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Search results 1801 to 1900 out of 2060 for Cxcl12

0.031s

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Name: C-X-C motif chemokine ligand 12; targeted mutation 4.1, Takashi Nagasawa
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele
Name: transgene insertion, E Forsberg
Allele Type: Transgenic
Attribute String: Epitope tag, Inducible, Inserted expressed sequence, Reporter
Allele
Name: C-X-C motif chemokine ligand 12; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: transgene insertion L289, Noriaki Ono
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Allele
Name: transgene insertion 2, Jason G Cyster
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Strain
Attribute String: mutant strain, transgenic
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Publication
First Author: Nie Y
Year: 2008
Journal: J Exp Med
Title: CXCR4 is required for the quiescence of primitive hematopoietic cells.
Volume: 205
Issue: 4
Pages: 777-83
GO Term
Genotype
Symbol: Tg(Ins2-Cxcl12)2Cys/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Kitchen SG
Year: 1997
Journal: J Virol
Title: CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus.
Volume: 71
Issue: 9
Pages: 6928-34
Publication
First Author: Anton PA
Year: 2000
Journal: AIDS
Title: Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue.
Volume: 14
Issue: 12
Pages: 1761-5
Publication
First Author: Inngjerdingen M
Year: 2001
Journal: Blood
Title: Expression and regulation of chemokine receptors in human natural killer cells.
Volume: 97
Issue: 2
Pages: 367-75
Publication
First Author: Iikura M
Year: 2001
Journal: J Leukoc Biol
Title: Chemokine receptors in human basophils: inducible expression of functional CXCR4.
Volume: 70
Issue: 1
Pages: 113-20
Publication
First Author: Gupta SK
Year: 1998
Journal: J Biol Chem
Title: Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines.
Volume: 273
Issue: 7
Pages: 4282-7
Publication
First Author: Zamarchi R
Year: 2002
Journal: Clin Exp Immunol
Title: Expression and functional activity of CXCR-4 and CCR-5 chemokine receptors in human thymocytes.
Volume: 127
Issue: 2
Pages: 321-30
Publication
First Author: Sun Y
Year: 2002
Journal: J Biol Chem
Title: Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation.
Volume: 277
Issue: 51
Pages: 49212-9
Publication
First Author: Jordan NJ
Year: 1999
Journal: J Clin Invest
Title: Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells.
Volume: 104
Issue: 8
Pages: 1061-9
Protein Domain
Type: Family
Description: CXC chemokine receptor 4 (CXCR4), also known as fusin, which is a specific receptor for a CXCL12 (or SDF1). CXCR4 has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types [, , , , ]. In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cells []. Upon binding to CXCR4, CXCL12 causes mobilisation of intracellular calcium and chemotaxis [, , ]. CXCL12 is known to be important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence. CXCR4 has a rather broad activity, and has been linked to cardiac, cerebellar gastric vasculature development [, ]and to hematopoiesis []. Atypical chemokine receptor 2 (ACKR2/D6) []is a chemokine-scavenging receptor or chemokine decoy receptor. It is capable of internalising and effectively scavenging its ligands through beta-arrestin-dependent activation of the cofilin pathway [, ]. ACKR2 is highly promiscuous and can bin the majority of (if not all) inflammatory CC-chemokines []. It plays an essential role in the resolution of the inflammatory response [, , ]. Although it lacks the canonical DRYLAIV motif necessary for classical signalling, ACKR2/D6 may be involved in 'atypical' signaling pathways downstream of ligand binding []. It has been shown to be involved in regulating vessel density [].
Publication
First Author: Graham GJ
Year: 2013
Journal: J Pathol
Title: Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6.
Volume: 229
Issue: 2
Pages: 168-75
Publication
First Author: Borroni EM
Year: 2013
Journal: Sci Signal
Title: β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.
Volume: 6
Issue: 273
Pages: ra30.1-11, S1-3
Publication
First Author: Graham GJ
Year: 2009
Journal: Eur J Immunol
Title: D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes.
Volume: 39
Issue: 2
Pages: 342-51
Publication
First Author: Fra AM
Year: 2003
Journal: J Immunol
Title: Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6.
Volume: 170
Issue: 5
Pages: 2279-82
Publication
First Author: Weber M
Year: 2004
Journal: Mol Biol Cell
Title: The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines.
Volume: 15
Issue: 5
Pages: 2492-508
Publication  
First Author: Graham GJ
Year: 2015
Journal: Front Immunol
Title: D6/ACKR2.
Volume: 6
Pages: 280
Publication
First Author: McKimmie CS
Year: 2013
Journal: Blood
Title: An analysis of the function and expression of D6 on lymphatic endothelial cells.
Volume: 121
Issue: 18
Pages: 3768-77
Publication
First Author: Jamieson T
Year: 2005
Journal: Nat Immunol
Title: The chemokine receptor D6 limits the inflammatory response in vivo.
Volume: 6
Issue: 4
Pages: 403-11
Publication
First Author: Lee KM
Year: 2014
Journal: EMBO J
Title: The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.
Volume: 33
Issue: 21
Pages: 2564-80
Protein
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: true
Publication
First Author: Grimberg E
Year: 2003
Journal: J Cell Sci
Title: Synaptotagmin III is a critical factor for the formation of the perinuclear endocytic recycling compartment and determination of secretory granules size.
Volume: 116
Issue: Pt 1
Pages: 145-54
Protein Domain
Type: Family
Description: Synaptotagmin-3 (SYT3) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains. Most of the synaptotagmins have a unique N-terminal domain that is involved in membrane anchoring or specific ligand binding. SYT3 is required for the formation and delivery of cargo to the perinuclear endocytic recycling compartment (ERC) []. Among synaptotagmins 1-11, SYT3 is the only one that is expressed in T cells. It is essential for chemokine receptor CXCR4 recycling in T cells and thereby affects CXCL12 chemokine-induced migration [].
HT Experiment
Series Id: E-GEOD-39438
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Cadinu P
Year: 2024
Journal: Cell
Title: Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.
Volume: 187
Issue: 8
Pages: 2010-2028.e30
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cxcl12-icre/ERT2)L289Nono/? Cxcl12/Cxcl12<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Burns JM
Year: 2006
Journal: J Exp Med
Title: A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.
Volume: 203
Issue: 9
Pages: 2201-13
Publication
First Author: Gerrits H
Year: 2008
Journal: Genesis
Title: Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice.
Volume: 46
Issue: 5
Pages: 235-45
Publication
First Author: Shimizu N
Year: 2000
Journal: J Virol
Title: A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses.
Volume: 74
Issue: 2
Pages: 619-26
Publication
First Author: Rajagopal S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.
Volume: 107
Issue: 2
Pages: 628-32
Publication
First Author: Hattermann K
Year: 2010
Journal: Cancer Res
Title: The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects.
Volume: 70
Issue: 8
Pages: 3299-308
Publication
First Author: Miao Z
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
Volume: 104
Issue: 40
Pages: 15735-40
Publication
First Author: Zabel BA
Year: 2009
Journal: J Immunol
Title: Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands.
Volume: 183
Issue: 5
Pages: 3204-11
Protein Domain
Type: Family
Description: Just like classical chemokine receptors, atypical chemokine receptors (ACKRs) are seven-transmembrane-helix (7TM) receptors that bind chemokines []. However, they lack the canonical DRYLAIV motif necessary for GPCR coupling to G proteins and induction of classical signalling pathways. Instead, ACKRs internalise their chemokine ligands, which may subsequently affect chemokine availability. The ACKR family comprises five members: Duffy Antigen Receptor for Chemokines (DARC, ACKR1), D6 (ACKR2), CXCR7 (ACKR3), CCRL1 (ACKR4) and CCRL2 (ACKR5) [].Atypical chemokine receptor 3 (ACKR3), previously known as CXC chemokine receptor 7 (CXCR7), is regarded as a scavenger for CXCL12 and, to a lesser extent, for CXCL11 []. Unlike other CXC chemokine receptors, ACKR3 does not elicit classical chemokine receptor signalling via typical G protein-mediated pathways [], but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway [, ].ACKR3/CXCR7 has been identified on memory B cells and in mammals is found in bone, brain, heart and kidney [, ]. It has been shown to act as a novel coreceptor for several immunodeficiency virus strains, which infect brain-derived cells []. Studies in zebrafish have also revealed a critical role in vascular formation and angiogenesis during development []. ACKR3/CXCR7 is a functional receptor for CXCL12 in astrocytomas/glioblastomas and mediates resistance to drug-induced apoptosis []. It has been shown to promote growth of tumors formed from breast and lung cancer cells [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Col1a1*2.3-GFP)1Rowe/? Tg(Cxcl12-icre/ERT2)L289Nono/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Veerman KM
Year: 2007
Journal: Nat Immunol
Title: Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs.
Volume: 8
Issue: 5
Pages: 532-9
Publication
First Author: Phee H
Year: 2010
Journal: Nat Immunol
Title: Regulation of thymocyte positive selection and motility by GIT2.
Volume: 11
Issue: 6
Pages: 503-11
Publication
First Author: Welford AF
Year: 2011
Journal: J Clin Invest
Title: TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice.
Volume: 121
Issue: 5
Pages: 1969-73
Publication
First Author: Good-Jacobson KL
Year: 2015
Journal: J Exp Med
Title: c-Myb is required for plasma cell migration to bone marrow after immunization or infection.
Volume: 212
Issue: 7
Pages: 1001-9
Publication
First Author: Otani Y
Year: 2012
Journal: FEBS Lett
Title: Suppression of metastases of small cell lung cancer cells in mice by a peptidic CXCR4 inhibitor TF14016.
Volume: 586
Issue: 20
Pages: 3639-44
Publication
First Author: Nibbs RJ
Year: 2013
Journal: Nat Rev Immunol
Title: Immune regulation by atypical chemokine receptors.
Volume: 13
Issue: 11
Pages: 815-29
Publication
First Author: Bachelerie F
Year: 2014
Journal: Nat Immunol
Title: New nomenclature for atypical chemokine receptors.
Volume: 15
Issue: 3
Pages: 207-8
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Nishimura S
Year: 2013
Journal: Cell Metab
Title: Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation.
Volume: 18
Issue: 5
Pages: 759-766
Publication
First Author: Kim HH
Year: 2023
Journal: Cell Rep
Title: xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity.
Volume: 42
Issue: 6
Pages: 112636
Publication
First Author: Katayama Y
Year: 2006
Journal: Cell
Title: Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow.
Volume: 124
Issue: 2
Pages: 407-21
Publication
First Author: Okada T
Year: 2002
Journal: J Exp Med
Title: Chemokine requirements for B cell entry to lymph nodes and Peyer's patches.
Volume: 196
Issue: 1
Pages: 65-75
Publication
First Author: Fielding C
Year: 2022
Journal: Nat Commun
Title: Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis.
Volume: 13
Issue: 1
Pages: 543
Publication
First Author: Schloss MJ
Year: 2022
Journal: Nat Immunol
Title: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis.
Volume: 23
Issue: 4
Pages: 605-618
Publication
First Author: Balzano M
Year: 2019
Journal: Cell Rep
Title: Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche.
Volume: 26
Issue: 12
Pages: 3257-3271.e8
Publication
First Author: Giannini S
Year: 2020
Journal: Nat Commun
Title: β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
Volume: 11
Issue: 1
Pages: 356
Publication
First Author: Williamson MR
Year: 2023
Journal: Nat Commun
Title: Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke.
Volume: 14
Issue: 1
Pages: 6341
Publication
First Author: Chakraborty M
Year: 2024
Journal: J Immunol
Title: Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells.
Volume: 212
Issue: 7
Pages: 1075-1080
Publication
First Author: Omatsu M
Year: 2023
Journal: Nat Commun
Title: THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.
Volume: 14
Issue: 1
Pages: 5534
Publication  
First Author: Yoshihara T
Year: 2023
Journal: J Exp Med
Title: Aldh1a2 + fibroblastic reticular cells regulate lymphocyte recruitment in omental milky spots.
Volume: 220
Issue: 5
Publication
First Author: Mazo IB
Year: 2005
Journal: Immunity
Title: Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells.
Volume: 22
Issue: 2
Pages: 259-70
Publication
First Author: Kikuchi T
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Dock2 participates in bone marrow lympho-hematopoiesis.
Volume: 367
Issue: 1
Pages: 90-6
Publication
First Author: Keppler SJ
Year: 2018
Journal: Cell Rep
Title: The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses.
Volume: 24
Issue: 3
Pages: 619-629
Publication
First Author: Juarez JG
Year: 2012
Journal: Blood
Title: Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice.
Volume: 119
Issue: 3
Pages: 707-16
Publication
First Author: Kara N
Year: 2023
Journal: Dev Cell
Title: Endothelial and Leptin Receptor(+) cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow.
Volume: 58
Issue: 5
Pages: 348-360.e6
Publication
First Author: Berahovich RD
Year: 2010
Journal: J Immunol
Title: CXCR7 protein is not expressed on human or mouse leukocytes.
Volume: 185
Issue: 9
Pages: 5130-9
Publication
First Author: Plotkin J
Year: 2003
Journal: J Immunol
Title: Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus.
Volume: 171
Issue: 9
Pages: 4521-7
Publication
First Author: Ahn S
Year: 2022
Journal: Oncogene
Title: CXCR4 and CXCR7 signaling promotes tumor progression and obesity-associated epithelial-mesenchymal transition in prostate cancer cells.
Volume: 41
Issue: 41
Pages: 4633-4644
Publication
First Author: Das Gupta D
Year: 2022
Journal: Cell Death Differ
Title: IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.
Volume: 29
Issue: 11
Pages: 2163-2176
Publication  
First Author: Batista S
Year: 2014
Journal: Nat Commun
Title: Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis.
Volume: 5
Pages: 5054
Publication
First Author: Moratz C
Year: 2004
Journal: Mol Cell Biol
Title: Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice.
Volume: 24
Issue: 13
Pages: 5767-75
Publication
First Author: Zhang B
Year: 2012
Journal: Cancer Cell
Title: Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia.
Volume: 21
Issue: 4
Pages: 577-92
Publication  
First Author: Cash-Padgett T
Year: 2016
Journal: Neurosci Res
Title: Increased stereotypy in conditional Cxcr4 knockout mice.
Volume: 105
Pages: 75-9
Publication
First Author: Collins JM
Year: 2024
Journal: Dev Cell
Title: YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development.
Volume: 59
Issue: 2
Pages: 211-227.e5
Publication
First Author: Upadhaya S
Year: 2020
Journal: Cell Stem Cell
Title: Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche.
Volume: 27
Issue: 2
Pages: 336-345.e4
Publication
First Author: Gesuita L
Year: 2022
Journal: Cell Rep
Title: Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity.
Volume: 40
Issue: 7
Pages: 111209
Publication
First Author: Cui H
Year: 2022
Journal: Sci Adv
Title: CXCL12/CXCR4-Rac1-mediated migration of osteogenic precursor cells contributes to pathological new bone formation in ankylosing spondylitis.
Volume: 8
Issue: 14
Pages: eabl8054
Publication
First Author: Hargreaves DC
Year: 2001
Journal: J Exp Med
Title: A coordinated change in chemokine responsiveness guides plasma cell movements.
Volume: 194
Issue: 1
Pages: 45-56
Publication
First Author: Le Y
Year: 2007
Journal: Immunity
Title: SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.
Volume: 27
Issue: 5
Pages: 811-23
Publication
First Author: von Vietinghoff S
Year: 2008
Journal: J Immunol
Title: Homeostatic regulation of blood neutrophil counts.
Volume: 181
Issue: 8
Pages: 5183-8
Publication
First Author: Pello OM
Year: 2006
Journal: Blood
Title: SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade.
Volume: 108
Issue: 12
Pages: 3928-37
Publication
First Author: Petkau G
Year: 2018
Journal: Eur J Immunol
Title: MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice.
Volume: 48
Issue: 6
Pages: 975-989
Publication  
First Author: Cai F
Year: 2019
Journal: Mol Cell Endocrinol
Title: CXCL12-regulated miR-370-3p functions as a tumor suppressor gene by targeting HMGA2 in nonfunctional pituitary adenomas.
Volume: 488
Pages: 25-35
Publication
First Author: Bénard A
Year: 2021
Journal: Nat Commun
Title: Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.
Volume: 12
Issue: 1
Pages: 1112
Publication
First Author: Li J
Year: 2022
Journal: Nat Commun
Title: S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.
Volume: 13
Issue: 1
Pages: 1481
Publication
First Author: Miao R
Year: 2022
Journal: Nat Commun
Title: Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size.
Volume: 13
Issue: 1
Pages: 4611
Publication
First Author: Feng J
Year: 2023
Journal: Blood
Title: Haplodeficiency of the 9p21 tumor suppressor locus causes myeloid disorders driven by the bone marrow microenvironment.
Volume: 142
Issue: 5
Pages: 460-476
Publication
First Author: Pu T
Year: 2024
Journal: Sci Adv
Title: Stromal-derived MAOB promotes prostate cancer growth and progression.
Volume: 10
Issue: 6
Pages: eadi4935
Protein
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: true
Publication
First Author: Huber TB
Year: 2002
Journal: J Immunol
Title: Expression of functional CCR and CXCR chemokine receptors in podocytes.
Volume: 168
Issue: 12
Pages: 6244-52
Publication
First Author: Whitman MC
Year: 2019
Journal: Hum Mol Genet
Title: Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans.
Volume: 28
Issue: 18
Pages: 3113-3125