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Search results 1701 to 1800 out of 2795 for Egfr

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Type Details Score
Publication
17361012 | J:124325
First Author: Charalambous CT
Year: 2007
Journal: Carcinogenesis
Title: Latent membrane protein 1-induced EGFR signalling is negatively regulated by TGF alpha prior to neoplasia.
Volume: 28
Issue: 8
Pages: 1839-48
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Publication
37827343 | J:343195
 
First Author: Qiao L
Year: 2023
Journal: Cell Signal
Title: NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
Volume: 112
Pages: 110922
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Publication
25121353 | J:215571
First Author: Fang Y
Year: 2014
Journal: Biochem J
Title: A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition.
Volume: 463
Issue: 3
Pages: 383-92
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Publication
28195529 | J:241209
   
First Author: Kedzierski L
Year: 2017
Journal: Elife
Title: Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.
Volume: 6
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Allele
Eldr<Gt(IST14721A11)Tigm> | MGI:5254076
 
Name: Egfr long non-coding downstream RNA; gene trap IST14721A11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Genotype
Genotype
Symbol: Eldr/Eldr
Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Publication
35732128 | J:332326
First Author: Kenchappa RS
Year: 2022
Journal: Cell Rep
Title: Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma.
Volume: 39
Issue: 12
Pages: 110991
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Publication
16730237 | J:110131
First Author: Ji H
Year: 2006
Journal: Cancer Cell
Title: The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Volume: 9
Issue: 6
Pages: 485-95
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Publication
25843712 | J:228161
First Author: Blakely CM
Year: 2015
Journal: Cell Rep
Title: NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer.
Volume: 11
Issue: 1
Pages: 98-110
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Publication
21690342 | J:181819
First Author: Jin K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.
Volume: 109
Issue: 8
Pages: 2736-41
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Publication
39303667 | J:354994
 
First Author: Tran TTT
Year: 2024
Journal: EBioMedicine
Title: Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer.
Volume: 108
Pages: 105356
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Publication
33570794 | J:309536
First Author: Chiu LY
Year: 2021
Journal: FASEB J
Title: PARP-1 involves in UVB-induced inflammatory response in keratinocytes and skin injury via regulation of ROS-dependent EGFR transactivation and p38 signaling.
Volume: 35
Issue: 3
Pages: e21393
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Publication
21159643 | J:167601
First Author: Zhang C
Year: 2010
Journal: Cancer Res
Title: Tip30 deletion in MMTV-Neu mice leads to enhanced EGFR signaling and development of estrogen receptor-positive and progesterone receptor-negative mammary tumors.
Volume: 70
Issue: 24
Pages: 10224-33
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Publication
30679620 | J:275436
First Author: Park J
Year: 2019
Journal: Sci Rep
Title: A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer.
Volume: 9
Issue: 1
Pages: 648
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Publication
25347743 | J:224258
First Author: Sangrar W
Year: 2015
Journal: Oncogene
Title: Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems.
Volume: 34
Issue: 31
Pages: 4109-17
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Publication
33878394 | J:306548
 
First Author: Chaudhary S
Year: 2021
Journal: Cancer Lett
Title: Dual blockade of EGFR and CDK4/6 delays head and neck squamous cell carcinoma progression by inducing metabolic rewiring.
Volume: 510
Pages: 79-92
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Publication
33028660 | J:303971
First Author: Ohkawa Y
Year: 2021
Journal: Mol Cancer Res
Title: Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM.
Volume: 19
Issue: 1
Pages: 150-161
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Publication
17545620 | J:122175
First Author: Schmelz EM
Year: 2007
Journal: Cancer Res
Title: Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein.
Volume: 67
Issue: 11
Pages: 5389-96
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Publication
25009231 | J:215676
First Author: Rebouissou S
Year: 2014
Journal: Sci Transl Med
Title: EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype.
Volume: 6
Issue: 244
Pages: 244ra91
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Publication
26282169 | J:225972
First Author: Soucheray M
Year: 2015
Journal: Cancer Res
Title: Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition.
Volume: 75
Issue: 20
Pages: 4372-83
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Publication
28855674 | J:255809
First Author: El-Hashim AZ
Year: 2017
Journal: Sci Rep
Title: Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model.
Volume: 7
Issue: 1
Pages: 9919
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Publication
31811906 | J:283706
 
First Author: Yue Y
Year: 2020
Journal: Cancer Lett
Title: 2'-Hydroxyflavanone inhibits the progression of pancreatic cancer cells and sensitizes the chemosensitivity of EGFR inhibitors via repressing STAT3 signaling.
Volume: 471
Pages: 135-146
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Publication
31675376 | J:281665
First Author: El-Hashim AZ
Year: 2019
Journal: PLoS One
Title: Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma.
Volume: 14
Issue: 11
Pages: e0224163
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Publication
36385375 | J:332906
First Author: Jin C
Year: 2023
Journal: Oncogene
Title: MTDH-stabilized DDX17 promotes tumor initiation and progression through interacting with YB1 to induce EGFR transcription in Hepatocellular Carcinoma.
Volume: 42
Issue: 3
Pages: 169-183
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GO Term
GO:0007173 | epidermal growth factor receptor signaling pathway
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Publication
24746758 | J:317856
First Author: Dogan I
Year: 2014
Journal: Lung Cancer
Title: SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines.
Volume: 85
Issue: 1
Pages: 1-6
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Publication
18347145 | J:145378
First Author: Alferez D
Year: 2008
Journal: Mol Cancer Ther
Title: Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.
Volume: 7
Issue: 3
Pages: 590-8
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Publication
26581390 | J:265593
 
First Author: Holdman XB
Year: 2015
Journal: Breast Cancer Res
Title: Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer.
Volume: 17
Pages: 141
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Publication
21407195 | J:205661
 
First Author: Maretzky T
Year: 2011
Journal: Nat Commun
Title: Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.
Volume: 2
Pages: 229
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Publication
30070361 | J:267405
First Author: Ock S
Year: 2018
Journal: Int J Cancer
Title: Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation.
Volume: 143
Issue: 10
Pages: 2458-2469
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Publication
31465746 | J:294825
First Author: Agrahari G
Year: 2020
Journal: J Invest Dermatol
Title: Superoxide Dismutase 3 Inhibits LL-37/KLK-5-Mediated Skin Inflammation through Modulation of EGFR and Associated Inflammatory Cascades.
Volume: 140
Issue: 3
Pages: 656-665.e8
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Publication
36380187 | J:331598
First Author: Xu M
Year: 2022
Journal: Commun Biol
Title: Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
Volume: 5
Issue: 1
Pages: 1251
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Publication
24421325 | J:206451
First Author: Bañón-Rodríguez I
Year: 2014
Journal: EMBO J
Title: EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis.
Volume: 33
Issue: 2
Pages: 129-45
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Publication
26483553 | J:237587
First Author: Chiasson-MacKenzie C
Year: 2015
Journal: J Cell Biol
Title: NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.
Volume: 211
Issue: 2
Pages: 391-405
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Protein Coding Gene
MGI:2447773 | Fam83a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
33771918 | J:304008
 
First Author: Wu WF
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Estrogen receptor β and treatment with a phytoestrogen are associated with inhibition of nuclear translocation of EGFR in the prostate.
Volume: 118
Issue: 13
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Interaction Experiment
Aguirre A (2010)
Description: Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal.
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Interaction Experiment
Wu Y (2003)
Description: EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.
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Interaction Experiment
Li K (2021)
Description: Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.
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Publication
31213486 | J:278072
 
First Author: Pfefferle AD
Year: 2019
Journal: Dis Model Mech
Title: The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.
Volume: 12
Issue: 7
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Publication
26947075 | J:234564
First Author: Liou GY
Year: 2016
Journal: Cell Rep
Title: Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.
Volume: 14
Issue: 10
Pages: 2325-36
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Publication
25981042 | J:228452
First Author: Oshiumi H
Year: 2015
Journal: Cell Rep
Title: DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation.
Volume: 11
Issue: 8
Pages: 1193-207
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Publication
34576152 | J:313712
 
First Author: Hsu HL
Year: 2021
Journal: Int J Mol Sci
Title: Aryl Hydrocarbon Receptor Defect Attenuates Mitogen-Activated Signaling through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation.
Volume: 22
Issue: 18
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Publication
36689330 | J:352393
First Author: Müller L
Year: 2023
Journal: Cell Rep
Title: Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling.
Volume: 42
Issue: 1
Pages: 112031
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Publication
21516087 | J:171575
First Author: Lupberger J
Year: 2011
Journal: Nat Med
Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
Volume: 17
Issue: 5
Pages: 589-95
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Publication
25099735 | J:223117
First Author: Wang L
Year: 2014
Journal: Am J Physiol Cell Physiol
Title: Kcnj10 is a major type of K+ channel in mouse corneal epithelial cells and plays a role in initiating EGFR signaling.
Volume: 307
Issue: 8
Pages: C710-7
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Publication
22552292 | J:189319
First Author: Xu L
Year: 2012
Journal: Cancer Res
Title: Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET.
Volume: 72
Issue: 13
Pages: 3302-11
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Publication
29982425 | J:264297
First Author: Song JM
Year: 2018
Journal: Carcinogenesis
Title: Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway.
Volume: 39
Issue: 7
Pages: 911-920
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Publication
22761823 | J:187920
First Author: Rinella ES
Year: 2012
Journal: PLoS One
Title: Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials.
Volume: 7
Issue: 6
Pages: e39552
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Publication
12878043 | J:85007
First Author: Anna CH
Year: 2003
Journal: Toxicol Appl Pharmacol
Title: Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice.
Volume: 190
Issue: 2
Pages: 135-45
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Publication
17876047 | J:139838
First Author: Oehler-Jänne C
Year: 2007
Journal: Mol Cancer Ther
Title: Hypoxia modulation and radiosensitization by the novel dual EGFR and VEGFR inhibitor AEE788 in spontaneous and related allograft tumor models.
Volume: 6
Issue: 9
Pages: 2496-504
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Genotype
Genotype
Symbol: Eldr/Eldr<+>
Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N
Zygosity: ht
Has Mutant Allele: true
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Interaction Experiment
da Rocha JF (2021)
Description: APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis.
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GO Term
GO:0007176 | regulation of epidermal growth factor-activated receptor activity
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GO Term
GO:0038127 | ERBB signaling pathway
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Protein Coding Gene
MGI:1919128 | Fam83d
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8K2P2
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
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Protein
Q9D7I8
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Publication
32193290 | J:289110
First Author: Starrett JH
Year: 2020
Journal: Cancer Res
Title: Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations.
Volume: 80
Issue: 10
Pages: 2017-2030
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GO Term
GO:0005006 | epidermal growth factor receptor activity
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GO Term
GO:0042058 | regulation of epidermal growth factor receptor signaling pathway
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Interaction Experiment
Hartman Z (2012)
Description: HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling.
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Publication
23029159 | -
First Author: Ruiz OE
Year: 2012
Journal: PLoS One
Title: Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both EGFR and FGFR signaling in tracheal subcellular lumen formation.
Volume: 7
Issue: 9
Pages: e45649
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Publication
27769858 | -
First Author: Deshar R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4.
Volume: 480
Issue: 2
Pages: 280-287
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Publication
19644445 | -
First Author: Li R
Year: 2009
Journal: EMBO J
Title: ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.
Volume: 28
Issue: 18
Pages: 2763-76
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Publication
23757022 | -
First Author: Er EE
Year: 2013
Journal: Sci Signal
Title: AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.
Volume: 6
Issue: 279
Pages: ra45
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Publication
23222715 | -
First Author: Kostaras E
Year: 2013
Journal: Oncogene
Title: SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking.
Volume: 32
Issue: 44
Pages: 5220-32
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Protein Coding Gene
MGI:103310 | Ptprk
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1345139 | Spry1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P35822
Organism: Mus musculus/domesticus
Length: 1457  
Fragment?: false
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Protein
Q9QXV9
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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GO Term
GO:1901184 | regulation of ERBB signaling pathway
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Allele
Egfr<em1Smoc> | MGI:7289452
Name: epidermal growth factor receptor; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Tg(Sftpc-EGFR)1Takt | MGI:7382952
Name: transgene insertion 1, Takashi Takahashi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:7380746 | C57BL/6-Tg(Sftpc-EGFR)1Takt/Takt
Attribute String: coisogenic, mutant strain, transgenic
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Publication
26034286 | J:223387
First Author: Goff LA
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain.
Volume: 112
Issue: 22
Pages: 6855-62
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Publication
14752159 | -
First Author: Yoo AS
Year: 2004
Journal: Science
Title: Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development.
Volume: 303
Issue: 5658
Pages: 663-6
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Publication
11597398 | -
 
First Author: Yarden Y
Year: 2001
Journal: Eur J Cancer
Title: The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities.
Volume: 37 Suppl 4
Pages: S3-8
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Publication
12974390 | -
First Author: Wu Y
Year: 2003
Journal: Biol Chem
Title: EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.
Volume: 384
Issue: 8
Pages: 1215-26
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Protein Coding Gene
MGI:107935 | Lrig1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70193
Organism: Mus musculus/domesticus
Length: 1091  
Fragment?: false
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Interaction Term
MI:2200 | primesdb
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Publication
30772301 | J:283934
First Author: Uchiyama A
Year: 2019
Journal: J Invest Dermatol
Title: SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands.
Volume: 139
Issue: 8
Pages: 1809-1820.e8
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Allele
Tg(EGFR)1Jlj | MGI:1926351
Name: transgene insertion 1, Jose Luis Jorcano
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Tg(EGFR)2Jlj | MGI:1926352
Name: transgene insertion 2, Jose Luis Jorcano
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Tg(EGFR)3Jlj | MGI:1926353
Name: transgene insertion 3, Jose Luis Jorcano
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Tg(EGFR)4Jlj | MGI:1926355
Name: transgene insertion 4, Jose Luis Jorcano
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Tg(EGFR)5Jlj | MGI:1926356
Name: transgene insertion 5, Jose Luis Jorcano
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Tg(EGFR)0Jlj | MGI:1926833
Name: transgene insertion 0, Jose Luis Jorcano
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Col1a1<tm1(CAG-EGFR)Char> | MGI:3837824
Name: collagen, type I, alpha 1; targeted mutation 1, Al Charest
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(tetO-EGFR*)9Hev | MGI:5568395
Name: transgene insertion 9, Harold E Varmus
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6354756 | C57BL/6JSmoc-Egfr<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Egfr<tm1Smoc> | MGI:7289453
Name: epidermal growth factor receptor; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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GO Term
GO:0038004 | epidermal growth factor receptor ligand maturation
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GO Term
GO:0005154 | epidermal growth factor receptor binding
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Publication
18724389 | -
First Author: Chen C
Year: 2008
Journal: Oncogene
Title: The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11.
Volume: 27
Issue: 54
Pages: 6845-55
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Publication
17997974 | -
First Author: Bullock AN
Year: 2007
Journal: Structure
Title: Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
Volume: 15
Issue: 11
Pages: 1493-504
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Publication
33009641 | -
First Author: da Rocha JF
Year: 2021
Journal: Mol Neurobiol
Title: APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis.
Volume: 58
Issue: 2
Pages: 668-688
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Publication
18046415 | -
First Author: Zhang X
Year: 2007
Journal: Nature
Title: Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Volume: 450
Issue: 7170
Pages: 741-4
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Protein Domain
IPR021619 | Mig-6
Type: Domain
Description: When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains [].The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. SinceMig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive [].
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