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Search results 1801 to 1900 out of 1965 for Dnmt1

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Type Details Score
HT Experiment
GSE115477 | In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE94089 | DNA methylation regulates nephron progenitor cell renewal and differentiation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q8C4W6
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein Domain
IPR043449 | PHF20-like
Type: Family
Description: This entry includes PHF20 and PHF20L1 proteins.PHD finger protein 20 (PHF20) binds dimethyl lysine residues via its Tudor domain []. It is a component of the MLL1, MOF histone acetyltransferase []and NSL protein complexes [].PHF20L1 binds to monomethylated lysine 142 on DNA (cytosine-5) methyltransferase 1 (DNMT1). It has been shown to antagonize DNMT1 proteasomal degradation [].
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Genotype
Genotype
Symbol: Dnmt1/Dnmt1
Background: involves: 129S4/SvJae * BALB/c
Zygosity: ht
Has Mutant Allele: true
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HT Experiment
E-GEOD-43951 | Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis
Series Id: GSE43951
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
24492612 | -
First Author: Estève PO
Year: 2014
Journal: J Biol Chem
Title: Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.
Volume: 289
Issue: 12
Pages: 8277-87
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Publication
21389349 | -
First Author: Syeda F
Year: 2011
Journal: J Biol Chem
Title: The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.
Volume: 286
Issue: 17
Pages: 15344-51
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Protein Domain
IPR022702 | Cytosine_MeTrfase1_RFD
Type: Domain
Description: This domain is part of a cytosine specific DNA methyltransferase enzyme (DNMT). It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties [].A structure exists for the human cytosine specific DNA methyltransferase replication foci domain [].
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Publication
30620902 | J:272578
First Author: Liu J
Year: 2019
Journal: Dev Cell
Title: Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity.
Volume: 48
Issue: 1
Pages: 49-63.e7
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HT Experiment
GSE139413 | EED is required for Mouse Primordial Germ Cell Differentiation in the Embryonic Gonad
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE162903 | Base-editor-mediated multiplexed inactivation of DNA methyltransferases reveals essential roles of miRNAs in mouse gastrulation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE130735 | Genome-wide roles of DNA methyltransferases in mouse embryos
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Dnmt1<tm1(tetO)Cswt> | MGI:7860774
Name: DNA methyltransferase 1; targeted mutation 1, Christopher H Switzer
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Null/knockout
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Publication
22449972 | -
First Author: Adams-Cioaba MA
Year: 2012
Journal: FEBS Lett
Title: Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins.
Volume: 586
Issue: 6
Pages: 859-65
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Publication
22864287 | -
First Author: Cui G
Year: 2012
Journal: Nat Struct Mol Biol
Title: PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Volume: 19
Issue: 9
Pages: 916-24
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Protein Domain
IPR022255 | PHF20_AT-hook
Type: Domain
Description: PHD finger protein 20 (PHF20) is a Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. It consists of tandem Tudor domains at the N-terminal, an AT hook, a C2H2-type zinc finger, and a plant homeodomain (PHD) finger [, , ]. PHF20L1 binds to monomethylated lysine 142 on DNA (cytosine-5) methyltransferase 1 (DNMT1). It has been shown to antagonize DNMT1 proteasomal degradation [].This is the AT-hook domain found in PHD finger protein 20 (PHF20) and PHD finger protein 20-like (PHF20L) [, , ].
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HT Experiment
GSE74938 | RNA-seq profiling of mouse PGC (Mus musculus)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:2165101 | STOCK Dnmt1<tm3Jae> Hprt1<b-m3> Tg(pPWL512hyg)1Ems/J
Attribute String: mutant stock, transgenic, targeted mutation, spontaneous mutation
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Strain
MGI:7860776 | C57BL/6-Dnmt1<tm1(tetO)Cstw>/H
Attribute String: mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Dnmt1/Dnmt1 Hprt1/Hprt1 Tg(pPWL512hyg)1Ems/Tg(pPWL512hyg)1Ems
Background: STOCK Dnmt1 Hprt1 Tg(pPWL512hyg)1Ems/J
Zygosity: cx
Has Mutant Allele: true
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Protein
Q9JI44
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: false
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Publication
22072714 | J:228714
First Author: Badeaux AI
Year: 2012
Journal: J Biol Chem
Title: Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.
Volume: 287
Issue: 1
Pages: 429-37
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Publication
30396999 | -
First Author: Noblett N
Year: 2019
Journal: J Cell Biol
Title: DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons.
Volume: 218
Issue: 1
Pages: 125-133
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Publication
27908785 | -
First Author: Nitta Y
Year: 2017
Journal: Dev Biol
Title: DISCO Interacting Protein 2 regulates axonal bifurcation and guidance of Drosophila mushroom body neurons.
Volume: 421
Issue: 2
Pages: 233-244
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Publication
23733939 | J:197383
First Author: Qian Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: The DMAP interaction domain of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase is a substrate recognition module.
Volume: 110
Issue: 25
Pages: 10246-51
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Publication
19521673 | -
First Author: Anderson GR
Year: 2009
Journal: Cell Biochem Biophys
Title: The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling.
Volume: 54
Issue: 1-3
Pages: 33-46
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Publication
12761221 | -
First Author: Chatterjee TK
Year: 2003
Journal: J Biol Chem
Title: Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants.
Volume: 278
Issue: 32
Pages: 30261-71
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Publication
12140291 | -
First Author: Liu Z
Year: 2002
Journal: J Biol Chem
Title: RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6.
Volume: 277
Issue: 40
Pages: 37832-9
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Protein Domain
IPR037956 | RGS6_RGS
Type: Domain
Description: This entry represents the RGS domain of RGS6 (regulator of G-protein signaling 6). RGS6 is a member of the R7 RGS protein subfamily. Other members of the R7 subfamily (Neuronal RGS) include: RGS7, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control []. RGS6 exists in multiple splice isoforms with identical RGS domains, but possess complete or incomplete GGL domains and distinct N- and C-terminal domains []. RGS6 interacts with SCG10, a neuronal growth-associated protein and therefore regulates neuronal differentiation []. Another RGS6-binding protein is DMAP1, a component of the Dnmt1 complex involved in repression of newly replicated genes [].
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Protein Domain
IPR010506 | DMAP1-bd
Type: Domain
Description: This is a ~120-amino acid protein-protein interaction module that binds DMAP1 (DNA methyltransferase-associated protein 1), a transcriptional co-repressor. It is found at the N terminus of DNMT1 (DNA methyltransferase 1) []and animal disco-interacting protein 2 (DIP-2), a protein that maintains morphology of mature neurons [, ]. This domain is also found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTA) and gamma (GNPTG) from animals, which are members of a complex that catalyses the initial step in the formation of the mannose 6-phopsphate targeting signal on newly synthesized lysosomal acid hydrolases. The DMAP1-binding domain mediates the selective binding GlcNAc-1-phosphotranferase to acid hydrolases [, ].The DMAP1-binding domain is predicted to adopt a long helix-turn-helix structure that is rich in leucine residues [].
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Publication
36045674 | J:327921
 
First Author: Luo Y
Year: 2022
Journal: Front Immunol
Title: EZH2 restricts Tcf7 DNA methylation and promotes TFH differentiation during acute viral infection.
Volume: 13
Pages: 942465
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HT Experiment
GSE66029 | Functional characterization of DNA methylation in the oligodendrocyte lineage [RNASeq_development]
Series Id: E-GEOD-66029
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE139126 | Dominant role of DNA methylation over H3K9me3 in ERV silencing during embryonic endoderm development [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-23530 | WT vs Hypomethylated DRG Gene Expression
Series Id: GSE23530
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-52477 | Lsh regulates LTR retrotransposon repression independent of Dnmt3b function (RNA-Seq)
Series Id: GSE52477
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
25505245 | -
First Author: Qian Y
Year: 2015
Journal: J Biol Chem
Title: Analysis of mucolipidosis II/III GNPTAB missense mutations identifies domains of UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase involved in catalytic function and lysosomal enzyme recognition.
Volume: 290
Issue: 5
Pages: 3045-56
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Publication
16246164 | J:103658
First Author: Berger J
Year: 2005
Journal: Biochem Soc Trans
Title: Role of MBD2 in gene regulation and tumorigenesis.
Volume: 33
Issue: Pt 6
Pages: 1537-40
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Publication
30397232 | J:269799
First Author: Oba S
Year: 2018
Journal: Sci Rep
Title: Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells.
Volume: 8
Issue: 1
Pages: 16338
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Publication
31387996 | J:279496
First Author: Lee HH
Year: 2019
Journal: Nat Commun
Title: TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging.
Volume: 10
Issue: 1
Pages: 3536
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Publication
36030260 | J:327972
First Author: Al-Dabet MM
Year: 2022
Journal: Nat Commun
Title: Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression.
Volume: 13
Issue: 1
Pages: 5062
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Publication
30540937 | J:271529
First Author: Ibrahim ML
Year: 2018
Journal: Cell Rep
Title: Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.
Volume: 25
Issue: 11
Pages: 3036-3046.e6
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Publication
17214966 | J:117852
First Author: Negishi M
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing.
Volume: 353
Issue: 4
Pages: 992-8
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Publication
19667129 | J:153844
First Author: Yamakoshi K
Year: 2009
Journal: J Cell Biol
Title: Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.
Volume: 186
Issue: 3
Pages: 393-407
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Publication
26617245 | J:251590
 
First Author: Grasso D
Year: 2015
Journal: Sci Rep
Title: Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.
Volume: 5
Pages: 17549
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Publication
37660134 | J:340313
First Author: Hay AD
Year: 2023
Journal: Nat Commun
Title: Epigenetic inheritance is unfaithful at intermediately methylated CpG sites.
Volume: 14
Issue: 1
Pages: 5336
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Publication
30258352 | J:310664
 
First Author: Saunders J
Year: 2018
Journal: Front Mol Neurosci
Title: Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain.
Volume: 11
Pages: 332
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Publication
19228594 | J:152947
First Author: Takashima S
Year: 2009
Journal: Biol Reprod
Title: Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects.
Volume: 81
Issue: 1
Pages: 155-64
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Publication
23142729 | J:193745
First Author: Meng X
Year: 2013
Journal: J Leukoc Biol
Title: A novel tylophorine analog W-8 up-regulates forkhead boxP3 expression and ameliorates murine colitis.
Volume: 93
Issue: 1
Pages: 83-93
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Publication
35679863 | J:326056
First Author: Lowe MG
Year: 2022
Journal: Dev Cell
Title: EED is required for mouse primordial germ cell differentiation in the embryonic gonad.
Volume: 57
Issue: 12
Pages: 1482-1495.e5
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Publication
25451918 | J:218761
First Author: Lu LY
Year: 2015
Journal: J Biol Chem
Title: Topoisomerase II regulates the maintenance of DNA methylation.
Volume: 290
Issue: 2
Pages: 851-60
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Publication
29968706 | J:265029
First Author: Kim KY
Year: 2018
Journal: Nat Commun
Title: Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.
Volume: 9
Issue: 1
Pages: 2583
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Publication
19502488 | J:150052
First Author: Ruzov A
Year: 2009
Journal: Development
Title: MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos.
Volume: 136
Issue: 13
Pages: 2277-86
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Publication
25280994 | J:220212
First Author: Funaki S
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Inhibition of maintenance DNA methylation by Stella.
Volume: 453
Issue: 3
Pages: 455-60
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Publication
25822089 | J:231791
First Author: Liao J
Year: 2015
Journal: Nat Genet
Title: Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
Volume: 47
Issue: 5
Pages: 469-78
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Publication
27554592 | J:241452
 
First Author: Zhao Q
Year: 2016
Journal: Nat Commun
Title: Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals.
Volume: 7
Pages: 12464
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Protein
Q3UPE8
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: true
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Protein
A2AV92
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
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Publication
11399089 | J:72444
First Author: Gowher H
Year: 2001
Journal: J Mol Biol
Title: Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites.
Volume: 309
Issue: 5
Pages: 1201-8
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Publication
11919202 | J:150927
First Author: Gowher H
Year: 2002
Journal: J Biol Chem
Title: Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases.
Volume: 277
Issue: 23
Pages: 20409-14
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Publication
19056828 | J:173043
First Author: Kim JK
Year: 2009
Journal: Nucleic Acids Res
Title: UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells.
Volume: 37
Issue: 2
Pages: 493-505
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Publication
24781204 | J:216844
First Author: Harten SK
Year: 2014
Journal: Mamm Genome
Title: The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development.
Volume: 25
Issue: 7-8
Pages: 293-303
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Publication
9425235 | J:48248
First Author: Yoder JA
Year: 1998
Journal: Hum Mol Genet
Title: A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast.
Volume: 7
Issue: 2
Pages: 279-84
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Publication
9592134 | J:48082
First Author: Okano M
Year: 1998
Journal: Nucleic Acids Res
Title: Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells.
Volume: 26
Issue: 11
Pages: 2536-40
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Publication
19845771 | J:158320
First Author: Negishi M
Year: 2009
Journal: Genes Cells
Title: Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.
Volume: 14
Issue: 11
Pages: 1347-57
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Publication
32781171 | J:360179
 
First Author: Wang P
Year: 2020
Journal: Eur J Pharmacol
Title: Caffeic acid phenethyl ester, a coffee polyphenol, inhibits DNA methylation in vitro and in vivo.
Volume: 887
Pages: 173464
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Publication
18411339 | J:136278
First Author: Yamashita M
Year: 2008
Journal: J Exp Med
Title: Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.
Volume: 205
Issue: 5
Pages: 1109-20
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Publication
17429846 | J:123548
First Author: Sawalha AH
Year: 2007
Journal: Eur J Immunol
Title: Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice.
Volume: 37
Issue: 5
Pages: 1407-13
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Publication
38153351 | J:355704
First Author: Wang Z
Year: 2023
Journal: Immunohorizons
Title: Egr2 Deletion in Autoimmune-Prone C57BL6/lpr Mice Suppresses the Expression of Methylation-Sensitive Dlk1-Dio3 Cluster MicroRNAs.
Volume: 7
Issue: 12
Pages: 898-907
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Publication
27915032 | J:255363
First Author: Carvajal AE
Year: 2017
Journal: Biochim Biophys Acta
Title: Reelin expression is up-regulated in mice colon in response to acute colitis and provides resistance against colitis.
Volume: 1863
Issue: 2
Pages: 462-473
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Publication
23912340 | J:203130
First Author: Connelly JJ
Year: 2013
Journal: Hum Mol Genet
Title: Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis.
Volume: 22
Issue: 25
Pages: 5107-20
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Publication
23144318 | J:194111
First Author: Rahal OM
Year: 2013
Journal: Carcinogenesis
Title: Suppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programming.
Volume: 34
Issue: 2
Pages: 464-74
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Publication
28373182 | J:242302
First Author: Rossi EL
Year: 2017
Journal: Cancer Res
Title: Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice.
Volume: 77
Issue: 9
Pages: 2500-2511
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Publication
27893715 | J:241235
First Author: Huang PH
Year: 2017
Journal: Oncogene
Title: TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1.
Volume: 36
Issue: 16
Pages: 2202-2214
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Publication
16397253 | J:105165
First Author: McCabe MT
Year: 2006
Journal: Cancer Res
Title: Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Volume: 66
Issue: 1
Pages: 385-92
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Publication
17178860 | J:116759
First Author: Morey SR
Year: 2006
Journal: Cancer Res
Title: DNA methylation pathway alterations in an autochthonous murine model of prostate cancer.
Volume: 66
Issue: 24
Pages: 11659-67
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Publication
37852324 | J:357937
First Author: Olichwier A
Year: 2024
Journal: Biochim Biophys Acta Mol Cell Res
Title: SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes.
Volume: 1871
Issue: 1
Pages: 119608
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Publication
19099580 | J:142335
First Author: Ashe A
Year: 2008
Journal: Genome Biol
Title: A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development.
Volume: 9
Issue: 12
Pages: R182
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Publication
28143904 | J:259532
 
First Author: Marin TL
Year: 2017
Journal: Sci Signal
Title: AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.
Volume: 10
Issue: 464
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Publication
37686163 | J:340291
 
First Author: Sukowati C
Year: 2023
Journal: Int J Mol Sci
Title: PD-L1 Downregulation and DNA Methylation Inhibition for Molecular Therapy against Cancer Stem Cells in Hepatocellular Carcinoma.
Volume: 24
Issue: 17
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Publication
25918249 | J:309316
First Author: Wang N
Year: 2015
Journal: Oncotarget
Title: Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation.
Volume: 6
Issue: 12
Pages: 9854-76
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Publication
37725888 | J:340813
 
First Author: Wang P
Year: 2023
Journal: Redox Biol
Title: Accumulation of endogenous adenosine improves cardiomyocyte metabolism via epigenetic reprogramming in an ischemia-reperfusion model.
Volume: 67
Pages: 102884
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Publication
34613814 | J:334112
First Author: Zhang H
Year: 2021
Journal: Sci Transl Med
Title: Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis.
Volume: 13
Issue: 614
Pages: eabd1206
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Publication
36123357 | J:328945
First Author: Wang Z
Year: 2022
Journal: Nat Commun
Title: Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm.
Volume: 13
Issue: 1
Pages: 5447
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