|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1701 to 1800 out of 1888 for Hes1

<< First    < Previous  |  Next >    Last >>
0.015s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
Q6PE09
Organism: Mus musculus/domesticus
Length: 544  
Fragment?: false
•
•
•
•
•
Protein
Q6ZPN6
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: true
•
•
•
•
•
Protein
Q8R0G3
Organism: Mus musculus/domesticus
Length: 571  
Fragment?: false
•
•
•
•
•
Protein
Q3TDA1
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
•
•
•
•
•
Protein
Q3V156
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
•
•
•
•
•
Protein
A0A3Q4L2S6
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
•
•
•
•
•
Protein
D3Z7I9
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: true
•
•
•
•
•
Protein
E9Q6C1
Organism: Mus musculus/domesticus
Length: 656  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J0F9
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
•
•
•
•
•
Protein
Q571D2
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: true
•
•
•
•
•
Protein
Q8R1X8
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
•
•
•
•
•
Protein
Q3UZK3
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
•
•
•
•
•
Protein
A0A5F8MQ99
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
•
•
•
•
•
Protein
A0A3Q4EG54
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: false
•
•
•
•
•
Protein
Q6PG70
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
•
•
•
•
•
Protein
Q5QNQ4
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
•
•
•
•
•
Protein
A0A3Q4EI24
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: false
•
•
•
•
•
Protein
Q8K0C7
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: false
•
•
•
•
•
Protein
Q5FWX7
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
•
•
•
•
•
Publication
8017104 | -
First Author: Jiang B
Year: 1994
Journal: Yeast
Title: A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein.
Volume: 10
Issue: 3
Pages: 341-53
•
•
•
•
•
Publication
17428193 | -
First Author: Suchanek M
Year: 2007
Journal: Biochem J
Title: The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.
Volume: 405
Issue: 3
Pages: 473-80
•
•
•
•
•
Publication
16897474 | -
First Author: Skirpan AL
Year: 2006
Journal: Plant Mol Biol
Title: Identification and characterization of PiORP1, a Petunia oxysterol-binding-protein related protein involved in receptor-kinase mediated signaling in pollen, and analysis of the ORP gene family in Arabidopsis.
Volume: 61
Issue: 4-5
Pages: 553-65
•
•
•
•
•
Publication
15746430 | -
First Author: Wang PY
Year: 2005
Journal: Science
Title: OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation.
Volume: 307
Issue: 5714
Pages: 1472-6
•
•
•
•
•
Publication
34283201 | -
 
First Author: Encinar Del Dedo J
Year: 2021
Journal: J Cell Biol
Title: Coupled sterol synthesis and transport machineries at ER-endocytic contact sites.
Volume: 220
Issue: 10
•
•
•
•
•
Publication
11238399 | -
First Author: Beh CT
Year: 2001
Journal: Genetics
Title: Overlapping functions of the yeast oxysterol-binding protein homologues.
Volume: 157
Issue: 3
Pages: 1117-40
•
•
•
•
•
Publication
29487131 | -
First Author: Tian S
Year: 2018
Journal: J Biol Chem
Title: Oxysterol-binding protein homologs mediate sterol transport from the endoplasmic reticulum to mitochondria in yeast.
Volume: 293
Issue: 15
Pages: 5636-5648
•
•
•
•
•
Protein
Q5F209
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
•
•
•
•
•
Protein
A0A3Q4EG41
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: false
•
•
•
•
•
Protein
A0A0N4SVU7
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR018494 | Oxysterol-bd_CS
Type: Conserved_site
Description: A number of eukaryotic proteins that seem to be involved with sterol synthesis and/or its regulation have been found []to be evolutionary related. These include mammalian oxysterol-binding protein (OSBP), a protein of about 800 amino-acid residues that binds a variety of oxysterols (oxygenated derivatives of cholesterol) [, ]; yeast Osh1, a protein of 859 residues that also plays a role in ergosterol synthesis []; yeast proteins Hes1 and Kes1, highly related proteins of 434 residues that seem to play a role in ergosterol synthesis [, ]; Probable transporter efuK from the fungi Hormonema carpetanum, which is involved in the biosynthesis of enfumafungin [[cite30051576]]; and OSBP-related proteins (ORP) from plants such as Arabidopsis thaliana [].Thisentry represents a sequence region in these proteins that contains a conserved pentapetide.
•
•
•
•
•
Protein Domain
IPR000648 | Oxysterol-bd
Type: Family
Description: A number of eukaryotic proteins that seem to be involved with sterol synthesis and/or its regulation have been found []to be evolutionary related. These include mammalian oxysterol-binding protein (OSBP), a protein of about 800 amino-acid residues that binds a variety of oxysterols (oxygenated derivatives of cholesterol) [, ]; yeast Osh1, a protein of 859 residues that also plays a role in ergosterol synthesis []; yeast proteins Hes1 and Kes1, highly related proteins of 434 residues that seem to play a role in ergosterol synthesis [, ]; Probable transporter efuK from the fungi Hormonema carpetanum, which is involved in the biosynthesis of enfumafungin [[cite30051576]]; and OSBP-related proteins (ORP) from plants such as Arabidopsis thaliana [].
•
•
•
•
•
Protein Domain
IPR037239 | OSBP_sf
Type: Homologous_superfamily
Description: A number of eukaryotic proteins that seem to be involved with sterol synthesis and/or its regulation have been found []to be evolutionary related. These include mammalian oxysterol-binding protein (OSBP), a protein of about 800 amino-acid residues that binds a variety of oxysterols (oxygenated derivatives of cholesterol) [, ]; yeast Osh1, a protein of 859 residues that also plays a role in ergosterol synthesis []; yeast proteins Hes1 and Kes1, highly related proteins of 434 residues that seem to play a role in ergosterol synthesis [, ]; Probable transporter efuK from the fungi Hormonema carpetanum, which is involved in the biosynthesis of enfumafungin [[cite30051576]]; and OSBP-related proteins (ORP) from plants such as Arabidopsis thaliana [].The core structure of OSBP has a large meander β-sheet of 12 strands wrapped around the N-terminal (distorted) alpha-hairpin. It shares some similarity with transmembrane β-barrel proteins.
•
•
•
•
•
Publication
26272820 | J:226180
First Author: Chen YH
Year: 2015
Journal: Genes Dev
Title: Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways.
Volume: 29
Issue: 16
Pages: 1677-82
•
•
•
•
•
Publication
11545715 | J:88447
First Author: Solecki DJ
Year: 2001
Journal: Neuron
Title: Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation.
Volume: 31
Issue: 4
Pages: 557-68
•
•
•
•
•
Genotype
Genotype
Symbol: Rbpj/Rbpj Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hes1/Hes1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Protein
V9GXX3
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: true
•
•
•
•
•
Publication
9570950 | J:47548
First Author: Nishimura M
Year: 1998
Journal: Genomics
Title: Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split.
Volume: 49
Issue: 1
Pages: 69-75
•
•
•
•
•
Publication
12050162 | J:224744
First Author: Sakamoto K
Year: 2002
Journal: J Biol Chem
Title: The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.
Volume: 277
Issue: 33
Pages: 29399-405
•
•
•
•
•
Publication
18430783 | J:139790
First Author: Sakamoto K
Year: 2008
Journal: J Cell Sci
Title: Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells.
Volume: 121
Issue: Pt 10
Pages: 1613-23
•
•
•
•
•
Publication
14567914 | J:86140
First Author: Hu QD
Year: 2003
Journal: Cell
Title: F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.
Volume: 115
Issue: 2
Pages: 163-75
•
•
•
•
•
Publication
16282354 | J:105139
First Author: Udagawa J
Year: 2006
Journal: Endocrinology
Title: The role of leptin in the development of the cerebral cortex in mouse embryos.
Volume: 147
Issue: 2
Pages: 647-58
•
•
•
•
•
Publication
22364862 | J:182740
First Author: Moya IM
Year: 2012
Journal: Dev Cell
Title: Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
Volume: 22
Issue: 3
Pages: 501-14
•
•
•
•
•
Publication
17849436 | J:125513
First Author: Fujikura J
Year: 2007
Journal: Dev Dyn
Title: Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development.
Volume: 236
Issue: 10
Pages: 2779-91
•
•
•
•
•
Publication
27939883 | J:241719
First Author: Nakata T
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.
Volume: 482
Issue: 4
Pages: 1296-1303
•
•
•
•
•
Publication
31251913 | J:286805
First Author: Wang H
Year: 2019
Journal: Cell
Title: Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
Volume: 178
Issue: 1
Pages: 135-151.e19
•
•
•
•
•
Publication
18048645 | J:131591
First Author: Varnum-Finney B
Year: 2008
Journal: Blood
Title: Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus.
Volume: 111
Issue: 5
Pages: 2615-20
•
•
•
•
•
Publication
19345332 | J:147433
First Author: Santaguida M
Year: 2009
Journal: Cancer Cell
Title: JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.
Volume: 15
Issue: 4
Pages: 341-52
•
•
•
•
•
Publication
31671073 | J:295396
First Author: Bousquet Mur E
Year: 2020
Journal: J Clin Invest
Title: Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma.
Volume: 130
Issue: 2
Pages: 612-624
•
•
•
•
•
Publication
22897852 | J:191822
First Author: Maraver A
Year: 2012
Journal: Cancer Cell
Title: Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.
Volume: 22
Issue: 2
Pages: 222-34
•
•
•
•
•
Publication
25574842 | J:220391
First Author: Maraver A
Year: 2015
Journal: J Clin Invest
Title: NOTCH pathway inactivation promotes bladder cancer progression.
Volume: 125
Issue: 2
Pages: 824-30
•
•
•
•
•
Publication
38958606 | J:360648
 
First Author: McKimpson WM
Year: 2024
Journal: J Cell Biol
Title: Calorie restriction activates a gastric Notch-FOXO1 pathway to expand ghrelin cells.
Volume: 223
Issue: 10
•
•
•
•
•
Publication
20832754 | J:164199
First Author: Espinosa L
Year: 2010
Journal: Cancer Cell
Title: The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.
Volume: 18
Issue: 3
Pages: 268-81
•
•
•
•
•
Publication
34772946 | J:314664
First Author: Harada Y
Year: 2021
Journal: Nat Commun
Title: Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module.
Volume: 12
Issue: 1
Pages: 6562
•
•
•
•
•
Publication
24894568 | J:274177
 
First Author: Jiang H
Year: 2014
Journal: Nat Commun
Title: Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia.
Volume: 5
Pages: 3838
•
•
•
•
•
Publication
19109490 | J:143882
First Author: Havrda MC
Year: 2008
Journal: J Neurosci
Title: Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis.
Volume: 28
Issue: 52
Pages: 14074-86
•
•
•
•
•
Publication
31239441 | J:277824
First Author: Kawaue T
Year: 2019
Journal: Nat Commun
Title: Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development.
Volume: 10
Issue: 1
Pages: 2780
•
•
•
•
•
Publication
27821476 | J:244936
 
First Author: Myllymäki MN
Year: 2017
Journal: Mol Cell Biol
Title: Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.
Volume: 37
Issue: 2
•
•
•
•
•
Publication
12629177 | J:82269
First Author: Chojnacki A
Year: 2003
Journal: J Neurosci
Title: Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells.
Volume: 23
Issue: 5
Pages: 1730-41
•
•
•
•
•
Publication
15110721 | J:90645
First Author: Kan L
Year: 2004
Journal: Dev Biol
Title: Sox1 acts through multiple independent pathways to promote neurogenesis.
Volume: 269
Issue: 2
Pages: 580-94
•
•
•
•
•
Publication
11756438 | J:75093
First Author: Berechid BE
Year: 2002
Journal: J Biol Chem
Title: Identification and characterization of presenilin-independent Notch signaling.
Volume: 277
Issue: 10
Pages: 8154-65
•
•
•
•
•
Publication
15367661 | J:93032
First Author: Nuthall HN
Year: 2004
Journal: Mol Cell Biol
Title: Phosphorylation of serine 239 of Groucho/TLE1 by protein kinase CK2 is important for inhibition of neuronal differentiation.
Volume: 24
Issue: 19
Pages: 8395-407
•
•
•
•
•
Publication
17250806 | J:118223
First Author: Minamizato T
Year: 2007
Journal: Biochem Biophys Res Commun
Title: CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways.
Volume: 354
Issue: 2
Pages: 567-73
•
•
•
•
•
Publication
18956012 | J:141082
First Author: Kageyama R
Year: 2008
Journal: Nat Neurosci
Title: Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition.
Volume: 11
Issue: 11
Pages: 1247-51
•
•
•
•
•
Publication
19250647 | J:145935
First Author: Riz I
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.
Volume: 380
Issue: 2
Pages: 361-5
•
•
•
•
•
Publication
28240738 | J:275253
 
First Author: Obora K
Year: 2017
Journal: Sci Rep
Title: Inflammation-induced miRNA-155 inhibits self-renewal of neural stem cells via suppression of CCAAT/enhancer binding protein β (C/EBPβ) expression.
Volume: 7
Pages: 43604
•
•
•
•
•
Publication
34647690 | J:356134
First Author: Zhao L
Year: 2021
Journal: Adv Sci (Weinh)
Title: Obesity Impairs Embryonic Myogenesis by Enhancing BMP Signaling within the Dermomyotome.
Volume: 8
Issue: 22
Pages: e2102157
•
•
•
•
•
Protein
D3YWU9
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
•
•
•
•
•
Protein
B9EJ86
Organism: Mus musculus/domesticus
Length: 889  
Fragment?: false
•
•
•
•
•
Protein
Q8CI95
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
•
•
•
•
•
Protein
S4R1M9
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
•
•
•
•
•
Protein
Q9DBS9
Organism: Mus musculus/domesticus
Length: 855  
Fragment?: false
•
•
•
•
•
Protein
Q3B7Z2
Organism: Mus musculus/domesticus
Length: 805  
Fragment?: false
•
•
•
•
•
Protein
Q5QNQ6
Organism: Mus musculus/domesticus
Length: 908  
Fragment?: false
•
•
•
•
•
Protein
Q9ER64
Organism: Mus musculus/domesticus
Length: 874  
Fragment?: false
•
•
•
•
•
Protein
Q8BXR9
Organism: Mus musculus/domesticus
Length: 959  
Fragment?: false
•
•
•
•
•
Protein
A2A8Z1
Organism: Mus musculus/domesticus
Length: 736  
Fragment?: false
•
•
•
•
•
Protein
F6UHR6
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
•
•
•
•
•
Protein
Q80UX3
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
•
•
•
•
•
Protein
G5E8A0
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
•
•
•
•
•
Protein
D3Z194
Organism: Mus musculus/domesticus
Length: 850  
Fragment?: false
•
•
•
•
•
Protein
A2A716
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
•
•
•
•
•
Protein
F8VQM4
Organism: Mus musculus/domesticus
Length: 791  
Fragment?: false
•
•
•
•
•
Protein
F8WH20
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
•
•
•
•
•
Protein
A0A1S6GWJ0
Organism: Mus musculus/domesticus
Length: 754  
Fragment?: false
•
•
•
•
•
Protein
A0A5F8MPC5
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: true
•
•
•
•
•
Protein
E9PXZ2
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
•
•
•
•
•
Protein
D3YTT6
Organism: Mus musculus/domesticus
Length: 886  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J150
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
•
•
•
•
•
Protein
A0A338P6F2
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
•
•
•
•
•
Protein
S4R296
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
•
•
•
•
•
Protein
G5E833
Organism: Mus musculus/domesticus
Length: 898  
Fragment?: false
•
•
•
•
•
Protein
Q5DTM2
Organism: Mus musculus/domesticus
Length: 1002  
Fragment?: true
•
•
•
•
•
Protein
Q3TAX1
Organism: Mus musculus/domesticus
Length: 781  
Fragment?: true
•
•
•
•
•
Protein
F8WIZ7
Organism: Mus musculus/domesticus
Length: 967  
Fragment?: false
•
•
•
•
•
Protein
A0A0A6YXH3
Organism: Mus musculus/domesticus
Length: 746  
Fragment?: false
•
•
•
•
•
Publication
28928395 | J:254771
First Author: Larsen HL
Year: 2017
Journal: Nat Commun
Title: Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis.
Volume: 8
Issue: 1
Pages: 605
•
•
•
•
•
Publication
17283045 | J:121406
First Author: Ma X
Year: 2007
Journal: Mol Cell Biol
Title: Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation.
Volume: 27
Issue: 8
Pages: 3056-64
•
•
•
•
•
Publication
17362910 | J:121317
First Author: William DA
Year: 2007
Journal: Dev Biol
Title: Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model.
Volume: 305
Issue: 1
Pages: 172-86
•
•
•
•
•
Publication
11486044 | J:70797
First Author: Iso T
Year: 2001
Journal: Mol Cell Biol
Title: HERP, a new primary target of Notch regulated by ligand binding.
Volume: 21
Issue: 17
Pages: 6071-9
•
•
•
•
•
Publication
23990620 | J:203433
First Author: Rao KN
Year: 2013
Journal: Blood
Title: Ikaros limits basophil development by suppressing C/EBP-α expression.
Volume: 122
Issue: 15
Pages: 2572-81
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom