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Search results 1701 to 1800 out of 2368 for Tpr

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Type Details Score
Publication
First Author: Parashar V
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Rgg protein structure-function and inhibition by cyclic peptide compounds.
Volume: 112
Issue: 16
Pages: 5177-82
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Publication
First Author: Wilkening RV
Year: 2017
Journal: J Biol Chem
Title: Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond.
Volume: 292
Issue: 50
Pages: 20544-20557
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Publication
First Author: Li Z
Year: 2013
Journal: Nat Struct Mol Biol
Title: Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle.
Volume: 20
Issue: 8
Pages: 929-35
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Publication
First Author: Dores-Silva PR
Year: 2012
Journal: Arch Biochem Biophys
Title: Low resolution structural characterization of the Hsp70-interacting protein - Hip - from Leishmania braziliensis emphasizes its high asymmetry.
Volume: 520
Issue: 2
Pages: 88-98
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Publication
First Author: Prapapanich V
Year: 1996
Journal: Mol Cell Biol
Title: Mutational analysis of the hsp70-interacting protein Hip.
Volume: 16
Issue: 11
Pages: 6200-7
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Publication
First Author: Webb MA
Year: 2001
Journal: Cell Stress Chaperones
Title: Orthologs in Arabidopsis thaliana of the Hsp70 interacting protein Hip.
Volume: 6
Issue: 3
Pages: 247-55
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Publication
First Author: Tallada VA
Year: 2002
Journal: Yeast
Title: Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects.
Volume: 19
Issue: 13
Pages: 1139-51
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Publication
First Author: Broadley SA
Year: 2001
Journal: Mol Cell Biol
Title: Peripheral mitochondrial inner membrane protein, Mss2p, required for export of the mitochondrially coded Cox2p C tail in Saccharomyces cerevisiae.
Volume: 21
Issue: 22
Pages: 7663-72
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Publication
First Author: Saracco SA
Year: 2002
Journal: Mol Biol Cell
Title: Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane.
Volume: 13
Issue: 4
Pages: 1122-31
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Publication
First Author: Kane MS
Year: 2016
Journal: Brain
Title: Aberrant splicing induced by the most common EPG5 mutation in an individual with Vici syndrome.
Volume: 139
Issue: Pt 9
Pages: e52
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Publication
First Author: Tanackovic G
Year: 2011
Journal: Am J Hum Genet
Title: A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa.
Volume: 88
Issue: 5
Pages: 643-9
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Protein Domain
Type: Domain
Description: This entry represents a middle TPR-like domain in EPG5 (Ectopic P granules protein 5 homolog). EPG5 is involved in autophagy and is a large 2282 amino acid protein found in Aedes aegypti. The domain shares structural similarity with TPR motifs but may have diverged sequence characteristics. This domain is found across eukaryotes including vertebrates, arthropods and nematodes. The function of this domain remains to be determined [].
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Protein Domain
Type: Domain
Description: This entry represents a TPR repeat domain found in human pre-mRNA splicing factor 6 (PRP6), Crooked neck-like protein 1 from Danio rerio and similar proteins found in eukaryotes. PRP6 is involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. It enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation [, , ].
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Protein Domain
Type: Domain
Description: This entry represents the N-terminal TPR-containing domain of human calcineurin-binding protein 1 (CABIN1) and similar proteins mainly found in animals and plants. CABIN1 is a component of the HIRA complex, which also includes UBN1, UBN2, ASF1A and HIRA []. The HIRA complex is involved in replication-independent chromatin assembly and deposition of histone H3.3. CABIN1 proteins contain multiple TPR repeats. Some members of this group, such as plant Calcineurin-binding protein 1, also show an HIR3_bundle domain ().
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Protein Domain
Type: Domain
Description: This entry represents the middle TPR domain of SUV2 (SENSITIVE TO UV 2) proteins found in plants.SUV2 is a DNA damage response protein required for tolerance to various DNA-damaging agents and cell cycle checkpoint control. The full-length protein contains a nuclear localisation signal and coiled-coil region in this N-terminal domain, followed by a C-terminal phosphatase tensin-type domain. SUV2 functions in G2/M cell cycle arrest in response to DNA damage and aluminium-dependent root growth inhibition [, ].
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Protein Domain
Type: Domain
Description: This entry represents the C-terminal domain in FlcA. This domain contains TPR repeats.In spirochetes, flagella are located within the periplasm. FlcA is one of several structural proteins involved in the formation of the flagellar collar. The conserved N-terminal domain of about 40 amino acids and the C-terminal region domain of about 650 amino acids are separated by a long and variable-length stretch of low-complexity sequence [].
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Protein Domain
Type: Domain
Description: This domain is found at the C-terminal of HTH-type transcriptional regulator Rgg (also called RopB) from Streptococcus gordonii, and similar proteins predominantly found in Firmicutes. Rgg is a peptide pheromone receptor that directly binds pheromones transported to the cytosol. The large C-terminal repeat domain contains five HTH folds and a capping helix that form a right-handed superhelical structure, resembling a TPR domain superhelix [, , , , ]. This domain is found associated with the N-terminal helix-turn-helix DNA-binding domain .
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Protein Domain
Type: Domain
Description: The Hsc70/Hsp70-interacting protein (Hip, also p48 or suppressor of tumorigenicity ST13) functions as a regulator of the cyclic action of Hsp70. Hip forms homodimers, and this entry represents the N-terminal dimerization domain, which may not be directly involved in its regulatory function. A central domain of Hip that contains TPR repeats binds the ATPase domain of Hsp70 and slows the release of ADP [, , , ].
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Protein Domain
Type: Family
Description: Members resemble the peptide maturation dehydrogenase SagB of thiazole and oxazole modification systems, and occur in a what appears to be a new type of peptide modification system. One adjacent marker is a new type of nitrile hydratase alpha subunit-related putative precursor, , distantly related the NHLP leader peptide family . Another is a large protein, , with regions similar to adenylate cyclases and TPR proteins.
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Protein Domain
Type: Family
Description: ER membrane protein complex subunit 2 (EMC2, also known as tetratricopeptide repeat protein 35) is a tetratricopeptide repeat-containing protein, and a component of the ER membrane protein complex (EMC), which is required for efficient folding of proteins in the endoplasmic reticulum (ER) []. This entry also includes TPR repeat protein Oca3 from the fission yeast Schizosaccharomyces pombe which may be involved in cell cycle regulation [].
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Protein Domain
Type: Domain
Description: This entry represents a TPR-like domain found in PEX8 and related eukaryotic peroxisomal membrane proteins. PEX8 proteins are essential components of the machinery required for the import of peroxisomal matrix proteins []. PEX8 binding to the N-terminal region of the PEX5 cargo receptor induces conformational changes in the TPR domains, decreasing their binding affinity to cargo and facilitating the release of PTS1 proteins within the peroxisome []. The specific function of this TPR-like region remains to be determined.
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Protein Domain
Type: Domain
Description: This entry represents a domain found in trafficking protein particle complex subunit 11 (Trappc11), which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage []. The C terminus of this region contains TPR repeats.In zebrafish, Trappc11 is also known as protein foie gras. It has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease [].
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Protein Domain
Type: Family
Description: The Ycf3/AcsC/BcsC/TPR family is involved in various cellular processes. The Ycf3 subfamily members are essential for the assembly of the photosystem I complex, possibly acting as chaperone-like factors for the assembly of PSI subunits. The AcsC/BcsC subfamily is implicated in bacterial cellulose synthesis, playing a crucial role in maximizing the production of this extracellular polysaccharide. Additionally, the family includes proteins with TPR repeats, which are typically involved in protein-protein interactions; however, their specific functions in this context are not detailed.
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Protein Domain
Type: Repeat
Description: This entry represents a sensor domain consisting of 7 TPR repeats forming a tightly-wound solenoid structure harbouring adeep central pocket. The TPR-S binding pocket is lined with several conserved aromatic and polar residues predicted to bind a NAD -derived nucleotide in prokaryotic NAD -derived nucleotide-activated effector conflict systems. It has been acquired at the base of the choanoflagellate-animal lineage as a core component of the ASK signalosome [].
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Protein Domain
Type: Domain
Description: This entry represents the N-terminal domain of the mitochondrial protein MSS2. MSS2 is required to stabilise mitochondrial cytochrome C oxidase subunit 2 (COX2) and to translocate the C-terminal domain of COX2 through the inner membrane []. The full-length protein contains C-terminal TPR repeats (). MSS2 is found in the mitochondrial inner membrane and interacts with COX18 []. The specific function of this N-terminal domain remains to be determined.
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Protein Domain
Type: Domain
Description: This entry represents the C-terminal TPR domain of LAG2, a cullin- associated NEDD8-dissociated protein homologue. This domain is found in proteins involved in SCF E3 ubiquitin ligase complex regulation from fungi. LAG2 acts as an assembly factor and F-box protein exchange factor for SCF complexes and interacts with unneddylated cullin CDC53 [, ]. The C-terminal region of this protein contains a neddylation site and is involved in longevity assurance. The function of this domain remains to be determined.
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Publication
First Author: Baillat D
Year: 2005
Journal: Cell
Title: Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
Volume: 123
Issue: 2
Pages: 265-76
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Publication  
First Author: Zheng H
Year: 2020
Journal: Science
Title: Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Volume: 370
Issue: 6520
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Publication
First Author: Thompson DA
Year: 1999
Journal: Genetics
Title: Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination.
Volume: 153
Issue: 2
Pages: 621-41
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Publication
First Author: Nie X
Year: 2014
Journal: Biol Open
Title: The HIRA complex that deposits the histone H3.3 is conserved in Arabidopsis and facilitates transcriptional dynamics.
Volume: 3
Issue: 9
Pages: 794-802
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Protein
Organism: Mus musculus/domesticus
Length: 1856  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1325  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1994  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 855  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1111  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1111  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 561  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1149  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1849  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1269  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1211  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1849  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1212  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1205  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1204  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: true
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Protein
Organism: Mus musculus/domesticus
Length: 855  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1313  
Fragment?: true
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Protein
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 1149  
Fragment?: false
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Publication  
First Author: Shamoto N
Year: 2018
Journal: Cells
Title: CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility.
Volume: 7
Issue: 9
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Publication
First Author: Tsukahara F
Year: 1998
Journal: J Biochem
Title: Molecular characterization of the mouse mtprd gene, a homologue of human TPRD: unique gene expression suggesting its critical role in the pathophysiology of Down syndrome.
Volume: 123
Issue: 6
Pages: 1055-63
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Publication
First Author: Becker W
Year: 1994
Journal: J Biol Chem
Title: Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.
Volume: 269
Issue: 36
Pages: 22586-92
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Publication
First Author: Malek SN
Year: 1996
Journal: J Biol Chem
Title: p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.
Volume: 271
Issue: 12
Pages: 6952-62
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Publication
First Author: Smith JB
Year: 1996
Journal: Arch Biochem Biophys
Title: The glucocorticoid attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains.
Volume: 330
Issue: 2
Pages: 290-300
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Publication
First Author: Clairfeuille T
Year: 2015
Journal: J Biol Chem
Title: Structure and Membrane Binding Properties of the Endosomal Tetratricopeptide Repeat (TPR) Domain-containing Sorting Nexins SNX20 and SNX21.
Volume: 290
Issue: 23
Pages: 14504-17
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Publication
First Author: Lor?s P
Year: 2019
Journal: Am J Hum Genet
Title: Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility.
Volume: 105
Issue: 6
Pages: 1148-1167
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Publication
First Author: West JD
Year: 2019
Journal: J Am Heart Assoc
Title: Antagonism of the Thromboxane-Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy.
Volume: 8
Issue: 21
Pages: e011902
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Publication
First Author: Wang Q
Year: 2018
Journal: Blood
Title: Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.
Volume: 132
Issue: 12
Pages: 1279-1292
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Publication
First Author: Wang L
Year: 2024
Journal: Mol Neurobiol
Title: FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet.
Volume: 61
Issue: 3
Pages: 1479-1494
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Publication
First Author: Echeverr?a PC
Year: 2009
Journal: Mol Cell Biol
Title: Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.
Volume: 29
Issue: 17
Pages: 4788-97
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Publication
First Author: B?dard J
Year: 2007
Journal: J Biol Chem
Title: Functional similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (Hip).
Volume: 282
Issue: 29
Pages: 21404-14
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Publication
First Author: Van Der Spuy J
Year: 2000
Journal: Biochem J
Title: Heat shock cognate protein 70 chaperone-binding site in the co-chaperone murine stress-inducible protein 1 maps to within three consecutive tetratricopeptide repeat motifs.
Volume: 345 Pt 3
Issue: Pt 3
Pages: 645-51
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Publication
First Author: Park M
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Two rearranged MET alleles in MNNG-HOS cells reveal the orientation of MET on chromosome 7 to other markers tightly linked to the cystic fibrosis locus.
Volume: 85
Issue: 8
Pages: 2667-71
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Publication
First Author: Koga H
Year: 1999
Journal: J Biol Chem
Title: Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase.
Volume: 274
Issue: 35
Pages: 25051-60
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Publication
First Author: Katoh M
Year: 2003
Journal: Int J Oncol
Title: Identification and characterization of TPARM gene in silico.
Volume: 23
Issue: 4
Pages: 1213-7
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Publication
First Author: Yadav RP
Year: 2019
Journal: J Biol Chem
Title: Interaction of the tetratricopeptide repeat domain of aryl hydrocarbon receptor-interacting protein-like 1 with the regulatory P? subunit of phosphodiesterase 6.
Volume: 294
Issue: 43
Pages: 15795-15807
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Publication
First Author: Galigniana MD
Year: 2010
Journal: Mol Cell Biol
Title: The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events.
Volume: 30
Issue: 5
Pages: 1285-98
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Publication
First Author: Murad JP
Year: 2012
Journal: Biochem Pharmacol
Title: The C-terminal segment of the second extracellular loop of the thromboxane A2 receptor plays an important role in platelet aggregation.
Volume: 83
Issue: 1
Pages: 88-96
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Publication
First Author: Krenn V
Year: 2012
Journal: J Cell Biol
Title: Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction.
Volume: 196
Issue: 4
Pages: 451-67
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Publication
First Author: Meyer AJ
Year: 2011
Journal: J Cell Sci
Title: Structural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling.
Volume: 124
Issue: Pt 9
Pages: 1433-44
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Publication
First Author: Yap K
Year: 2012
Journal: Genes Dev
Title: Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention.
Volume: 26
Issue: 11
Pages: 1209-23
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Publication
First Author: H?mono M
Year: 2022
Journal: BMC Biol
Title: The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.
Volume: 20
Issue: 1
Pages: 13
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Publication
First Author: Jiang B
Year: 2015
Journal: J Biol Chem
Title: Carboxyl terminus of HSC70-interacting protein (CHIP) down-regulates NF-?B-inducing kinase (NIK) and suppresses NIK-induced liver injury.
Volume: 290
Issue: 18
Pages: 11704-14
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Publication
First Author: Shimamoto S
Year: 2008
Journal: J Biol Chem
Title: Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain.
Volume: 283
Issue: 42
Pages: 28246-58
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Publication
First Author: Leznicki P
Year: 2015
Journal: J Cell Sci
Title: Binding of SGTA to Rpn13 selectively modulates protein quality control.
Volume: 128
Issue: 17
Pages: 3187-96
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Publication
First Author: Liem KF Jr
Year: 2012
Journal: J Cell Biol
Title: The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.
Volume: 197
Issue: 6
Pages: 789-800
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Publication
First Author: Colella P
Year: 2011
Journal: Hum Mol Genet
Title: Non-erythropoietic erythropoietin derivatives protect from light-induced and genetic photoreceptor degeneration.
Volume: 20
Issue: 11
Pages: 2251-62
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Publication
First Author: Encalada SE
Year: 2011
Journal: Cell
Title: Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles.
Volume: 144
Issue: 4
Pages: 551-65
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Publication
First Author: Stokin GB
Year: 2005
Journal: Science
Title: Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.
Volume: 307
Issue: 5713
Pages: 1282-8
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Genotype
Symbol: Klc1/Klc1<+> Tg(APP695)3Dbo/?
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
First Author: Miller JD
Year: 1995
Journal: J Cell Biol
Title: The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane.
Volume: 128
Issue: 3
Pages: 273-82
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Publication
First Author: Strub K
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Isolation of a cDNA clone of the 14-kDa subunit of the signal recognition particle by cross-hybridization of differently primed polymerase chain reactions.
Volume: 86
Issue: 24
Pages: 9747-51
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
First Author: Fleischer TC
Year: 2006
Journal: Genes Dev
Title: Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes.
Volume: 20
Issue: 10
Pages: 1294-307
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Protein
Organism: Mus musculus/domesticus
Length: 444  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Protein
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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