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Search results 1701 to 1800 out of 1952 for Cdkn2a

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Type Details Score
Publication  
First Author: Mich JK
Year: 2014
Journal: Elife
Title: Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain.
Volume: 3
Pages: e02669
Publication
First Author: Rad R
Year: 2015
Journal: Nat Genet
Title: A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.
Volume: 47
Issue: 1
Pages: 47-56
Publication
First Author: Rahme GJ
Year: 2023
Journal: Cell
Title: Modeling epigenetic lesions that cause gliomas.
Volume: 186
Issue: 17
Pages: 3674-3685.e14
Publication
First Author: Searcy MB
Year: 2023
Journal: Nat Commun
Title: PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors.
Volume: 14
Issue: 1
Pages: 7291
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Publication
First Author: Baker DJ
Year: 2016
Journal: Nature
Title: Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Volume: 530
Issue: 7589
Pages: 184-9
Publication  
First Author: Kawaguchi K
Year: 2021
Journal: Biochem Biophys Res Commun
Title: An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice.
Volume: 541
Pages: 43-49
Strain
Attribute String: coisogenic, mutant strain, transgenic
Publication
First Author: Farr JN
Year: 2017
Journal: Nat Med
Title: Targeting cellular senescence prevents age-related bone loss in mice.
Volume: 23
Issue: 9
Pages: 1072-1079
Publication  
First Author: Xu M
Year: 2015
Journal: Elife
Title: Targeting senescent cells enhances adipogenesis and metabolic function in old age.
Volume: 4
Pages: e12997
Publication
First Author: Yao Z
Year: 2020
Journal: Cancer Res
Title: Therapy-Induced Senescence Drives Bone Loss.
Volume: 80
Issue: 5
Pages: 1171-1182
Strain
Attribute String: congenic, mutant strain, transgenic
Publication
First Author: Demaria M
Year: 2014
Journal: Dev Cell
Title: An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Volume: 31
Issue: 6
Pages: 722-33
Publication  
First Author: Wiley CD
Year: 2019
Journal: JCI Insight
Title: Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis.
Volume: 4
Issue: 24
Publication
First Author: Wiley CD
Year: 2019
Journal: Cell Rep
Title: SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells.
Volume: 28
Issue: 13
Pages: 3329-3337.e5
Publication
First Author: Chinta SJ
Year: 2018
Journal: Cell Rep
Title: Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.
Volume: 22
Issue: 4
Pages: 930-940
Publication
First Author: Alimirah F
Year: 2020
Journal: Cancer Res
Title: Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling.
Volume: 80
Issue: 17
Pages: 3606-3619
Publication
First Author: Pereira BI
Year: 2019
Journal: Nat Commun
Title: Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.
Volume: 10
Issue: 1
Pages: 2387
Publication
First Author: Yan H
Year: 2024
Journal: Sci Rep
Title: Primary oocytes with cellular senescence features are involved in ovarian aging in mice.
Volume: 14
Issue: 1
Pages: 13606
Publication
First Author: He Y
Year: 2020
Journal: Aging Cell
Title: Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.
Volume: 19
Issue: 3
Pages: e13117
Publication
First Author: Talma N
Year: 2021
Journal: Aging Cell
Title: Identification of distinct and age-dependent p16(High) microglia subtypes.
Volume: 20
Issue: 10
Pages: e13450
Publication
First Author: Demaria M
Year: 2017
Journal: Cancer Discov
Title: Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Volume: 7
Issue: 2
Pages: 165-176
Publication
First Author: Acklin S
Year: 2020
Journal: Sci Rep
Title: Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice.
Volume: 10
Issue: 1
Pages: 14170
Publication
First Author: Rocha LR
Year: 2020
Journal: Aging Cell
Title: Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension.
Volume: 19
Issue: 2
Pages: e13089
Publication
First Author: van Vliet T
Year: 2021
Journal: Mol Cell
Title: Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.
Volume: 81
Issue: 9
Pages: 2041-2052.e6
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Ppm1d/Ppm1d Tg(IghMyc)22Bri/?
Background: involves: 129 * C57BL * FVB/N * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a Tg(NES-TVA)J12Ech/?
Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a<+>
Background: involves: 129S1/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Bmi1/Bmi1 Apc/Apc<+> Cdkn2a/Cdkn2a Tg(Vil1-cre)20Syr/?
Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a Tg(CKMM-tTA)A3Rhvh/? Tg(tetO-Hgf,-EGFP)24Tcre/?
Background: involves: 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Tg(CKMM-tTA)A3Rhvh/? Tg(tetO-Hgf,-EGFP)24Tcre/?
Background: involves: 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a Pax7/Pax7 Tg(CKMM-tTA)A3Rhvh/? Tg(tetO-Hgf,-EGFP)24Tcre/?
Background: involves: 129S2/SvPas * 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a Pax7/Pax7<+> Tg(CKMM-tTA)A3Rhvh/? Tg(tetO-Hgf,-EGFP)24Tcre/?
Background: involves: 129S2/SvPas * 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a Nop53/Nop53 Tg(Lck-cre)#Jxm/?
Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(Cdkn2a/luc/RFP/TK)1Cmps/?
Background: B6.Cg-Tg(Cdkn2a/luc/RFP/TK)1Cmps/J
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Isono K
Year: 2005
Journal: Mol Cell Biol
Title: Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes.
Volume: 25
Issue: 15
Pages: 6694-706
Publication
First Author: Adorno M
Year: 2013
Journal: Nature
Title: Usp16 contributes to somatic stem-cell defects in Down's syndrome.
Volume: 501
Issue: 7467
Pages: 380-4
Publication
First Author: Wiedemeyer WR
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM.
Volume: 107
Issue: 25
Pages: 11501-6
Publication
First Author: Young LV
Year: 2021
Journal: Am J Physiol Cell Physiol
Title: Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells.
Volume: 321
Issue: 1
Pages: C94-C103
Publication
First Author: Schreiner B
Year: 2003
Journal: Genes Chromosomes Cancer
Title: Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice.
Volume: 38
Issue: 3
Pages: 240-8
Publication
First Author: Grootaert MO
Year: 2015
Journal: Autophagy
Title: Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis.
Volume: 11
Issue: 11
Pages: 2014-2032
Publication
First Author: O'Hara SP
Year: 2017
Journal: J Biol Chem
Title: ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A.
Volume: 292
Issue: 12
Pages: 4833-4846
Publication
First Author: Subkhankulova T
Year: 2010
Journal: Mol Cell Neurosci
Title: Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors.
Volume: 45
Issue: 2
Pages: 151-62
Publication
First Author: Leung C
Year: 2004
Journal: Nature
Title: Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.
Volume: 428
Issue: 6980
Pages: 337-41
Publication  
First Author: Cheng X
Year: 2021
Journal: Redox Biol
Title: Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity.
Volume: 40
Pages: 101863
Publication
First Author: Ko KP
Year: 2023
Journal: Gastroenterology
Title: Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion.
Volume: 165
Issue: 3
Pages: 613-628.e20
Publication
First Author: Festing MF
Year: 1998
Journal: Genomics
Title: At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice.
Volume: 53
Issue: 2
Pages: 129-36
Publication
First Author: Hacker E
Year: 2006
Journal: Cancer Res
Title: Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.
Volume: 66
Issue: 6
Pages: 2946-52
Publication
First Author: Watanabe H
Year: 2022
Journal: JBMR Plus
Title: Transcription Factor Hematopoietically Expressed Homeobox Protein (Hhex) Negatively Regulates Osteoclast Differentiation by Controlling Cyclin-Dependent Kinase Inhibitors.
Volume: 6
Issue: 4
Pages: e10608
Publication
First Author: Musi N
Year: 2018
Journal: Aging Cell
Title: Tau protein aggregation is associated with cellular senescence in the brain.
Volume: 17
Issue: 6
Pages: e12840
Publication  
First Author: Banerjee K
Year: 2023
Journal: J Clin Invest
Title: SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations.
Volume: 133
Issue: 18
Publication
First Author: Tokarsky-Amiel R
Year: 2013
Journal: Cancer Res
Title: Dynamics of senescent cell formation and retention revealed by p14ARF induction in the epidermis.
Volume: 73
Issue: 9
Pages: 2829-39
Publication
First Author: Ma KH
Year: 2018
Journal: Glia
Title: Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury.
Volume: 66
Issue: 11
Pages: 2487-2502
Publication
First Author: Dudakovic A
Year: 2018
Journal: J Biol Chem
Title: Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice.
Volume: 293
Issue: 33
Pages: 12894-12907
Publication
First Author: Kadariya Y
Year: 2009
Journal: Cancer Res
Title: Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.
Volume: 69
Issue: 14
Pages: 5961-9
Publication
First Author: Heltemes-Harris LM
Year: 2016
Journal: Oncogene
Title: Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.
Volume: 35
Issue: 26
Pages: 3454-64
Publication
First Author: Baell JB
Year: 2018
Journal: Nature
Title: Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Volume: 560
Issue: 7717
Pages: 253-257
Publication
First Author: Visel A
Year: 2010
Journal: Nature
Title: Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice.
Volume: 464
Issue: 7287
Pages: 409-12
Publication
First Author: Zhuang SM
Year: 2000
Journal: Cancer Lett
Title: Mutation analysis of the pRb pathway in 2',3'-dideoxycytidine- and 1, 3-butadiene-induced mouse lymphomas.
Volume: 152
Issue: 2
Pages: 129-34
Publication
First Author: Walker GJ
Year: 2002
Journal: J Invest Dermatol
Title: Pathways to melanoma development: lessons from the mouse.
Volume: 119
Issue: 4
Pages: 783-92
Publication
First Author: Chaum E
Year: 2015
Journal: Mamm Genome
Title: Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium.
Volume: 26
Issue: 5-6
Pages: 210-21
Publication
First Author: Scruggs AM
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: Loss of CDKN2B Promotes Fibrosis via Increased Fibroblast Differentiation Rather Than Proliferation.
Volume: 59
Issue: 2
Pages: 200-214
Publication
First Author: De Silva TM
Year: 2018
Journal: Hypertension
Title: Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging.
Volume: 72
Issue: 1
Pages: 227-234
Publication
First Author: Mishra A
Year: 2020
Journal: Carcinogenesis
Title: Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing.
Volume: 41
Issue: 3
Pages: 334-344
Publication
First Author: Wu H
Year: 2021
Journal: Cancer Res
Title: mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK.
Volume: 81
Issue: 12
Pages: 3174-3186
Publication  
First Author: Versemann L
Year: 2022
Journal: Cancers (Basel)
Title: TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer.
Volume: 14
Issue: 14
Publication  
First Author: Bahn YJ
Year: 2023
Journal: J Clin Invest
Title: CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism.
Volume: 133
Issue: 13
Publication
First Author: Chini CCS
Year: 2020
Journal: Nat Metab
Title: CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels.
Volume: 2
Issue: 11
Pages: 1284-1304
Publication
First Author: Salam R
Year: 2023
Journal: Nat Commun
Title: Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma.
Volume: 14
Issue: 1
Pages: 441
Publication
First Author: Kim DE
Year: 2020
Journal: Aging Cell
Title: Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.
Volume: 19
Issue: 3
Pages: e13072
Publication
First Author: Fuentes-Flores A
Year: 2023
Journal: EMBO Mol Med
Title: Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury.
Volume: 15
Issue: 12
Pages: e17907
Publication
First Author: Aguayo-Mazzucato C
Year: 2017
Journal: Cell Metab
Title: β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance.
Volume: 25
Issue: 4
Pages: 898-910.e5
Publication
First Author: Bussian TJ
Year: 2018
Journal: Nature
Title: Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Volume: 562
Issue: 7728
Pages: 578-582
Publication
First Author: Sahu SK
Year: 2024
Journal: Sci Transl Med
Title: Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging.
Volume: 16
Issue: 764
Pages: eadg1777
Publication
First Author: Jeon OH
Year: 2017
Journal: Nat Med
Title: Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Volume: 23
Issue: 6
Pages: 775-781
Genotype
Symbol: Cdkn2a/Cdkn2a Sclt1/? TgTn(sb-T2/Onc)76Dla/?
Background: involves: 129X1/SvJ * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a Sclt1/? TgTn(sb-T2/Onc)68Dla/?
Background: involves: 129X1/SvJ * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a Pdgfrb/Pdgfrb
Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a
Background: involves: 129S1/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Cdkn2a/Cdkn2a<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Sachdeva R
Year: 2012
Journal: PLoS One
Title: Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization.
Volume: 7
Issue: 11
Pages: e51125
Publication
First Author: Koppens MA
Year: 2016
Journal: Gastroenterology
Title: Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells.
Volume: 151
Issue: 4
Pages: 684-697.e12
Publication
First Author: Chen SN
Year: 2019
Journal: Circ Res
Title: DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations.
Volume: 124
Issue: 6
Pages: 856-873
Publication
First Author: Rollins LA
Year: 1998
Journal: Mol Carcinog
Title: Role of tumor suppressor genes in transplacental lung carcinogenesis.
Volume: 21
Issue: 3
Pages: 177-84
Publication  
First Author: Dassano A
Year: 2013
Journal: BMC Genomics
Title: Multigenic nature of the mouse pulmonary adenoma progression 1 locus.
Volume: 14
Pages: 152
Publication
First Author: Kooi IE
Year: 2017
Journal: Genes Chromosomes Cancer
Title: Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma.
Volume: 56
Issue: 3
Pages: 231-242
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory