|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1701 to 1800 out of 1990 for Gk

<< First    < Previous  |  Next >    Last >>
0.037s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
12059963 | J:113986
First Author: Roy BC
Year: 2002
Journal: Genes Cells
Title: SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus.
Volume: 7
Issue: 6
Pages: 607-17
•
•
•
•
•
Publication
23217261 | J:195098
First Author: Tsukita S
Year: 2012
Journal: Cell Metab
Title: Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals.
Volume: 16
Issue: 6
Pages: 825-32
•
•
•
•
•
Publication
2014265 | -
First Author: Gumbiner B
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.
Volume: 88
Issue: 8
Pages: 3460-4
•
•
•
•
•
Publication
8408213 | -
First Author: Balda MS
Year: 1993
Journal: J Cell Biol
Title: Assembly of the tight junction: the role of diacylglycerol.
Volume: 123
Issue: 2
Pages: 293-302
•
•
•
•
•
Protein Domain
IPR020590 | Guanylate_kinase_CS
Type: Conserved_site
Description: Guanylate kinase () (GK) []catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes(such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown [, , ]to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.Proteins containing one or more copies of the DHR domain, an SH3 domain as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologues) [], andinclude Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junction protein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); vertebrate 55kDa erythrocyte membrane protein (p55); Caenorhabditis elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However these proteins retain the residues known, in GK, to be involved in the binding of GMP.This signature pattern covers a highly conserved region that contains two arginine and a tyrosine which are involved in GMP-binding.
•
•
•
•
•
Protein Domain
IPR005419 | ZO-2
Type: Family
Description: The zona occuldens proteins (ZO-1, ZO-2 and ZO-3) are a family of tight junction associated proteins that function as cross-linkers, anchoring the TJ strand proteins to the actin-based cytoskeleton []. Each protein contains three PDZ (postsynaptic density, disc-large, ZO-1) domains, a single SH3 (Src Homology-3) domain and a GK (guanylate kinase) domain, the presence of which identifies them as members of the membrane-associated guanylate kinase (MAGUK) protein family. They also share an acidic domain at the C-terminal region of the molecules not found in other MAGUK proteins. It has been demonstrated that the first PDZ domain is involved in binding the C-terminal -Y-V motif of claudins []. By contrast, the occludin-binding domain of ZO-1 has been shown to lie in the GK and acidic domains []. Although the precise location of the actin-binding motif has not been elucidated, it appears to be within the C-terminal half of the molecules, since transfection of this region into fibroblasts induces co-localisation of ZO-1 and ZO-2 with actin fibres.This entry represents ZO-2, which was first identified as a 160kDa protein that co-immunoprecipitates with ZO-1 []. It shares ~65% overall similarity with ZO-1 and ZO-3 proteins, with highest levels of similarity in the MAGUK and acid domains. In vitro binding studies indicate that ZO-2 may interact directly with ZO-1 through its second PDZ domain, although it does not appear to bind directly to ZO-3.
•
•
•
•
•
Protein Domain
IPR005420 | ZO-3
Type: Family
Description: The zona occuldens proteins (ZO-1, ZO-2 and ZO-3) are a family of tight junction associated proteins that function as cross-linkers, anchoring the TJ strand proteins to the actin-based cytoskeleton []. Each protein contains three PDZ (postsynaptic density, disc-large, ZO-1) domains, a single SH3 (Src Homology-3) domain and a GK (guanylate kinase) domain, the presence of which identifies them as members of the membrane-associated guanylate kinase (MAGUK) protein family. They also share an acidic domain at the C-terminal region of the molecules not found in other MAGUK proteins. It has been demonstrated that the first PDZ domain is involved in binding the C-terminal -Y-V motif of claudins []. By contrast, the occludin-binding domain of ZO-1 has been shown to lie in the GK and acidic domains []. Although the precise location of the actin-binding motif has not been elucidated, it appears to be within the C-terminal half of the molecules, since transfection of this region into fibroblasts induces co-localisation of ZO-1 and ZO-2 with actin fibres.This entry represents ZO-3, which was first identified as a 130kDa protein that co-immunoprecipitates with ZO-1 []. It shares ~65% overall similarity with ZO-1 and ZO-2 proteins, with highest levels of similarity in the MAGUK and acid domains. In vitro binding studies indicate that ZO-3 may interact directly with ZO-1 through its second PDZ domain, although it does not appear to bind directly to ZO-2 [].
•
•
•
•
•
Protein Domain
IPR035597 | ZO-1_SH3
Type: Domain
Description: This entry represents the SH3 domain of ZO-1.The zona occuldens proteins (ZO-1, ZO-2 and ZO-3) are a family of tight junction associated proteins that function as cross-linkers, anchoring the TJ strand proteins to the actin-based cytoskeleton []. Each protein contains three PDZ (postsynaptic density, disc-large, ZO-1) domains, a single SH3 (Src Homology-3) domain and a catalytically inactive GK (guanylate kinase) domain, the presence of which identifies them as members of the membrane-associated guanylate kinase (MAGUK) protein family. The signature PDZ-SH3-GuK tandem of MAGUKs may form a structural supramodule with three domains interacting with each other to assemble into an integral structural unit [, ]. They also share an acidic domain at the C-terminal region of the molecules not found in other MAGUK proteins. It has been demonstrated that the first PDZ domain is involved in binding the C-terminal -Y-V motif of claudins []. By contrast, the occludin-binding domain of ZO-1 has been shown to lie in the GK and acidic domains []. Although the precise location of the actin-binding motif has not been elucidated, it appears to be within the C-terminal half of the molecules, since transfection of this region into fibroblasts induces co-localisation of ZO-1 and ZO-2 with actin fibres.
•
•
•
•
•
Protein Domain
IPR035598 | ZO-2_SH3
Type: Domain
Description: This entry represents the SH3 domain of ZO-2.The zona occuldens proteins (ZO-1, ZO-2 and ZO-3) are a family of tight junction associated proteins that function as cross-linkers, anchoring the TJ strand proteins to the actin-based cytoskeleton []. Each protein contains three PDZ (postsynaptic density, disc-large, ZO-1) domains, a single SH3 (Src Homology-3) domain and a catalytically inactive GK (guanylate kinase) domain, the presence of which identifies them as members of the membrane-associated guanylate kinase (MAGUK) protein family. Thesignature PDZ-SH3-GuK tandem of MAGUKs may form a structural supramodule with three domains interacting with each other to assemble into an integral structural unit [, ]. They also share an acidic domain at the C-terminal region of the molecules not found in other MAGUK proteins. It has been demonstrated that the first PDZ domain is involved in binding the C-terminal -Y-V motif of claudins []. By contrast, the occludin-binding domain of ZO-1 has been shown to lie in the GK and acidic domains []. Although the precise location of the actin-binding motif has not been elucidated, it appears to be within the C-terminal half of the molecules, since transfection of this region into fibroblasts induces co-localisation of ZO-1 and ZO-2 with actin fibres.
•
•
•
•
•
Protein Domain
IPR008144 | Guanylate_kin-like_dom
Type: Domain
Description: Guanylate kinase () (GK) []catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes(such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown [, , ]to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.Proteins containing one or more copies of the DHR domain, an SH3 domain as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologues) [], andinclude Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junction protein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); vertebrate 55kDa erythrocyte membrane protein (p55); Caenorhabditis elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3.There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However these proteins retain the residues known, in GK, to be involved in the binding of GMP.
•
•
•
•
•
Publication
30017584 | J:265834
First Author: Hung PJ
Year: 2018
Journal: Mol Cell
Title: MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
Volume: 71
Issue: 2
Pages: 332-342.e8
•
•
•
•
•
Publication
28882873 | J:269226
First Author: Trigueros-Motos L
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.
Volume: 37
Issue: 11
Pages: 2147-2155
•
•
•
•
•
Publication
19562077 | J:150183
First Author: Rubio-Aliaga I
Year: 2009
Journal: PLoS One
Title: Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
Volume: 4
Issue: 6
Pages: e6054
•
•
•
•
•
Publication
26099046 | J:224865
First Author: Wang J
Year: 2015
Journal: Nat Med
Title: Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.
Volume: 21
Issue: 7
Pages: 820-6
•
•
•
•
•
Publication
33496845 | J:314090
First Author: Vona B
Year: 2021
Journal: Hum Genet
Title: A biallelic variant in CLRN2 causes non-syndromic hearing loss in humans.
Volume: 140
Issue: 6
Pages: 915-931
•
•
•
•
•
Publication
17558408 | -
First Author: van Heel DA
Year: 2007
Journal: Nat Genet
Title: A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
Volume: 39
Issue: 7
Pages: 827-9
•
•
•
•
•
Publication
21892162 | -
First Author: Hahn CN
Year: 2011
Journal: Nat Genet
Title: Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia.
Volume: 43
Issue: 10
Pages: 1012-7
•
•
•
•
•
Publication
32246942 | J:347533
First Author: Factor DC
Year: 2020
Journal: Cell
Title: Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS.
Volume: 181
Issue: 2
Pages: 382-395.e21
•
•
•
•
•
Publication
36883955 | J:336656
First Author: Faget DV
Year: 2023
Journal: Cancer Discov
Title: p38MAPKα Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy.
Volume: 13
Issue: 6
Pages: 1454-1477
•
•
•
•
•
Publication
30970248 | J:276965
First Author: Delbridge ARD
Year: 2019
Journal: Cell Rep
Title: Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.
Volume: 27
Issue: 2
Pages: 442-454.e5
•
•
•
•
•
Publication
27322743 | J:239966
First Author: Nolan E
Year: 2016
Journal: Nat Med
Title: RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.
Volume: 22
Issue: 8
Pages: 933-9
•
•
•
•
•
Publication
23933982 | J:201890
First Author: Robbins CS
Year: 2013
Journal: Nat Med
Title: Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
Volume: 19
Issue: 9
Pages: 1166-72
•
•
•
•
•
Publication
32541024 | J:291515
First Author: Wang Y
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade.
Volume: 117
Issue: 27
Pages: 15818-15826
•
•
•
•
•
Publication
33328477 | J:301420
First Author: Liu J
Year: 2020
Journal: Nat Commun
Title: Eosinophils improve cardiac function after myocardial infarction.
Volume: 11
Issue: 1
Pages: 6396
•
•
•
•
•
Publication
38881440 | J:353353
First Author: Shamsuzzaman S
Year: 2024
Journal: Circulation
Title: Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition.
Volume: 150
Issue: 9
Pages: 687-705
•
•
•
•
•
Publication
28636844 | J:322844
First Author: Jaiswal S
Year: 2017
Journal: N Engl J Med
Title: Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.
Volume: 377
Issue: 2
Pages: 111-121
•
•
•
•
•
Publication
31996024 | J:292412
First Author: Loaiza N
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans.
Volume: 40
Issue: 4
Pages: 973-985
•
•
•
•
•
Publication
29562203 | J:272415
First Author: O'Reilly LA
Year: 2018
Journal: Immunity
Title: Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
Volume: 48
Issue: 3
Pages: 570-583.e8
•
•
•
•
•
Publication
33691097 | J:334258
First Author: Bambouskova M
Year: 2021
Journal: Cell Rep
Title: Itaconate confers tolerance to late NLRP3 inflammasome activation.
Volume: 34
Issue: 10
Pages: 108756
•
•
•
•
•
Publication
30021146 | J:289210
First Author: Mandal P
Year: 2018
Journal: Immunity
Title: Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Volume: 49
Issue: 1
Pages: 42-55.e6
•
•
•
•
•
Publication
28970238 | J:251008
First Author: Sun L
Year: 2017
Journal: J Exp Med
Title: HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.
Volume: 214
Issue: 11
Pages: 3263-3277
•
•
•
•
•
Publication
29666415 | J:265475
First Author: Silva MC
Year: 2018
Journal: Nat Commun
Title: Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.
Volume: 9
Issue: 1
Pages: 1513
•
•
•
•
•
Publication
26020946 | J:224773
First Author: Nurnberg ST
Year: 2015
Journal: PLoS Genet
Title: Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.
Volume: 11
Issue: 5
Pages: e1005155
•
•
•
•
•
Publication
29670287 | J:261637
First Author: Bambouskova M
Year: 2018
Journal: Nature
Title: Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Volume: 556
Issue: 7702
Pages: 501-504
•
•
•
•
•
Publication
32644975 | J:302351
First Author: Li T
Year: 2020
Journal: J Clin Invest
Title: Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection.
Volume: 130
Issue: 10
Pages: 5397-5412
•
•
•
•
•
Publication
26642438 | J:233176
First Author: Dickey AS
Year: 2016
Journal: Nat Med
Title: PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
Volume: 22
Issue: 1
Pages: 37-45
•
•
•
•
•
Publication
30755422 | J:276228
First Author: McRae HM
Year: 2019
Journal: Blood
Title: PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
Volume: 133
Issue: 16
Pages: 1729-1741
•
•
•
•
•
Publication
24278461 | J:209773
First Author: Gewies A
Year: 2013
Journal: PLoS One
Title: Prdm6 is essential for cardiovascular development in vivo.
Volume: 8
Issue: 11
Pages: e81833
•
•
•
•
•
Publication
25599561 | J:223848
First Author: Vasanthakumar A
Year: 2015
Journal: Nat Immunol
Title: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.
Volume: 16
Issue: 3
Pages: 276-85
•
•
•
•
•
Publication
28889989 | J:255247
First Author: Vasanthakumar A
Year: 2017
Journal: Cell Rep
Title: The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues.
Volume: 20
Issue: 12
Pages: 2906-2920
•
•
•
•
•
Publication
24316982 | J:205496
First Author: Bard-Chapeau EA
Year: 2014
Journal: Nat Genet
Title: Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.
Volume: 46
Issue: 1
Pages: 24-32
•
•
•
•
•
Publication
26595889 | J:234689
First Author: Rankin LC
Year: 2016
Journal: Nat Immunol
Title: Complementarity and redundancy of IL-22-producing innate lymphoid cells.
Volume: 17
Issue: 2
Pages: 179-86
•
•
•
•
•
Publication
24519940 | J:212438
First Author: Afrazi A
Year: 2014
Journal: J Biol Chem
Title: Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.
Volume: 289
Issue: 14
Pages: 9584-99
•
•
•
•
•
Publication
32541654 | J:292184
First Author: Ng AP
Year: 2020
Journal: Nat Commun
Title: An Erg-driven transcriptional program controls B cell lymphopoiesis.
Volume: 11
Issue: 1
Pages: 3013
•
•
•
•
•
Publication
33110235 | J:301792
First Author: Nimmakayala RK
Year: 2021
Journal: Oncogene
Title: Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma.
Volume: 40
Issue: 1
Pages: 215-231
•
•
•
•
•
Publication
22733781 | J:186398
First Author: Good M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium.
Volume: 109
Issue: 28
Pages: 11330-5
•
•
•
•
•
Publication
18308289 | J:258545
First Author: Berkovic SF
Year: 2008
Journal: Am J Hum Genet
Title: Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis.
Volume: 82
Issue: 3
Pages: 673-84
•
•
•
•
•
Publication
34653248 | J:326030
First Author: Docampo MD
Year: 2022
Journal: Blood
Title: Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.
Volume: 139
Issue: 15
Pages: 2392-2405
•
•
•
•
•
Publication
18719666 | J:185494
First Author: Brommage R
Year: 2008
Journal: Obesity (Silver Spring)
Title: High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes.
Volume: 16
Issue: 10
Pages: 2362-7
•
•
•
•
•
Publication
35714308 | J:336985
First Author: Agrawal M
Year: 2022
Journal: Blood
Title: TET2-mutant clonal hematopoiesis and risk of gout.
Volume: 140
Issue: 10
Pages: 1094-1103
•
•
•
•
•
Publication
31915375 | J:293270
First Author: Gate D
Year: 2020
Journal: Nature
Title: Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.
Volume: 577
Issue: 7790
Pages: 399-404
•
•
•
•
•
Publication
39110589 | J:353609
First Author: DeVore SB
Year: 2024
Journal: Cell Rep
Title: Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease.
Volume: 43
Issue: 8
Pages: 114589
•
•
•
•
•
Publication
37566656 | J:339077
First Author: Whisler J
Year: 2023
Journal: Sci Adv
Title: Emergent mechanical control of vascular morphogenesis.
Volume: 9
Issue: 32
Pages: eadg9781
•
•
•
•
•
Publication
37095396 | J:344021
First Author: Udeochu JC
Year: 2023
Journal: Nat Neurosci
Title: Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Volume: 26
Issue: 5
Pages: 737-750
•
•
•
•
•
Publication
38582079 | J:348746
First Author: Parra Bravo C
Year: 2024
Journal: Cell
Title: Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
Volume: 187
Issue: 10
Pages: 2446-2464.e22
•
•
•
•
•
Publication
32976798 | J:298360
First Author: Sharma A
Year: 2020
Journal: Cell
Title: Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma.
Volume: 183
Issue: 2
Pages: 377-394.e21
•
•
•
•
•
Publication
22534796 | J:285866
First Author: Williams JS
Year: 2012
Journal: Am J Hypertens
Title: Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension.
Volume: 25
Issue: 7
Pages: 812-7
•
•
•
•
•
Publication
31042466 | J:288458
First Author: Ni M
Year: 2019
Journal: Cell Rep
Title: Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans.
Volume: 27
Issue: 5
Pages: 1376-1386.e6
•
•
•
•
•
Publication
37770424 | J:358259
First Author: Garnish SE
Year: 2023
Journal: Nat Commun
Title: A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
Volume: 14
Issue: 1
Pages: 6046
•
•
•
•
•
Publication
24509633 | J:207450
First Author: Klapoetke NC
Year: 2014
Journal: Nat Methods
Title: Independent optical excitation of distinct neural populations.
Volume: 11
Issue: 3
Pages: 338-46
•
•
•
•
•
Publication
23162013 | J:216915
First Author: Leeper NJ
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation.
Volume: 33
Issue: 1
Pages: e1-e10
•
•
•
•
•
Publication
24770696 | J:225223
 
First Author: Aksoy I
Year: 2014
Journal: Nat Commun
Title: Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells.
Volume: 5
Pages: 3719
•
•
•
•
•
Publication
27846469 | J:237206
 
First Author: Wang Y
Year: 2016
Journal: Science
Title: A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.
Volume: 354
Issue: 6308
•
•
•
•
•
Publication
27857075 | J:242860
 
First Author: Teh CE
Year: 2016
Journal: Nat Commun
Title: Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.
Volume: 7
Pages: 13353
•
•
•
•
•
Publication
29114065 | J:251967
First Author: Tsai F
Year: 2017
Journal: J Exp Med
Title: Bim suppresses the development of SLE by limiting myeloid inflammatory responses.
Volume: 214
Issue: 12
Pages: 3753-3773
•
•
•
•
•
Publication
27895035 | J:262013
First Author: Eken SM
Year: 2017
Journal: Circ Res
Title: MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions.
Volume: 120
Issue: 4
Pages: 633-644
•
•
•
•
•
Publication
29856956 | J:262836
First Author: Kim MY
Year: 2018
Journal: Cell
Title: Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Volume: 173
Issue: 6
Pages: 1439-1453.e19
•
•
•
•
•
Publication
30894016 | J:295352
First Author: Centa M
Year: 2019
Journal: Circulation
Title: Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Volume: 139
Issue: 21
Pages: 2466-2482
•
•
•
•
•
Publication
33004675 | J:297654
 
First Author: Darwich NF
Year: 2020
Journal: Science
Title: Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau.
Volume: 370
Issue: 6519
•
•
•
•
•
Publication
34270411 | J:343923
   
First Author: Siegle JH
Year: 2021
Journal: Elife
Title: Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology.
Volume: 10
•
•
•
•
•
Publication
34488832 | J:357117
First Author: Farmer BC
Year: 2021
Journal: Mol Neurodegener
Title: APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.
Volume: 16
Issue: 1
Pages: 62
•
•
•
•
•
Publication
34733286 | J:312918
 
First Author: Koda S
Year: 2021
Journal: Front Immunol
Title: β2-Adrenergic Receptor Enhances the Alternatively Activated Macrophages and Promotes Biliary Injuries Caused by Helminth Infection.
Volume: 12
Pages: 754208
•
•
•
•
•
Publication
37076617 | J:340018
First Author: Bergholz JS
Year: 2023
Journal: Nature
Title: PI3Kβ controls immune evasion in PTEN-deficient breast tumours.
Volume: 617
Issue: 7959
Pages: 139-146
•
•
•
•
•
Publication
38092754 | J:343423
First Author: Muta Y
Year: 2023
Journal: Nat Commun
Title: Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Volume: 14
Issue: 1
Pages: 8075
•
•
•
•
•
Publication
38652660 | J:349812
First Author: Schäfer A
Year: 2024
Journal: Cell Rep
Title: Mapping of susceptibility loci for Ebola virus pathogenesis in mice.
Volume: 43
Issue: 5
Pages: 114127
•
•
•
•
•
HT Experiment
E-GEOD-3843 | Transcription profiling of liver from wild type vs glycerol kinase knockout mice to understand the molecular pathogenesis of GKD
Series Id: GSE3843
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
25800971 | J:223949
 
First Author: Kiselycznyk C
Year: 2015
Journal: Behav Brain Res
Title: NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism.
Volume: 287
Pages: 89-95
•
•
•
•
•
Protein
Q9D3X0
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
•
•
•
•
•
Protein
Q3TNZ0
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
•
•
•
•
•
Protein
B1AUH6
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: false
•
•
•
•
•
Publication
9765552 | -
First Author: Fujita T
Year: 1998
Journal: Plant Physiol
Title: Comparative analysis of the regulation of expression and structures of two evolutionarily divergent genes for Delta1-pyrroline-5-carboxylate synthetase from tomato.
Volume: 118
Issue: 2
Pages: 661-74
•
•
•
•
•
Publication
9531559 | -
First Author: Haskins J
Year: 1998
Journal: J Cell Biol
Title: ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.
Volume: 141
Issue: 1
Pages: 199-208
•
•
•
•
•
Protein Domain
IPR000965 | GPR_dom
Type: Domain
Description: Gamma-glutamyl phosphate reductase () (GPR) is the enzyme that catalyses the second step in the biosynthesis of proline from glutamate, the NADP-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. In bacteria (gene proA) and yeast [](gene PRO2), GPR is a monofunctional protein, while in plants and mammals, it is a bifunctional enzyme (P5CS) []that consists of two domains, an N-terminal glutamate 5-kinase domain () and a C-terminal GPR domain. In humans, the P5CS (ALDH18A1), an inner mitochondrial membrane enzyme, is essential to the de novo synthesis of the amino acids proline and arginine []. Tomato (Lycopersicon esculentum) has both the prokaryotic-like polycistronic operons encoding GK and GPR (PRO1, ALDH19) and the full-length, bifunctional P5CS (PRO2, ALDH18B1) [].This entry represents the C-terminal GPR domain of the gamma-glutamyl phosphate reductase.
•
•
•
•
•
Publication
3528172 | -
First Author: Stevenson BR
Year: 1986
Journal: J Cell Biol
Title: Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.
Volume: 103
Issue: 3
Pages: 755-66
•
•
•
•
•
Protein
Q8VCB6
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
•
•
•
•
•
Protein
G3UYV3
Organism: Mus musculus/domesticus
Length: 31  
Fragment?: true
•
•
•
•
•
Protein
F6VMK9
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR005418 | ZO-1
Type: Family
Description: The zona occuldens proteins (ZO-1, ZO-2 and ZO-3) are a family of tight junction associated proteins that function as cross-linkers, anchoring the TJ strand proteins to the actin-based cytoskeleton []. Each protein contains three PDZ (postsynaptic density, disc-large, ZO-1) domains, a single SH3 (Src Homology-3) domain and a catalytically inactive GK (guanylate kinase) domain, the presence of which identifies them as members of the membrane-associated guanylate kinase (MAGUK) protein family. The signature PDZ-SH3-GuK tandem of MAGUKs may form a structural supramodule with three domains interacting with each other to assemble into an integral structural unit [, ]. They also share an acidic domain at the C-terminal region of the molecules not found in other MAGUK proteins. It has been demonstrated that the first PDZ domain is involved in binding the C-terminal -Y-V motif of claudins []. By contrast, the occludin-binding domain of ZO-1 has been shown to lie in the GK and acidic domains []. Although the precise location of the actin-binding motif has not been elucidated, it appears to be within the C-terminal half of the molecules, since transfection of this region into fibroblasts induces co-localisation of ZO-1 and ZO-2 with actin fibres.This entry represents ZO-1, which was first identified as a 220kDa antigen for a monoclonal antibody raised to junction-enriched cell fractions []. The protein shares ~65% overall similarity with ZO-2 and ZO-3 proteins, with highest levels of similarity in the MAGUK and acid domains. The structure of ZO-1 is distinct from the other ZO protein family members in that it contains a ZU5 domain at the C-terminal end of the molecule, although the function of this domain is unknown. Binding and tranfection studies indicate that ZO-1 is capable of associating with ZO-2 and ZO-3 through binding of the second PDZ domains [].
•
•
•
•
•
Protein
Q64520
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
•
•
•
•
•
Protein
Q3TEN9
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
•
•
•
•
•
Protein
Q8C635
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
•
•
•
•
•
Protein
Q3TET2
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
•
•
•
•
•
Protein
Q8BW08
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: true
•
•
•
•
•
Protein
E9Q7K1
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
•
•
•
•
•
Protein
B1ASZ3
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
•
•
•
•
•
Protein
F7CD87
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
•
•
•
•
•
Protein
Q0VDQ2
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
•
•
•
•
•
Protein
Q9WU64
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
•
•
•
•
•
Protein
Q8BP37
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
•
•
•
•
•
Publication
22030391 | -
First Author: Nomme J
Year: 2011
Journal: J Biol Chem
Title: The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1.
Volume: 286
Issue: 50
Pages: 43352-60
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom