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Search results 1701 to 1800 out of 1899 for Rag2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:4838641 | B6.129S-Rag2<tm1Fwa>/Tac
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:4838781 | B6.Cg-Ptprc<a> Pepc<b> Rag2<tm1Fwa>/Tac
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Rag2<em3Cya> | MGI:7657315
Name: recombination activating gene 2; endonuclease-mediated mutation 3, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Rag2<em4Cya> | MGI:7657316
Name: recombination activating gene 2; endonuclease-mediated mutation 4, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
9462518 | J:78376
First Author: Ranger AM
Year: 1998
Journal: Immunity
Title: Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.
Volume: 8
Issue: 1
Pages: 125-34
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Genotype
Genotype
Symbol: Nfatc1/Nfatc1
Background: chimera involves: 129S2/SvPas
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:6438696 | C.129S(B6)-Rag2<tm1Fwa>/Tac
Attribute String: mutant strain, congenic, targeted mutation
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Allele
Aby | MGI:5752853
 
Name: mutant Aby
Allele Type: Spontaneous
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Allele
Rag2<tm1Smoc> | MGI:6460647
Name: recombination activating gene 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Publication
8861909 | -
First Author: Difilippantonio MJ
Year: 1996
Journal: Cell
Title: RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.
Volume: 87
Issue: 2
Pages: 253-62
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Publication
28213501 | J:252723
First Author: Fisher MR
Year: 2017
Journal: J Immunol
Title: Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks.
Volume: 198
Issue: 7
Pages: 2943-2956
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Publication
31134127 | J:285484
 
First Author: Zhao Y
Year: 2019
Journal: Front Genet
Title: Biological Characteristics of Severe Combined Immunodeficient Mice Produced by CRISPR/Cas9-Mediated Rag2 and IL2rg Mutation.
Volume: 10
Pages: 401
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Gene
5896 | RAG1
Type: gene
Organism: human
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Publication
8521468 | -
First Author: McBlane JF
Year: 1995
Journal: Cell
Title: Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.
Volume: 83
Issue: 3
Pages: 387-95
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Publication
9094713 | -
First Author: Agrawal A
Year: 1997
Journal: Cell
Title: RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination.
Volume: 89
Issue: 1
Pages: 43-53
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Publication
16111638 | -
First Author: West KL
Year: 2005
Journal: Immunity
Title: A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination.
Volume: 23
Issue: 2
Pages: 203-12
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Strain
MGI:5752856 | STOCK Aby/Ieg
Attribute String: Not specified
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Strain
MGI:6474665 | B6;129-Rag2<tm1Smoc>/Smoc
Attribute String: targeted mutation, mutant stock
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Allele
Rag2<em1Smoc> | MGI:7291964
Name: recombination activating gene 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7657589 | C57BL/6J-Rag2<em1Cya> Il2rg<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7657614 | BALB/cAn-Rag2<em1Cya> Il2rg<em3Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Aby/Aby<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aby/Aby
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:104779 | Prkdc
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Rag2<tm1Avla> | MGI:3713766
Name: recombination activating gene 2; targeted mutation 1, Anna Villa
Allele Type: Targeted
Attribute String: Hypomorph
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Allele
Rag1<tm1Jsek> | MGI:3840831
Name: recombination activating 1; targeted mutation 1, JoAnne Sekiguchi
Allele Type: Targeted
Attribute String: Hypomorph
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Genotype
Genotype
Symbol: Rag2/Rag2
Background: involves: 129S/SvEv * MF1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prkdc/Prkdc
Background: C.BKa-Prkdc
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0090013 | severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive
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DO Term
DOID:0060012 | recombinase activating gene 2 deficiency
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Publication
23076336 | J:243389
First Author: Reed NP
Year: 2013
Journal: Genes Immun
Title: Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.
Volume: 14
Issue: 1
Pages: 7-12
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CL Term
CL:0000956 | pre-B-I cell
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Allele
Rag2<tm1Libo> | MGI:3700748
Name: recombination activating gene 2; targeted mutation 1, Lisa Borghesi
Allele Type: Targeted
Attribute String: Null/knockout
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Protein Coding Gene
MGI:97848 | Rag1
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Rag2/Rag2
Background: involves: 129/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag1/Rag1
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060010 | Omenn syndrome
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DO Term
DOID:0112253 | combined cellular and humoral immune defects with granulomas
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Allele
Tg(Rag2-Igb)1Mnz | MGI:2387028
Name: transgene insertion 1, Michel C Nussenzweig
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6770503 | Balb/c-Rag2<em1> IL2rg/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Rag2/Rag2
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Gene
64421 | DCLRE1C
Type: gene
Organism: human
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Allele
Rag2<tm1Mao> | MGI:2450735
 
Name: recombination activating gene 2; targeted mutation 1, Marjorie A Oettinger
Allele Type: Targeted
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Publication
28344082 | J:241002
First Author: Legnini I
Year: 2017
Journal: Mol Cell
Title: Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.
Volume: 66
Issue: 1
Pages: 22-37.e9
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Protein
A0A494B9K3
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
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Protein
Q497T7
Organism: Mus musculus/domesticus
Length: 469  
Fragment?: true
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Protein
E0CYU4
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
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Protein
Q8BYP5
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: true
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Publication
27903978 | -
First Author: Peng L
Year: 2017
Journal: Oncotarget
Title: Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease.
Volume: 8
Issue: 1
Pages: 808-818
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Publication
28824721 | -
First Author: Liu C
Year: 2017
Journal: Theranostics
Title: Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction.
Volume: 7
Issue: 11
Pages: 2863-2877
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Protein Domain
IPR040010 | ZN608/ZN609
Type: Family
Description: Zinc finger proteins 608 and 609 (ZNF608/ZNF609) are putative transcription factors. ZNF608 represses the expression of ZNF609, which in turn represses recombination-activating gene 1 (Rag1) and Rag2 expression in thymocytes []. Interestingly, ZNF609 generates circular RNA (Cir-ZNF609), a novel kind of noncoding RNA that form loop structures without 5'-3' polarities and polyadenylated tails. Cir-ZNF609 has been found to regulate myoblast proliferation and AKT3 expression [, ]. Cir-ZNF609 has also been linked to vascular endothelial dysfunction [].
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Allele
Prkdc<scid> | MGI:1857113
 
Name: protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency
Allele Type: Spontaneous
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Allele
Tg(Rag2-EGFP)1Mnz | MGI:3784416
Name: transgene insertion 1, Michel C Nussenzweig
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:3810421 | FVB-Tg(Rag2-EGFP)1Mnz/J
Attribute String: coisogenic, transgenic
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Publication
23918956 | J:202497
First Author: Guy-Grand D
Year: 2013
Journal: J Exp Med
Title: Origin, trafficking, and intraepithelial fate of gut-tropic T cells.
Volume: 210
Issue: 9
Pages: 1839-54
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Allele
Iftap<tm1Mnz> | MGI:6140227
Name: intraflagellar transport associated protein; targeted mutation 1, Michel C Nussenzweig
Allele Type: Targeted
Attribute String: Modified isoform(s), No functional change
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Genotype
Genotype
Symbol: Rag2/Rag2
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag2/Rag2
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
12566417 | J:124688
First Author: Guy-Grand D
Year: 2003
Journal: J Exp Med
Title: Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice.
Volume: 197
Issue: 3
Pages: 333-41
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Publication
27129922 | J:246488
First Author: Kim HK
Year: 2016
Journal: Eur J Immunol
Title: Distinct IL-7 signaling in recent thymic emigrants versus mature naïve T cells controls T-cell homeostasis.
Volume: 46
Issue: 7
Pages: 1669-80
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Genotype
Genotype
Symbol: Cd79b/Cd79b Tg(Rag2-Igb)1Mnz/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag2/Rag2
Background: involves: 129S/SvEv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Iftap/Iftap
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Publication
29930553 | J:269563
 
First Author: Aili A
Year: 2018
Journal: Front Immunol
Title: CCR2 Signal Facilitates Thymic Egress by Priming Thymocyte Responses to Sphingosine-1-Phosphate.
Volume: 9
Pages: 1263
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Publication
20061408 | J:159493
First Author: Do JS
Year: 2010
Journal: J Immunol
Title: Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
Volume: 184
Issue: 4
Pages: 1675-9
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Publication
35032866 | J:333858
 
First Author: Démoulins T
Year: 2022
Journal: Virology
Title: Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection.
Volume: 567
Pages: 77-86
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Publication
17513799 | J:147822
First Author: Goldberg GL
Year: 2007
Journal: J Immunol
Title: Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation.
Volume: 178
Issue: 11
Pages: 7473-84
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Allele
Rag1/Rag2<tm1Mnz> | MGI:3720344
 
Name: recombination activating 1; targeted mutation 1, Michel C Nussenzweig
Allele Type: Targeted
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Allele
Rag1/Rag2<tm1Mnz> | MGI:3720345
 
Name: recombination activating gene 2; targeted mutation 1, Michel C Nussenzweig
Allele Type: Targeted
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Publication
22398309 | J:188179
First Author: Houston EG Jr
Year: 2012
Journal: Cell Immunol
Title: Homeostatic signals do not drive post-thymic T cell maturation.
Volume: 274
Issue: 1-2
Pages: 39-45
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Publication
35678373 | J:327139
   
First Author: Rane S
Year: 2022
Journal: Elife
Title: Towards a unified model of naive T cell dynamics across the lifespan.
Volume: 11
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Publication
25939024 | J:232834
First Author: Thiault N
Year: 2015
Journal: Nat Immunol
Title: Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors.
Volume: 16
Issue: 6
Pages: 628-34
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Genotype
Genotype
Symbol: Cd79b/Cd79b Tg(BCL2)22Wehi/? Tg(Rag2-Igb)1Mnz/?
Background: involves: 129S1/Sv * C57BL/6JWehi * SJL/JWehi
Zygosity: cx
Has Mutant Allele: true
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Publication
12629039 | J:159076
First Author: Yurchenko V
Year: 2003
Journal: Genes Dev
Title: The RAG1 N-terminal domain is an E3 ubiquitin ligase.
Volume: 17
Issue: 5
Pages: 581-5
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Publication
22988035 | J:190638
First Author: Romagnoli P
Year: 2012
Journal: J Immunol
Title: The thymic niche does not limit development of the naturally diverse population of mouse regulatory T lymphocytes.
Volume: 189
Issue: 8
Pages: 3831-7
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Publication
38061355 | J:353512
First Author: Textor J
Year: 2023
Journal: Cell Syst
Title: Machine learning analysis of the T cell receptor repertoire identifies sequence features of self-reactivity.
Volume: 14
Issue: 12
Pages: 1059-1073.e5
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Publication
17277104 | J:144001
First Author: Schwarz BA
Year: 2007
Journal: J Immunol
Title: Selective thymus settling regulated by cytokine and chemokine receptors.
Volume: 178
Issue: 4
Pages: 2008-17
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Publication
23613523 | J:198956
First Author: Hennion-Tscheltzoff O
Year: 2013
Journal: Blood
Title: TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy.
Volume: 121
Issue: 23
Pages: 4684-93
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Publication
32905761 | J:316002
First Author: Baranek T
Year: 2020
Journal: Cell Rep
Title: High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision.
Volume: 32
Issue: 10
Pages: 108116
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Publication
25482559 | J:222661
First Author: Korn LL
Year: 2014
Journal: Cell Rep
Title: Regulatory T cells occupy an isolated niche in the intestine that is antigen independent.
Volume: 9
Issue: 5
Pages: 1567-73
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Publication
26762709 | J:264846
First Author: Al-Chami E
Year: 2016
Journal: Aging Cell
Title: Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis.
Volume: 15
Issue: 2
Pages: 349-60
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Publication
20929851 | J:171734
First Author: Rubtsov YP
Year: 2010
Journal: Science
Title: Stability of the regulatory T cell lineage in vivo.
Volume: 329
Issue: 5999
Pages: 1667-71
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Publication
33207189 | J:301684
First Author: Verheijen M
Year: 2020
Journal: Cell Rep
Title: Fate Mapping Quantifies the Dynamics of B Cell Development and Activation throughout Life.
Volume: 33
Issue: 7
Pages: 108376
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Publication
23409179 | J:197200
First Author: Dong J
Year: 2013
Journal: PLoS One
Title: Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus.
Volume: 8
Issue: 2
Pages: e56378
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Genotype
Genotype
Symbol: Rag1/Rag2/Rag1/Rag2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rag1/Rag2/Rag1/Rag2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
11850834 | J:75006
First Author: Arentson E
Year: 2002
Journal: Oncogene
Title: Oncogenic potential of the DNA replication licensing protein CDT1.
Volume: 21
Issue: 8
Pages: 1150-8
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Publication
20122409 | J:158989
First Author: Grazini U
Year: 2010
Journal: Mol Cell
Title: The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining.
Volume: 37
Issue: 2
Pages: 282-93
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Publication
12001065 | J:77246
First Author: Hicar MD
Year: 2002
Journal: Genesis
Title: Embryonic expression and regulation of the large zinc finger protein KRC.
Volume: 33
Issue: 1
Pages: 8-20
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Publication
20889548 | J:165182
First Author: Ribeiro VS
Year: 2010
Journal: J Immunol
Title: Cutting edge: Thymic NK cells develop independently from T cell precursors.
Volume: 185
Issue: 9
Pages: 4993-7
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Publication
10490100 | J:57475
First Author: Marine JC
Year: 1999
Journal: Cell
Title: SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.
Volume: 98
Issue: 5
Pages: 609-16
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Publication
9645367 | J:48190
First Author: Crompton T
Year: 1998
Journal: Eur J Immunol
Title: Distinct roles of the interleukin-7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor alpha-deficient mice.
Volume: 28
Issue: 6
Pages: 1859-66
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Publication
28628091 | J:258991
First Author: Dolezal E
Year: 2017
Journal: Nat Immunol
Title: The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex.
Volume: 18
Issue: 8
Pages: 911-920
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Publication
28514688 | J:258946
First Author: Miyazaki M
Year: 2017
Journal: Immunity
Title: The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.
Volume: 46
Issue: 5
Pages: 818-834.e4
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Publication
36316474 | J:333184
First Author: Lee RD
Year: 2022
Journal: Nat Immunol
Title: Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.
Volume: 23
Issue: 12
Pages: 1763-1776
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Publication
17057722 | J:116103
First Author: Zhang F
Year: 2006
Journal: Nat Immunol
Title: Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608.
Volume: 7
Issue: 12
Pages: 1309-16
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Publication
34033676 | J:329657
 
First Author: Chen CC
Year: 2021
Journal: J Exp Med
Title: Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination.
Volume: 218
Issue: 8
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Publication
23438597 | J:203755
First Author: Lee BS
Year: 2013
Journal: Mol Cell Biol
Title: The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.
Volume: 33
Issue: 9
Pages: 1768-81
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Publication
9022004 | J:38447
First Author: Crompton T
Year: 1997
Journal: Eur J Immunol
Title: A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice.
Volume: 27
Issue: 1
Pages: 100-4
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Publication
15254250 | J:92238
First Author: De P
Year: 2004
Journal: Mol Cell Biol
Title: DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.
Volume: 24
Issue: 15
Pages: 6850-60
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