| Type |
Details |
Score |
| Publication |
| First Author: |
Castañeda-Bueno M |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. |
| Volume: |
109 |
| Issue: |
20 |
| Pages: |
7929-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sieroslawska A |
| Year: |
2010 |
| Journal: |
Neuro Endocrinol Lett |
| Title: |
Evaluation of genotoxic potential of neurotoxin anatoxin-a with the use of umuC test. |
| Volume: |
31 Suppl 2 |
|
| Pages: |
16-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McLaren A |
| Year: |
1981 |
| Journal: |
Genet Res |
| Title: |
GPI expression in female germ cells of the mouse. |
| Volume: |
37 |
| Issue: |
3 |
| Pages: |
303-9 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Bradley A |
| Year: |
1998 |
| Journal: |
Nat Genet |
| Title: |
The Ptentative nature of mouse knockouts. |
| Volume: |
20 |
| Issue: |
4 |
| Pages: |
322-3 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Hidalgo A |
| Year: |
2009 |
| Journal: |
Nat Med |
| Title: |
When integrins fail to integrate. |
| Volume: |
15 |
| Issue: |
3 |
| Pages: |
249-50 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Moon A |
| Year: |
1995 |
| Journal: |
Mol Biol Cell |
| Title: |
The ADF/cofilin proteins: stimulus-responsive modulators of actin dynamics. |
| Volume: |
6 |
| Issue: |
11 |
| Pages: |
1423-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rogaeva A |
| Year: |
2007 |
| Journal: |
J Neurosci Res |
| Title: |
The Freud-1/CC2D1A family: transcriptional regulators implicated in mental retardation. |
| Volume: |
85 |
| Issue: |
13 |
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2833-8 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Liadis N |
| Year: |
2007 |
| Journal: |
Diabetes |
| Title: |
Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models. |
| Volume: |
56 |
| Issue: |
9 |
| Pages: |
2302-11 |
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•
•
•
•
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| Publication |
| First Author: |
Sainsbury A |
| Year: |
2003 |
| Journal: |
Mol Cell Biol |
| Title: |
Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice. |
| Volume: |
23 |
| Issue: |
15 |
| Pages: |
5225-33 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
663
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
355
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alexandru A |
| Year: |
2011 |
| Journal: |
J Neurosci |
| Title: |
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. |
| Volume: |
31 |
| Issue: |
36 |
| Pages: |
12790-801 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mammoto T |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. |
| Volume: |
8 |
| Issue: |
9 |
| Pages: |
e73407 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fragkouli A |
| Year: |
2009 |
| Journal: |
Neuroscience |
| Title: |
Sex differences in water maze performance and cortical neurotrophin levels of LHX7 null mutant mice. |
| Volume: |
158 |
| Issue: |
4 |
| Pages: |
1224-33 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Ascani A |
| Year: |
2023 |
| Journal: |
Elife |
| Title: |
The role of B cells in immune cell activation in polycystic ovary syndrome. |
| Volume: |
12 |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Billich A |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. |
| Volume: |
8 |
| Issue: |
3 |
| Pages: |
e59630 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jacob A |
| Year: |
2021 |
| Journal: |
Brain Res |
| Title: |
Exercise alleviates symptoms of CNS lupus. |
| Volume: |
1765 |
|
| Pages: |
147478 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Tsukahara A |
| Year: |
1998 |
| Journal: |
Immunology |
| Title: |
An allogeneic microenvironment influences the phenotype of intermediate T-cell receptor cells expanding in MRL-lpr/lpr mice. |
| Volume: |
94 |
| Issue: |
2 |
| Pages: |
149-59 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Abrego-Peredo A |
| Year: |
2020 |
| Journal: |
PLoS One |
| Title: |
Naringenin mitigates autoimmune features in lupus-prone mice by modulation of T-cell subsets and cytokines profile. |
| Volume: |
15 |
| Issue: |
5 |
| Pages: |
e0233138 |
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•
•
•
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| First Author: |
Schwarting A |
| Year: |
1999 |
| Journal: |
J Immunol |
| Title: |
IL-12 drives IFN-gamma-dependent autoimmune kidney disease in MRL-Fas(lpr) mice. |
| Volume: |
163 |
| Issue: |
12 |
| Pages: |
6884-91 |
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•
•
•
•
•
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| Publication |
| First Author: |
Fuchs A |
| Year: |
2010 |
| Journal: |
J Neuropathol Exp Neurol |
| Title: |
Downregulation of the potassium chloride cotransporter KCC2 in vulnerable motoneurons in the SOD1-G93A mouse model of amyotrophic lateral sclerosis. |
| Volume: |
69 |
| Issue: |
10 |
| Pages: |
1057-70 |
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•
•
•
•
•
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| Publication |
| First Author: |
Sarikidi A |
| Year: |
2022 |
| Journal: |
Biomedicines |
| Title: |
Altered Immunomodulatory Responses in the CX3CL1/CX3CR1 Axis Mediated by hMSCs in an Early In Vitro SOD1(G93A) Model of ALS. |
| Volume: |
10 |
| Issue: |
11 |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Li A |
| Year: |
2024 |
| Journal: |
Elife |
| Title: |
Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice. |
| Volume: |
12 |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Spalloni A |
| Year: |
2006 |
| Journal: |
Exp Neurol |
| Title: |
Molecular and synaptic changes in the hippocampus underlying superior spatial abilities in pre-symptomatic G93A+/+ mice overexpressing the human Cu/Zn superoxide dismutase (Gly93 --> ALA) mutation. |
| Volume: |
197 |
| Issue: |
2 |
| Pages: |
505-14 |
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•
•
•
•
•
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| Publication |
| First Author: |
Fuchs A |
| Year: |
2013 |
| Journal: |
J Physiol |
| Title: |
Selective mitochondrial Ca2+ uptake deficit in disease endstage vulnerable motoneurons of the SOD1G93A mouse model of amyotrophic lateral sclerosis. |
| Volume: |
591 |
| Issue: |
10 |
| Pages: |
2723-45 |
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•
•
•
•
•
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| Publication |
| First Author: |
Chen G |
| Year: |
2014 |
| Journal: |
Am J Respir Crit Care Med |
| Title: |
Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity. |
| Volume: |
189 |
| Issue: |
3 |
| Pages: |
301-13 |
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•
•
•
•
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| First Author: |
Cronin A |
| Year: |
2011 |
| Journal: |
J Lipid Res |
| Title: |
Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase. |
| Volume: |
52 |
| Issue: |
4 |
| Pages: |
712-9 |
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•
•
•
•
•
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| First Author: |
Räisänen-Sokolowski A |
| Year: |
1998 |
| Journal: |
Am J Pathol |
| Title: |
Leukocyte-suppressing influences of interleukin (IL)-10 in cardiac allografts: insights from IL-10 knockout mice. |
| Volume: |
153 |
| Issue: |
5 |
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1491-500 |
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•
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| First Author: |
Sengul A |
| Year: |
2012 |
| Journal: |
Physiol Res |
| Title: |
Bone response to loading in mice with targeted disruption of the cartilage oligomeric matrix protein gene. |
| Volume: |
61 |
| Issue: |
6 |
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637-41 |
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•
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| First Author: |
Petri A |
| Year: |
2006 |
| Journal: |
J Mol Endocrinol |
| Title: |
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. |
| Volume: |
37 |
| Issue: |
2 |
| Pages: |
301-16 |
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•
•
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| First Author: |
Lu Y |
| Year: |
2004 |
| Journal: |
Mol Genet Genomics |
| Title: |
Scd1ab-Xyk: a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse. |
| Volume: |
272 |
| Issue: |
2 |
| Pages: |
129-37 |
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•
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| First Author: |
Zhang W |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. |
| Volume: |
107 |
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44 |
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18956-60 |
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| First Author: |
Shimizu A |
| Year: |
2020 |
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FASEB J |
| Title: |
Identification of transmembrane protein 168 mutation in familial Brugada syndrome. |
| Volume: |
34 |
| Issue: |
5 |
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6399-6417 |
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•
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| First Author: |
Hao Y |
| Year: |
2016 |
| Journal: |
Elife |
| Title: |
An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK. |
| Volume: |
5 |
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•
•
•
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| First Author: |
Bauer H |
| Year: |
2005 |
| Journal: |
Nat Genet |
| Title: |
The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. |
| Volume: |
37 |
| Issue: |
9 |
| Pages: |
969-73 |
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| First Author: |
Li J |
| Year: |
2014 |
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Invest Ophthalmol Vis Sci |
| Title: |
Endothelial TWIST1 promotes pathological ocular angiogenesis. |
| Volume: |
55 |
| Issue: |
12 |
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8267-77 |
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| First Author: |
de Zélicourt A |
| Year: |
2022 |
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EMBO Mol Med |
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CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype. |
| Volume: |
14 |
| Issue: |
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e12860 |
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Song Z |
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2016 |
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J Biol Chem |
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Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice. |
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291 |
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43 |
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22630-22637 |
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Fusco J |
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2017 |
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Sci Rep |
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GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor. |
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7 |
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1 |
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9100 |
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Straiker A |
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2013 |
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Neurobiol Dis |
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Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons. |
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56 |
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Ramzy A |
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2018 |
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Endocrinology |
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Insulin-Deficient Mouse β-Cells Do Not Fully Maturebut Can Be Remedied Through Insulin Replacementby Islet Transplantation. |
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159 |
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Ehlers A |
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2018 |
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Mucosal Immunol |
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BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes. |
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11 |
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97-111 |
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Fang X |
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2019 |
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Proc Natl Acad Sci U S A |
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Ferroptosis as a target for protection against cardiomyopathy. |
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Bult A |
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J Neurosci |
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STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum. |
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Curr Biol |
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Sleep fragmentation and motor restlessness in a Drosophila model of Restless Legs Syndrome. |
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4 |
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Hönig A |
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2002 |
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Mol Cell Biol |
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Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72. |
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22 |
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Drexler SK |
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Proc Natl Acad Sci U S A |
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Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. |
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Hosur V |
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2017 |
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BMC Res Notes |
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Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease. |
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10 |
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Kopecky C |
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2024 |
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J Cachexia Sarcopenia Muscle |
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Effect of insulin insufficiency on ultrastructure and function in skeletal muscle. |
| Volume: |
15 |
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Aguirre A |
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2010 |
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Nature |
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Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. |
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467 |
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7313 |
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Mori H |
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Biochem Biophys Res Commun |
| Title: |
Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. |
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359 |
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4 |
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| First Author: |
Jin K |
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Proc Natl Acad Sci U S A |
| Title: |
FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. |
| Volume: |
102 |
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Schlagel CJ |
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J Immunol |
| Title: |
Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. |
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129 |
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Pereverzev A |
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2002 |
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Mol Endocrinol |
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Disturbances in glucose-tolerance, insulin-release, and stress-induced hyperglycemia upon disruption of the Ca(v)2.3 (alpha 1E) subunit of voltage-gated Ca(2+) channels. |
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16 |
| Issue: |
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Elgheznawy A |
| Year: |
2023 |
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Front Immunol |
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Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. |
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Fütterer A |
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2012 |
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Cell Death Differ |
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Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development. |
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| First Author: |
Rasley A |
| Year: |
2004 |
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J Immunol |
| Title: |
Substance P augments Borrelia burgdorferi-induced prostaglandin E2 production by murine microglia. |
| Volume: |
172 |
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9 |
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| First Author: |
Ohta A |
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2000 |
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J Immunol |
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Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen. |
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165 |
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2 |
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| First Author: |
Jude BA |
| Year: |
2009 |
| Journal: |
J Bacteriol |
| Title: |
Levels of the secreted Vibrio cholerae attachment factor GbpA are modulated by quorum-sensing-induced proteolysis. |
| Volume: |
191 |
| Issue: |
22 |
| Pages: |
6911-7 |
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the N-acetylglucosamine-binding protein A (GbpA) of various pathogenic bacteria, including Vibrio cholerae, which is the etiologic agent of cholera in humans. GbpA binds to chitin and specifically to the chitin monomer N-acetylglucosamine (GlcNAc), a sugar residue that is also found on the surface of epithelial cells. Intestinal colonization of V. cholerae occurs in a stepwise fashion, initiating with attachment to the small intestinal epithelium []. This attachment is followed by expression of the toxin co-regulated pilus, microcolony formation, and cholera toxin production. GlcNAc binding protein A (GbpA) is a secreted attachment factor, which functions in attachment to environmental chitin sources as well as to intestinal substrates. GbpA is expressed and secreted at low-cell densities and is suppressed at high cell-densities and in particular in cells that produced HapR, the central regulator of the cell density dependent quorum sensing system of V. cholerae. HapR activates the expression of genes encoding the secreted proteases HapA and PrtV, which degrade GbpA; suggested that the fluctuation of GbpA levels is a consequence of the levels of bacterial proteases in response to quorum sensing signals. This provides a mechanism for GbpA-mediated attachment to, and detachment from, surfaces in response to environmental cues []. |
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| Protein Domain |
| Type: |
Family |
| Description: |
Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyse the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition []. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid synthesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules [, ].Proteins in this family include Nudt7 and Nudt8. Nudt7 mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs []. This entry also includes yeast Pcd1, which act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives [, ]. |
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| Publication |
| First Author: |
Capela A |
| Year: |
2006 |
| Journal: |
Dev Biol |
| Title: |
LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1. |
| Volume: |
291 |
| Issue: |
2 |
| Pages: |
300-13 |
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| Publication |
| First Author: |
Ishikawa K |
| Year: |
2005 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion. |
| Volume: |
333 |
| Issue: |
2 |
| Pages: |
590-5 |
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| Publication |
| First Author: |
Tang Z |
| Year: |
2024 |
| Journal: |
Dev Cell |
| Title: |
A subset of neutrophils activates anti-tumor immunity and inhibits non-small-cell lung cancer progression. |
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| Publication |
| First Author: |
Rongvaux A |
| Year: |
2008 |
| Journal: |
J Immunol |
| Title: |
Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. |
| Volume: |
181 |
| Issue: |
7 |
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4685-95 |
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| Publication |
| First Author: |
Sacchi V |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164. |
| Volume: |
111 |
| Issue: |
19 |
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6952-7 |
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| Publication |
| First Author: |
Barella LF |
| Year: |
2019 |
| Journal: |
J Clin Invest |
| Title: |
β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion. |
| Volume: |
130 |
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| Pages: |
3732-3737 |
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| Publication |
| First Author: |
Zaiss DM |
| Year: |
2002 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
PI31 is a modulator of proteasome formation and antigen processing. |
| Volume: |
99 |
| Issue: |
22 |
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Campbell GJ |
| Year: |
2020 |
| Journal: |
Int J Mol Sci |
| Title: |
The Role of CDKs and CDKIs in Murine Development. |
| Volume: |
21 |
| Issue: |
15 |
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| Publication |
| First Author: |
Nawshad A |
| Year: |
2003 |
| Journal: |
J Cell Biol |
| Title: |
TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. |
| Volume: |
163 |
| Issue: |
6 |
| Pages: |
1291-301 |
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| Publication |
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Ip CK |
| Year: |
2021 |
| Journal: |
STAR Protoc |
| Title: |
An optimized protocol for establishing a chronic stress model in mice. |
| Volume: |
2 |
| Issue: |
2 |
| Pages: |
100448 |
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| Publication |
| First Author: |
Amiri A |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis. |
| Volume: |
32 |
| Issue: |
17 |
| Pages: |
5880-90 |
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| Publication |
| First Author: |
Beck A |
| Year: |
2017 |
| Journal: |
Endocrinology |
| Title: |
Functional Characterization of Transient Receptor Potential (TRP) Channel C5 in Female Murine Gonadotropes. |
| Volume: |
158 |
| Issue: |
4 |
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887-902 |
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| First Author: |
Uruno A |
| Year: |
2020 |
| Journal: |
Mol Cell Biol |
| Title: |
Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer's Disease Model Mice. |
| Volume: |
40 |
| Issue: |
6 |
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| First Author: |
Lu L |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. |
| Volume: |
107 |
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4 |
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1437-42 |
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| Publication |
| First Author: |
Tejada-Jiménez M |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Algae and humans share a molybdate transporter. |
| Volume: |
108 |
| Issue: |
16 |
| Pages: |
6420-5 |
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| SO Term |
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| SO Term |
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