| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang F |
| Year: |
2011 |
| Journal: |
PLoS One |
| Title: |
Deterministic and stochastic allele specific gene expression in single mouse blastomeres. |
| Volume: |
6 |
| Issue: |
6 |
| Pages: |
e21208 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo G |
| Year: |
2010 |
| Journal: |
Dev Cell |
| Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
| Volume: |
18 |
| Issue: |
4 |
| Pages: |
675-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yokoyama S |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
836-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators, MGI curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen J |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
| Volume: |
100 |
| Issue: |
17 |
| Pages: |
9918-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedel RH |
| Year: |
2007 |
| Journal: |
Brief Funct Genomic Proteomic |
| Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
180-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gray PA |
| Year: |
2004 |
| Journal: |
Science |
| Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
| Volume: |
306 |
| Issue: |
5705 |
| Pages: |
2255-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thompson CL |
| Year: |
2014 |
| Journal: |
Neuron |
| Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
| Volume: |
83 |
| Issue: |
2 |
| Pages: |
309-323 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Visel A |
| Year: |
2004 |
| Journal: |
Nucleic Acids Res |
| Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
| Volume: |
32 |
| Issue: |
Database issue |
| Pages: |
D552-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stryke D |
| Year: |
2003 |
| Journal: |
Nucleic Acids Res |
| Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
278-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
|
| Pages: |
686034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE14216 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
E-GEOD-19367 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang S |
| Year: |
2017 |
| Journal: |
FEBS Lett |
| Title: |
DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells. |
| Volume: |
591 |
| Issue: |
13 |
| Pages: |
1929-1939 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen YT |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
16087 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsiami F |
| Year: |
2024 |
| Journal: |
Acta Neuropathol Commun |
| Title: |
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
125 |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| lncRNA Gene |
| Type: |
lncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| ncRNA Gene |
| Type: |
ncRNA_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
DNA methyltransferase Dnmt1 associates with histone deacetylase activity. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
DNMT1 interacts with the developmental transcriptional repressor HESX1. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1620
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
ATM mediates pRB function to control DNMT1 protein stability and DNA methylation |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Z |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity. |
| Volume: |
279 |
| Issue: |
14 |
| Pages: |
14120-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Strand KA |
| Year: |
2020 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. |
| Volume: |
40 |
| Issue: |
8 |
| Pages: |
1854-1869 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1502
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Allele |
| Name: |
DNA methyltransferase 1; targeted mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Robertson KD |
| Year: |
2000 |
| Journal: |
Nat Genet |
| Title: |
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. |
| Volume: |
25 |
| Issue: |
3 |
| Pages: |
338-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Frauer C |
| Year: |
2011 |
| Journal: |
PLoS One |
| Title: |
Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1. |
| Volume: |
6 |
| Issue: |
2 |
| Pages: |
e16627 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gowher H |
| Year: |
2005 |
| Journal: |
Biochemistry |
| Title: |
De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases. |
| Volume: |
44 |
| Issue: |
29 |
| Pages: |
9899-904 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smets M |
| Year: |
2017 |
| Journal: |
Hum Mol Genet |
| Title: |
DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation. |
| Volume: |
26 |
| Issue: |
8 |
| Pages: |
1522-1534 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nishiyama A |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
1222 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tatematsu KI |
| Year: |
2000 |
| Journal: |
Genes Cells |
| Title: |
MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. |
| Volume: |
5 |
| Issue: |
8 |
| Pages: |
677-88 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Guoqiang Gu |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Datta J |
| Year: |
2003 |
| Journal: |
J Cell Biochem |
| Title: |
Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1. |
| Volume: |
88 |
| Issue: |
5 |
| Pages: |
855-64 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion CJ101, GENSAT Project at Rockefeller University |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
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| HT Experiment |
| Series Id: |
E-GEOD-79018 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
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| Publication |
| First Author: |
Corona M |
| Year: |
1991 |
| Journal: |
Anat Histol Embryol |
| Title: |
[The sensitive nerve endings of the clitoris of the sow (Sus scrofa domesticus)]. |
| Volume: |
20 |
| Issue: |
4 |
| Pages: |
369-77 |
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents DNA (cytosine-5)-methyltransferase 1 (Dnmt1; ), which methylates CpG residues, with a preference for hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Dnmt1 mediates transcriptional repression (silencing) by establishing a repressive transcription complex where the N terminus of Dnmt1 binds to HDAC2 (histone deacetylase-2) as well as to DMAP1 (Dnmt1-associated protein) []. LSH, which is related to the SNF2 chromatin-remodelling ATPases, is also required for efficient DNA methylation []. |
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| HT Experiment |
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| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
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| Allele |
| Name: |
DNA methyltransferase 1; targeted mutation 3, Rudolf Jaenisch |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
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| Strain |
| Attribute String: |
mutant stock, transgenic |
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| Genotype |
| Symbol: |
Dnmt1/Dnmt1 |
| Background: |
involves: 129S4/SvJae * BALB/c |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
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| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents a domain found in DNA methyltransferase 1-associated protein 1 (DMAP1). DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). The chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex. The non-catalytic N terminus of DNMT1 binds to HDAC2 and DMAP1, and can mediate transcriptional repression. DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase, providing a platform for how histones may become deacetylated in heterochromatin following replication []. |
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