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Search results 1701 to 1800 out of 12470 for Impact

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Type Details Score
HT Experiment
GSE214876 | Effect of deletion of ERRalpha, ERRbeta and/or ERRgamma on gene expression in soleus and extensor digitorum longus (EDL) skeletal muscles
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE210649 | Gut microbiota depletion delays peripheral nerve development and impairs neuromuscular junction maturation
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE269588 | Plekhg5 regulates the unconventional secretion of Sod1 by presynaptic secretory autophagy
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE235514 | ESR1+ luminal epithelial cells contribute to androgen-independent prostate survival in the absence of SRD5A2
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE85646 | Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1
 
Experiment Type: RNA-Seq
Study Type: Baseline and WT vs. Mutant
Source: GEO
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HT Experiment
GSE168630 | Cell-specific alterations in the activation of the Pitx1 regulatory landscape caused by the loss of a single enhancer (RNA-seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE168632 | Cell-specific alterations in the activation of the Pitx1 regulatory landscape caused by the loss of a single enhancer (scRNA-seq)
 
Experiment Type: RNA-Seq
Study Type: Baseline and WT vs. Mutant
Source: GEO
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HT Experiment
GSE271281 | An essential role for Cmtr2 in mammalian embryonic development [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE242321 | Mutations in unfolded protein response regulator ATF6 cause hearing and vision loss syndrome
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE245295 | Reorganization of pancreas circadian transcriptome with aging
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE190012 | Single nucleus analysis of brain tissues from DAP12 loss-of-function (Kdelta75) mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE212336 | A spatiotemporal map of the mouse brain reveals white matter tracts as vulnerable foci of aging
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE251734 | Mitochondrial DNA quantity Counteracts ROS damage in oocytes during female reproductive aging
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE254467 | Thyroid hormone receptor beta (THRB) dependent regulation of diurnal hepatic lipid metabolism in adult male mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE270283 | BirthSeq, a new method to isolate and analyze dated cells in different vertebrates
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE273927 | Spatial transcriptomics reveals tanscriptional perturbations leading to uterine squamous metaplasia, atrophy, and infertility in a mouse model of RTHa
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
14500989 | -
First Author: Murakami M
Year: 2003
Journal: J Mol Neurosci
Title: Structures of the murine genes for the beta1- and beta4-subunits of the voltage-dependent calcium channel.
Volume: 21
Issue: 1
Pages: 13-21
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Publication
12525704 | J:81361
First Author: Suzumori N
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.
Volume: 100
Issue: 2
Pages: 550-5
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Protein
D3YVF0
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
H3BIV5
Organism: Mus musculus/domesticus
Length: 752  
Fragment?: false
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Protein
E9Q6E8
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q69Z97
Organism: Mus musculus/domesticus
Length: 826  
Fragment?: true
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Protein
Q3UQ78
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
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Protein
F6UY95
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: true
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Protein
Q8BMG4
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q5U409
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q6ZPH8
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: true
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Protein
Q3TZA9
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: true
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Protein
Q810L0
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
E9Q7L5
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Publication
27596536 | -
 
First Author: Borniego MB
Year: 2016
Journal: Virology
Title: Bioinformatic and mutational analysis of ophiovirus movement proteins, belonging to the 30K superfamily.
Volume: 498
Pages: 172-180
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Publication
10414294 | -
 
First Author: Smith SM
Year: 1999
Journal: Ann N Y Acad Sci
Title: Neuronal voltage-activated calcium channels: on the roles of the alpha 1E and beta 3 subunits.
Volume: 868
Pages: 175-98
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Publication
15170217 | -
First Author: Chen YH
Year: 2004
Journal: Nature
Title: Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels.
Volume: 429
Issue: 6992
Pages: 675-80
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Publication
9272572 | -
First Author: Mangoni ME
Year: 1997
Journal: Receptors Channels
Title: Characterisation of alpha 1A Ba2+, Sr2+ and Ca2+ currents recorded with the ancillary beta 1-4 subunits.
Volume: 5
Issue: 1
Pages: 1-14
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Publication
20725088 | -
First Author: Bonnefont J
Year: 2011
Journal: Cell Death Differ
Title: Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.
Volume: 18
Issue: 2
Pages: 293-303
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Publication
25331888 | -
First Author: Heim KP
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1.
Volume: 111
Issue: 44
Pages: 15746-51
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Publication
17002978 | -
First Author: Liang SL
Year: 2006
Journal: IUBMB Life
Title: RNase L: its biological roles and regulation.
Volume: 58
Issue: 9
Pages: 508-14
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Publication
11333017 | -
First Author: Dong B
Year: 2001
Journal: RNA
Title: Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p.
Volume: 7
Issue: 3
Pages: 361-73
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Publication
11941539 | -
First Author: Rökman A
Year: 2002
Journal: Am J Hum Genet
Title: Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.
Volume: 70
Issue: 5
Pages: 1299-304
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Publication
12415269 | -
First Author: Casey G
Year: 2002
Journal: Nat Genet
Title: RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases.
Volume: 32
Issue: 4
Pages: 581-3
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Publication
16869093 | -
 
First Author: Kieffer N
Year: 2006
Journal: Bull Soc Sci Med Grand Duche Luxemb
Title: Involvement of the RNAse L gene in prostate cancer.
Issue: 1
Pages: 21-8
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Publication
14704272 | -
First Author: Dai S
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: RF2b, a rice bZIP transcription activator, interacts with RF2a and is involved in symptom development of rice tungro disease.
Volume: 101
Issue: 2
Pages: 687-92
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Publication
20408988 | -
First Author: Ordiz MI
Year: 2010
Journal: Plant Biotechnol J
Title: Functional analysis of the activation domain of RF2a, a rice transcription factor.
Volume: 8
Issue: 7
Pages: 835-44
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Publication
30010769 | -
First Author: Tsugama D
Year: 2018
Journal: Ann Bot
Title: Calcium signalling regulates the functions of the bZIP protein VIP1 in touch responses in Arabidopsis thaliana.
Volume: 122
Issue: 7
Pages: 1219-1229
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Publication
27208231 | -
First Author: Tsugama D
Year: 2016
Journal: Plant Physiol
Title: The bZIP Protein VIP1 Is Involved in Touch Responses in Arabidopsis Roots.
Volume: 171
Issue: 2
Pages: 1355-65
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Publication
25093810 | -
First Author: Tsugama D
Year: 2014
Journal: PLoS One
Title: Analysis of functions of VIP1 and its close homologs in osmosensory responses of Arabidopsis thaliana.
Volume: 9
Issue: 8
Pages: e103930
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Publication
12050117 | -
First Author: Fryer CJ
Year: 2002
Journal: Genes Dev
Title: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.
Volume: 16
Issue: 11
Pages: 1397-411
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Publication
21637813 | -
First Author: Decroly E
Year: 2011
Journal: PLoS Pathog
Title: Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.
Volume: 7
Issue: 5
Pages: e1002059
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Publication
27170751 | -
First Author: Zeng C
Year: 2016
Journal: J Virol
Title: Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales.
Volume: 90
Issue: 15
Pages: 6675-6685
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Publication
21931546 | -
First Author: Nga PT
Year: 2011
Journal: PLoS Pathog
Title: Discovery of the first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes.
Volume: 7
Issue: 9
Pages: e1002215
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Publication
26041874 | -
First Author: Lehmann KC
Year: 2015
Journal: J Gen Virol
Title: Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins.
Volume: 96
Issue: 9
Pages: 2643-2655
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Publication
32709886 | -
First Author: Viswanathan T
Year: 2020
Journal: Nat Commun
Title: Structural basis of RNA cap modification by SARS-CoV-2.
Volume: 11
Issue: 1
Pages: 3718
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Publication
2022266 | -
First Author: Katz E
Year: 1991
Journal: Fertil Steril
Title: Increased circulating levels of bromocriptine after vaginal compared with oral administration.
Volume: 55
Issue: 5
Pages: 882-4
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Protein Domain
IPR046440 | AV_NSP11N_COV_NSP15M
Type: Domain
Description: Positive-stranded RNA (+RNA) viruses that belong to the order Nidovirales infect a wide range of vertebrates (families Arteriviridae and Coronaviridae) or invertebrates (Mesoniviridae and Roniviridae). Examples of nidoviruses with high economic and societal impact are the arterivirus porcine reproductive and respiratory syndrome virus (PRRSV) and the zoonotic coronaviruses (CoVs) causing severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and Covid-19 (SARS-CoV-2) in humans. The replicase gene encodes two polyproteins, pp1a and pp1ab, which are proteolytically processed to nonstructural proteins (NSPs). Among the NSPs found in Nidovirales, nonstructural protein 15 (NSP15) from coronaviruses (CoV) and NSP11 from arteriviruses (AV) participate in the viral replication process and in the evasion of the host immune system. They contain in their C-terminal region a conserved endoribonuclease domain called nidoviral uridylate-specific endoribonuclease (NendoU) with cleavage specificity for single- and double-stranded RNA 5' of uridine nucleotides to produce a 2'-3'-cyclic phosphate end product. Arterivirus Nsp11 contains two conserved compact domains: the N-terminal domain (NTD) and C-terminal domain (NendoU), whereas CoV NSP15 folds into three domains: N-terminal, middle domain, and C-terminal catalytic NendoU domain. No counterpart corresponding to the NTD of CoV NSP15 exists in AV NSP11. The NTD of AV NSP11 is small and related to NSP15 middle domain, which may serve as an interaction hub with other proteins and RNA [, , , , , ].This domain contains a central β-sheet flanked by two small α-helices on either side [, , ].
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Protein Domain
IPR044759 | bZIP_RF2
Type: Domain
Description: This is the bZIP domain found in plant transcription factors with similarity to Oryza sativa RF2a and RF2b, which are important for plant development. RF2a and b interact, as homodimers or heterodimers, with each other, and activate transcription from the RTBV (rice tungro bacilliform virus) promoter, which is regulated by sequence-specific DNA-binding proteins that bind to the essential cis element BoxII. They show differences in binding affinities to BoxII, expression patterns in different rice organs, and subcellular localisation. Transgenic rice with increased RF2a and RF2b display increased resistance to rice tungro disease (RTD) with no impact on plant development [, ].bZIP domains from Arabidopsis have been classified into 11 groups (groups A-I and S), the ones included in this entry belong to group I such as VIP1 or PosF21 (also known as bZIP transcription factor 59) [, , , ].bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription [].
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Protein Domain
IPR046370 | MAML_N_sf
Type: Homologous_superfamily
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR046369 | MAML1-3
Type: Family
Description: This family includes the neurogenic mastermind-like proteins 1-3 (MAML1-3) from chordates, which act as critical transcriptional co-activators for Notch signaling [, ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.They consist of an N-terminal domain which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors [, ]]. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR042745 | RNase-L_RNase
Type: Domain
Description: Ribonuclease L (RNase L) is a highly regulated, latent endoribonuclease (thus the 'L' in RNase L) and is widely expressed in most mammalian tissues. It is involved in the mediation of the antiviral and pro-apoptotic activities of the interferon-inducible 2-5A system, which blocks infections by certain types of viruses through cleavage of viral and cellular single-stranded RNA [, ]. RNase L is unique in that it is composed of threemajor domains; N terminus regulatory ankyrin repeat domain (ARD), followed by a linker, a protein kinase (PK)-like domain and a C-terminal ribonuclease (RNase) domain. The RNase domain has homology with IRE1, also containing both a kinase and an endoribonuclease, that functions in the unfolded protein response (UPR) []. RNase L has been shown to have an impact on the pathogenesis of prostate cancer; the RNase L gene, RNASEL, has been identified as a strong candidate for the hereditary prostate cancer 1 (HPC1) allele [, , ]. The broad range of biological functions of RNase offers a possibility for RNase L as a therapeutic target.This entry represents the RNase domain of RNase L.
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Protein Domain
IPR046438 | NIV_2_O_MTASE
Type: Domain
Description: Positive-stranded RNA (RNA) viruses that belong to the order Nidovirales infect a wide range of vertebrates (families Arteriviridae and Coronaviridae) or invertebrates (Mesoniviridae and Roniviridae). Examples of nidoviruses with high economic and societal impact are the arterivirus porcine reproductive and respiratory syndrome virus (PRRSV) and the zoonotic coronaviruses (CoVs) causing severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and Covid-19 (SARS-CoV-2) in humans.The 3'-terminal region of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a 2'-O-methyltransferase (2'-O-MTase), known as non structural protein (NSP) 16 in CoV and implicated in methylation of the 5' cap structure of nidoviral mRNAs. Assembly of a cap1 structure at the 5' end of viral mRNA assists in translation and evading host defense. The cap structure consists of a 7-methylguanosine (m7G) linked to the first nucleotide of the RNA transcript through a 5'-5' triphosphate bridge. The CoV NSP16 methyltransferase forms an obligatory complex with NSP10 to efficiently convert client mRNA species from the cap-0 ((me7)G(0)pppA(1)) to the cap-1 form ((me7)G(0)pppA(1m)) by methylating the ribose 2'-O of the first nucleotide of the nascent mRNA using S-adenosyl methionine (SAM) as the methyl donor [, , , ].The nidovirus 2'-O-MTase domain exhibits the characteristic fold of the class I MTase family, comprising a β-sheet flanked by α-helices and loops. The nidovirus 2'-O-MTase domain harbors a catalytic K-D-K-E tetrad that is conserved among 2'-O-MTases [, , ].
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Protein Domain
IPR019082 | Mastermind-like_N
Type: Domain
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR035760 | CACNB3_SH3
Type: Domain
Description: The beta4 subunit of voltage-dependent calcium channels (Ca(V)s) is one of four beta subunits present in vertebrates. It is highly expressed in the brain, predominantly in the cerebellum []. Ca(V)s are multi-protein complexes that regulate the entry of calcium into cells. They impact muscle contraction, neuronal migration, hormone and neurotransmitter release, and the activation of calcium-dependent signaling pathways. They are composed of four subunits: alpha1, alpha2delta, beta, and gamma. The beta subunit is a soluble and intracellular protein that interacts with the transmembrane alpha1 subunit. It facilitates the trafficking and proper localization of the alpha1 subunit to the cellular plasma membrane []. Vertebrates contain four different beta subunits from distinct genes (beta1-4); each exists as multiple splice variants []. All are expressed in the brain while other tissues show more specific expression patterns. The beta subunits show similarity to MAGUK (membrane-associated guanylate kinase) proteins in that they contain SH3 and inactive guanylate kinase (GuK) domains; however, they do not appear to contain a PDZ domain [].This entry represents the SH3 domain of the subunit beta-3.
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Protein Domain
IPR003915 | PKD_2
Type: Family
Description: Polycystic kidney diseases (PKD) are disorders characterised by large numbers of cysts distributed throughout grossly-enlarged kidneys. Cystdevelopment is associated with impairment of kidney function, and ultimately kidney failure and death [, ]. Most cases of autosomal dominant PKD result from mutations in the PKD1 gene that cause premature protein termination. A second gene for autosomal dominant polycystic kidney disease has been identified by positional cloning []. The predicted 968-amino acid sequence of the PKD2 gene product (polycystin-2) contains 6 transmembrane domains, with intracellular N- and C-termini. Polycystin-2 shares some similarity with the family of voltage-activated calcium (and sodium) channels, and contains a potential calcium-binding domain [].Polycystin-2 is strongly expressed in ovary, foetal and adult kidney, testis, and small intestine. Polycystin-1 requires the presence of this protein for stable expression and is believed to interact with it via its C terminus. All mutations between exons 1 and 11 result in a truncated polycystin-2 that lacks a calcium-binding EF-hand domain and the cytoplasmic domains required for the interaction of polycystin-2 with polycystin-1 []. PKD2, although clinically milder than PKD1, has a deleterious impact on life expectancy.
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Publication
4557539 | J:5286
First Author: Lane PW
Year: 1972
Journal: J Hered
Title: Two new mutations in linkage group XVI of the house mouse. Flaky tail and varitint-waddler-J.
Volume: 63
Issue: 3
Pages: 135-40
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Publication
32641386 | J:327647
First Author: Wu K
Year: 2020
Journal: J Immunol
Title: Group 2 Innate Lymphoid Cells Must Partner with the Myeloid-Macrophage Lineage for Long-Term Postviral Lung Disease.
Volume: 205
Issue: 4
Pages: 1084-1101
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Publication
30538336 | J:282653
First Author: Zuberbuehler MK
Year: 2019
Journal: Nat Immunol
Title: The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells.
Volume: 20
Issue: 1
Pages: 73-85
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Publication
31570496 | J:285229
 
First Author: Parker ME
Year: 2020
Journal: J Exp Med
Title: c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program.
Volume: 217
Issue: 1
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Publication
28825702 | J:259296
First Author: Berthault C
Year: 2017
Journal: Nat Immunol
Title: Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver.
Volume: 18
Issue: 10
Pages: 1139-1149
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Publication
32160524 | J:288599
First Author: Flamar AL
Year: 2020
Journal: Immunity
Title: Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity.
Volume: 52
Issue: 4
Pages: 606-619.e6
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Publication
30770814 | J:275414
First Author: Cho HS
Year: 2019
Journal: Nat Commun
Title: The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine.
Volume: 10
Issue: 1
Pages: 784
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Publication
27141929 | J:259458
First Author: Chea S
Year: 2016
Journal: Sci Signal
Title: Notch signaling in group 3 innate lymphoid cells modulates their plasticity.
Volume: 9
Issue: 426
Pages: ra45
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Publication
31332039 | J:345778
 
First Author: Leung GA
Year: 2019
Journal: Development
Title: The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development.
Volume: 146
Issue: 14
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Publication
25965565 | J:221406
First Author: Obeng EA
Year: 2015
Journal: Cancer Cell
Title: Charting the "Splice" Routes to MDS.
Volume: 27
Issue: 5
Pages: 607-9
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Publication
27166941 | J:235374
First Author: Cairns RA
Year: 2016
Journal: Cell Metab
Title: Lung Cancer Resets the Liver's Metabolic Clock.
Volume: 23
Issue: 5
Pages: 767-9
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Publication
33417830 | J:302329
First Author: Davies DM
Year: 2021
Journal: Cancer Cell
Title: Crosstown Traffic: Lymphodepleting Chemotherapy Drives CAR T Cells.
Volume: 39
Issue: 2
Pages: 138-140
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HT Experiment
GSE69940 | Genome-wide analysis of embryonic gene expression in the absence of Prox1 compared to wild type
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE247566 | Temporal gene expression changes and affected pathways in neurodevelopment of a mouse model of Smith-Lemli-Opitz syndrome
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-6238 | Transcription profiling of hippocampus and retina from two rare inbred mouse models of accelerated neurological senescence ( SAMP8 and SAMP10) and a related wild type strain SAMR1 to study molecular senescence of the retina and hippocampus
Series Id: GSE6238
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
E-GEOD-25017 | The miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor
Series Id: GSE25017
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
E-GEOD-11035 | Transcription profiling of mouse from wild type, heterozygous and 5HTT knockouts
Series Id: GSE11035
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-9743 | Transcription profiling of mouse mutant Dstn<corn1> cornea vs. wild type
Series Id: GSE9743
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-30651 | Conditional elimination of c-Met signaling in the liver aggravates oxidative stress and cholestasis, and deregulates lipid metabolism, under a high cholesterol diet
Series Id: GSE30651
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-73131 | Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet beta-cell Endoplasmic Reticulum Stress and Proliferation
Series Id: GSE73131
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-81959 | Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Series Id: GSE81959
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
E-GEOD-70179 | Maternal bile acid transporter deficiency promotes neonatal demise
Series Id: GSE70179
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-65506 | Graded Expression Changes Determine Phenotype Severity In Mouse Models of CRX-Associated Retinopathy
Series Id: GSE65506
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-43620 | Effects of sodium tungstate administration in Irs2 -/- mice
Series Id: GSE43620
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-MTAB-9597 | A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysema following smoking cessation or switching to e-vapor products
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE80083 | TBX18 regulates the differentiation of periductal smooth muscle stroma and the maintenance of epithelial integrity in the prostate
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE248747 | Combined absence of Trp53 target genes Zmat3, Puma and p21 cause a high incidence of cancer in mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-48811 | Visceral obesity in murine pregnancy
Series Id: GSE48811
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE154516 | Transforming growth factor beta signaling and decidual development in mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE236219 | Age-related histone loss and altered histone acetylation in mouse retinal pigment epithelium. [polyA RNA]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE236220 | Age-related histone loss and altered histone acetylation in mouse retinal pigment epithelium. [Total RNA]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE229225 | DNA methylation constrains nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-35293 | Altered gene expression in the small intestine of IE-Cpr-null mice
Series Id: GSE35293
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE228284 | MiR-29a-deficiency Causes Thickening of the Basilar Membrane and Age-related Hearing Loss by Upregulating Collagen IV and Laminin
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE252364 | Effect of methionine/choline deficient diet on liver and suprachiasmatic nucleus circadian transcriptome.
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE210398 | Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE255946 | Notum Regulates the Cusp and Root Patterns in Mouse Molar
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE168448 | Atlas of the aging mouse colon
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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