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Search results 1701 to 1800 out of 3113 for Rac1

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0.019s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
Q8BUR4
Organism: Mus musculus/domesticus
Length: 1865  
Fragment?: false
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Publication
27941791 | J:251393
First Author: Hahm E
Year: 2017
Journal: Nat Med
Title: Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Volume: 23
Issue: 1
Pages: 100-106
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Protein Coding Gene
MGI:1858414 | Ngef
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:894315 | Rap1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1277173 | Arhgef25
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1927550 | Ykt6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891766 | Camkk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107771 | Abr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95768 | Gna13
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98355 | Sos2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109137 | Rasgrf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2145425 | Depdc1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109153 | Ktn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349423 | Racgap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926063 | Nckap1l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104686 | Crkl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98822 | Tfrc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2685385 | Kalrn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109356 | Snap23
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3040696 | Prex1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2441869 | Arhgef11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2159344 | Vangl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109211 | Pkn2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2444812 | Camkk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858952 | Arhgef5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338801 | Cyfip1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1352757 | Iqgap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2142567 | Arhgef18
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103263 | Mcf2l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106624 | Myo9b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1927223 | Pard6a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96932 | Mcf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108117 | Emd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105068 | Rab7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q80Z96
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
Q6P9R4
Organism: Mus musculus/domesticus
Length: 1405  
Fragment?: false
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Protein
Q5SSL4
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
P47941
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
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Protein
E9Q7D5
Organism: Mus musculus/domesticus
Length: 1581  
Fragment?: false
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Protein
Q99JI6
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
P51150
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
Q9WVM1
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
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Protein
Q8C078
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
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Protein
Q8VBY2
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
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Protein
P27601
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
Q9JKF1
Organism: Mus musculus/domesticus
Length: 1657  
Fragment?: false
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Protein
Q61595
Organism: Mus musculus/domesticus
Length: 1327  
Fragment?: false
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Protein
P70392
Organism: Mus musculus/domesticus
Length: 1189  
Fragment?: false
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Protein
Q9CWR0
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
O08579
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
Q8BH88
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
Q8CHT1
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Protein
Q9Z101
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
Q02384
Organism: Mus musculus/domesticus
Length: 1333  
Fragment?: false
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Protein
Q8BWW9
Organism: Mus musculus/domesticus
Length: 983  
Fragment?: false
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Protein
Q69ZK0
Organism: Mus musculus/domesticus
Length: 1650  
Fragment?: false
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Protein
Q62351
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
O09044
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
Q9CQW1
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
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Protein
Q9QY06
Organism: Mus musculus/domesticus
Length: 2114  
Fragment?: false
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Protein
Q8BLE2
Organism: Mus musculus/domesticus
Length: 1031  
Fragment?: false
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Protein
Q68FM7
Organism: Mus musculus/domesticus
Length: 1552  
Fragment?: false
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Publication
30814219 | J:273200
First Author: Landin Malt A
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Par3 is essential for the establishment of planar cell polarity of inner ear hair cells.
Volume: 116
Issue: 11
Pages: 4999-5008
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Protein
A0A2I3BRI9
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
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Publication
10931870 | -
First Author: Harris TW
Year: 2000
Journal: J Cell Biol
Title: Mutations in synaptojanin disrupt synaptic vesicle recycling.
Volume: 150
Issue: 3
Pages: 589-600
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Publication
27559170 | -
First Author: Geng J
Year: 2016
Journal: J Neurosci
Title: Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools.
Volume: 36
Issue: 34
Pages: 8882-94
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Publication
8999801 | -
First Author: Sone M
Year: 1997
Journal: Science
Title: Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers.
Volume: 275
Issue: 5299
Pages: 543-7
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Publication
21192692 | -
First Author: Shepherd TR
Year: 2011
Journal: Biochemistry
Title: Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.
Volume: 50
Issue: 8
Pages: 1296-308
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Publication
24377522 | -
First Author: Zhao ZY
Year: 2013
Journal: Asian Pac J Cancer Prev
Title: TIAM2 enhances non-small cell lung cancer cell invasion and motility.
Volume: 14
Issue: 11
Pages: 6305-9
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Publication
21469146 | -
First Author: Chen JS
Year: 2012
Journal: Int J Cancer
Title: Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer.
Volume: 130
Issue: 6
Pages: 1302-13
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Protein Domain
IPR043537 | Tiam1/Tiam2/Sif
Type: Family
Description: T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) is a guanine exchange factor (GEF) for CDC42 and the Rho-family GTPase Rac1, which plays an important role in cell-matrix adhesion and in cell migration [, ]. Tiam1 is involved in multiple steps of tumorigenesis [].Tiam2 has been shown to localise to the nuclear envelope and to regulate Rac1 activity at the nuclear envelope which regulates the perinuclear actin cap []. It has been shown to promote invasion and motility of non-small cell lung cancer cells []. It has also been shown to promote epithelial-to-mesenchymal transition and results in proliferation and invasion in liver cancer cells []. This entry includes a group of guanine nucleotide exchange factors, including Tiam1/2 from humans and Sif from Drosophila [, , ]. Tiam1/2 are activators of the Rho GTPase Rac1 and critical for cell morphology, adhesion, migration, and polarity [].
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Protein Domain
IPR015047 | SYNJ1/2_RRM
Type: Domain
Description: This domain represents the RNA recognition motif found in Synaptojanin proteins.Synaptojanins are phosphoinositide phosphatases known to play an important role in vesicle recycling by promoting the uncoating of clathrin following synaptic vesicle uptake [, , , , ]. Synaptojanin-1 contains an N-terminal domain homologous to the cytoplasmic portion of the yeast protein Sac1p [], a central inositol 5-phosphatase domain followed by a putative RNA recognition motif (RRM), and a C-terminal proline-rich region mediating the binding of synaptojanin-1 to various SH3 domain-containing proteins including amphiphysin, SH3p4, SH3p8, SH3p13, and Grb2 []. Synaptojanin-2 is a ubiquitously expressed central regulatory enzyme in the phosphoinositide-signaling cascade []. As a novel Rac1 effector regulating an early step of clathrin-mediated endocytosis, synaptojanin-2 acts as a polyphosphoinositide phosphatase, directly and specifically interacting with Rac1 in a GTP-dependent manner. Synaptojanin-2 shows high sequence homology to the N-terminal Sac1p homology domain [], the central inositol 5-phosphatase domain, and the putative RNA recognition motif (RRM) of synaptojanin-1, but differs in the proline-rich region.
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Publication
23904264 | -
First Author: Edwards M
Year: 2013
Journal: Mol Biol Cell
Title: Physiological role of the interaction between CARMIL1 and capping protein.
Volume: 24
Issue: 19
Pages: 3047-55
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Publication
17762203 | -
First Author: Wilhelm M
Year: 2007
Journal: Dev Neurosci
Title: Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH.
Volume: 29
Issue: 4-5
Pages: 355-62
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Protein Domain
IPR029764 | CARMIL1
Type: Family
Description: This entry represents leucine-rich repeat-containing protein 16A (LRRC16A). In humans it is also known as CARMIL1, which belongs to the CARMIL (capping protein, Arp2/3 and Myosin-I linker) family. CARMIL family members are potential regulators of actin capping proteins, which control the polymerisation of actin filaments by capping their barbed ends [, ]. CARMIL1 is essential for cell migration and may control lamellipodial actin assembly via effects on Trio and Rac1 [, ].
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Protein Domain
IPR035612 | SH3RF3_SH3_3
Type: Domain
Description: This entry represents the third SH3 domain, located in the middle, of SH3RF3.SH3RF3 (also known as POSH2) is a scaffold protein with E3 ubiquitin-protein ligase activity []. It was identified in the screen for interacting partners of p21-activated kinase 2 (PAK2). It may play a role in regulating JNK mediated apoptosis in certain conditions []. It also interacts with GTP-loaded Rac1 []. SH3RF3 is highly homologous to SH3RF1; it also contains an N-terminal RING finger domain and four SH3 domains.
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Protein
Q0KL02
Organism: Mus musculus/domesticus
Length: 3102  
Fragment?: false
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Publication
28196591 | J:239673
First Author: Baker MJ
Year: 2017
Journal: Cancer Cell
Title: Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis.
Volume: 31
Issue: 2
Pages: 167-169
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Publication
16516881 | J:109564
First Author: Li MZ
Year: 2006
Journal: Dev Biol
Title: Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening.
Volume: 292
Issue: 2
Pages: 555-64
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Publication
16959567 | -
First Author: Prehna G
Year: 2006
Journal: Cell
Title: Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors.
Volume: 126
Issue: 5
Pages: 869-80
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Protein
Q60992
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Publication
31445077 | J:293537
 
First Author: Kojima H
Year: 2019
Journal: Neurobiol Learn Mem
Title: The role of CaMKII-Tiam1 complex on learning and memory.
Volume: 166
Pages: 107070
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Protein Coding Gene
MGI:2138281 | Lbr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1927230 | Trio
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104580 | Rapgef1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2157953 | Rbm39
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97852 | Rap1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1321389 | Vamp3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96079 | Hgf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96969 | Met
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929494 | Arhgap35
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913758 | Lamtor1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2429765 | Dock1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1860493 | Arhgef7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920591 | Arhgef6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1339656 | Pak3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P63024
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: false
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Protein
P62835
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q8VH51
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q61093
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom