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Search results 1801 to 1900 out of 2692 for Esr1

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Type Details Score
Protein
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 371  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
GXD Expression  
Probe: MGI:6885984
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3554328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6886052
Age: postnatal adult
Note: Sparse expression is seen in the medial amygdala (MeA); 4.6% of Esr1 positive neurons cells express it.
Specimen Label: 3C
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6886026
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3554328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6886073
Age: postnatal adult
Note: Dense expression is seen in the medial amygdala (MeA); 87.1% of Esr1 positive neurons cells express it.
Specimen Label: 3C
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6885982
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3591628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6886048
Age: postnatal adult
Note: Sparse expression is seen in the ventromedial hypothalamus ventrolateralis (VMHvl); 8.2% of Esr1 positive neurons cells express it.
Specimen Label: 3C
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6886015
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3591628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6886072
Age: postnatal adult
Note: Dense expression is seen in the ventromedial hypothalamus ventrolateralis (VMHvl); 90.7% of Esr1 positive neurons cells express it.
Specimen Label: 3C
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6885984
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Female
Emaps: EMAPS:3591628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6886052
Age: postnatal adult
Note: Expression is restricted to the ventrolateral component of the Esr1 positive cells in the ventromedial hypothalamus ventrolateralis (VMHvl).
Specimen Label: 7C
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6885986
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3665528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6886028
Age: postnatal adult
Note: Dense expression is seen in the preoptic hypothalamus (POA); 76.1% of Esr1 positive neurons cells express it.
Specimen Label: 3C
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6885993
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3665528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6886027
Age: postnatal adult
Note: Sparse expression is seen in the preoptic hypothalamus (POA); 5.2% of Esr1 positive neurons cells express it.
Specimen Label: 3C
Detected: true
Specimen Num: 2
Protein Domain
Type: Domain
Description: This domain is characteristic of UVSB PI-3 kinase, MEI-41 and ESR1 [].
GXD Expression  
Probe: MGI:6885992
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3772628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6886031
Age: postnatal adult
Note: Dense expression is seen in the principal component of the bed nucleus of the stria terminalis (BNSTpr); 90% of Esr1 positive neurons cells express it.
Specimen Label: 3C
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6885994
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3772628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6886053
Age: postnatal adult
Note: Sparse expression is seen in the principal component of the bed nucleus of the stria terminalis (BNSTpr); 6.5% of Esr1 positive neurons cells express it.
Specimen Label: 3C
Detected: true
Specimen Num: 2
Allele
Name: estrogen receptor 1 (alpha); endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
GXD Expression  
Probe: MGI:6885998
Assay Type: RNA in situ
Annotation Date: 2022-03-04
Strength: Present
Sex: Male
Emaps: EMAPS:3772628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6886029
Age: postnatal adult
Note: Expression is seen in the principal component of the bed nucleus of the stria terminalis (BNSTpr). Some, but not all, of these neurons overlap with the Esr1 positive population.
Specimen Label: 6B
Detected: true
Specimen Num: 2
Allele
Name: estrogen receptor 1 (alpha); endonuclease-mediated mutation 1, Nirao Shah
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: WT1 transcription factor; targeted mutation 2.1, William T Pu
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Allele
Name: estrogen receptor 1 (alpha); endonuclease-mediated mutation 7, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Protein
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
Publication
First Author: Fujita K
Year: 2003
Journal: Genes Cells
Title: Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone.
Volume: 8
Issue: 6
Pages: 559-71
Publication
First Author: Bu H
Year: 2004
Journal: Biochem Biophys Res Commun
Title: ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.
Volume: 317
Issue: 1
Pages: 54-9
Protein Domain
Type: Family
Description: Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors [].
Protein Domain
Type: Family
Description: This entry includes Fcf2 from budding yeasts and DNTTIP2 from animals. Fcf2 is involved in pre-rRNA processing []. DNTTIP2 regulates the transcriptional activity of DNTT and ESR1 [, ].
Protein Domain
Type: Family
Description: GREB1 (gene regulated in breast cancer 1 protein) is a ESR1 (estrogen receptor 1)-upregulated protein that may regulate estrogen action and it is associated with estrogen-stimulated cell proliferation []. It acts as a regulator of hormone-dependent cancer growth in breast, ovarian and prostate cancers [, , , ]. This protein may be a target to inhibit tumour-promoting pathways both downstream and independent of ESR1 as a possible treatment strategy.This entry represents a protein family that includes Protein GREB1 and similar proteins from chordates.
Allele
Name: transgene insertion 1, Glasgow University Veterinary Faculty
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Strain
Attribute String: endonuclease-mediated mutation, mutant stock
Allele
Name: collagen, type I, alpha 1; targeted mutation 27, The Netherlands Cancer Institute
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence
Genotype
Symbol: Esr1/Esr1<+>
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Protein
Organism: Mus musculus/domesticus
Length: 1913  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1954  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1926  
Fragment?: false
Publication
First Author: Rae JM
Year: 2005
Journal: Breast Cancer Res Treat
Title: GREB 1 is a critical regulator of hormone dependent breast cancer growth.
Volume: 92
Issue: 2
Pages: 141-9
Publication
First Author: Rae JM
Year: 2006
Journal: Prostate
Title: GREB1 is a novel androgen-regulated gene required for prostate cancer growth.
Volume: 66
Issue: 8
Pages: 886-94
Publication    
First Author: Lee E
Year: 2019
Journal: Elife
Title: GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance.
Volume: 8
Protein Domain
Type: Domain
Description: GREB1 (gene regulated in breast cancer 1 protein) is a ESR1 (estrogen receptor 1)-upregulated protein that may regulate estrogen action and it is associated with estrogen-stimulated cell proliferation []. It acts as a regulator of hormone-dependent cancer growth in breast, ovarian and prostate cancers [, , , ]. This protein may be a target to inhibit tumour-promoting pathways both downstream and independent of ESR1 as a possible treatment strategy.This entry represents the C-terminal domain of GREB1 and similar proteins, which may adopt a twisted α/β structure comprising parallel β-sheetσ connected by α-helices that surround the sheet, as revealed from structure predictions.
Protein Domain
Type: Domain
Description: GREB1 (gene regulated in breast cancer 1 protein) is a ESR1 (estrogen receptor 1)-upregulated protein that may regulate estrogen action and it is associated with estrogen-stimulated cell proliferation []. It acts as a regulator of hormone-dependent cancer growth in breast, ovarian and prostate cancers [, , , ]. This protein may be a target to inhibit tumour-promoting pathways both downstream and independent of ESR1 as a possible treatment strategy.This entry represents a the N-terminal domain of GREB1 and similar proteins, whose function is not yet known. Structure predictions suggest that it may have an α/β fold.
Allele
Name: transgene insertion 1, Vicki L Davis
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Blyth K
Year: 2000
Journal: Oncogene
Title: Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice.
Volume: 19
Issue: 6
Pages: 773-82
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Thomas Ludwig
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Allele
Name: pancreas specific transcription factor, 1a; targeted mutation 2, Christopher VE Wright
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Allele
Name: forkhead box A2; targeted mutation 2, Anna M Moon
Allele Type: Targeted
Attribute String: Hypomorph, Inducible, Recombinase
Allele
Name: WT1 transcription factor; targeted mutation 2, William T Pu
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Publication
First Author: Castet A
Year: 2004
Journal: Nucleic Acids Res
Title: Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition.
Volume: 32
Issue: 6
Pages: 1957-66
Publication
First Author: Christian M
Year: 2004
Journal: J Biol Chem
Title: Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140.
Volume: 279
Issue: 15
Pages: 15645-51
Publication
First Author: Poliandri AH
Year: 2011
Journal: J Biol Rhythms
Title: Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140).
Volume: 26
Issue: 3
Pages: 187-99
Protein
Organism: Mus musculus/domesticus
Length: 758  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 991  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
Protein Domain
Type: Domain
Description: Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the fourth (C-terminal) repression domain of nuclear receptor-interacting protein 1 [, ].
Protein Domain
Type: Family
Description: Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the third repression domain of nuclear receptor-interacting protein 1 [, ].
Protein Domain
Type: Domain
Description: Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the second repression domain of nuclear receptor-interacting protein 1 [, ].
Protein Domain
Type: Domain
Description: Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the first (N-terminal) repression domain of nuclear receptor-interacting protein 1 [, ].
Protein Domain
Type: Family
Description: Histone-lysine N-methyltransferase 2D (KMT2D, also known as MLL2; ) is a catalytic component of the MLL2/3 complex (also named ASCOM complex) []and methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D is recruited by ESR1 and acts as a coactivator of the oestrogen receptor alpha [].
Protein
Organism: Mus musculus/domesticus
Length: 1161  
Fragment?: false
Publication
First Author: Cavaillès V
Year: 1995
Journal: EMBO J
Title: Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.
Volume: 14
Issue: 15
Pages: 3741-51
Publication
First Author: Subramaniam N
Year: 1999
Journal: J Biol Chem
Title: Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids.
Volume: 274
Issue: 25
Pages: 18121-7
Publication
First Author: Couse JF
Year: 1997
Journal: Mol Carcinog
Title: Accelerated onset of uterine tumors in transgenic mice with aberrant expression of the estrogen receptor after neonatal exposure to diethylstilbestrol.
Volume: 19
Issue: 4
Pages: 236-42
Allele
Name: transgene insertion 1, Ueli Suter
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Publication
First Author: Niessen K
Year: 2010
Journal: Blood
Title: ALK1 signaling regulates early postnatal lymphatic vessel development.
Volume: 115
Issue: 8
Pages: 1654-61
Strain
Attribute String: targeted mutation, mutant stock
Strain
Attribute String: congenic, mutant strain, targeted mutation
Strain
Attribute String: mutant stock, targeted mutation
Publication
First Author: Suffee N
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Atrial natriuretic peptide regulates adipose tissue accumulation in adult atria.
Volume: 114
Issue: 5
Pages: E771-E780
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Gerard Evan
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inducible, Inserted expressed sequence, Reporter
Allele
Name: transcription factor 3; targeted mutation 6, Yuan Zhuang
Allele Type: Targeted
Attribute String: Inducible
Allele
Name: TEK receptor tyrosine kinase; targeted mutation 1.1, Hans-Reimer Rodewald
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase
Allele
Name: estrogen receptor 1 (alpha); targeted mutation 1.1, CheMyong Ko
Allele Type: Targeted
Attribute String: Recombinase
Allele
Name: estrogen receptor 1 (alpha); endonuclease-mediated mutation 1, Kenneth S Korach
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
Allele
Name: estrogen receptor 1 (alpha); endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: estrogen receptor 1 (alpha); endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Gerard Evan
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Inserted expressed sequence, Reporter
Allele
Name: achaete-scute family bHLH transcription factor 3; targeted mutation 2.1, Catherine E Ovitt
Allele Type: Targeted
Attribute String: Inducible, Recombinase, Reporter
Allele
Name: transgene insertion 1, Iannis Talianidis
Allele Type: Transgenic
Attribute String: Epitope tag, Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Foxa2/Foxa2
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Wt1/Wt1<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Lee YS
Year: 2002
Journal: Biol Reprod
Title: Activating signal cointegrator 1 is highly expressed in murine testicular Leydig cells and enhances the ligand-dependent transactivation of androgen receptor.
Volume: 67
Issue: 5
Pages: 1580-7
Publication
First Author: Matsuo Y
Year: 2020
Journal: Nat Struct Mol Biol
Title: RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
Volume: 27
Issue: 4
Pages: 323-332
Protein Domain
Type: Family
Description: Activating signal cointegrator 1 (TRIP4) is a transcription coactivator that interacts with nuclear receptors, including thyroid hormone receptor [], the androgen receptor []and ESR1 [], provided ligand is bound to the receptor. This interaction facilitates nuclear receptor-mediated transcription. TRIP4 contains a C4-type zinc finger. It is polyufmylated by the UFM1-conjugating system and deufmylated by the protease UFSP2; ufmylation promotes the recruitment of additional transcriptional coactivators []. This entry also includes the uncharacterized proteins C1A6.01c from the fission yeast and Rqt4 from baker's yeast. Rqt4 is part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation [].
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Allele
Name: transgene insertion F, Vicki L Davis
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
Allele
Name: transgene insertion 1, Robert Feil
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Allele
Name: transgelin; targeted mutation 1, Robert Feil
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Publication    
First Author: Grove M
Year: 2024
Journal: Elife
Title: TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves.
Volume: 13
Publication
First Author: Dumas L
Year: 2015
Journal: Glia
Title: Multicolor analysis of oligodendrocyte morphology, interactions, and development with Brainbow.
Volume: 63
Issue: 4
Pages: 699-717
Allele
Name: transgene insertion 2, Ueli Suter
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Strain
Attribute String: targeted mutation, mutant stock
Publication
First Author: Badea TC
Year: 2003
Journal: J Neurosci
Title: A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse.
Volume: 23
Issue: 6
Pages: 2314-22
Publication
First Author: Holmes JB
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication.
Volume: 112
Issue: 30
Pages: 9334-9
Publication    
First Author: Wolf G
Year: 2020
Journal: Elife
Title: KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage.
Volume: 9
Publication
First Author: Guo K
Year: 2007
Journal: Endocrinology
Title: Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities.
Volume: 148
Issue: 8
Pages: 3987-97
Publication
First Author: Lord CA
Year: 2009
Journal: J Immunol
Title: Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1.
Volume: 182
Issue: 5
Pages: 2948-58