Type |
Details |
Score |
Publication |
First Author: |
Qu D |
Year: |
2007 |
Journal: |
Neuron |
Title: |
Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. |
Volume: |
55 |
Issue: |
1 |
Pages: |
37-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar A |
Year: |
2005 |
Journal: |
Neuron |
Title: |
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. |
Volume: |
48 |
Issue: |
2 |
Pages: |
303-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carter AM |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Phosphoprotein-based biomarkers as predictors for cancer therapy. |
Volume: |
117 |
Issue: |
31 |
Pages: |
18401-18411 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko SY |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors. |
Volume: |
116 |
Issue: |
5 |
Pages: |
1770-1775 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stromsdorfer KL |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice. |
Volume: |
16 |
Issue: |
7 |
Pages: |
1851-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lindqvist J |
Year: |
2017 |
Journal: |
J Cell Sci |
Title: |
Nestin contributes to skeletal muscle homeostasis and regeneration. |
Volume: |
130 |
Issue: |
17 |
Pages: |
2833-2842 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rei D |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway. |
Volume: |
112 |
Issue: |
23 |
Pages: |
7291-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pujol CN |
Year: |
2020 |
Journal: |
Sci Signal |
Title: |
Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis. |
Volume: |
13 |
Issue: |
618 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Humbert S |
Year: |
2000 |
Journal: |
Neuroreport |
Title: |
Synaptic localization of p39, a neuronal activator of cdk5. |
Volume: |
11 |
Issue: |
10 |
Pages: |
2213-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakurai T |
Year: |
2008 |
Journal: |
J Cell Biol |
Title: |
Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. |
Volume: |
183 |
Issue: |
2 |
Pages: |
339-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taniguchi M |
Year: |
2012 |
Journal: |
Neuron |
Title: |
Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. |
Volume: |
73 |
Issue: |
1 |
Pages: |
108-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi JH |
Year: |
2014 |
Journal: |
Genes Dev |
Title: |
Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming. |
Volume: |
28 |
Issue: |
21 |
Pages: |
2361-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gupta P |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer. |
Volume: |
40 |
Issue: |
7 |
Pages: |
111218 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zou J |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. |
Volume: |
115 |
Issue: |
17 |
Pages: |
E4101-E4110 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie L |
Year: |
2012 |
Journal: |
Dev Cell |
Title: |
Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. |
Volume: |
23 |
Issue: |
2 |
Pages: |
280-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eom T |
Year: |
2013 |
Journal: |
Elife |
Title: |
NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. |
Volume: |
2 |
|
Pages: |
e00178 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ho UY |
Year: |
2021 |
Journal: |
Commun Biol |
Title: |
WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. |
Volume: |
4 |
Issue: |
1 |
Pages: |
645 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
190
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
97
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
96
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Arragain S |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. |
Volume: |
285 |
Issue: |
37 |
Pages: |
28425-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Antoine JC |
Year: |
1999 |
Journal: |
Arch Neurol |
Title: |
Antiamphiphysin antibodies are associated with various paraneoplastic neurological syndromes and tumors. |
Volume: |
56 |
Issue: |
2 |
Pages: |
172-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anton BP |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli. |
Volume: |
105 |
Issue: |
6 |
Pages: |
1826-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nicolet Y |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation. |
Volume: |
32 |
Issue: |
13 |
Pages: |
4015-25 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The methylthiotransferase (MTTase) or miaB-like family is named after the (dimethylallyl)adenosine tRNA MTTase miaB protein, which catalyses a C-H to C-S bond conversion in the methylthiolation of tRNA. A related bacterial enzyme RimO performs a similar methylthiolation, but on a protein substrate. RimO acts on the ribosomal protein S12 and forms a separate MTTase subfamily. The miaB-subfamily includes mammalian CDK5 regulatory subunit-associated proteins and similar proteins in other eukaryotes. Two other subfamilies, yqeV and CDKAL1, are named after a Bacillus subtilis and a human protein, respectively. While yqeV-like proteins are found in bacteria, CDKAL1 subfamily members occur in eukaryotes and in archaebacteria [].The likely MTTases from these 4 subfamilies contain an N-terminal MTTase domain, a central radical generating fold and a C-terminal TRAM domain (see ). The core forms a radical SAM fold (or AdoMet radical), containing a cysteine motif CxxxCxxC that binds a [4Fe-4S]cluster [, , ]. A reducing equivalent from the [4Fe-4S]+ cluster is used to cleave S-adenosylmethionine (SAM) to generate methionine and a 5'-deoxyadenosyl radical. The latter is thought to produce a reactive substrate radical that is amenable to sulphur insertion [, ]. The N-terminal MTTase domain contains 3 cysteines that bind a second [4Fe-4S]cluster, in addition to the radical-generating [4Fe-4S]cluster, which could be involved in the thiolation reaction. The C-terminal TRAM domain is not shared with other radical SAM proteins outside the MTTase family. The TRAM domain can bind to RNA substrate and seems to be important for substrate recognition. The tertiary structure of the central radical SAM fold has six beta/alpha motifs resembling a three-quarter TIM barrel core []. The N-terminal MTTase domain might form an additional [beta/alpha]2 TIM barrel unit []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The methylthiotransferase (MTTase) or miaB-like family is named after the (dimethylallyl)adenosine tRNA MTTase miaB protein, which catalyses a C-H to C-S bond conversion in the methylthiolation of tRNA. A related bacterial enzyme rimO performs a similar methylthiolation, but on a protein substrate. RimO acts on the ribosomal protein S12 and forms a separate MTTase subfamily. The miaB-subfamily includes mammalian CDK5 regulatory subunit-associated proteins and similar proteins in other eukaryotes. Two other subfamilies, yqeV and CDKAL1, are named after a Bacillus subtilis and a human protein, respectively. While yqeV-like proteins are found in bacteria, CDKAL1 subfamily members occur in eukaryotes and in archaebacteria. The likely MTTases from these 4 subfamilies contain an N-terminal MTTase domain, a central radical generating fold and a C-terminal TRAM domain (see ). The core forms a radical SAM fold (or AdoMet radical), containing a cysteine motif CxxxCxxC that binds a [4Fe-4S]cluster [, , ]. A reducing equivalent from the [4Fe-4S]+ cluster is used to cleave S-adenosylmethionine (SAM) to generate methionine and a 5'-deoxyadenosyl radical. The latter is thought to produce a reactive substrate radical that is amenable to sulphur insertion [, ]. The N-terminal MTTase domain contains 3 cysteines that bind a second [4Fe-4S]cluster, in addition to the radical-generating [4Fe-4S]cluster, which could be involved in the thiolation reaction. The C-terminal TRAM domain is not shared with other radical SAM proteins outside the MTTase family. The TRAM domain can bind to RNA substrate and seems to be important for substrate recognition. The tertiary structure of the central radical SAM fold has six beta/alpha motifs resembling a three-quarter TIM barrel core (see ) []. The N-terminal MTTase domain might form an additional [beta/alpha]2 TIM barrel unit []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Conserved_site |
Description: |
The methylthiotransferase (MTTase) or miaB-like family is named after the (dimethylallyl)adenosine tRNA MTTase miaB protein, which catalyses a C-H to C-S bond conversion in the methylthiolation of tRNA. A related bacterial enzyme rimO performs a similar methylthiolation, but on a protein substrate. RimO acts on the ribosomal protein S12 andforms a separate MTTase subfamily. The miaB-subfamily includes mammalian CDK5 regulatory subunit-associated proteins and similar proteins in other eukaryotes. Two other subfamilies, yqeV and CDKAL1, are named after a Bacillus subtilis and a human protein, respectively. While yqeV-like proteins are found in bacteria, CDKAL1 subfamily members occur in eukaryotes and in archaebacteria. The likely MTTases from these 4 subfamilies contain an N-terminal MTTase domain, a central radical generating fold and a C-terminal TRAM domain (see ). The core forms a radical SAM fold (or AdoMet radical), containing a cysteine motif CxxxCxxC that binds a [4Fe-4S]cluster [, , ]. A reducing equivalent from the [4Fe-4S]+ cluster is used to cleave S-adenosylmethionine (SAM) to generate methionine and a 5'-deoxyadenosyl radical. The latter is thought to produce a reactive substrate radical that is amenable to sulphur insertion [, ]. The N-terminal MTTase domain contains 3 cysteines that bind a second [4Fe-4S]cluster, in addition to the radical-generating [4Fe-4S]cluster, which could be involved in the thiolation reaction. The C-terminal TRAM domain is not shared with other radical SAM proteins outside the MTTase family. The TRAM domain can bind to RNA substrate and seems to be important for substrate recognition. The tertiary structure of the central radical SAM fold has six beta/alpha motifs resembling a three-quarter TIM barrel core (see ) []. The N-terminal MTTase domain might form an additional [beta/alpha]2 TIM barrel unit []. This entry represents a conserved site containing three of the conserved cysteines that form the motif in the central radical SAM fold. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Amphiphysins belong to the expanding BAR (Bin-Amphiphysin-Rvsp) family proteins, all members of which share a highly conserved N-terminal BAR domain, which has predicted coiled-coil structures required for amphiphysin dimerisation and plasma membrane interaction []. Almost all members also share a conserved C-terminal Src homology 3 (SH3) domain, which mediates their interactions with the GTPase dynamin and the inositol-5'-phosphatase synaptojanin 1 in vertebrates and with actin in yeast. The central region of all these proteins is most variable. In mammals, the central region of amphiphysin I and amphiphysin IIa contains a proline-arginine-rich region for endophilin binding and a CLAP domain, for binding to clathrin and AP-2. The interactions mediated by both the central and C-terminal domains are believed to be modulated by protein phosphorylation [, ].Amphiphysins are proteins involved in clathrin-mediated endocytosis clathrin-mediated endocytosis, actin function, and signalling pathways [, ].Amphiphysin 1 was first identified in 1992 as a brain protein that was partially-associated with synaptic vesicles. Following its cloning, it was also realised to be a human auto-antigen that is detected in a rare neurological disease, Stiff-Man Syndrome, and also in certain types of cancer []. Amphiphysin 1 senses and facilitates membrane curvature to mediate synaptic vesicles invagination and fission during newly retrieved presynaptic vesicle formation and also acts as a linker protein binding with dynamin, clathrin, Amphiphysin II, and other dephosphins in the clathrin-coated complex. Amphiphysin 1 is cleaved an asparagine endopeptidase (AEP), which generates afragment that increases with aging. This fragment disrupts the normal endocytic function of Amphiphysin 1, leading to synaptic dysfunction, as it activates CDK5 inducing tau hyperphosphorylation. Therefore, Amphiphysin 1 posttranslational modification contributes to pathogenesis of Alzheimer's disease, being the AEP a therapeutic target []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The methylthiotransferase (MTTase) or miaB-like family is named after the (dimethylallyl)adenosine tRNA MTTase miaB protein, which catalyses a C-H to C-S bond conversion in the methylthiolation of tRNA. A related bacterial enzyme rimO performs a similar methylthiolation, but on a protein substrate. RimO acts on the ribosomal protein S12 and forms a separate MTTase subfamily. The miaB-subfamily includes mammalian CDK5 regulatory subunit-associated proteins and similar proteins in other eukaryotes. Two other subfamilies, yqeV and CDKAL1, are named after a Bacillus subtilis and a human protein, respectively. While yqeV-like proteins are found in bacteria, CDKAL1 subfamily members occur in eukaryotes and in archaebacteria. The likely MTTases from these 4 subfamilies contain an N-terminal MTTase domain, a central radical generating fold and a C-terminal TRAM domain (see ). The core forms a radical SAM fold (or AdoMet radical), containing a cysteine motif CxxxCxxC that binds a [4Fe-4S]cluster [, , ]. A reducing equivalent from the [4Fe-4S]+ cluster is used to cleave S-adenosylmethionine (SAM) to generate methionine and a 5'-deoxyadenosyl radical. The latter is thought to produce a reactive substrate radical that is amenable to sulphur insertion [, ]. The N-terminal MTTase domain contains 3 cysteines that bind a second [4Fe-4S]cluster, in addition to the radical-generating [4Fe-4S]cluster, which could be involved in the thiolation reaction. The C-terminal TRAM domain is not shared with other radical SAM proteins outside the MTTase family. The TRAM domain can bind to RNA substrate and seems to be important for substrate recognition. The tertiary structure of the central radical SAM fold has six beta/alpha motifs resembling a three-quarter TIM barrel core (see ) []. The N-terminal MTTase domain might form an additional [beta/alpha]2 TIM barrel unit []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Toyo-oka K |
Year: |
2003 |
Journal: |
Nat Genet |
Title: |
14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. |
Volume: |
34 |
Issue: |
3 |
Pages: |
274-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toyo-Oka K |
Year: |
2005 |
Journal: |
Hum Mol Genet |
Title: |
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. |
Volume: |
14 |
Issue: |
21 |
Pages: |
3113-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pao PC |
Year: |
2011 |
Journal: |
Cell Death Differ |
Title: |
A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells. |
Volume: |
18 |
Issue: |
11 |
Pages: |
1791-804 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fernando P |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Bin1 SRC homology 3 domain acts as a scaffold for myofiber sarcomere assembly. |
Volume: |
284 |
Issue: |
40 |
Pages: |
27674-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beffert U |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. |
Volume: |
24 |
Issue: |
8 |
Pages: |
1897-906 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bai B |
Year: |
2012 |
Journal: |
Circulation |
Title: |
Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. |
Volume: |
126 |
Issue: |
6 |
Pages: |
729-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laporte V |
Year: |
2008 |
Journal: |
Brain Res |
Title: |
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice. |
Volume: |
1231 |
|
Pages: |
132-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paratcha G |
Year: |
2006 |
Journal: |
Mol Cell Neurosci |
Title: |
GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream. |
Volume: |
31 |
Issue: |
3 |
Pages: |
505-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hallows JL |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
p35/p25 is not essential for tau and cytoskeletal pathology or neuronal loss in Niemann-Pick type C disease. |
Volume: |
26 |
Issue: |
10 |
Pages: |
2738-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ba L |
Year: |
2017 |
Journal: |
J Huazhong Univ Sci Technolog Med Sci |
Title: |
Aberrant activation of Cdc2/cyclin B1 is involved in initiation of cytoskeletal pathology in murine Niemann-Pick disease type C. |
Volume: |
37 |
Issue: |
5 |
Pages: |
732-739 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bu B |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model. |
Volume: |
22 |
Issue: |
15 |
Pages: |
6515-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cherubini M |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease. |
Volume: |
1852 |
Issue: |
10 Pt A |
Pages: |
2145-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li C |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E. |
Volume: |
24 |
Issue: |
27 |
Pages: |
6161-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patzke H |
Year: |
2003 |
Journal: |
J Neurosci |
Title: |
Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. |
Volume: |
23 |
Issue: |
7 |
Pages: |
2769-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wong DP |
Year: |
2023 |
Journal: |
Cancer Res Commun |
Title: |
p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated NK-cell Dysfunction. |
Volume: |
3 |
Issue: |
5 |
Pages: |
793-806 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwon YT |
Year: |
1999 |
Journal: |
J Comp Neurol |
Title: |
Callosal axon guidance defects in p35(-/-) mice. |
Volume: |
415 |
Issue: |
2 |
Pages: |
218-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qin X |
Year: |
2017 |
Journal: |
Am J Pathol |
Title: |
Inhibition of Early Growth Response 1 in the Hippocampus Alleviates Neuropathology and Improves Cognition in an Alzheimer Model with Plaques and Tangles. |
Volume: |
187 |
Issue: |
8 |
Pages: |
1828-1847 |
|
•
•
•
•
•
|
Publication |
First Author: |
Orr ME |
Year: |
2014 |
Journal: |
Neurobiol Aging |
Title: |
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. |
Volume: |
35 |
Issue: |
6 |
Pages: |
1233-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chu J |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e70991 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitazawa M |
Year: |
2006 |
Journal: |
Am J Pathol |
Title: |
Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. |
Volume: |
168 |
Issue: |
6 |
Pages: |
1986-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Medina-Vera D |
Year: |
2022 |
Journal: |
Br J Pharmacol |
Title: |
d-Pinitol promotes tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism: A new potential approach for tauopathies? |
Volume: |
179 |
Issue: |
19 |
Pages: |
4655-4672 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giannopoulos PF |
Year: |
2013 |
Journal: |
Biol Psychiatry |
Title: |
5-lipoxygenase activating protein reduction ameliorates cognitive deficit, synaptic dysfunction, and neuropathology in a mouse model of Alzheimer's disease. |
Volume: |
74 |
Issue: |
5 |
Pages: |
348-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han P |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. |
Volume: |
25 |
Issue: |
50 |
Pages: |
11542-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muyllaert D |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration. |
Volume: |
172 |
Issue: |
2 |
Pages: |
470-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giusti-RodrÃguez P |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1). |
Volume: |
31 |
Issue: |
44 |
Pages: |
15751-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mount MP |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). |
Volume: |
288 |
Issue: |
20 |
Pages: |
14362-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Im DS |
Year: |
2022 |
Journal: |
BMC Biol |
Title: |
Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition. |
Volume: |
20 |
Issue: |
1 |
Pages: |
115 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi S |
Year: |
2004 |
Journal: |
J Neurochem |
Title: |
Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25. |
Volume: |
88 |
Issue: |
5 |
Pages: |
1295-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Prochazkova M |
Year: |
2017 |
Journal: |
Mol Pain |
Title: |
Peripheral and orofacial pain sensation is unaffected by the loss of p39. |
Volume: |
13 |
|
Pages: |
1744806917737205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verstegen AM |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses. |
Volume: |
34 |
Issue: |
21 |
Pages: |
7266-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robin G |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome. |
Volume: |
26 |
Issue: |
14 |
Pages: |
2649-2666 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohshima T |
Year: |
2005 |
Journal: |
J Neurochem |
Title: |
Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice. |
Volume: |
94 |
Issue: |
4 |
Pages: |
917-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pareek TK |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cyclin-dependent kinase 5 activity regulates pain signaling. |
Volume: |
103 |
Issue: |
3 |
Pages: |
791-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
He X |
Year: |
2014 |
Journal: |
J Neurochem |
Title: |
Cdk5/p35 is required for motor coordination and cerebellar plasticity. |
Volume: |
131 |
Issue: |
1 |
Pages: |
53-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park KHJ |
Year: |
2017 |
Journal: |
Neuroscience |
Title: |
p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington's disease. |
Volume: |
352 |
|
Pages: |
79-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barrett T |
Year: |
2019 |
Journal: |
Neuroscience |
Title: |
p35 Hemizygous Deletion in 5xFAD Mice Increases Aβ Plaque Load in Males but Not in Females. |
Volume: |
417 |
|
Pages: |
45-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao LL |
Year: |
2019 |
Journal: |
Front Aging Neurosci |
Title: |
Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1. |
Volume: |
11 |
|
Pages: |
108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toba J |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice. |
Volume: |
473 |
Issue: |
4 |
Pages: |
1039-1044 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang W |
Year: |
2020 |
Journal: |
Neurosci Lett |
Title: |
FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro. |
Volume: |
738 |
|
Pages: |
135322 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Anti-diabetes drug pioglitazone ameliorates synaptic defects in AD transgenic mice by inhibiting cyclin-dependent kinase5 activity. |
Volume: |
10 |
Issue: |
4 |
Pages: |
e0123864 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amini M |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury. |
Volume: |
33 |
Issue: |
13 |
Pages: |
5773-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paul S |
Year: |
2022 |
Journal: |
eNeuro |
Title: |
Cyclin-Dependent Kinase 5 Regulates cPLA2 Activity and Neuroinflammation in Parkinson's Disease. |
Volume: |
9 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Rao MV |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. |
Volume: |
34 |
Issue: |
28 |
Pages: |
9222-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barroso E |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice. |
Volume: |
1832 |
Issue: |
8 |
Pages: |
1241-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saito T |
Year: |
2016 |
Journal: |
J Neurosci |
Title: |
Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression. |
Volume: |
36 |
Issue: |
38 |
Pages: |
9933-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamazaki Y |
Year: |
2020 |
Journal: |
Brain Res |
Title: |
Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4. |
Volume: |
1736 |
|
Pages: |
146762 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang M |
Year: |
2017 |
Journal: |
Mol Cell Proteomics |
Title: |
The Glial Cell-Derived Neurotrophic Factor (GDNF)-responsive Phosphoprotein Landscape Identifies Raptor Phosphorylation Required for Spermatogonial Progenitor Cell Proliferation. |
Volume: |
16 |
Issue: |
6 |
Pages: |
982-997 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vagnozzi AN |
Year: |
2018 |
Journal: |
Aging Cell |
Title: |
Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice. |
Volume: |
17 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yang T |
Year: |
2020 |
Journal: |
Acta Neuropathol Commun |
Title: |
Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
156 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giannopoulos PF |
Year: |
2018 |
Journal: |
Aging Cell |
Title: |
Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice. |
Volume: |
17 |
Issue: |
3 |
Pages: |
e12759 |
|
•
•
•
•
•
|
Publication |
First Author: |
Montenegro-Venegas C |
Year: |
2022 |
Journal: |
EMBO Rep |
Title: |
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP. |
Volume: |
23 |
Issue: |
8 |
Pages: |
e53659 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gassen NC |
Year: |
2015 |
Journal: |
Sci Signal |
Title: |
Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. |
Volume: |
8 |
Issue: |
404 |
Pages: |
ra119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takano T |
Year: |
2014 |
Journal: |
Mol Biol Cell |
Title: |
LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes. |
Volume: |
25 |
Issue: |
11 |
Pages: |
1755-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deprez F |
Year: |
2016 |
Journal: |
Eur J Neurosci |
Title: |
Partial inactivation of GABAA receptors containing the α5 subunit affects the development of adult-born dentate gyrus granule cells. |
Volume: |
44 |
Issue: |
5 |
Pages: |
2258-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong C |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Functional Role of Cyclin-Dependent Kinase 5 in the Regulation of Melanogenesis and Epidermal Structure. |
Volume: |
7 |
Issue: |
1 |
Pages: |
13783 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kato G |
Year: |
2019 |
Journal: |
eNeuro |
Title: |
Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice. |
Volume: |
6 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Liu GT |
Year: |
2022 |
Journal: |
EMBO J |
Title: |
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission. |
Volume: |
41 |
Issue: |
9 |
Pages: |
e109352 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choe EA |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. |
Volume: |
27 |
Issue: |
35 |
Pages: |
9503-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dhavan R |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. |
Volume: |
22 |
Issue: |
18 |
Pages: |
7879-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patrick GN |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. |
Volume: |
273 |
Issue: |
37 |
Pages: |
24057-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma E |
Year: |
1999 |
Journal: |
Biochem Biophys Res Commun |
Title: |
A Drosophila CDK5alpha-like molecule and its possible role in response to O(2) deprivation. |
Volume: |
261 |
Issue: |
2 |
Pages: |
459-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hammond V |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35. |
Volume: |
24 |
Issue: |
2 |
Pages: |
576-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Griffin SV |
Year: |
2004 |
Journal: |
Am J Pathol |
Title: |
Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. |
Volume: |
165 |
Issue: |
4 |
Pages: |
1175-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Veeranna |
Year: |
2011 |
Journal: |
Neurobiol Aging |
Title: |
Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. |
Volume: |
32 |
Issue: |
11 |
Pages: |
2016-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang WQ |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Cdk5-mediated phosphorylation of Axin directs axon formation during cerebral cortex development. |
Volume: |
31 |
Issue: |
38 |
Pages: |
13613-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie MJ |
Year: |
2013 |
Journal: |
Cereb Cortex |
Title: |
WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration. |
Volume: |
23 |
Issue: |
6 |
Pages: |
1410-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho DH |
Year: |
2014 |
Journal: |
Free Radic Biol Med |
Title: |
Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116) signaling cascade in endothelial cells and mice. |
Volume: |
76 |
|
Pages: |
96-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang M |
Year: |
2018 |
Journal: |
Behav Brain Res |
Title: |
The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect. |
Volume: |
337 |
|
Pages: |
280-286 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao L |
Year: |
2020 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells. |
Volume: |
61 |
Issue: |
1 |
Pages: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu B |
Year: |
2020 |
Journal: |
Brain Res |
Title: |
Dendrobium nobile Lindl alkaloid and metformin ameliorate cognitive dysfunction in senescence-accelerated mice via suppression of endoplasmic reticulum stress. |
Volume: |
1741 |
|
Pages: |
146871 |
|
•
•
•
•
•
|