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Search results 17101 to 17200 out of 2418182 for a

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Type Details Score
Publication
32835767 | J:296671
 
First Author: Murphy A
Year: 2020
Journal: Cancer Lett
Title: Nuclear protein 1 imparts oncogenic potential and chemotherapeutic resistance in cancer.
Volume: 494
Pages: 132-141
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Publication
22790200 | J:317845
First Author: Li A
Year: 2012
Journal: Small GTPases
Title: Melanoblasts on the move: Rac1 sets the pace.
Volume: 3
Issue: 2
Pages: 115-9
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Publication
26484241 | J:355986
 
First Author: Reynders A
Year: 2015
Journal: Genom Data
Title: Analysis of cutaneous MRGPRD free nerve endings and C-LTMRs transcriptomes by RNA-sequencing.
Volume: 5
Pages: 132-5
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Publication
23836885 | J:356423
First Author: Sugathan A
Year: 2013
Journal: Mol Cell Biol
Title: Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver.
Volume: 33
Issue: 18
Pages: 3594-610
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Publication
17438289 | J:121109
First Author: Fisch S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.
Volume: 104
Issue: 17
Pages: 7074-9
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Publication
26621731 | J:228199
First Author: Sun S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.
Volume: 112
Issue: 50
Pages: E6993-7002
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Publication
37147343 | J:352462
First Author: Hamberger F
Year: 2023
Journal: Sci Rep
Title: An inducible model for genetic manipulation and fate-tracing of PDGFRβ-expressing fibrogenic cells in the liver.
Volume: 13
Issue: 1
Pages: 7322
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Publication
21576822 | J:173904
First Author: Clauss M
Year: 2011
Journal: J Clin Invest
Title: Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice.
Volume: 121
Issue: 6
Pages: 2470-9
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Publication
31721177 | J:296767
First Author: Fukuda A
Year: 2020
Journal: FEBS Lett
Title: Imprinted X-chromosome inactivation impacts primitive endoderm differentiation in mouse blastocysts.
Volume: 594
Issue: 5
Pages: 913-923
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Publication
24069385 | J:207340
First Author: Li L
Year: 2013
Journal: PLoS One
Title: SCD1 Expression is dispensable for hepatocarcinogenesis induced by AKT and Ras oncogenes in mice.
Volume: 8
Issue: 9
Pages: e75104
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GO Term
GO:0051750 | delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity
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Publication
22157652 | -
First Author: Sakurai A
Year: 2012
Journal: Cell Res
Title: Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer.
Volume: 22
Issue: 1
Pages: 23-32
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Publication
39326823 | J:355386
 
First Author: Chongtham A
Year: 2024
Journal: Exp Neurol
Title: Common and divergent pathways in early stages of glutamate and tau-mediated toxicities in neurodegeneration.
Volume: 382
Pages: 114967
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Publication
16714546 | J:109239
First Author: Cernetich A
Year: 2006
Journal: Infect Immun
Title: Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection.
Volume: 74
Issue: 6
Pages: 3190-203
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Publication
21677773 | J:174136
First Author: Bobrowska A
Year: 2011
Journal: PLoS One
Title: Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease.
Volume: 6
Issue: 6
Pages: e20696
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Publication
14963232 | J:88653
First Author: Haubensak W
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis.
Volume: 101
Issue: 9
Pages: 3196-201
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Publication
- | J:68592
   
First Author: Reymond A
Year: 2001
Journal: GenBank Submission
Title: Mus musculus tripartite motif protein TRIM23 mRNA, partial cds
Pages: AF230400
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Publication
23060003 | J:195899
First Author: Gupta A
Year: 2013
Journal: Prostate
Title: Mash1 expression is induced in neuroendocrine prostate cancer upon the loss of Foxa2.
Volume: 73
Issue: 6
Pages: 582-9
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Publication
15534372 | J:94537
First Author: Roers A
Year: 2004
Journal: J Exp Med
Title: T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation.
Volume: 200
Issue: 10
Pages: 1289-97
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Publication
24958875 | J:212172
First Author: Diaz-Horta O
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: FAM65B is a membrane-associated protein of hair cell stereocilia required for hearing.
Volume: 111
Issue: 27
Pages: 9864-8
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Publication
12631285 | -
First Author: Yamazaki T
Year: 2003
Journal: Eur J Biochem
Title: A possible physiological function and the tertiary structure of a 4-kDa peptide in legumes.
Volume: 270
Issue: 6
Pages: 1269-76
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Publication
32123114 | J:286769
First Author: Hermans D
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity.
Volume: 117
Issue: 11
Pages: 6047-6055
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Publication
16888235 | J:128048
First Author: Baldán A
Year: 2006
Journal: Arterioscler Thromb Vasc Biol
Title: Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow.
Volume: 26
Issue: 10
Pages: 2301-7
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Allele
Rpe65<tm1Lrcb> | MGI:3771723
 
Name: retinal pigment epithelium 65; targeted mutation 1, Christian Grimm
Allele Type: Targeted
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Publication
21041624 | J:166609
First Author: Su F
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer.
Volume: 107
Issue: 46
Pages: 19997-20002
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Publication
30257949 | J:266413
First Author: Andreani V
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function.
Volume: 115
Issue: 41
Pages: E9630-E9639
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Publication
18524893 | J:137156
First Author: Desmazières A
Year: 2008
Journal: J Neurosci
Title: Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution.
Volume: 28
Issue: 23
Pages: 5891-900
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Publication
11025211 | J:65442
First Author: Monsoro-Burq A
Year: 2000
Journal: Mech Dev
Title: Left-right asymmetry in BMP4 signalling pathway during chick gastrulation.
Volume: 97
Issue: 1-2
Pages: 105-8
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Publication
27428899 | J:240123
First Author: Xiao Y
Year: 2016
Journal: Nat Med
Title: Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.
Volume: 22
Issue: 8
Pages: 906-14
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Publication
5213409 | J:280834
First Author: Krischke W
Year: 1963
Journal: Arch Geschwulstforsch
Title: [Additional experiments on the dependence of the action of the myelocytic leukemia virus of the mouse on different biological conditions of the infected animals].
Volume: 20
Issue: 1
Pages: 22-9
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Publication
18981162 | J:141072
First Author: Ahrens R
Year: 2008
Journal: J Immunol
Title: Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis.
Volume: 181
Issue: 10
Pages: 7390-9
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Allele
Tg(YAC128)#Hay | MGI:5432149
Name: transgene insertion, Michael Hayden
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
33147463 | J:306551
First Author: Mabe NW
Year: 2020
Journal: Cell Rep
Title: G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program.
Volume: 33
Issue: 5
Pages: 108341
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Publication
11896581 | J:118583
First Author: Dajee M
Year: 2002
Journal: Oncogene
Title: Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation.
Volume: 21
Issue: 10
Pages: 1527-38
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Publication
25368159 | J:216752
First Author: Tezuka T
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses.
Volume: 111
Issue: 46
Pages: 16556-61
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Publication
38492219 | J:346466
First Author: Carey A
Year: 2024
Journal: Cell Rep
Title: Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis.
Volume: 43
Issue: 3
Pages: 113967
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Publication
23565292 | -
First Author: Burke C
Year: 2013
Journal: PLoS One
Title: Harnessing single cell sorting to identify cell division genes and regulators in bacteria.
Volume: 8
Issue: 4
Pages: e60964
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Protein Domain
IPR046769 | DOCKER_Lobe_A
Type: Domain
Description: This entry represents a conserved region within a number of eukaryotic dedicator of cytokinesis proteins (DOCK), which are guanine nucleotide exchange factors (GEFs) [, , ], that activate some small GTPases by exchanging bound GDP for free GTP such as Rac. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis []. These proteins have a DOCK-homology region 1 (DHR-1, also known as DOCK-type C2 domain) at the N-terminal and a DHR-2 (also known as DOCKER domain) at the C-terminal. The DOCKER domain () is a GEF catalytic domain organised into three lobes, A, B and C, with the Rho-family binding site and catalytic centre generated entirely from lobes B and C. This entry represents Lobe A, formed from an antiparallel array of α-helices that adopts a tetratricopeptide repeat-like fold, which through extensive contacts with lobe B, stabilises DHR-2 domain [, ].
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Protein Domain
IPR007340 | Opacity-associatedA
Type: Domain
Description: The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A []. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation []. The OapA protein contains a C-terminal OapA domain, which in the E. coli protein YtfB has been shown to bind to peptidoglycan []. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments []. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links such as []. The OapA domain is distantly related to another peptidoglycan binding domain.
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Protein Domain
IPR001654 | Marek_A
Type: Family
Description: Herpesviruses have been implicated as a cause of tumours in a number of species. The common tumour condition of the fowl is caused by Meleagrid herpesvirus 1 (MeHV-1). Although infection is ubiquitous, only a proportion of fowl develop tumours, and the precise details of the process of tumour induction remains to be elucidated. Secretory glycoprotein GP57-65 precursor (glycoprotein A - GA) is thought to play an immunoevasive role in the pathogenesis of Marek's disease. It is a candidate for causing the early-stage immunosuppression that occurs after MDHV infection. The protein is predominantly secreted, but a small amount of mature GP57-65 is anchored in the plasma membrane, or held by other interactions. GA is similar to Herpesvirus glycoprotein C, and belongs to the immunoglobulin gene superfamily [, ].
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Protein Domain
IPR011762 | COA_CT_N
Type: Domain
Description: Acetyl-coenzyme A carboxylase () (ACC), a member of the biotin-dependent enzyme family, catalyses the formation of malonyl-coenzyme A (CoA) and regulates fatty acid biosynthesis and oxidation. Biotin-dependent carboxylase enzymes perform a two step reaction: enzyme-bound biotin is first carboxylated by bicarbonate and ATP and the carboxyl group temporarily bound to biotin is subsequently transferred to an acceptor substrate such as acetyl-CoA. The carboxyltransferase domain performs the second part of the reaction [, ].The N- and C-terminal regions of the carboxyltransferase domain share similar polypeptide backbone folds, with a central β-β-alpha superhelix []. The CoA molecule is mostly associated with the N subdomain. In bacterial acetyl coenzyme A carboxylase the N and C subdomains are encoded by two different polypeptides.This entry represents the N-terminal subdomain and contains the bacterial ACC beta-subunit.
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Protein Domain
IPR011763 | COA_CT_C
Type: Domain
Description: Acetyl-coenzyme A carboxylase () (ACC), a member of thebiotin-dependent enzyme family, catalyses the formation of malonyl-coenzyme A(CoA) and regulates fatty acid biosynthesis and oxidation. Biotin-dependentcarboxylase enzymes perform a two step reaction: enzyme-bound biotin is firstcarboxylated by bicarbonate and ATP and the carboxyl group temporarily boundto biotin is subsequently transferred to an acceptor substrate such asacetyl-CoA. The carboxyltransferase domain performs the second part of thereaction [, ].The N- and C-terminal regions of the carboxyltransferase domain share similar polypeptide backbone folds, with a central β-β-alpha superhelix []. The CoA molecule is mostly associated with the N subdomain.In bacterial acetyl coenzyme A carboxylase the N and C subdomains are encodedby two different polypeptides.The acetyl-coenzyme A carboxyltransferase domain is also found in the following enzymes:Methylcrotonyl-CoA carboxylase beta chain, mitochondrial precursor.Glutaconyl-CoA decarboxylase alpha subunit.Propionyl-CoA carboxylase beta chain (PCCase).This domain is the C subdomain and recognizes also the alpha-subunit of bacterial ACC.
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Protein
A0A0U1RP30
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
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Publication
11023546 | J:65240
First Author: Shiraishi A
Year: 2000
Journal: Carcinogenesis
Title: Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase.
Volume: 21
Issue: 10
Pages: 1879-83
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Publication
17804586 | J:126806
First Author: Sclafani A
Year: 2007
Journal: Am J Physiol Regul Integr Comp Physiol
Title: CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice.
Volume: 293
Issue: 5
Pages: R1823-32
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Publication
11437490 | J:70152
First Author: Corthay A
Year: 2001
Journal: J Autoimmun
Title: Evaluation of the percentage of peripheral T cells with two different T cell receptor alpha-chains and of their potential role in autoimmunity.
Volume: 16
Issue: 4
Pages: 423-9
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Publication
19190084 | J:147108
First Author: Yokota A
Year: 2009
Journal: Int Immunol
Title: GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity.
Volume: 21
Issue: 4
Pages: 361-77
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Publication
21614075 | J:172115
First Author: Jain A
Year: 2011
Journal: Nature
Title: Probing cellular protein complexes using single-molecule pull-down.
Volume: 473
Issue: 7348
Pages: 484-8
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Protein
Q66JY7
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
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Publication
8681381 | J:33629
First Author: Boström H
Year: 1996
Journal: Cell
Title: PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.
Volume: 85
Issue: 6
Pages: 863-73
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Publication
36040301 | J:348622
   
First Author: Sumser A
Year: 2022
Journal: Elife
Title: Fast, high-throughput production of improved rabies viral vectors for specific, efficient and versatile transsynaptic retrograde labeling.
Volume: 11
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Allele
Tg(Mt1-GH1)4Sni | MGI:3057172
Name: transgene insertion 4, Ken Snibson
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
12439753 | -
First Author: Pandey A
Year: 2002
Journal: Oncogene
Title: Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases.
Volume: 21
Issue: 52
Pages: 8029-36
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Publication
17442598 | J:123577
First Author: Hidalgo A
Year: 2007
Journal: Immunity
Title: Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44.
Volume: 26
Issue: 4
Pages: 477-489
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Publication
22841666 | J:191324
First Author: Ziegler A
Year: 2012
Journal: Cancer Lett
Title: Teneurin protein family: an emerging role in human tumorigenesis and drug resistance.
Volume: 326
Issue: 1
Pages: 1-7
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Publication
26061636 | J:233812
First Author: Szwarc MM
Year: 2015
Journal: PLoS One
Title: Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors.
Volume: 10
Issue: 6
Pages: e0128467
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Publication
16908867 | J:135846
First Author: Sarkar A
Year: 2006
Journal: Am J Respir Crit Care Med
Title: Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18.
Volume: 174
Issue: 9
Pages: 1003-10
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Publication
26791832 | J:230821
First Author: Sclafani A
Year: 2016
Journal: Am J Physiol Regul Integr Comp Physiol
Title: SGLT1 sugar transporter/sensor is required for post-oral glucose appetition.
Volume: 310
Issue: 7
Pages: R631-9
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Publication
34413083 | J:311106
 
First Author: Moore A
Year: 2021
Journal: eNeuro
Title: Syn3 Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance.
Volume: 8
Issue: 5
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Publication
32169167 | J:358567
First Author: Fumagalli A
Year: 2020
Journal: Cell Stem Cell
Title: Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.
Volume: 26
Issue: 4
Pages: 569-578.e7
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Publication
22912808 | J:187708
First Author: Aljakna A
Year: 2012
Journal: PLoS One
Title: Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol.
Volume: 7
Issue: 8
Pages: e43139
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Publication
9834182 | J:49322
First Author: Zúñiga A
Year: 1999
Journal: Development
Title: Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity.
Volume: 126
Issue: 1
Pages: 13-21
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Publication
11209052 | J:67041
First Author: Steppan CM
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: A family of tissue-specific resistin-like molecules.
Volume: 98
Issue: 2
Pages: 502-6
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Publication
18713754 | J:141036
First Author: Fantauzzo KA
Year: 2008
Journal: Hum Mol Genet
Title: A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice.
Volume: 17
Issue: 22
Pages: 3539-51
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Publication
27036007 | J:232117
First Author: Liu P
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Anabolic actions of Notch on mature bone.
Volume: 113
Issue: 15
Pages: E2152-61
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Publication
31685615 | J:282343
First Author: Sagai T
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization.
Volume: 116
Issue: 47
Pages: 23636-23642
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Publication
23913971 | J:205804
First Author: Kole A
Year: 2013
Journal: J Immunol
Title: Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis.
Volume: 191
Issue: 5
Pages: 2771-9
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Protein Coding Gene
MGI:1913327 | Aurkaip1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30111646 | J:264376
 
First Author: Shipman WD
Year: 2018
Journal: Sci Transl Med
Title: A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity.
Volume: 10
Issue: 454
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Publication
23610400 | J:197348
First Author: Liu J
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation.
Volume: 110
Issue: 19
Pages: 7814-9
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Publication
8535084 | J:28729
First Author: Gandarillas A
Year: 1995
Journal: Mamm Genome
Title: The 5' noncoding region of the mouse involucrin gene: comparison with the human gene and genes encoding other cornified envelope precursors.
Volume: 6
Issue: 9
Pages: 680-2
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Publication
16894357 | J:144402
First Author: Miralles F
Year: 2006
Journal: Lab Invest
Title: Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis.
Volume: 86
Issue: 10
Pages: 1020-36
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Publication
26349656 | J:347951
First Author: Higashimori A
Year: 2016
Journal: Mucosal Immunol
Title: Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy.
Volume: 9
Issue: 3
Pages: 659-68
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Publication
36745673 | J:333368
First Author: Aldea D
Year: 2023
Journal: PLoS Genet
Title: Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development.
Volume: 19
Issue: 2
Pages: e1010614
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Publication
7773404 | -
 
First Author: Schmidt H
Year: 1995
Journal: Microbiology
Title: The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers.
Volume: 141 ( Pt 5)
Pages: 1085-92
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Publication
21499244 | -
First Author: Ma C
Year: 2011
Journal: Nat Struct Mol Biol
Title: Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex.
Volume: 18
Issue: 5
Pages: 542-9
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Publication
12871971 | -
First Author: Sheu L
Year: 2003
Journal: J Biol Chem
Title: Regulation of insulin exocytosis by Munc13-1.
Volume: 278
Issue: 30
Pages: 27556-63
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Publication
18787382 | -
First Author: Yuan QX
Year: 2008
Journal: J Endocrinol Invest
Title: Characterization of Munc13-1 and insulin secretion during pancreatic development in rats.
Volume: 31
Issue: 7
Pages: 630-5
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Protein Domain
IPR018707 | LpxR
Type: Family
Description: This entry represents a group of bacterial proteins that include the lipid A deacylase LpxR from Salmonella typhimurium. LpxR is an outer membrane protein that catalyses the removal of the the 3'-acyloxyacyl moiety from lipid A. It requires Ca2+ for its activity. This enzyme folds into a 12-stranded antiparallel β-barrel with the N- and C- terminal ends pointing towards the periplasm and three extracellular loops consisting of α-helical regions at the opposite side of the β-barrel [].
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Protein Domain
IPR004752 | AmpG_permease/AT-1
Type: Family
Description: This family consists of AmpG-like permease and acetyl-coenzyme A transporter 1 (AT-1). AT-1 is a probable acetyl-CoA transporter necessary for O-acetylation of gangliosides []. The signal transducer encoded by AmpG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers []. The AmpG protein probably acts as a permease in the beta-lactamase induction system and in peptidoglycan recycling.
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Protein Domain
IPR036916 | Sda_sf
Type: Homologous_superfamily
Description: Members of this protein group contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilised by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A) [].
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Protein Domain
IPR032865 | Prok-E2_A
Type: Family
Description: This entry represents the member A of the E2/UBC superfamily of proteins found in several bacteria. The active site residues are very similar to the eukaryotic E2 proteins [, ]. Members of this family are usually fused to E1 and JAB domains C-terminal to the E2 domain. The protein is usually in the gene neighbourhood of a gene encoding a distinct metallobetalactamase family protein [].
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Protein Domain
IPR015064 | Sda
Type: Family
Description: Members of this protein group contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilised by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A) [].
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Protein Domain
IPR027082 | Unc13A
Type: Family
Description: Protein Unc-13 homologue A plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway []. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion, and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP) [, , ]. It is essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses []. It is also involved in secretory granule priming in insulin secretion [, ].
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Protein Domain
IPR027623 | AmmeMemoSam_A
Type: Family
Description: Members of this protein family belong to the same domain family as AMMECR1 , a mammalian protein whose deficit is involved in the association of Alport syndrome, midface hypoplasia, intellectual disability and elliptocytosis in humans []. Members of the present family occur as part of a three gene system with a homologue of the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility), and an uncharacterised radical SAM enzyme [].
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Protein Domain
IPR013540 | ChitinaseA_N
Type: Domain
Description: This domain is found in a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it may be involved in interaction with the enzyme substrate, chitin [, ]. It is separated by a hinge region from the catalytic domain (); this hinge region is probably mobile, allowing the N-terminal domain to have different relative positions in solution [].
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Publication
16267821 | J:103417
First Author: Ivanova A
Year: 2005
Journal: Genesis
Title: In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A.
Volume: 43
Issue: 3
Pages: 129-35
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Publication
34732574 | J:325512
 
First Author: Wang Y
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner.
Volume: 118
Issue: 45
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Publication
16330324 | J:129667
First Author: Akpinar P
Year: 2005
Journal: Cell Metab
Title: Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.
Volume: 2
Issue: 6
Pages: 385-97
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Publication
8975712 | J:37710
First Author: Tsukiyama-Kohara K
Year: 1996
Journal: Genomics
Title: Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2.
Volume: 38
Issue: 3
Pages: 353-63
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Publication
18316029 | J:133218
First Author: Mesaros A
Year: 2008
Journal: Cell Metab
Title: Activation of Stat3 signaling in AgRP neurons promotes locomotor activity.
Volume: 7
Issue: 3
Pages: 236-48
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Publication
20643337 | J:162632
First Author: Balasubramani A
Year: 2010
Journal: Immunity
Title: Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.
Volume: 33
Issue: 1
Pages: 35-47
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Publication
25715649 | J:221047
First Author: Shenoy A
Year: 2015
Journal: EMBO J
Title: Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.
Volume: 34
Issue: 9
Pages: 1180-94
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Publication
25137049 | J:221002
First Author: Sauter KA
Year: 2014
Journal: PLoS One
Title: The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.
Volume: 9
Issue: 8
Pages: e105429
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Publication
24251118 | J:223189
 
First Author: Han C
Year: 2013
Journal: Redox Biol
Title: The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice.
Volume: 1
Pages: 498-507
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Publication
30215699 | J:266554
First Author: Aoyagi K
Year: 2018
Journal: Endocrinology
Title: VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice.
Volume: 159
Issue: 11
Pages: 3674-3688
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Publication
26406118 | J:227070
 
First Author: Hehnly H
Year: 2015
Journal: Elife
Title: A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells.
Volume: 4
Pages: e09384
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Allele
Tbc1d20<bs> | MGI:1856684
 
Name: TBC1 domain family, member 20; blind-sterile
Allele Type: Spontaneous
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Publication
24813889 | J:210596
First Author: Pollock A
Year: 2014
Journal: Cell Rep
Title: Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathway.
Volume: 7
Issue: 4
Pages: 1184-96
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Publication
12714586 | J:84913
First Author: Lu KP
Year: 2003
Journal: J Biol Chem
Title: Redox regulation of a novel L1Md-A2 retrotransposon in vascular smooth muscle cells.
Volume: 278
Issue: 30
Pages: 28201-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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