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Search results 1701 to 1777 out of 1777 for Spp1

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Type Details Score
Publication
11756451 | J:75337
First Author: Le Stunff H
Year: 2002
Journal: J Biol Chem
Title: Characterization of murine sphingosine-1-phosphate phosphohydrolase.
Volume: 277
Issue: 11
Pages: 8920-7
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Publication
26954670 | J:251729
First Author: Calyjur PC
Year: 2016
Journal: PLoS One
Title: The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors.
Volume: 11
Issue: 3
Pages: e0150748
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Publication
26477312 | J:226088
First Author: Manda KR
Year: 2016
Journal: Oncogene
Title: NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence.
Volume: 35
Issue: 25
Pages: 3282-92
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Publication
30188931 | J:265523
First Author: Strathmann EA
Year: 2018
Journal: PLoS One
Title: Evaluation of potential effects of Plastin 3 overexpression and low-dose SMN-antisense oligonucleotides on putative biomarkers in spinal muscular atrophy mice.
Volume: 13
Issue: 9
Pages: e0203398
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Publication
27237608 | J:235511
 
First Author: Ii H
Year: 2016
Journal: Bone
Title: Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis.
Volume: 90
Pages: 37-49
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Publication
34003775 | J:316899
First Author: Bommi PV
Year: 2021
Journal: Cancer Res
Title: The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells.
Volume: 81
Issue: 10
Pages: 2760-2773
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Publication
23624921 | J:212364
First Author: Tripathi P
Year: 2014
Journal: Oncogene
Title: Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms.
Volume: 33
Issue: 14
Pages: 1840-9
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Publication
33840251 | J:331628
First Author: Nagasaki A
Year: 2021
Journal: J Dent Res
Title: Delivery of Alkaline Phosphatase Promotes Periodontal Regeneration in Mice.
Volume: 100
Issue: 9
Pages: 993-1001
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Publication
10369926 | J:56050
First Author: Kaiser P
Year: 1999
Journal: Immunogenetics
Title: The chicken 9E3/CEF4 CXC chemokine is the avian orthologue of IL8 and maps to chicken chromosome 4 syntenic with genes flanking the mammalian chemokine cluster.
Volume: 49
Issue: 7-8
Pages: 673-84
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Publication
32865099 | J:304215
First Author: Shirakawa K
Year: 2020
Journal: J Am Heart Assoc
Title: MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin-Producing Reparative Macrophages After Myocardial Infarction.
Volume: 9
Issue: 18
Pages: e017071
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Publication
2679356 | -
 
First Author: Black LW
Year: 1989
Journal: Annu Rev Microbiol
Title: DNA packaging in dsDNA bacteriophages.
Volume: 43
Pages: 267-92
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Publication
11382219 | -
First Author: Lang AS
Year: 2001
Journal: Arch Microbiol
Title: The gene transfer agent of Rhodobacter capsulatus and "constitutive transduction" in prokaryotes.
Volume: 175
Issue: 4
Pages: 241-9
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Publication
33127392 | J:331136
First Author: Verboven E
Year: 2021
Journal: Gastroenterology
Title: Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis.
Volume: 160
Issue: 3
Pages: 847-862
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Publication
33768568 | J:322315
First Author: Di-Luoffo M
Year: 2021
Journal: Hepatology
Title: A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin-4 in Tumor Progression.
Volume: 74
Issue: 3
Pages: 1445-1460
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Genotype
Genotype
Symbol: Fas/Fas Spp1/Spp1
Background: involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp
Zygosity: cx
Has Mutant Allele: true
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Publication
25077564 | J:267999
 
First Author: Riccardo F
Year: 2014
Journal: BMC Genomics
Title: Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers.
Volume: 15 Suppl 3
Pages: S1
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Publication
12399927 | -
First Author: Lang AS
Year: 2002
Journal: J Mol Evol
Title: Evolutionary implications of phylogenetic analyses of the gene transfer agent (GTA) of Rhodobacter capsulatus.
Volume: 55
Issue: 5
Pages: 534-43
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Publication
18554323 | -
First Author: Burts ML
Year: 2008
Journal: Mol Microbiol
Title: EsaC substrate for the ESAT-6 secretion pathway and its role in persistent infections of Staphylococcus aureus.
Volume: 69
Issue: 3
Pages: 736-46
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Publication
15657139 | -
First Author: Burts ML
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.
Volume: 102
Issue: 4
Pages: 1169-74
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Publication
11742990 | -
First Author: Roguev A
Year: 2001
Journal: EMBO J
Title: The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4.
Volume: 20
Issue: 24
Pages: 7137-48
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Protein Domain
IPR016811 | ORC6_fun
Type: Family
Description: The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded in yeast by ORC1-6 []. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle []. ORC directs DNA replication throughout the genome and is required for its initiation [, , ]. ORC bound at replication origins serves as the foundation for assembly of the pre-replicative complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-7 complex [, , ]. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase [, , ]. Cell cycle-regulated phosphorylation of ORC2, ORC6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase [, , , ]. In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR) [, , ]. ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers [, , ]. Both ORC1 and ORC5 bind ATP, although only ORC1 has ATPase activity []. The binding of ATP by ORC1 is required for ORC binding to DNA and is essential for cell viability []. The ATPase activity of ORC1 is involved in formation of the pre-RC [, , ]. ATP binding by ORC5 is crucial for the stability of ORC as a whole. Only the ORC1-5 subunits are required for origin binding; ORC6 is essential for maintenance of pre-RCs once formed []. Interactions within ORC suggest that ORC2-3-6 may form a core complex []. ORC homologues have been found in various eukaryotes, including fission yeast, insects, amphibians, and humans []. This entry represents subunit 6, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1 and with trimethylated histone H3; phosphorylated by Cdc28 [, ]. In Saccharomyces cerevisiae (Baker's yeast), both ends of the Orc6 interact with Cdt1 []and the N terminus mediates an interaction with the S-phase cyclin Clb5 [].
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Protein Domain
IPR008721 | ORC6
Type: Family
Description: The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded in yeast by ORC1-6 []. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle []. ORC directs DNA replication throughout the genome and is required for its initiation [, , ]. ORC bound at replication origins serves as the foundation for assembly of the pre-replicative complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-7 complex [, , ]. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase [, , ]. Cell cycle-regulated phosphorylation of ORC2, ORC6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase [, , , ]. In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR) [, , ]. ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers [, , ]. Both ORC1 and ORC5 bind ATP, although only ORC1 has ATPase activity []. The binding of ATP by ORC1 is required for ORC binding to DNA and is essential for cell viability []. The ATPase activity of ORC1 is involved in formation of the pre-RC [, , ]. ATP binding by ORC5 is crucial for the stability of ORC as a whole. Only the ORC1-5 subunits are required for origin binding; ORC6 is essential for maintenance of pre-RCs once formed []. Interactions within ORC suggest that ORC2-3-6 may form a core complex []. ORC homologues have been found in various eukaryotes, including fission yeast, insects, amphibians, and humans []. This entry represents subunit 6, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1 and with trimethylated histone H3; phosphorylated by Cdc28 [, ]. In Saccharomyces cerevisiae (Baker's yeast), both ends of the Orc6 interact with Cdt1 []and the N terminus mediates an interaction with the S-phase cyclin Clb5 [].
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Publication
14574415 | -
First Author: Ubersax JA
Year: 2003
Journal: Nature
Title: Targets of the cyclin-dependent kinase Cdk1.
Volume: 425
Issue: 6960
Pages: 859-64
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Publication
15105375 | -
First Author: Wilmes GM
Year: 2004
Journal: Genes Dev
Title: Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch.
Volume: 18
Issue: 9
Pages: 981-91
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Publication
18006685 | -
First Author: Chen S
Year: 2007
Journal: Genes Dev
Title: Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.
Volume: 21
Issue: 22
Pages: 2897-907
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Publication
11687631 | -
First Author: Miller T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.
Volume: 98
Issue: 23
Pages: 12902-7
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Publication
11914271 | -
First Author: Bell SP
Year: 2002
Journal: Genes Dev
Title: The origin recognition complex: from simple origins to complex functions.
Volume: 16
Issue: 6
Pages: 659-72
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Protein
Q9WUJ8
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
A0A1B0GR56
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
Q66JV6
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
A0A1B0GRE5
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
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Protein
A0A1B0GSE2
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Publication
22771211 | -
First Author: Roy A
Year: 2012
Journal: Structure
Title: Small terminase couples viral DNA binding to genome-packaging ATPase activity.
Volume: 20
Issue: 8
Pages: 1403-13
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Publication
31400548 | -
 
First Author: Dixit AB
Year: 2019
Journal: Virology
Title: A viral small terminase subunit (TerS) twin ring pac synapsis DNA packaging model is supported by fluorescent fusion proteins.
Volume: 536
Pages: 39-48
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Publication
12466275 | -
First Author: Baumann RG
Year: 2003
Journal: J Biol Chem
Title: Isolation and characterization of T4 bacteriophage gp17 terminase, a large subunit multimer with enhanced ATPase activity.
Volume: 278
Issue: 7
Pages: 4618-27
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Protein
Q80V17
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: false
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Protein
Q80V59
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: true
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Protein
Q91Z33
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
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Protein
A0A0U1RNP2
Organism: Mus musculus/domesticus
Length: 1173  
Fragment?: true
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Publication
17241905 | -
 
First Author: Chesnokov IN
Year: 2007
Journal: Int Rev Cytol
Title: Multiple functions of the origin recognition complex.
Volume: 256
Pages: 69-109
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Publication
17825065 | -
First Author: Matsuda K
Year: 2007
Journal: FEMS Yeast Res
Title: Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.
Volume: 7
Issue: 8
Pages: 1263-9
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Publication
1579162 | -
First Author: Bell SP
Year: 1992
Journal: Nature
Title: ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.
Volume: 357
Issue: 6374
Pages: 128-34
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Publication
7585959 | -
First Author: Bell SP
Year: 1995
Journal: Cell
Title: The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing.
Volume: 83
Issue: 4
Pages: 563-8
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Publication
16716188 | -
First Author: Gibson DG
Year: 2006
Journal: Genes Cells
Title: Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.
Volume: 11
Issue: 6
Pages: 557-73
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Publication
7892251 | -
First Author: Rao H
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.
Volume: 92
Issue: 6
Pages: 2224-8
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Publication
7781615 | -
First Author: Rowley A
Year: 1995
Journal: EMBO J
Title: Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.
Volume: 14
Issue: 11
Pages: 2631-41
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Publication
16228006 | -
First Author: Speck C
Year: 2005
Journal: Nat Struct Mol Biol
Title: ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.
Volume: 12
Issue: 11
Pages: 965-71
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Publication
10966477 | -
 
First Author: Kelly TJ
Year: 2000
Journal: Annu Rev Biochem
Title: Regulation of chromosome replication.
Volume: 69
Pages: 829-80
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Publication
12045100 | -
 
First Author: Bell SP
Year: 2002
Journal: Annu Rev Biochem
Title: DNA replication in eukaryotic cells.
Volume: 71
Pages: 333-74
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Publication
15680967 | -
First Author: Stillman B
Year: 2005
Journal: FEBS Lett
Title: Origin recognition and the chromosome cycle.
Volume: 579
Issue: 4
Pages: 877-84
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Publication
11572976 | -
First Author: Weinreich M
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle.
Volume: 98
Issue: 20
Pages: 11211-7
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Publication
11429609 | -
First Author: Nguyen VQ
Year: 2001
Journal: Nature
Title: Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms.
Volume: 411
Issue: 6841
Pages: 1068-73
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Publication
16024805 | -
First Author: Archambault V
Year: 2005
Journal: Mol Cell Biol
Title: Disruption of mechanisms that prevent rereplication triggers a DNA damage response.
Volume: 25
Issue: 15
Pages: 6707-21
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Publication
8622770 | -
First Author: Triolo T
Year: 1996
Journal: Nature
Title: Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.
Volume: 381
Issue: 6579
Pages: 251-3
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Publication
9171055 | -
First Author: Fox CA
Year: 1997
Journal: Science
Title: The origin recognition complex, SIR1, and the S phase requirement for silencing.
Volume: 276
Issue: 5318
Pages: 1547-51
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Publication
9038340 | -
First Author: Klemm RD
Year: 1997
Journal: Cell
Title: Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.
Volume: 88
Issue: 4
Pages: 493-502
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Publication
11459976 | -
First Author: Klemm RD
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: ATP bound to the origin recognition complex is important for preRC formation.
Volume: 98
Issue: 15
Pages: 8361-7
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Publication
15610739 | -
First Author: Bowers JL
Year: 2004
Journal: Mol Cell
Title: ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.
Volume: 16
Issue: 6
Pages: 967-78
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Publication
16387651 | -
First Author: Randell JC
Year: 2006
Journal: Mol Cell
Title: Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.
Volume: 21
Issue: 1
Pages: 29-39
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Publication
17053779 | -
First Author: Semple JW
Year: 2006
Journal: EMBO J
Title: An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes.
Volume: 25
Issue: 21
Pages: 5150-8
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Publication
9442876 | -
 
First Author: Dutta A
Year: 1997
Journal: Annu Rev Cell Dev Biol
Title: Initiation of DNA replication in eukaryotic cells.
Volume: 13
Pages: 293-332
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Protein
Q9CWW7
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
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Protein
E9PYH6
Organism: Mus musculus/domesticus
Length: 1716  
Fragment?: false
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Protein
Q8CFT2
Organism: Mus musculus/domesticus
Length: 1985  
Fragment?: false
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Protein
Q541B1
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
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Protein
Q3UIZ4
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
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Publication
19144319 | J:143718
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
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Publication
17242355 | -
First Author: Villén J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Large-scale phosphorylation analysis of mouse liver.
Volume: 104
Issue: 5
Pages: 1488-93
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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