|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1701 to 1800 out of 2155 for Maf

0.019s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
First Author: Manzanares M
Year: 1997
Journal: Nature
Title: Segmental regulation of Hoxb-3 by kreisler.
Volume: 387
Issue: 6629
Pages: 191-5
Publication  
First Author: Pajcini KV
Year: 2017
Journal: Sci Signal
Title: MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.
Volume: 10
Issue: 505
Publication
First Author: Defalco T
Year: 2013
Journal: Biol Reprod
Title: Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.
Volume: 88
Issue: 4
Pages: 91
Publication
First Author: Paul BJ
Year: 2021
Journal: Dev Dyn
Title: The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse.
Volume: 250
Issue: 10
Pages: 1463-1476
Publication
First Author: Montgomery AB
Year: 2023
Journal: Cell Rep
Title: Tissue-resident, extravascular Ly6c(-) monocytes are critical for inflammation in the synovium.
Volume: 42
Issue: 5
Pages: 112513
Publication
First Author: Vicente-DueƱas C
Year: 2012
Journal: EMBO J
Title: A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors.
Volume: 31
Issue: 18
Pages: 3704-17
Strain
Attribute String: radiation induced mutation, spontaneous mutation, mutant stock
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, targeted mutation
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Genotype
Symbol: Mafb/Mafb
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Maf/Maf<+>
Background: involves: 102/El * C3H/El * C57BL/6El
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb Tg(Isl1-EGFP*)1Slp/?
Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Maf/Maf
Background: C57BL/6N-Maf/MbpMmucd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Maf/Maf<+>
Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * ICR)
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+>
Background: involves: C3H/He * CBA
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+>
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Maf/Maf Tg(Vil1-cre)997Gum/?
Background: involves: 129P2/OlaHsd * C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: VƔzquez-Echeverrƭa C
Year: 2008
Journal: Dev Biol
Title: Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.
Volume: 322
Issue: 1
Pages: 167-78
Publication
First Author: Lim L
Year: 2018
Journal: Nat Neurosci
Title: Optimization of interneuron function by direct coupling of cell migration and axonal targeting.
Volume: 21
Issue: 7
Pages: 920-931
Publication
First Author: Manzanares M
Year: 2002
Journal: EMBO J
Title: Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain.
Volume: 21
Issue: 3
Pages: 365-76
Publication
First Author: Xu G
Year: 2013
Journal: Nat Med
Title: Thioredoxin-interacting protein regulates insulin transcription through microRNA-204.
Volume: 19
Issue: 9
Pages: 1141-6
Publication
First Author: Nishimura W
Year: 2009
Journal: Dev Biol
Title: Expression of MafA in pancreatic progenitors is detrimental for pancreatic development.
Volume: 333
Issue: 1
Pages: 108-20
Publication
First Author: Pogenberg V
Year: 2014
Journal: Structure
Title: Design of a bZip transcription factor with homo/heterodimer-induced DNA-binding preference.
Volume: 22
Issue: 3
Pages: 466-77
Publication
First Author: Artner I
Year: 2008
Journal: J Endocrinol
Title: MafA is a dedicated activator of the insulin gene in vivo.
Volume: 198
Issue: 2
Pages: 271-9
Publication
First Author: Sing A
Year: 2009
Journal: Cell
Title: A vertebrate Polycomb response element governs segmentation of the posterior hindbrain.
Volume: 138
Issue: 5
Pages: 885-97
Publication
First Author: Matsushita S
Year: 2016
Journal: Endocrinology
Title: Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization.
Volume: 157
Issue: 2
Pages: 844-57
Publication
First Author: Vicente-DueƱas C
Year: 2012
Journal: Cell Cycle
Title: Loss of p53 exacerbates multiple myeloma phenotype by facilitating the reprogramming of hematopoietic stem/progenitor cells to malignant plasma cells by MafB.
Volume: 11
Issue: 20
Pages: 3896-900
Publication
First Author: Yung AR
Year: 2018
Journal: Cell Rep
Title: Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS.
Volume: 22
Issue: 7
Pages: 1666-1680
Publication
First Author: Lecoin L
Year: 2022
Journal: Nat Commun
Title: Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Volume: 13
Issue: 1
Pages: 3284
Publication
First Author: Elwakeel E
Year: 2022
Journal: Cancer Res
Title: Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis.
Volume: 82
Issue: 7
Pages: 1380-1395
Genotype
Symbol: Mafa/Mafa<+>
Background: involves: ICR
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+>
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Maf/Maf<+>
Background: C57BL/6N-Maf/MbpMmucd
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+> a/A
Background: involves: C3H/HeJ
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+>
Background: involves: 129P2/OlaHsd
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafa/Mafa<+>
Background: either: (involves: 129 * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafa/Mafa<+>
Background: involves: 129S6/SvEvTac
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafa/Mafa Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mafa/Mafa<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+>
Background: involves: 129P2/OlaHsd * CD-1
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Maf/Maf Mafb/Mafb
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Alcantara MC
Year: 2022
Journal: iScience
Title: Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice.
Volume: 25
Issue: 12
Pages: 105609
Publication
First Author: Bourane S
Year: 2009
Journal: Neuron
Title: Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling.
Volume: 64
Issue: 6
Pages: 857-70
Publication  
First Author: DurƔn Alonso MB
Year: 2021
Journal: Front Cell Dev Biol
Title: Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea.
Volume: 9
Pages: 679325
Publication
First Author: Zhao L
Year: 2005
Journal: J Biol Chem
Title: The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.
Volume: 280
Issue: 12
Pages: 11887-94
Publication
First Author: Ogino H
Year: 1998
Journal: Science
Title: Induction of lens differentiation by activation of a bZIP transcription factor, L-Maf.
Volume: 280
Issue: 5360
Pages: 115-8
Publication
First Author: Olbrot M
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.
Volume: 99
Issue: 10
Pages: 6737-42
Protein Domain
Type: Family
Description: Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus []. The small Maf proteins might contribute to oncogenic processes by participating in antioxidant responses, while large Maf proteins have been directly implicated in carcinogenesis []. This entry represents MafA. MafA plays a critical role in the regulation of crystalline genes and lens development [, ]. It also binds the insulin enhancer element RIPE3b and regulates the insulin gene transcription [, , ].
Allele
Name: transgene insertion 6666, Laurie H Glimcher
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Bikoff JB
Year: 2016
Journal: Cell
Title: Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits.
Volume: 165
Issue: 1
Pages: 207-219
Genotype
Symbol: Mafb/Mafb Tg(Neurog1-cre)1Jejo/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+> Tg(Isl1-EGFP*)1Slp/?
Background: involves: 129S4/SvJae * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mafa/Mafa Mafb/Mafb
Background: involves: 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+> Meis2/Meis2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mafb/Mafb<+> Rr180/Rr180
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mafa/Mafa Mafb/Mafb Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129 * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Egr2/Egr2<+> Maf/Maf
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Maf/Maf Mafb/Mafb Tg(Vil1-cre)997Gum/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Rondon-Galeano M
Year: 2020
Journal: Dev Dyn
Title: MAFB modulates the maturation of lymphatic vascular networks in mice.
Volume: 249
Issue: 10
Pages: 1201-1216
Publication
First Author: Stam FJ
Year: 2012
Journal: Development
Title: Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program.
Volume: 139
Issue: 1
Pages: 179-90
Publication
First Author: Smink JJ
Year: 2009
Journal: EMBO J
Title: Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.
Volume: 28
Issue: 12
Pages: 1769-81
Publication
First Author: Hulander M
Year: 1998
Journal: Nat Genet
Title: The winged helix transcription factor Fkh10 is required for normal development of the inner ear.
Volume: 20
Issue: 4
Pages: 374-6
Publication
First Author: Zhao X
Year: 2012
Journal: J Biol Chem
Title: MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells.
Volume: 287
Issue: 37
Pages: 31155-64
Publication
First Author: Voiculescu O
Year: 2001
Journal: Development
Title: Hindbrain patterning: Krox20 couples segmentation and specification of regional identity.
Volume: 128
Issue: 24
Pages: 4967-78
Publication
First Author: Sturgeon K
Year: 2011
Journal: Development
Title: Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression.
Volume: 138
Issue: 1
Pages: 65-74
Publication
First Author: Kim H
Year: 2017
Journal: Sci Rep
Title: The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages.
Volume: 7
Issue: 1
Pages: 7591
Publication
First Author: Kitamura YI
Year: 2005
Journal: Cell Metab
Title: FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Volume: 2
Issue: 3
Pages: 153-63
Publication
First Author: Zhu K
Year: 2020
Journal: Nat Commun
Title: Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice.
Volume: 11
Issue: 1
Pages: 484
Publication
First Author: Kim FA
Year: 2005
Journal: Mech Dev
Title: The vHNF1 homeodomain protein establishes early rhombomere identity by direct regulation of Kreisler expression.
Volume: 122
Issue: 12
Pages: 1300-9
Publication
First Author: Kim K
Year: 2007
Journal: Blood
Title: MafB negatively regulates RANKL-mediated osteoclast differentiation.
Volume: 109
Issue: 8
Pages: 3253-9
Publication
First Author: Beaty TH
Year: 2010
Journal: Nat Genet
Title: A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.
Volume: 42
Issue: 6
Pages: 525-9
Publication
First Author: Roger JE
Year: 2010
Journal: J Biol Chem
Title: Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation.
Volume: 285
Issue: 33
Pages: 25637-44
Publication
First Author: Hang Y
Year: 2011
Journal: Trends Endocrinol Metab
Title: MafA and MafB activity in pancreatic β cells.
Volume: 22
Issue: 9
Pages: 364-73
Publication
First Author: Zankl A
Year: 2012
Journal: Am J Hum Genet
Title: Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB.
Volume: 90
Issue: 3
Pages: 494-501
Publication  
First Author: Jayaram H
Year: 2012
Journal: Exp Eye Res
Title: Focus on molecules: neural retina leucine zipper (NRL).
Volume: 104
Pages: 99-100
Publication
First Author: Mears AJ
Year: 2001
Journal: Nat Genet
Title: Nrl is required for rod photoreceptor development.
Volume: 29
Issue: 4
Pages: 447-52
Publication
First Author: Bessant DA
Year: 1999
Journal: Nat Genet
Title: A mutation in NRL is associated with autosomal dominant retinitis pigmentosa.
Volume: 21
Issue: 4
Pages: 355-6
Publication
First Author: Neveling K
Year: 2012
Journal: Hum Mutat
Title: Next-generation genetic testing for retinitis pigmentosa.
Volume: 33
Issue: 6
Pages: 963-72
Publication
First Author: Nishiguchi KM
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function.
Volume: 101
Issue: 51
Pages: 17819-24
Protein Domain
Type: Family
Description: Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus.MafB plays critical roles in a variety of cellular differentiation processes, including in kidney podocytes [], macrophages [, ], and pancreatic islet alpha and beta-cells, which are responsible for the production of the hormones glucagon and insulin respectively. MafB is also expressed in alpha-cells in adult pancreas and is important for their function [, , , ].Mutations in Maf gene cause multicentric carpotarsal osteolysis syndrome (MCTO), which is a rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis [].
Protein Domain
Type: Family
Description: Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, Nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus.Neural retina-specific leucine zipper protein (Nrl) is a member of the Maf family of transcription factors that regulates the expression of rod-specific genes, including rhodopsin [, , ]. Mutations in Nrl cause retinitis pigmentosa 27 (RP27), which is a retinal dystrophy belonging to the group of pigmentary retinopathies [, ], and retinal degeneration autosomal recessive clumped pigment type (RDCP), which is a retinopathy characterised by night blindness since early childhood, consistent with a severe reduction in rod function [].
Publication  
First Author: Yu WM
Year: 2013
Journal: Elife
Title: A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing.
Volume: 2
Pages: e01341
Publication
First Author: Quadros RM
Year: 2017
Journal: Genome Biol
Title: Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins.
Volume: 18
Issue: 1
Pages: 92
Publication
First Author: Ho IC
Year: 1998
Journal: J Exp Med
Title: c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms.
Volume: 188
Issue: 10
Pages: 1859-66
Publication
First Author: Snijders AM
Year: 2005
Journal: Genome Res
Title: Mapping segmental and sequence variations among laboratory mice using BAC array CGH.
Volume: 15
Issue: 2
Pages: 302-11
HT Experiment
Series Id: GSE29558
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Yamamoto K
Year: 2013
Journal: J Biol Chem
Title: A novel function of Onecut1 protein as a negative regulator of MafA gene expression.
Volume: 288
Issue: 30
Pages: 21648-58
Publication
First Author: Guo S
Year: 2013
Journal: J Clin Invest
Title: Inactivation of specific β cell transcription factors in type 2 diabetes.
Volume: 123
Issue: 8
Pages: 3305-16
Publication
First Author: Wang S
Year: 2008
Journal: Dev Biol
Title: Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.
Volume: 317
Issue: 2
Pages: 531-40
Publication
First Author: Kato T
Year: 2006
Journal: Cell Metab
Title: Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
Volume: 4
Issue: 2
Pages: 143-54
Publication
First Author: Noguchi H
Year: 2021
Journal: Sci Rep
Title: In vivo evaluation of GG2-GG1/A2 element activity in the insulin promoter region using the CRISPR-Cas9 system.
Volume: 11
Issue: 1
Pages: 20290
Publication
First Author: Nishida H
Year: 2008
Journal: Congenit Anom (Kyoto)
Title: Gene expression analyses on embryonic external genitalia: identification of regulatory genes possibly involved in masculinization processes.
Volume: 48
Issue: 2
Pages: 63-7