| Type |
Details |
Score |
| Genotype |
| Symbol: |
Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> |
| Background: |
involves: 129S6/SvEvTac |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Allele |
| Name: |
MKS transition zone complex subunit 1; heart, lung and blood 614 |
| Allele Type: |
Chemically induced (ENU) |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Hiroshi Hamada |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 9A, Hiroshi Hamada |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 35, Hiroshi Hamada |
| Allele Type: |
Transgenic |
| Attribute String: |
Epitope tag, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, transgenic |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, chemically induced mutation, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, chemically induced mutation, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal |
| Background: |
involves: 129S/SvEv * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal |
| Background: |
involves: 129S/SvEv * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Eomes/Eomes<+> Nodal/Nodal |
| Background: |
involves: 129S/SvEv * C57BL/6 * CBA |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal |
| Background: |
involves: 129S/SvEv * MF1 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal |
| Background: |
involves: 129S1/Sv |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal |
| Background: |
involves: 129S/SvEv * ICR |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal Zic2/Zic2 |
| Background: |
129S.Cg-Nodal Zic2 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> |
| Background: |
C57BL/6N-Nodal/H |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal |
| Background: |
involves: 129S/SvEv * ICR |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Lemd3/Lemd3 Nodal/Nodal |
| Background: |
involves: 129 * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Arl13b/Arl13b Nodal/Nodal<+> |
| Background: |
C3.Cg-Arl13b Nodal |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal |
| Background: |
involves: 129S/SvEv * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal |
| Background: |
involves: 129S/SvEv |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE76261 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Elizabeth J Robertson |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 29A, Hiroshi Hamada |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 3A, Hiroshi Hamada |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 35, Hiroshi Hamada |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mks1/Mks1 |
| Background: |
involves: C3H * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
64
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Haffner C |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. |
| Volume: |
282 |
| Issue: |
14 |
| Pages: |
10632-8 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Nicalin is a Nodal signalling antagonist and a distant homologue of the gamma-secretase component Nicastrin []. In humans, Nicalin forms a complex with NOMO (Nodal modulator) and controls the assembly and stability of this complex []. |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Acvr1c/Acvr1c Nodal/Nodal<+> |
| Background: |
involves: 129P2/OlaHsd * 129/Sv |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gdf1/Gdf1 Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Acvr2a/Acvr2a Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129S1/Sv * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Lefty2/Lefty2 Nodal/Nodal<+> |
| Background: |
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6Cr |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Eomes/Eomes<+> Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Drap1/Drap1 Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129S6/SvEvTac |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> Nog/Nog |
| Background: |
involves: 129S/SvEv * 129S1/Sv |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Chrd/Chrd Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal Trim33/Trim33 |
| Background: |
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> Trim33/Trim33 |
| Background: |
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Col2a1/Col2a1 Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
involves: C57BL/6 * C57BL/6NTac |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> Zic2/Zic2 |
| Background: |
129S.Cg-Nodal Zic2 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal Zic2/Zic2<+> |
| Background: |
129S.Cg-Nodal Zic2 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> Zic2/Zic2 |
| Background: |
129S.Cg-Nodal Zic2 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Invs/Invs Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * FVB/N |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Foxa2/Foxa2 Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ednrb/Ednrb Nodal/Nodal<+> |
| Background: |
involves: 101/Rl * 129S/SvEv * C3H/Rl |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| MP Term |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
425
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
467
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Çolakoğlu G |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system. |
| Volume: |
111 |
| Issue: |
3 |
| Pages: |
E394-403 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This is the β-sandwich domain found in ER membrane protein complex subunit 7 (EMC7) [, ], which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane protein biogenesis. It mediates the insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins in an energy-independent manner, both post-translational insertion of tail-anchored proteins and co-translational insertion of multipass membrane proteins [, ]. This entry includes UPF0620 protein C83.10 from S. pombe, an orthologue from animal EMC7.This domain is also found in nodal modulators, which have been identified as part of a protein complex that participates in the nodal signalling pathway during vertebrate development []. |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 16, Hiroshi Hamada |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Nodal-cre)1Rob/? |
| Background: |
involves: C57BL/6 * CBA |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Meox2/Meox2<+> Nodal/Nodal |
| Background: |
involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Smad2/Smad2<+> Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129S4/SvJae |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Foxa2/Foxa2<+> Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cer1/Cer1 Lefty1/Lefty1 Nodal/Nodal<+> |
| Background: |
involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cer1/Cer1 Lefty1/Lefty1 Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129S7/SvEvBrd * CD-1 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> Tgif1/Tgif1 Tgif2/Tgif2 |
| Background: |
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Col2a1/Col2a1<+> Nodal/Nodal<+> |
| Background: |
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal Mesp1/Mesp1<+> Tg(Pitx2-lacZ)1Mbf/? |
| Background: |
involves: 129S1/Sv * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> Smad2/Smad2<+> |
| Background: |
involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Foxa2/Foxa2<+> Nodal/Nodal<+> |
| Background: |
involves: 129/Sv * 129X1/SvJ |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hoxb1/Hoxb1<+> Nodal/Nodal |
| Background: |
involves: 129S6/SvEvTac |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the cerberus family of proteins. Cerberus is a cytokine that may play a role in anterior neural induction and somite formation during embryogenesis, in part through a BMP-inhibitory mechanism []. It can regulate Nodal signalling during gastrulation as well as the formation and patterning of the primitive streak. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
672
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
551
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar A |
| Year: |
2007 |
| Journal: |
Genesis |
| Title: |
Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord. |
| Volume: |
45 |
| Issue: |
12 |
| Pages: |
729-36 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Tony Wyss-Coray |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 8, Hiroshi Hamada |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|