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Search results 1701 to 1800 out of 2041 for Rhoa

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Type Details Score
Publication
32816052 | J:315644
First Author: Stiffel VM
Year: 2020
Journal: Calcif Tissue Int
Title: The EphA4 Signaling is Anti-catabolic in Synoviocytes but Pro-anabolic in Articular Chondrocytes.
Volume: 107
Issue: 6
Pages: 576-592
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Publication
34547282 | J:316409
First Author: Ge W
Year: 2022
Journal: Gastroenterology
Title: miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis.
Volume: 162
Issue: 1
Pages: 269-284
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Publication
34815397 | J:315171
First Author: Gurusamy M
Year: 2021
Journal: Nat Commun
Title: G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Volume: 12
Issue: 1
Pages: 6798
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Publication
28472098 | J:248532
First Author: Masubuchi Y
Year: 2017
Journal: PLoS One
Title: T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells.
Volume: 12
Issue: 5
Pages: e0176841
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Publication
23260665 | J:318671
First Author: Charalampopoulos I
Year: 2012
Journal: Cell Rep
Title: Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor.
Volume: 2
Issue: 6
Pages: 1563-70
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Publication
30379592 | J:318526
First Author: Haupt J
Year: 2019
Journal: Mol Biol Cell
Title: ACVR1R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification.
Volume: 30
Issue: 1
Pages: 17-29
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Publication
25084760 | J:325345
First Author: Moutinho M
Year: 2015
Journal: Mol Neurobiol
Title: Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.
Volume: 51
Issue: 3
Pages: 1489-503
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Publication
26726844 | J:320610
First Author: Auguste D
Year: 2016
Journal: Small GTPases
Title: Disease-causing mutations of RhoGDIα induce Rac1 hyperactivation in podocytes.
Volume: 7
Issue: 2
Pages: 107-21
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Publication
26989201 | J:320356
First Author: Healy JA
Year: 2016
Journal: Blood
Title: GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.
Volume: 127
Issue: 22
Pages: 2723-31
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Publication
35477750 | J:324773
First Author: Chen J
Year: 2022
Journal: Oncogene
Title: Targeting anillin inhibits tumorigenesis and tumor growth in hepatocellular carcinoma via impairing cytokinesis fidelity.
Volume: 41
Issue: 22
Pages: 3118-3130
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Publication
35616334 | J:330429
 
First Author: Paes de Faria J
Year: 2022
Journal: Development
Title: Pinch2 regulates myelination in the mouse central nervous system.
Volume: 149
Issue: 13
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Publication
35710398 | J:326691
First Author: Mahly A
Year: 2022
Journal: BMC Biol
Title: Anillin governs mitotic rounding during early epidermal development.
Volume: 20
Issue: 1
Pages: 145
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Publication
37729426 | J:343793
First Author: Mukhopadhyay S
Year: 2023
Journal: Cancer Res
Title: Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy.
Volume: 83
Issue: 24
Pages: 4095-4111
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Publication
38307937 | J:346398
First Author: Miao J
Year: 2024
Journal: Exp Mol Med
Title: The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β.
Volume: 56
Issue: 2
Pages: 395-407
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Publication
35624196 | J:355076
First Author: Wu M
Year: 2022
Journal: Neurochem Res
Title: Rho-Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology.
Volume: 47
Issue: 9
Pages: 2757-2772
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Publication
12009891 | -
First Author: Garavini H
Year: 2002
Journal: Biochemistry
Title: Crystal structure of the core domain of RhoE/Rnd3: a constitutively activated small G protein.
Volume: 41
Issue: 20
Pages: 6303-10
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Protein
G3UYD6
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
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Protein
Q80WU2
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Publication
16042565 | -
First Author: Riento K
Year: 2005
Journal: Biochem Soc Trans
Title: Function and regulation of RhoE.
Volume: 33
Issue: Pt 4
Pages: 649-51
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Publication
16493413 | -
First Author: Chardin P
Year: 2006
Journal: Nat Rev Mol Cell Biol
Title: Function and regulation of Rnd proteins.
Volume: 7
Issue: 1
Pages: 54-62
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Protein
Q8C8B2
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Protein
Q3TA34
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: true
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Protein
H3BK10
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
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Protein
Q3TZA8
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: true
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Protein
H3BIZ5
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Protein
Q9D0J3
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Protein
D3Z1X5
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: true
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Protein
H3BIW1
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein
Q8BYV7
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
H3BL29
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
A2ALX7
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Protein
A2ALX6
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
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Publication
22700192 | -
First Author: Jeyabalan J
Year: 2012
Journal: J Endocrinol
Title: Mice lacking AMP-activated protein kinase α1 catalytic subunit have increased bone remodelling and modified skeletal responses to hormonal challenges induced by ovariectomy and intermittent PTH treatment.
Volume: 214
Issue: 3
Pages: 349-58
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Publication
29288408 | J:272348
First Author: Wu W
Year: 2018
Journal: J Physiol Biochem
Title: Muscle-specific deletion of Prkaa1 enhances skeletal muscle lipid accumulation in mice fed a high-fat diet.
Volume: 74
Issue: 2
Pages: 195-205
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Protein Domain
IPR039137 | AMPKA1_C
Type: Domain
Description: AMPK, a serine/threonine protein kinase (STK), catalyzes the transfer of the gamma-phosphoryl group from ATP to S/T residues on protein substrates. It acts as a sensor for the energy status of the cell and is activated by cellular stresses that lead to ATP depletion such as hypoxia, heat shock, and glucose deprivation, among others. AMPK is a heterotrimer of three subunits: alpha, beta, and gamma []. The alpha subunit is the catalytic subunit and it contains an N-terminal kinase domain, a putative autoinhibitory domain (AID) and a C-terminal region required for beta subunit binding. The beta scaffolding subunit mediates AMPK assembly by bridging alpha and gamma subunits. The C-terminal domain of the AMPK alpha 1 subunit interacts with the C-terminal region of the beta subunit to form a tightalpha-beta complex that is associated with the gamma subunit. The AMPK alpha subunit auto-inhibitory region interacts with the kinase domain; this inhibition is negated by the interaction with the AMPK gamma subunit [].AMPK has been implicated in a number of diseases related to energy metabolism including type 2 diabetes, obesity and cancer [, ]. AMPK is activated by rising AMP concentrations coupled with falling ATP concentrations. Activation of AMPK is also dependent on the phosphorylation of alpha subunit by upstream kinases such as LKB1 [].Vertebrates contain two isoforms of the alpha subunit, alpha1 and alpha2, which are encoded by different genes, PRKAA1 and PRKAA2, respectively, and show varying expression patterns. AMPKalpha1 is the predominant isoform expressed in bone; it plays a role in bone remodeling in response to hormonal regulation []. AMPK alpha1 impacts the regulation of fat metabolism []. It also mediates the vasoprotective effects of estrogen through phosphorylation of another in vivo substrate, RhoA [].
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Protein
P97434
Organism: Mus musculus/domesticus
Length: 1024  
Fragment?: false
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Protein
Q99KW3
Organism: Mus musculus/domesticus
Length: 2014  
Fragment?: false
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Protein
Q5SWZ5
Organism: Mus musculus/domesticus
Length: 2269  
Fragment?: false
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Protein
G5E8W1
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: true
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Protein
A0A2U3TZ82
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
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Protein
F6RND9
Organism: Mus musculus/domesticus
Length: 1010  
Fragment?: true
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Protein
A0A2R8VI29
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: true
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Protein
F6S5I0
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: true
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Protein
Q8CBS0
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: false
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Protein
J9JI90
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
Q3U2M9
Organism: Mus musculus/domesticus
Length: 1330  
Fragment?: true
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Protein
Q8C8T6
Organism: Mus musculus/domesticus
Length: 1008  
Fragment?: true
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Protein Coding Gene
MGI:97583 | Pik3r1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P26450
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Publication
10490598 | J:65159
First Author: Joberty G
Year: 1999
Journal: Mol Cell Biol
Title: The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
Volume: 19
Issue: 10
Pages: 6585-97
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Publication
20215560 | J:175344
First Author: McCoy KL
Year: 2010
Journal: Mol Pharmacol
Title: PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.
Volume: 77
Issue: 6
Pages: 1005-15
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Publication
21900451 | J:180032
First Author: Kim JH
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization.
Volume: 302
Issue: 1
Pages: F103-15
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Publication
16336954 | J:105719
First Author: Xie Z
Year: 2006
Journal: Cardiovasc Res
Title: Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.
Volume: 69
Issue: 2
Pages: 491-501
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Publication
37311604 | J:340100
First Author: You JS
Year: 2023
Journal: J Cachexia Sarcopenia Muscle
Title: RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice.
Volume: 14
Issue: 4
Pages: 1880-1893
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Publication
25810298 | J:241626
First Author: Wei Y
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis.
Volume: 35
Issue: 4
Pages: 796-803
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Publication
30354246 | J:285130
First Author: Sakai K
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages.
Volume: 38
Issue: 11
Pages: 2590-2600
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Publication
26586201 | J:240014
First Author: Schill EM
Year: 2016
Journal: Dev Biol
Title: Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse.
Volume: 409
Issue: 2
Pages: 473-88
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Publication
29107092 | J:263342
 
First Author: Kapfhamer J
Year: 2018
Journal: Mol Cell Endocrinol
Title: The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.
Volume: 470
Pages: 179-187
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Publication
22923642 | J:193436
First Author: Aravamudan B
Year: 2012
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Caveolin-1 knockout mice exhibit airway hyperreactivity.
Volume: 303
Issue: 8
Pages: L669-81
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Publication
34518307 | J:314180
First Author: Matsuki T
Year: 2021
Journal: J Neurosci
Title: STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.
Volume: 41
Issue: 43
Pages: 8887-8903
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Publication
17475819 | J:147540
First Author: Ahrabi AK
Year: 2007
Journal: J Am Soc Nephrol
Title: PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice.
Volume: 18
Issue: 6
Pages: 1740-53
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Publication
30879335 | J:326702
First Author: Scholz B
Year: 2019
Journal: Circ Arrhythm Electrophysiol
Title: HDAC (Histone Deacetylase) Inhibitor Valproic Acid Attenuates Atrial Remodeling and Delays the Onset of Atrial Fibrillation in Mice.
Volume: 12
Issue: 3
Pages: e007071
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Publication
20442405 | J:165360
First Author: Lim ST
Year: 2010
Journal: J Biol Chem
Title: Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.
Volume: 285
Issue: 28
Pages: 21526-36
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Publication
30972066 | J:281980
 
First Author: Purvis GSD
Year: 2019
Journal: Front Immunol
Title: Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes.
Volume: 10
Pages: 571
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Publication
26268269 | J:280490
First Author: Brähler S
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.
Volume: 309
Issue: 7
Pages: F617-26
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Publication
25542002 | J:237548
First Author: Song Y
Year: 2014
Journal: PLoS One
Title: ARAP3 functions in hematopoietic stem cells.
Volume: 9
Issue: 12
Pages: e116107
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Publication
37511238 | J:339166
 
First Author: Yiu TW
Year: 2023
Journal: Int J Mol Sci
Title: Transglutaminase 2 Facilitates Murine Wound Healing in a Strain-Dependent Manner.
Volume: 24
Issue: 14
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Publication
29896304 | J:264924
First Author: Park KR
Year: 2018
Journal: Theranostics
Title: Dysregulation of 5-hydroxytryptamine 6 receptor accelerates maturation of bone-resorbing osteoclasts and induces bone loss.
Volume: 8
Issue: 11
Pages: 3087-3098
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Publication
33958714 | J:331596
First Author: Mayer CA
Year: 2022
Journal: Pediatr Res
Title: Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice.
Volume: 91
Issue: 6
Pages: 1391-1398
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Publication
29447006 | J:273816
First Author: Wang S
Year: 2018
Journal: FASEB J
Title: Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
Volume: 32
Issue: 7
Pages: 3765-3781
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Publication
27689009 | J:289469
First Author: Bian H
Year: 2016
Journal: Mol Metab
Title: Myocardin-related transcription factor A (MRTFA) regulates the fate of bone marrow mesenchymal stem cells and its absence in mice leads to osteopenia.
Volume: 5
Issue: 10
Pages: 970-979
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Publication
23595951 | J:213293
First Author: Zhang J
Year: 2013
Journal: Circ Res
Title: Cyclooxygenase-2-derived prostaglandin Eâ‚‚ promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor.
Volume: 113
Issue: 2
Pages: 104-14
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Publication
22701760 | J:186780
First Author: Cook DR
Year: 2011
Journal: Genes Cancer
Title: The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.
Volume: 2
Issue: 10
Pages: 932-42
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Publication
37317855 | J:339451
First Author: Kleinjan ML
Year: 2023
Journal: Arterioscler Thromb Vasc Biol
Title: CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA.
Volume: 43
Issue: 8
Pages: 1441-1454
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Publication
21695258 | J:174444
First Author: Yu D
Year: 2011
Journal: PLoS One
Title: Murine missing in metastasis (MIM) mediates cell polarity and regulates the motility response to growth factors.
Volume: 6
Issue: 6
Pages: e20845
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Publication
23275618 | J:194937
First Author: Rajagopal S
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.
Volume: 304
Issue: 5
Pages: G527-35
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Publication
32066583 | J:286579
First Author: Xie C
Year: 2020
Journal: J Neurosci
Title: Astrocytic YAP Promotes the Formation of Glia Scars and Neural Regeneration after Spinal Cord Injury.
Volume: 40
Issue: 13
Pages: 2644-2662
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Publication
21411727 | J:175672
First Author: Shum WW
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.
Volume: 301
Issue: 1
Pages: C31-43
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Publication
31004356 | J:289215
First Author: Zhang Z
Year: 2019
Journal: J Cell Physiol
Title: N-myc downstream-regulated gene 2 controls astrocyte morphology via Rho-GTPase signaling.
Volume: 234
Issue: 11
Pages: 20847-20858
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Publication
15123714 | J:182402
First Author: Rundle DR
Year: 2004
Journal: J Biol Chem
Title: PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles.
Volume: 279
Issue: 28
Pages: 29728-39
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Publication
20697350 | J:164892
First Author: Titz B
Year: 2010
Journal: Oncogene
Title: The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
Volume: 29
Issue: 44
Pages: 5895-910
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Publication
9445394 | J:45635
 
First Author: Katayama K
Year: 1998
Journal: Biochem J
Title: Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver.
Volume: 329 ( Pt 3)
Pages: 647-52
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Publication
9620089 | J:47913
First Author: SundarRaj N
Year: 1998
Journal: Invest Ophthalmol Vis Sci
Title: A Rho-associated protein kinase: differentially distributed in limbal and corneal epithelia.
Volume: 39
Issue: 7
Pages: 1266-72
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Publication
15275855 | J:94242
First Author: Nawshad A
Year: 2004
Journal: Arch Oral Biol
Title: Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT).
Volume: 49
Issue: 9
Pages: 675-89
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Publication
15591319 | J:97054
First Author: Li F
Year: 2005
Journal: J Biol Chem
Title: Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1.
Volume: 280
Issue: 8
Pages: 6986-92
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Publication
17463321 | J:137811
First Author: Yano M
Year: 2007
Journal: Circ Res
Title: Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages.
Volume: 100
Issue: 10
Pages: 1442-51
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Publication
19693014 | J:152155
First Author: Wu YI
Year: 2009
Journal: Nature
Title: A genetically encoded photoactivatable Rac controls the motility of living cells.
Volume: 461
Issue: 7260
Pages: 104-8
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Publication
21734098 | J:176280
First Author: Bondeva T
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Advanced glycation end products inhibit adhesion ability of differentiated podocytes in a neuropilin-1-dependent manner.
Volume: 301
Issue: 4
Pages: F852-70
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Publication
25683353 | J:222293
First Author: Han Y
Year: 2015
Journal: J Neurochem
Title: Noise-induced cochlear F-actin depolymerization is mediated via ROCK2/p-ERM signaling.
Volume: 133
Issue: 5
Pages: 617-28
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Publication
26079709 | J:227434
 
First Author: Lee JY
Year: 2015
Journal: Neurobiol Dis
Title: MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death.
Volume: 82
Pages: 141-151
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Publication
30142209 | J:265344
First Author: Oda Y
Year: 2018
Journal: PLoS One
Title: Bone marrow stromal cells from low-turnover osteoporotic mouse model are less sensitive to the osteogenic effects of fluvastatin.
Volume: 13
Issue: 8
Pages: e0202857
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Publication
30444969 | J:268560
First Author: Tang J
Year: 2019
Journal: Exp Cell Res
Title: ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.
Volume: 374
Issue: 1
Pages: 46-68
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Publication
31339573 | J:280870
First Author: Peng Z
Year: 2019
Journal: J Neurochem
Title: Inhibition of Notch1 signaling promotes neuronal differentiation and improves functional recovery in spinal cord injury through suppressing the activation of Ras homolog family member A.
Volume: 150
Issue: 6
Pages: 709-722
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Publication
32352989 | J:288300
First Author: Guo X
Year: 2020
Journal: PLoS One
Title: Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- γC- terminal fragments.
Volume: 15
Issue: 4
Pages: e0231739
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Publication
32787521 | J:318566
First Author: Krueger I
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases.
Volume: 40
Issue: 10
Pages: 2391-2403
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Publication
30834544 | J:345842
First Author: Slaymi C
Year: 2019
Journal: Biol Cell
Title: The atypical RhoU/Wrch1 Rho GTPase controls cell proliferation and apoptosis in the gut epithelium.
Volume: 111
Issue: 5
Pages: 121-141
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Protein
Q6PAN3
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
Q9D9C2
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
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Protein
A0A494B9M9
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Protein
A0A2X0U4H9
Organism: Mus musculus/domesticus
Length: 976  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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