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Search results 1701 to 1800 out of 2112 for Tlr2

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Type Details Score
Publication
29345344 | J:257455
First Author: Cappelletti M
Year: 2018
Journal: J Leukoc Biol
Title: Differential outcomes of TLR2 engagement in inflammation-induced preterm birth.
Volume: 103
Issue: 3
Pages: 535-543
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Publication
26608921 | J:234162
First Author: Perez J
Year: 2016
Journal: J Immunol
Title: Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 Expression.
Volume: 196
Issue: 1
Pages: 168-81
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GO Term
GO:0034134 | toll-like receptor 2 signaling pathway
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GO Term
GO:0035661 | MyD88-dependent toll-like receptor 2 signaling pathway
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Publication
18768838 | J:139111
First Author: Phulwani NK
Year: 2008
Journal: J Immunol
Title: TLR2 expression in astrocytes is induced by TNF-alpha- and NF-kappa B-dependent pathways.
Volume: 181
Issue: 6
Pages: 3841-9
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Publication
16713974 | J:113359
First Author: Hu X
Year: 2006
Journal: Immunity
Title: IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
Volume: 24
Issue: 5
Pages: 563-74
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Publication
37800687 | J:360040
First Author: Soni C
Year: 2023
Journal: J Immunol
Title: Cutting Edge: TLR2 Signaling in B Cells Promotes Autoreactivity to DNA via IL-6 Secretion.
Volume: 211
Issue: 10
Pages: 1475-1480
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Publication
26283364 | J:226711
First Author: Koymans KJ
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3).
Volume: 112
Issue: 35
Pages: 11018-23
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Publication
29196459 | J:257356
First Author: Qadri M
Year: 2018
Journal: J Immunol
Title: Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines.
Volume: 200
Issue: 2
Pages: 758-767
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Publication
17290304 | J:120747
First Author: Schauber J
Year: 2007
Journal: J Clin Invest
Title: Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
Volume: 117
Issue: 3
Pages: 803-11
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Publication
30364936 | J:274215
First Author: Cao D
Year: 2019
Journal: Carcinogenesis
Title: 18β-glycyrrhetinic acid inhibited mitochondrial energy metabolism and gastric carcinogenesis through methylation-regulated TLR2 signaling pathway.
Volume: 40
Issue: 2
Pages: 234-245
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Publication
20400705 | J:160991
First Author: Liu J
Year: 2010
Journal: J Immunol
Title: ST2 negatively regulates TLR2 signaling, but is not required for bacterial lipoprotein-induced tolerance.
Volume: 184
Issue: 10
Pages: 5802-8
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Publication
34784389 | J:315185
First Author: Nogueira DS
Year: 2021
Journal: PLoS Pathog
Title: Eosinophils mediate SIgA production triggered by TLR2 and TLR4 to control Ascaris suum infection in mice.
Volume: 17
Issue: 11
Pages: e1010067
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Publication
21320497 | J:170332
First Author: Byun EH
Year: 2011
Journal: FEBS Lett
Title: Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor.
Volume: 585
Issue: 5
Pages: 814-20
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Publication
23247210 | J:192532
First Author: Song S
Year: 2013
Journal: FEBS Lett
Title: PDT-induced HSP70 externalization up-regulates NO production via TLR2 signal pathway in macrophages.
Volume: 587
Issue: 2
Pages: 128-35
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Publication
- | J:321768
     
First Author: Sung PS
Year: 2022
Journal: bioRxiv
Title: CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation.
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Allele
Tlr2<em2(TLR2)Smoc> | MGI:7292805
Name: toll-like receptor 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
31412243 | J:300930
First Author: Huggins MA
Year: 2019
Journal: Cell Rep
Title: Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.
Volume: 28
Issue: 7
Pages: 1729-1743.e5
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Publication
20385881 | J:161005
First Author: Keck S
Year: 2010
Journal: J Immunol
Title: Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1.
Volume: 184
Issue: 10
Pages: 5809-18
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Publication
31849990 | J:298460
 
First Author: John V
Year: 2019
Journal: Front Immunol
Title: Caveolin-1 Controls Vesicular TLR2 Expression, p38 Signaling and T Cell Suppression in BCG Infected Murine Monocytic Myeloid-Derived Suppressor Cells.
Volume: 10
Pages: 2826
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Publication
16982907 | J:139314
First Author: Jouault T
Year: 2006
Journal: J Immunol
Title: Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling.
Volume: 177
Issue: 7
Pages: 4679-87
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Publication
15944255 | J:100790
First Author: Patel M
Year: 2005
Journal: J Immunol
Title: TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells.
Volume: 174
Issue: 12
Pages: 7558-63
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Publication
25166617 | J:247932
First Author: Richard AL
Year: 2014
Journal: PLoS Pathog
Title: TLR2 signaling decreases transmission of Streptococcus pneumoniae by limiting bacterial shedding in an infant mouse Influenza A co-infection model.
Volume: 10
Issue: 8
Pages: e1004339
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Publication
31636238 | J:282141
First Author: Zhang E
Year: 2019
Journal: J Immunol
Title: TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity.
Volume: 203
Issue: 11
Pages: 2872-2886
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Publication
32278833 | J:296919
 
First Author: Shi X
Year: 2020
Journal: J Mol Cell Cardiol
Title: MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1.
Volume: 143
Pages: 1-14
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GO Term
GO:0034136 | negative regulation of toll-like receptor 2 signaling pathway
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GO Term
GO:0034137 | positive regulation of toll-like receptor 2 signaling pathway
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GO Term
GO:0034135 | regulation of toll-like receptor 2 signaling pathway
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Publication
19617307 | J:154138
First Author: Cabanski M
Year: 2009
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Genome-wide transcriptional profiling of mononuclear phagocytes recruited to mouse lungs in response to alveolar challenge with the TLR2 agonist Pam3CSK4.
Volume: 297
Issue: 4
Pages: L608-18
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Strain
MGI:6429669 | C57BL/6JSmoc-Tlr2<em2(TLR2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
12938227 | J:85452
First Author: Hiromatsu T
Year: 2003
Journal: Eur J Immunol
Title: NK T cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice.
Volume: 33
Issue: 9
Pages: 2511-9
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Publication
35628290 | J:337127
 
First Author: Wang F
Year: 2022
Journal: Int J Mol Sci
Title: Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization.
Volume: 23
Issue: 10
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Allele
Tlr2<lngd> | MGI:3717224
 
Name: toll-like receptor 2; languid
Allele Type: Chemically induced (ENU)
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Allele
Tlr2<tm1(cre)Dfil> | MGI:6385316
Name: toll-like receptor 2; targeted mutation 1, Dominik Filipp
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Tlr2<tm2(cre/ERT2)Dfil> | MGI:6385317
Name: toll-like receptor 2; targeted mutation 2, Dominik Filipp
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Strain
MGI:3717368 | C57BL/6J-Tlr2<lngd>
Attribute String: coisogenic, chemically induced mutation, mutant strain
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Strain
MGI:4462250 | C57BL/6J-Tlr2<lngd>/Mmucd
Attribute String: mutant strain, coisogenic, chemically induced mutation
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Genotype
Genotype
Symbol: Tlr2/Tlr2
Background: C57BL/6J-Tlr2
Zygosity: hm
Has Mutant Allele: true
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Publication
25689444 | -
First Author: Pathak SK
Year: 2015
Journal: Nat Immunol
Title: Corrigendum: Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages.
Volume: 16
Issue: 3
Pages: 326
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tlr2/Tlr2<+>
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
11441107 | J:114041
First Author: Bulut Y
Year: 2001
Journal: J Immunol
Title: Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.
Volume: 167
Issue: 2
Pages: 987-94
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Protein Domain
IPR027190 | TLR1
Type: Family
Description: Toll-like receptor 1 (TLR1) participates in the innate immune response to microbial agents. TLR1 cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides [, ]. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
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HT Experiment
E-GEOD-21845 | Comparison of murine colonic mucosal DNA between postnatal day 90 C57BL/6 wild type (WT) and their toll-like receptor 2 knockout (Tlr2-/-) counterparts by methylation specific amplification microarray (MSAM), and whole genomic gene expression profiling
Series Id: GSE21845
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
10854325 | J:64697
First Author: Burns K
Year: 2000
Journal: Nat Cell Biol
Title: Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
Volume: 2
Issue: 6
Pages: 346-51
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Publication
12697090 | -
First Author: Takeda K
Year: 2002
Journal: J Endotoxin Res
Title: Recognition of lipopeptides by Toll-like receptors.
Volume: 8
Issue: 6
Pages: 459-63
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Publication
18288963 | -
First Author: Schorey JS
Year: 2008
Journal: Curr Drug Targets
Title: The pattern recognition receptor Dectin-1: from fungi to mycobacteria.
Volume: 9
Issue: 2
Pages: 123-9
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Publication
21677049 | -
First Author: Saijo S
Year: 2011
Journal: Int Immunol
Title: Dectin-1 and Dectin-2 in innate immunity against fungi.
Volume: 23
Issue: 8
Pages: 467-72
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Publication
22015804 | -
First Author: Yadav BS
Year: 2012
Journal: Exp Mol Pathol
Title: Molecular modeling and docking characterization of Dectin-1 (PAMP) receptor of Bubalus bubalis.
Volume: 92
Issue: 1
Pages: 7-12
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Protein Domain
IPR041799 | TOLIP_CUE
Type: Domain
Description: Tollip (Toll-interacting protein) is a component of the IL-1RI pathway which contains an N-terminal C2 domain and a C-terminal CUE domain. Tollip binds to the cytoplasmic TIR domain of IL-1Rs after IL-1 stimulation. It is sufficient for recruitment of IRAK to IL-1Rs and negatively regulates IL-1-induced signaling by inhibiting IRAK phosphorylation. In addition, Tollip directly interacts with toll-like receptors TLR2 and TLR4, and plays an inhibitory role in TLR-mediated cell activation through suppressing phosphorylation and kinase activity of IRAK. Moreover, Tollip can associate with GAT domains of Tom1 and its related proteins Tom1L1 and Tom1L2, and facilitate the recruitment of clathrin onto endosomes [, ].
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Protein Domain
IPR027187 | TLR6
Type: Family
Description: Toll-like receptor 6 (TLR6) participates in the innate immune response to Gram-positive bacteria and fungi. TLRs recognize specific molecular patterns present only in micro-organisms. TLR1 and TLR6 are involved in the discrimination of a subtle difference between triacyl and diacyl lipopeptides through interaction with TLR2 []. Cooperatively with TLR2, TLR6 recognises mycoplasmal macrophage-activating lipopeptide-2 (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and Borrelia burgdorferi outer surface protein A lipoprotein (OspA-L) []. TLR6 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [].
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Protein Domain
IPR042808 | CLEC7A
Type: Family
Description: C-type lectin domain family 7 member A (CLEC7A), also known as Dectin-1, is a beta-glucan receptor that binds beta-1,3 and beta-1,6 glucans and collaborates with with TLR2 to activate a macrophage's proinflammatory response to a mycobacterial infection []. It is a type II transmembrane protein of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region []. Its cytoplasmic tail contains an immunoreceptor tyrosine based activation motif (ITAM) that signals in part through the spleen tyrosine kinase and in collaboration with Toll-like receptors. It plays an important role in the host defense against fungal infection [, ].
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tlr2/Tlr2<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
23238562 | J:193330
First Author: Gandhi A
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice.
Volume: 266
Issue: 3
Pages: 430-8
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Publication
9387238 | -
 
First Author: Bigi F
Year: 1997
Journal: Microbiology
Title: A novel 27 kDa lipoprotein antigen from Mycobacterium bovis.
Volume: 143 ( Pt 11)
Pages: 3599-605
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Publication
14998516 | -
First Author: Bigi F
Year: 2004
Journal: Microbes Infect
Title: The knockout of the lprG-Rv1410 operon produces strong attenuation of Mycobacterium tuberculosis.
Volume: 6
Issue: 2
Pages: 182-7
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Publication
15294983 | -
First Author: Gehring AJ
Year: 2004
Journal: J Immunol
Title: Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.
Volume: 173
Issue: 4
Pages: 2660-8
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Publication
12581360 | -
First Author: Steyn AJ
Year: 2003
Journal: Mol Microbiol
Title: Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family.
Volume: 47
Issue: 4
Pages: 1075-89
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Protein Domain
IPR009830 | LppX/LprAFG
Type: Family
Description: This entry consists of several lipoproteins mainly from Mycobacterium species, collectively known as the LppX/LprAFG family. Proteins in this entry include:LprG () from Mycobacterium tuberculosis: an immunogenic 27kDa membrane-associated lipoprotein []. Expression of the LprG protein is essential for the growth of M. tuberculosis in immunocompetent mice []. Purification of LprG showed that it inhibits MHC-II antigen processing in primary human macrophages, providing a mechanism to avoid the host MHC-II-restricted CD4+ T cell response which is considered essential for control of M. tuberculosis infection []. LppX: a lipoprotein required for the translocation of complex lipids to the outer membrane of Mycobacterium tuberculosis. Its structure consists of a U-shaped β-half-barrel with a large hydrophobic cavity []. LprF: a membrane lipoprotein involved in the kdp signal transduction pathway, thought to be the primary response to osmotic stress [].lprA: a lipoprotein agonist of TLR2 that regulates innate immunity and APC function [].
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Publication
10679411 | J:60339
First Author: Beutler B
Year: 2000
Journal: Curr Opin Immunol
Title: Tlr4: central component of the sole mammalian LPS sensor.
Volume: 12
Issue: 1
Pages: 20-6
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Publication
16415872 | J:112608
First Author: Mansell A
Year: 2006
Journal: Nat Immunol
Title: Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.
Volume: 7
Issue: 2
Pages: 148-55
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Publication
14630816 | J:169792
First Author: Andreakos E
Year: 2004
Journal: Blood
Title: Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.
Volume: 103
Issue: 6
Pages: 2229-37
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Publication
12421970 | J:169799
First Author: Schilling D
Year: 2002
Journal: J Immunol
Title: Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages.
Volume: 169
Issue: 10
Pages: 5874-80
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Publication
26095366 | J:224868
First Author: Piao W
Year: 2015
Journal: Cell Rep
Title: A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza.
Volume: 11
Issue: 12
Pages: 1941-52
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Publication
16541102 | -
First Author: Sulzenbacher G
Year: 2006
Journal: EMBO J
Title: LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis.
Volume: 25
Issue: 7
Pages: 1436-44
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Publication
15670766 | J:95438
First Author: Iwaki D
Year: 2005
Journal: Biochem Biophys Res Commun
Title: The CD14 region spanning amino acids 57-64 is critical for interaction with the extracellular Toll-like receptor 2 domain.
Volume: 328
Issue: 1
Pages: 173-6
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Publication
16413499 | J:105881
First Author: Ward JR
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Potentiation of TLR4 signalling by plasmin activity.
Volume: 341
Issue: 2
Pages: 299-303
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Publication
16137770 | J:106407
First Author: Letiembre M
Year: 2005
Journal: J Neuroimmunol
Title: Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis.
Volume: 168
Issue: 1-2
Pages: 21-33
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Publication
11751856 | -
First Author: Zhang G
Year: 2002
Journal: J Biol Chem
Title: Negative regulation of toll-like receptor-mediated signaling by Tollip.
Volume: 277
Issue: 9
Pages: 7059-65
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Publication
23728346 | J:212589
First Author: Kennedy CL
Year: 2014
Journal: Oncogene
Title: Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis.
Volume: 33
Issue: 19
Pages: 2540-6
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Publication
15845454 | J:97989
First Author: Rogers NC
Year: 2005
Journal: Immunity
Title: Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.
Volume: 22
Issue: 4
Pages: 507-17
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Publication
15864310 | J:98954
First Author: Matsuzawa A
Year: 2005
Journal: Nat Immunol
Title: ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
Volume: 6
Issue: 6
Pages: 587-92
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Publication
12471095 | J:341401
First Author: Yamamoto M
Year: 2002
Journal: J Immunol
Title: Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
Volume: 169
Issue: 12
Pages: 6668-72
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Publication
18438411 | J:136290
First Author: Kawagoe T
Year: 2008
Journal: Nat Immunol
Title: Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
Volume: 9
Issue: 6
Pages: 684-91
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Publication
18190779 | J:131296
First Author: Rekhter M
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation.
Volume: 367
Issue: 3
Pages: 642-8
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Publication
31995749 | J:287687
First Author: Piao W
Year: 2020
Journal: Cell Rep
Title: Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration.
Volume: 30
Issue: 4
Pages: 1052-1062.e5
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Publication
15522205 | J:93526
First Author: Li Q
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Toll-like receptor 4 mutation impairs the macrophage TNFalpha response to peptidoglycan.
Volume: 325
Issue: 1
Pages: 91-6
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Publication
35085880 | J:325895
 
First Author: Peruń A
Year: 2022
Journal: Cell Immunol
Title: The CD36 and SR-A/CD204 scavenger receptors fine-tune Staphylococcus aureus-stimulated cytokine production in mouse macrophages.
Volume: 372
Pages: 104483
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Publication
19454352 | J:360215
First Author: Hise AG
Year: 2009
Journal: Cell Host Microbe
Title: An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans.
Volume: 5
Issue: 5
Pages: 487-97
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Publication
21646294 | J:176180
First Author: Wang S
Year: 2011
Journal: J Immunol
Title: MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.
Volume: 187
Issue: 1
Pages: 141-50
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Publication
21135164 | J:168800
First Author: Inoue M
Year: 2011
Journal: J Immunol
Title: Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses.
Volume: 186
Issue: 1
Pages: 19-23
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Publication
17982082 | J:153860
First Author: Pennini ME
Year: 2007
Journal: J Immunol
Title: CCAAT/enhancer-binding protein beta and delta binding to CIITA promoters is associated with the inhibition of CIITA expression in response to Mycobacterium tuberculosis 19-kDa lipoprotein.
Volume: 179
Issue: 10
Pages: 6910-8
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Publication
18769721 | J:162718
First Author: Bauler LD
Year: 2008
Journal: PLoS Pathog
Title: XIAP regulates cytosol-specific innate immunity to Listeria infection.
Volume: 4
Issue: 8
Pages: e1000142
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Publication
26104484 | J:223015
 
First Author: Kang S
Year: 2015
Journal: Nat Commun
Title: Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
Volume: 6
Pages: 7515
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Publication
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