 regulatory subunit-associated proteins and similar proteins in other eukaryotes. Two other subfamilies, yqeV and CDKAL1, are named after a Bacillus subtilis and a human protein, respectively. While yqeV-like proteins are found in bacteria, CDKAL1 subfamily members occur in eukaryotes and in archaebacteria. The likely MTTases from these 4 subfamilies contain an N-terminal MTTase domain, a central radical generating fold and a C-terminal TRAM domain (see ). The core forms a radical SAM fold (or AdoMet radical), containing a cysteine motif CxxxCxxC that binds a [4Fe-4S]cluster [, , ]. A reducing equivalent from the [4Fe-4S]+ cluster is used to cleave S-adenosylmethionine (SAM) to generate methionine and a 5'-deoxyadenosyl radical. The latter is thought to produce a reactive substrate radical that is amenable to sulphur insertion [, ]. The N-terminal MTTase domain contains 3 cysteines that bind a second [4Fe-4S]cluster, in addition to the radical-generating [4Fe-4S]cluster, which could be involved in the thiolation reaction. The C-terminal TRAM domain is not shared with other radical SAM proteins outside the MTTase family. The TRAM domain can bind to RNA substrate and seems to be important for substrate recognition. The tertiary structure of the central radical SAM fold has six beta/alpha motifs resembling a three-quarter TIM barrel core (see ) []. The N-terminal MTTase domain might form an additional [beta/alpha]2 TIM barrel unit []. This entry represents a conserved site containing three of the conserved cysteines that form the motif in the central radical SAM fold.
Protein Domain
Type: Family
Description: Amphiphysins belong to the expanding BAR (Bin-Amphiphysin-Rvsp) family proteins, all members of which share a highly conserved N-terminal BAR domain, which has predicted coiled-coil structures required for amphiphysin dimerisation and plasma membrane interaction []. Almost all members also share a conserved C-terminal Src homology 3 (SH3) domain, which mediates their interactions with the GTPase dynamin and the inositol-5'-phosphatase synaptojanin 1 in vertebrates and with actin in yeast. The central region of all these proteins is most variable. In mammals, the central region of amphiphysin I and amphiphysin IIa contains a proline-arginine-rich region for endophilin binding and a CLAP domain, for binding to clathrin and AP-2. The interactions mediated by both the central and C-terminal domains are believed to be modulated by protein phosphorylation [, ].Amphiphysins are proteins involved in clathrin-mediated endocytosis clathrin-mediated endocytosis, actin function, and signalling pathways [, ].Amphiphysin 1 was first identified in 1992 as a brain protein that was partially-associated with synaptic vesicles. Following its cloning, it was also realised to be a human auto-antigen that is detected in a rare neurological disease, Stiff-Man Syndrome, and also in certain types of cancer []. Amphiphysin 1 senses and facilitates membrane curvature to mediate synaptic vesicles invagination and fission during newly retrieved presynaptic vesicle formation and also acts as a linker protein binding with dynamin, clathrin, Amphiphysin II, and other dephosphins in the clathrin-coated complex. Amphiphysin 1 is cleaved an asparagine endopeptidase (AEP), which generates afragment that increases with aging. This fragment disrupts the normal endocytic function of Amphiphysin 1, leading to synaptic dysfunction, as it activates CDK5 inducing tau hyperphosphorylation. Therefore, Amphiphysin 1 posttranslational modification contributes to pathogenesis of Alzheimer's disease, being the AEP a therapeutic target [].
Protein Domain
Type: Domain
Description: The methylthiotransferase (MTTase) or miaB-like family is named after the (dimethylallyl)adenosine tRNA MTTase miaB protein, which catalyses a C-H to C-S bond conversion in the methylthiolation of tRNA. A related bacterial enzyme rimO performs a similar methylthiolation, but on a protein substrate. RimO acts on the ribosomal protein S12 and forms a separate MTTase subfamily. The miaB-subfamily includes mammalian CDK5 regulatory subunit-associated proteins and similar proteins in other eukaryotes. Two other subfamilies, yqeV and CDKAL1, are named after a Bacillus subtilis and a human protein, respectively. While yqeV-like proteins are found in bacteria, CDKAL1 subfamily members occur in eukaryotes and in archaebacteria. The likely MTTases from these 4 subfamilies contain an N-terminal MTTase domain, a central radical generating fold and a C-terminal TRAM domain (see ). The core forms a radical SAM fold (or AdoMet radical), containing a cysteine motif CxxxCxxC that binds a [4Fe-4S]cluster [, , ]. A reducing equivalent from the [4Fe-4S]+ cluster is used to cleave S-adenosylmethionine (SAM) to generate methionine and a 5'-deoxyadenosyl radical. The latter is thought to produce a reactive substrate radical that is amenable to sulphur insertion [, ]. The N-terminal MTTase domain contains 3 cysteines that bind a second [4Fe-4S]cluster, in addition to the radical-generating [4Fe-4S]cluster, which could be involved in the thiolation reaction. The C-terminal TRAM domain is not shared with other radical SAM proteins outside the MTTase family. The TRAM domain can bind to RNA substrate and seems to be important for substrate recognition. The tertiary structure of the central radical SAM fold has six beta/alpha motifs resembling a three-quarter TIM barrel core (see ) []. The N-terminal MTTase domain might form an additional [beta/alpha]2 TIM barrel unit [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Toyo-oka K
Year: 2003
Journal: Nat Genet
Title: 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.
Volume: 34
Issue: 3
Pages: 274-85
Publication
First Author: Toyo-Oka K
Year: 2005
Journal: Hum Mol Genet
Title: Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.
Volume: 14
Issue: 21
Pages: 3113-28
Publication
First Author: Pao PC
Year: 2011
Journal: Cell Death Differ
Title: A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells.
Volume: 18
Issue: 11
Pages: 1791-804
Publication
First Author: Fernando P
Year: 2009
Journal: J Biol Chem
Title: Bin1 SRC homology 3 domain acts as a scaffold for myofiber sarcomere assembly.
Volume: 284
Issue: 40
Pages: 27674-86
Publication
First Author: Beffert U
Year: 2004
Journal: J Neurosci
Title: Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.
Volume: 24
Issue: 8
Pages: 1897-906
Publication
First Author: Bai B
Year: 2012
Journal: Circulation
Title: Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis.
Volume: 126
Issue: 6
Pages: 729-40
Publication  
First Author: Laporte V
Year: 2008
Journal: Brain Res
Title: CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Volume: 1231
Pages: 132-42
Publication
First Author: Paratcha G
Year: 2006
Journal: Mol Cell Neurosci
Title: GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream.
Volume: 31
Issue: 3
Pages: 505-14
Publication
First Author: Hallows JL
Year: 2006
Journal: J Neurosci
Title: p35/p25 is not essential for tau and cytoskeletal pathology or neuronal loss in Niemann-Pick type C disease.
Volume: 26
Issue: 10
Pages: 2738-44
Publication
First Author: Ba L
Year: 2017
Journal: J Huazhong Univ Sci Technolog Med Sci
Title: Aberrant activation of Cdc2/cyclin B1 is involved in initiation of cytoskeletal pathology in murine Niemann-Pick disease type C.
Volume: 37
Issue: 5
Pages: 732-739
Publication
First Author: Bu B
Year: 2002
Journal: J Neurosci
Title: Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.
Volume: 22
Issue: 15
Pages: 6515-25
Publication
First Author: Cherubini M
Year: 2015
Journal: Biochim Biophys Acta
Title: Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease.
Volume: 1852
Issue: 10 Pt A
Pages: 2145-60
Publication
First Author: Li C
Year: 2004
Journal: J Neurosci
Title: Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E.
Volume: 24
Issue: 27
Pages: 6161-70
Publication
First Author: Patzke H
Year: 2003
Journal: J Neurosci
Title: Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.
Volume: 23
Issue: 7
Pages: 2769-78
Publication
First Author: Wong DP
Year: 2023
Journal: Cancer Res Commun
Title: p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction.
Volume: 3
Issue: 5
Pages: 793-806
Publication
First Author: Kwon YT
Year: 1999
Journal: J Comp Neurol
Title: Callosal axon guidance defects in p35(-/-) mice.
Volume: 415
Issue: 2
Pages: 218-29
Publication
First Author: Qin X
Year: 2017
Journal: Am J Pathol
Title: Inhibition of Early Growth Response 1 in the Hippocampus Alleviates Neuropathology and Improves Cognition in an Alzheimer Model with Plaques and Tangles.
Volume: 187
Issue: 8
Pages: 1828-1847
Publication
First Author: Orr ME
Year: 2014
Journal: Neurobiol Aging
Title: Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Volume: 35
Issue: 6
Pages: 1233-42
Publication
First Author: Chu J
Year: 2013
Journal: PLoS One
Title: Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.
Volume: 8
Issue: 8
Pages: e70991
Publication
First Author: Kitazawa M
Year: 2006
Journal: Am J Pathol
Title: Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice.
Volume: 168
Issue: 6
Pages: 1986-97
Publication
First Author: Medina-Vera D
Year: 2022
Journal: Br J Pharmacol
Title: d-Pinitol promotes tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?
Volume: 179
Issue: 19
Pages: 4655-4672
Publication
First Author: Giannopoulos PF
Year: 2013
Journal: Biol Psychiatry
Title: 5-lipoxygenase activating protein reduction ameliorates cognitive deficit, synaptic dysfunction, and neuropathology in a mouse model of Alzheimer's disease.
Volume: 74
Issue: 5
Pages: 348-56
Publication
First Author: Han P
Year: 2005
Journal: J Neurosci
Title: Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.
Volume: 25
Issue: 50
Pages: 11542-52
Publication
First Author: Muyllaert D
Year: 2008
Journal: Am J Pathol
Title: Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration.
Volume: 172
Issue: 2
Pages: 470-85
Publication
First Author: Giusti-Rodríguez P
Year: 2011
Journal: J Neurosci
Title: Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1).
Volume: 31
Issue: 44
Pages: 15751-6
Publication
First Author: Mount MP
Year: 2013
Journal: J Biol Chem
Title: Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Volume: 288
Issue: 20
Pages: 14362-71
Publication
First Author: Im DS
Year: 2022
Journal: BMC Biol
Title: Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition.
Volume: 20
Issue: 1
Pages: 115
Publication
First Author: Takahashi S
Year: 2004
Journal: J Neurochem
Title: Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25.
Volume: 88
Issue: 5
Pages: 1295-304
Publication  
First Author: Prochazkova M
Year: 2017
Journal: Mol Pain
Title: Peripheral and orofacial pain sensation is unaffected by the loss of p39.
Volume: 13
Pages: 1744806917737205
Publication
First Author: Verstegen AM
Year: 2014
Journal: J Neurosci
Title: Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
Volume: 34
Issue: 21
Pages: 7266-80
Publication
First Author: Robin G
Year: 2017
Journal: Hum Mol Genet
Title: Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome.
Volume: 26
Issue: 14
Pages: 2649-2666
Publication
First Author: Ohshima T
Year: 2005
Journal: J Neurochem
Title: Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice.
Volume: 94
Issue: 4
Pages: 917-25
Publication
First Author: Pareek TK
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Cyclin-dependent kinase 5 activity regulates pain signaling.
Volume: 103
Issue: 3
Pages: 791-6
Publication
First Author: He X
Year: 2014
Journal: J Neurochem
Title: Cdk5/p35 is required for motor coordination and cerebellar plasticity.
Volume: 131
Issue: 1
Pages: 53-64
Publication  
First Author: Park KHJ
Year: 2017
Journal: Neuroscience
Title: p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington's disease.
Volume: 352
Pages: 79-87
Publication  
First Author: Barrett T
Year: 2019
Journal: Neuroscience
Title: p35 Hemizygous Deletion in 5xFAD Mice Increases Aβ Plaque Load in Males but Not in Females.
Volume: 417
Pages: 45-56
Publication  
First Author: Cao LL
Year: 2019
Journal: Front Aging Neurosci
Title: Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1.
Volume: 11
Pages: 108
Publication
First Author: Toba J
Year: 2016
Journal: Biochem Biophys Res Commun
Title: PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice.
Volume: 473
Issue: 4
Pages: 1039-1044
Publication  
First Author: Zhang W
Year: 2020
Journal: Neurosci Lett
Title: FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro.
Volume: 738
Pages: 135322
Publication
First Author: Chen J
Year: 2015
Journal: PLoS One
Title: Anti-diabetes drug pioglitazone ameliorates synaptic defects in AD transgenic mice by inhibiting cyclin-dependent kinase5 activity.
Volume: 10
Issue: 4
Pages: e0123864
Publication
First Author: Amini M
Year: 2013
Journal: J Neurosci
Title: Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.
Volume: 33
Issue: 13
Pages: 5773-84
Publication  
First Author: Paul S
Year: 2022
Journal: eNeuro
Title: Cyclin-Dependent Kinase 5 Regulates cPLA2 Activity and Neuroinflammation in Parkinson's Disease.
Volume: 9
Issue: 6
Publication
First Author: Rao MV
Year: 2014
Journal: J Neurosci
Title: Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.
Volume: 34
Issue: 28
Pages: 9222-34
Publication
First Author: Barroso E
Year: 2013
Journal: Biochim Biophys Acta
Title: Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice.
Volume: 1832
Issue: 8
Pages: 1241-8
Publication
First Author: Saito T
Year: 2016
Journal: J Neurosci
Title: Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.
Volume: 36
Issue: 38
Pages: 9933-6
Publication  
First Author: Yamazaki Y
Year: 2020
Journal: Brain Res
Title: Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4.
Volume: 1736
Pages: 146762
Publication
First Author: Wang M
Year: 2017
Journal: Mol Cell Proteomics
Title: The Glial Cell-Derived Neurotrophic Factor (GDNF)-responsive Phosphoprotein Landscape Identifies Raptor Phosphorylation Required for Spermatogonial Progenitor Cell Proliferation.
Volume: 16
Issue: 6
Pages: 982-997
Publication  
First Author: Vagnozzi AN
Year: 2018
Journal: Aging Cell
Title: Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice.
Volume: 17
Issue: 1
Publication
First Author: Yang T
Year: 2020
Journal: Acta Neuropathol Commun
Title: Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice.
Volume: 8
Issue: 1
Pages: 156
Publication
First Author: Giannopoulos PF
Year: 2018
Journal: Aging Cell
Title: Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice.
Volume: 17
Issue: 3
Pages: e12759
Publication
First Author: Montenegro-Venegas C
Year: 2022
Journal: EMBO Rep
Title: Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP.
Volume: 23
Issue: 8
Pages: e53659
Publication
First Author: Gassen NC
Year: 2015
Journal: Sci Signal
Title: Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.
Volume: 8
Issue: 404
Pages: ra119
Publication
First Author: Takano T
Year: 2014
Journal: Mol Biol Cell
Title: LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes.
Volume: 25
Issue: 11
Pages: 1755-68
Publication
First Author: Deprez F
Year: 2016
Journal: Eur J Neurosci
Title: Partial inactivation of GABAA receptors containing the α5 subunit affects the development of adult-born dentate gyrus granule cells.
Volume: 44
Issue: 5
Pages: 2258-71
Publication
First Author: Dong C
Year: 2017
Journal: Sci Rep
Title: Functional Role of Cyclin-Dependent Kinase 5 in the Regulation of Melanogenesis and Epidermal Structure.
Volume: 7
Issue: 1
Pages: 13783
Publication  
First Author: Kato G
Year: 2019
Journal: eNeuro
Title: Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice.
Volume: 6
Issue: 2
Publication
First Author: Liu GT
Year: 2022
Journal: EMBO J
Title: Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission.
Volume: 41
Issue: 9
Pages: e109352
Publication
First Author: Choe EA
Year: 2007
Journal: J Neurosci
Title: Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1.
Volume: 27
Issue: 35
Pages: 9503-12
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First Author: Dhavan R
Year: 2002
Journal: J Neurosci
Title: The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner.
Volume: 22
Issue: 18
Pages: 7879-91
Publication
First Author: Patrick GN
Year: 1998
Journal: J Biol Chem
Title: p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.
Volume: 273
Issue: 37
Pages: 24057-64
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First Author: Ma E
Year: 1999
Journal: Biochem Biophys Res Commun
Title: A Drosophila CDK5alpha-like molecule and its possible role in response to O(2) deprivation.
Volume: 261
Issue: 2
Pages: 459-63
Publication
First Author: Hammond V
Year: 2004
Journal: J Neurosci
Title: Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35.
Volume: 24
Issue: 2
Pages: 576-87
Publication
First Author: Griffin SV
Year: 2004
Journal: Am J Pathol
Title: Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology.
Volume: 165
Issue: 4
Pages: 1175-85
Publication
First Author: Veeranna
Year: 2011
Journal: Neurobiol Aging
Title: Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments.
Volume: 32
Issue: 11
Pages: 2016-29
Publication
First Author: Fang WQ
Year: 2011
Journal: J Neurosci
Title: Cdk5-mediated phosphorylation of Axin directs axon formation during cerebral cortex development.
Volume: 31
Issue: 38
Pages: 13613-24
Publication
First Author: Xie MJ
Year: 2013
Journal: Cereb Cortex
Title: WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration.
Volume: 23
Issue: 6
Pages: 1410-23
Publication  
First Author: Cho DH
Year: 2014
Journal: Free Radic Biol Med
Title: Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116) signaling cascade in endothelial cells and mice.
Volume: 76
Pages: 96-106
Publication  
First Author: Huang M
Year: 2018
Journal: Behav Brain Res
Title: The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect.
Volume: 337
Pages: 280-286
Publication
First Author: Gao L
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells.
Volume: 61
Issue: 1
Pages: 1
Publication  
First Author: Liu B
Year: 2020
Journal: Brain Res
Title: Dendrobium nobile Lindl alkaloid and metformin ameliorate cognitive dysfunction in senescence-accelerated mice via suppression of endoplasmic reticulum stress.
Volume: 1741
Pages: 146871