Type |
Details |
Score |
Allele |
Name: |
C-X-C motif chemokine ligand 12; targeted mutation 4.1, Takashi Nagasawa |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, E Forsberg |
Allele Type: |
Transgenic |
Attribute String: |
Epitope tag, Inducible, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
C-X-C motif chemokine ligand 12; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion L289, Noriaki Ono |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 2, Jason G Cyster |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Nie Y |
Year: |
2008 |
Journal: |
J Exp Med |
Title: |
CXCR4 is required for the quiescence of primitive hematopoietic cells. |
Volume: |
205 |
Issue: |
4 |
Pages: |
777-83 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Ins2-Cxcl12)2Cys/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitchen SG |
Year: |
1997 |
Journal: |
J Virol |
Title: |
CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus. |
Volume: |
71 |
Issue: |
9 |
Pages: |
6928-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anton PA |
Year: |
2000 |
Journal: |
AIDS |
Title: |
Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue. |
Volume: |
14 |
Issue: |
12 |
Pages: |
1761-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inngjerdingen M |
Year: |
2001 |
Journal: |
Blood |
Title: |
Expression and regulation of chemokine receptors in human natural killer cells. |
Volume: |
97 |
Issue: |
2 |
Pages: |
367-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iikura M |
Year: |
2001 |
Journal: |
J Leukoc Biol |
Title: |
Chemokine receptors in human basophils: inducible expression of functional CXCR4. |
Volume: |
70 |
Issue: |
1 |
Pages: |
113-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gupta SK |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. |
Volume: |
273 |
Issue: |
7 |
Pages: |
4282-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zamarchi R |
Year: |
2002 |
Journal: |
Clin Exp Immunol |
Title: |
Expression and functional activity of CXCR-4 and CCR-5 chemokine receptors in human thymocytes. |
Volume: |
127 |
Issue: |
2 |
Pages: |
321-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun Y |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation. |
Volume: |
277 |
Issue: |
51 |
Pages: |
49212-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jordan NJ |
Year: |
1999 |
Journal: |
J Clin Invest |
Title: |
Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. |
Volume: |
104 |
Issue: |
8 |
Pages: |
1061-9 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
CXC chemokine receptor 4 (CXCR4), also known as fusin, which is a specific receptor for a CXCL12 (or SDF1). CXCR4 has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types [, , , , ]. In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cells []. Upon binding to CXCR4, CXCL12 causes mobilisation of intracellular calcium and chemotaxis [, , ]. CXCL12 is known to be important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence. CXCR4 has a rather broad activity, and has been linked to cardiac, cerebellar gastric vasculature development [, ]and to hematopoiesis []. Atypical chemokine receptor 2 (ACKR2/D6) []is a chemokine-scavenging receptor or chemokine decoy receptor. It is capable of internalising and effectively scavenging its ligands through beta-arrestin-dependent activation of the cofilin pathway [, ]. ACKR2 is highly promiscuous and can bin the majority of (if not all) inflammatory CC-chemokines []. It plays an essential role in the resolution of the inflammatory response [, , ]. Although it lacks the canonical DRYLAIV motif necessary for classical signalling, ACKR2/D6 may be involved in 'atypical' signaling pathways downstream of ligand binding []. It has been shown to be involved in regulating vessel density []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Graham GJ |
Year: |
2013 |
Journal: |
J Pathol |
Title: |
Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6. |
Volume: |
229 |
Issue: |
2 |
Pages: |
168-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borroni EM |
Year: |
2013 |
Journal: |
Sci Signal |
Title: |
β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. |
Volume: |
6 |
Issue: |
273 |
Pages: |
ra30.1-11, S1-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Graham GJ |
Year: |
2009 |
Journal: |
Eur J Immunol |
Title: |
D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes. |
Volume: |
39 |
Issue: |
2 |
Pages: |
342-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fra AM |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. |
Volume: |
170 |
Issue: |
5 |
Pages: |
2279-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weber M |
Year: |
2004 |
Journal: |
Mol Biol Cell |
Title: |
The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines. |
Volume: |
15 |
Issue: |
5 |
Pages: |
2492-508 |
|
•
•
•
•
•
|
Publication |
First Author: |
Graham GJ |
Year: |
2015 |
Journal: |
Front Immunol |
Title: |
D6/ACKR2. |
Volume: |
6 |
|
Pages: |
280 |
|
•
•
•
•
•
|
Publication |
First Author: |
McKimmie CS |
Year: |
2013 |
Journal: |
Blood |
Title: |
An analysis of the function and expression of D6 on lymphatic endothelial cells. |
Volume: |
121 |
Issue: |
18 |
Pages: |
3768-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jamieson T |
Year: |
2005 |
Journal: |
Nat Immunol |
Title: |
The chemokine receptor D6 limits the inflammatory response in vivo. |
Volume: |
6 |
Issue: |
4 |
Pages: |
403-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee KM |
Year: |
2014 |
Journal: |
EMBO J |
Title: |
The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. |
Volume: |
33 |
Issue: |
21 |
Pages: |
2564-80 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
50
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Grimberg E |
Year: |
2003 |
Journal: |
J Cell Sci |
Title: |
Synaptotagmin III is a critical factor for the formation of the perinuclear endocytic recycling compartment and determination of secretory granules size. |
Volume: |
116 |
Issue: |
Pt 1 |
Pages: |
145-54 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Synaptotagmin-3 (SYT3) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains. Most of the synaptotagmins have a unique N-terminal domain that is involved in membrane anchoring or specific ligand binding. SYT3 is required for the formation and delivery of cargo to the perinuclear endocytic recycling compartment (ERC) []. Among synaptotagmins 1-11, SYT3 is the only one that is expressed in T cells. It is essential for chemokine receptor CXCR4 recycling in T cells and thereby affects CXCL12 chemokine-induced migration []. |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-39438 |
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Cadinu P |
Year: |
2024 |
Journal: |
Cell |
Title: |
Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling. |
Volume: |
187 |
Issue: |
8 |
Pages: |
2010-2028.e30 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cxcl12-icre/ERT2)L289Nono/? Cxcl12/Cxcl12<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Burns JM |
Year: |
2006 |
Journal: |
J Exp Med |
Title: |
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. |
Volume: |
203 |
Issue: |
9 |
Pages: |
2201-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerrits H |
Year: |
2008 |
Journal: |
Genesis |
Title: |
Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. |
Volume: |
46 |
Issue: |
5 |
Pages: |
235-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimizu N |
Year: |
2000 |
Journal: |
J Virol |
Title: |
A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses. |
Volume: |
74 |
Issue: |
2 |
Pages: |
619-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajagopal S |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. |
Volume: |
107 |
Issue: |
2 |
Pages: |
628-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hattermann K |
Year: |
2010 |
Journal: |
Cancer Res |
Title: |
The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects. |
Volume: |
70 |
Issue: |
8 |
Pages: |
3299-308 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miao Z |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. |
Volume: |
104 |
Issue: |
40 |
Pages: |
15735-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zabel BA |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. |
Volume: |
183 |
Issue: |
5 |
Pages: |
3204-11 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Just like classical chemokine receptors, atypical chemokine receptors (ACKRs) are seven-transmembrane-helix (7TM) receptors that bind chemokines []. However, they lack the canonical DRYLAIV motif necessary for GPCR coupling to G proteins and induction of classical signalling pathways. Instead, ACKRs internalise their chemokine ligands, which may subsequently affect chemokine availability. The ACKR family comprises five members: Duffy Antigen Receptor for Chemokines (DARC, ACKR1), D6 (ACKR2), CXCR7 (ACKR3), CCRL1 (ACKR4) and CCRL2 (ACKR5) [].Atypical chemokine receptor 3 (ACKR3), previously known as CXC chemokine receptor 7 (CXCR7), is regarded as a scavenger for CXCL12 and, to a lesser extent, for CXCL11 []. Unlike other CXC chemokine receptors, ACKR3 does not elicit classical chemokine receptor signalling via typical G protein-mediated pathways [], but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway [, ].ACKR3/CXCR7 has been identified on memory B cells and in mammals is found in bone, brain, heart and kidney [, ]. It has been shown to act as a novel coreceptor for several immunodeficiency virus strains, which infect brain-derived cells []. Studies in zebrafish have also revealed a critical role in vascular formation and angiogenesis during development []. ACKR3/CXCR7 is a functional receptor for CXCL12 in astrocytomas/glioblastomas and mediates resistance to drug-induced apoptosis []. It has been shown to promote growth of tumors formed from breast and lung cancer cells []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Col1a1*2.3-GFP)1Rowe/? Tg(Cxcl12-icre/ERT2)L289Nono/? |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Veerman KM |
Year: |
2007 |
Journal: |
Nat Immunol |
Title: |
Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. |
Volume: |
8 |
Issue: |
5 |
Pages: |
532-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Phee H |
Year: |
2010 |
Journal: |
Nat Immunol |
Title: |
Regulation of thymocyte positive selection and motility by GIT2. |
Volume: |
11 |
Issue: |
6 |
Pages: |
503-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Welford AF |
Year: |
2011 |
Journal: |
J Clin Invest |
Title: |
TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice. |
Volume: |
121 |
Issue: |
5 |
Pages: |
1969-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Good-Jacobson KL |
Year: |
2015 |
Journal: |
J Exp Med |
Title: |
c-Myb is required for plasma cell migration to bone marrow after immunization or infection. |
Volume: |
212 |
Issue: |
7 |
Pages: |
1001-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Otani Y |
Year: |
2012 |
Journal: |
FEBS Lett |
Title: |
Suppression of metastases of small cell lung cancer cells in mice by a peptidic CXCR4 inhibitor TF14016. |
Volume: |
586 |
Issue: |
20 |
Pages: |
3639-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nibbs RJ |
Year: |
2013 |
Journal: |
Nat Rev Immunol |
Title: |
Immune regulation by atypical chemokine receptors. |
Volume: |
13 |
Issue: |
11 |
Pages: |
815-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bachelerie F |
Year: |
2014 |
Journal: |
Nat Immunol |
Title: |
New nomenclature for atypical chemokine receptors. |
Volume: |
15 |
Issue: |
3 |
Pages: |
207-8 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishimura S |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation. |
Volume: |
18 |
Issue: |
5 |
Pages: |
759-766 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HH |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity. |
Volume: |
42 |
Issue: |
6 |
Pages: |
112636 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama Y |
Year: |
2006 |
Journal: |
Cell |
Title: |
Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. |
Volume: |
124 |
Issue: |
2 |
Pages: |
407-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okada T |
Year: |
2002 |
Journal: |
J Exp Med |
Title: |
Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. |
Volume: |
196 |
Issue: |
1 |
Pages: |
65-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fielding C |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis. |
Volume: |
13 |
Issue: |
1 |
Pages: |
543 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schloss MJ |
Year: |
2022 |
Journal: |
Nat Immunol |
Title: |
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis. |
Volume: |
23 |
Issue: |
4 |
Pages: |
605-618 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balzano M |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche. |
Volume: |
26 |
Issue: |
12 |
Pages: |
3257-3271.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Giannini S |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis. |
Volume: |
11 |
Issue: |
1 |
Pages: |
356 |
|
•
•
•
•
•
|
Publication |
First Author: |
Williamson MR |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke. |
Volume: |
14 |
Issue: |
1 |
Pages: |
6341 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chakraborty M |
Year: |
2024 |
Journal: |
J Immunol |
Title: |
Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells. |
Volume: |
212 |
Issue: |
7 |
Pages: |
1075-1080 |
|
•
•
•
•
•
|
Publication |
First Author: |
Omatsu M |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer. |
Volume: |
14 |
Issue: |
1 |
Pages: |
5534 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshihara T |
Year: |
2023 |
Journal: |
J Exp Med |
Title: |
Aldh1a2 + fibroblastic reticular cells regulate lymphocyte recruitment in omental milky spots. |
Volume: |
220 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mazo IB |
Year: |
2005 |
Journal: |
Immunity |
Title: |
Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. |
Volume: |
22 |
Issue: |
2 |
Pages: |
259-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kikuchi T |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Dock2 participates in bone marrow lympho-hematopoiesis. |
Volume: |
367 |
Issue: |
1 |
Pages: |
90-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keppler SJ |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses. |
Volume: |
24 |
Issue: |
3 |
Pages: |
619-629 |
|
•
•
•
•
•
|
Publication |
First Author: |
Juarez JG |
Year: |
2012 |
Journal: |
Blood |
Title: |
Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. |
Volume: |
119 |
Issue: |
3 |
Pages: |
707-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kara N |
Year: |
2023 |
Journal: |
Dev Cell |
Title: |
Endothelial and Leptin Receptor(+) cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow. |
Volume: |
58 |
Issue: |
5 |
Pages: |
348-360.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berahovich RD |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
CXCR7 protein is not expressed on human or mouse leukocytes. |
Volume: |
185 |
Issue: |
9 |
Pages: |
5130-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Plotkin J |
Year: |
2003 |
Journal: |
J Immunol |
Title: |
Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. |
Volume: |
171 |
Issue: |
9 |
Pages: |
4521-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahn S |
Year: |
2022 |
Journal: |
Oncogene |
Title: |
CXCR4 and CXCR7 signaling promotes tumor progression and obesity-associated epithelial-mesenchymal transition in prostate cancer cells. |
Volume: |
41 |
Issue: |
41 |
Pages: |
4633-4644 |
|
•
•
•
•
•
|
Publication |
First Author: |
Das Gupta D |
Year: |
2022 |
Journal: |
Cell Death Differ |
Title: |
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity. |
Volume: |
29 |
Issue: |
11 |
Pages: |
2163-2176 |
|
•
•
•
•
•
|
Publication |
First Author: |
Batista S |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis. |
Volume: |
5 |
|
Pages: |
5054 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moratz C |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice. |
Volume: |
24 |
Issue: |
13 |
Pages: |
5767-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang B |
Year: |
2012 |
Journal: |
Cancer Cell |
Title: |
Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. |
Volume: |
21 |
Issue: |
4 |
Pages: |
577-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cash-Padgett T |
Year: |
2016 |
Journal: |
Neurosci Res |
Title: |
Increased stereotypy in conditional Cxcr4 knockout mice. |
Volume: |
105 |
|
Pages: |
75-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Collins JM |
Year: |
2024 |
Journal: |
Dev Cell |
Title: |
YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development. |
Volume: |
59 |
Issue: |
2 |
Pages: |
211-227.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Upadhaya S |
Year: |
2020 |
Journal: |
Cell Stem Cell |
Title: |
Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche. |
Volume: |
27 |
Issue: |
2 |
Pages: |
336-345.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gesuita L |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity. |
Volume: |
40 |
Issue: |
7 |
Pages: |
111209 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cui H |
Year: |
2022 |
Journal: |
Sci Adv |
Title: |
CXCL12/CXCR4-Rac1-mediated migration of osteogenic precursor cells contributes to pathological new bone formation in ankylosing spondylitis. |
Volume: |
8 |
Issue: |
14 |
Pages: |
eabl8054 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hargreaves DC |
Year: |
2001 |
Journal: |
J Exp Med |
Title: |
A coordinated change in chemokine responsiveness guides plasma cell movements. |
Volume: |
194 |
Issue: |
1 |
Pages: |
45-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Le Y |
Year: |
2007 |
Journal: |
Immunity |
Title: |
SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. |
Volume: |
27 |
Issue: |
5 |
Pages: |
811-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
von Vietinghoff S |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Homeostatic regulation of blood neutrophil counts. |
Volume: |
181 |
Issue: |
8 |
Pages: |
5183-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pello OM |
Year: |
2006 |
Journal: |
Blood |
Title: |
SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade. |
Volume: |
108 |
Issue: |
12 |
Pages: |
3928-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Petkau G |
Year: |
2018 |
Journal: |
Eur J Immunol |
Title: |
MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. |
Volume: |
48 |
Issue: |
6 |
Pages: |
975-989 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai F |
Year: |
2019 |
Journal: |
Mol Cell Endocrinol |
Title: |
CXCL12-regulated miR-370-3p functions as a tumor suppressor gene by targeting HMGA2 in nonfunctional pituitary adenomas. |
Volume: |
488 |
|
Pages: |
25-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bénard A |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections. |
Volume: |
12 |
Issue: |
1 |
Pages: |
1112 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy. |
Volume: |
13 |
Issue: |
1 |
Pages: |
1481 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miao R |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size. |
Volume: |
13 |
Issue: |
1 |
Pages: |
4611 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng J |
Year: |
2023 |
Journal: |
Blood |
Title: |
Haplodeficiency of the 9p21 tumor suppressor locus causes myeloid disorders driven by the bone marrow microenvironment. |
Volume: |
142 |
Issue: |
5 |
Pages: |
460-476 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pu T |
Year: |
2024 |
Journal: |
Sci Adv |
Title: |
Stromal-derived MAOB promotes prostate cancer growth and progression. |
Volume: |
10 |
Issue: |
6 |
Pages: |
eadi4935 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
378
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
272
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Huber TB |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Expression of functional CCR and CXCR chemokine receptors in podocytes. |
Volume: |
168 |
Issue: |
12 |
Pages: |
6244-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whitman MC |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans. |
Volume: |
28 |
Issue: |
18 |
Pages: |
3113-3125 |
|
•
•
•
•
•
|