| Type |
Details |
Score |
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
389
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
371
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
373
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6885984 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3554328 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886052 |
| Age: |
postnatal adult |
|
| Note: |
Sparse expression is seen in the medial amygdala (MeA); 4.6% of Esr1 positive neurons cells express it. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6886026 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3554328 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886073 |
| Age: |
postnatal adult |
|
| Note: |
Dense expression is seen in the medial amygdala (MeA); 87.1% of Esr1 positive neurons cells express it. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6885982 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3591628 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886048 |
| Age: |
postnatal adult |
|
| Note: |
Sparse expression is seen in the ventromedial hypothalamus ventrolateralis (VMHvl); 8.2% of Esr1 positive neurons cells express it. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6886015 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3591628 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886072 |
| Age: |
postnatal adult |
|
| Note: |
Dense expression is seen in the ventromedial hypothalamus ventrolateralis (VMHvl); 90.7% of Esr1 positive neurons cells express it. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6885984 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:3591628 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886052 |
| Age: |
postnatal adult |
|
| Note: |
Expression is restricted to the ventrolateral component of the Esr1 positive cells in the ventromedial hypothalamus ventrolateralis (VMHvl). |
| Specimen Label: |
7C |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6885986 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3665528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886028 |
| Age: |
postnatal adult |
|
| Note: |
Dense expression is seen in the preoptic hypothalamus (POA); 76.1% of Esr1 positive neurons cells express it. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6885993 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3665528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886027 |
| Age: |
postnatal adult |
|
| Note: |
Sparse expression is seen in the preoptic hypothalamus (POA); 5.2% of Esr1 positive neurons cells express it. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This domain is characteristic of UVSB PI-3 kinase, MEI-41 and ESR1 []. |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6885992 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3772628 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886031 |
| Age: |
postnatal adult |
|
| Note: |
Dense expression is seen in the principal component of the bed nucleus of the stria terminalis (BNSTpr); 90% of Esr1 positive neurons cells express it. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6885994 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3772628 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886053 |
| Age: |
postnatal adult |
|
| Note: |
Sparse expression is seen in the principal component of the bed nucleus of the stria terminalis (BNSTpr); 6.5% of Esr1 positive neurons cells express it. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Allele |
| Name: |
estrogen receptor 1 (alpha); endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6885998 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-03-04 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:3772628 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6886029 |
| Age: |
postnatal adult |
|
| Note: |
Expression is seen in the principal component of the bed nucleus of the stria terminalis (BNSTpr). Some, but not all, of these neurons overlap with the Esr1 positive population. |
| Specimen Label: |
6B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Allele |
| Name: |
estrogen receptor 1 (alpha); endonuclease-mediated mutation 1, Nirao Shah |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
WT1 transcription factor; targeted mutation 2.1, William T Pu |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
estrogen receptor 1 (alpha); endonuclease-mediated mutation 7, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
34
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fujita K |
| Year: |
2003 |
| Journal: |
Genes Cells |
| Title: |
Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
559-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bu H |
| Year: |
2004 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. |
| Volume: |
317 |
| Issue: |
1 |
| Pages: |
54-9 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes Fcf2 from budding yeasts and DNTTIP2 from animals. Fcf2 is involved in pre-rRNA processing []. DNTTIP2 regulates the transcriptional activity of DNTT and ESR1 [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
GREB1 (gene regulated in breast cancer 1 protein) is a ESR1 (estrogen receptor 1)-upregulated protein that may regulate estrogen action and it is associated with estrogen-stimulated cell proliferation []. It acts as a regulator of hormone-dependent cancer growth in breast, ovarian and prostate cancers [, , , ]. This protein may be a target to inhibit tumour-promoting pathways both downstream and independent of ESR1 as a possible treatment strategy.This entry represents a protein family that includes Protein GREB1 and similar proteins from chordates. |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Glasgow University Veterinary Faculty |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
endonuclease-mediated mutation, mutant stock |
|
•
•
•
•
•
|
| Allele |
| Name: |
collagen, type I, alpha 1; targeted mutation 27, The Netherlands Cancer Institute |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Epitope tag, Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Esr1/Esr1<+> |
| Background: |
involves: C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1913
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1954
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1926
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rae JM |
| Year: |
2005 |
| Journal: |
Breast Cancer Res Treat |
| Title: |
GREB 1 is a critical regulator of hormone dependent breast cancer growth. |
| Volume: |
92 |
| Issue: |
2 |
| Pages: |
141-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rae JM |
| Year: |
2006 |
| Journal: |
Prostate |
| Title: |
GREB1 is a novel androgen-regulated gene required for prostate cancer growth. |
| Volume: |
66 |
| Issue: |
8 |
| Pages: |
886-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee E |
| Year: |
2019 |
| Journal: |
Elife |
| Title: |
GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance. |
| Volume: |
8 |
|
|
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
GREB1 (gene regulated in breast cancer 1 protein) is a ESR1 (estrogen receptor 1)-upregulated protein that may regulate estrogen action and it is associated with estrogen-stimulated cell proliferation []. It acts as a regulator of hormone-dependent cancer growth in breast, ovarian and prostate cancers [, , , ]. This protein may be a target to inhibit tumour-promoting pathways both downstream and independent of ESR1 as a possible treatment strategy.This entry represents the C-terminal domain of GREB1 and similar proteins, which may adopt a twisted α/β structure comprising parallel β-sheetσ connected by α-helices that surround the sheet, as revealed from structure predictions. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
GREB1 (gene regulated in breast cancer 1 protein) is a ESR1 (estrogen receptor 1)-upregulated protein that may regulate estrogen action and it is associated with estrogen-stimulated cell proliferation []. It acts as a regulator of hormone-dependent cancer growth in breast, ovarian and prostate cancers [, , , ]. This protein may be a target to inhibit tumour-promoting pathways both downstream and independent of ESR1 as a possible treatment strategy.This entry represents a the N-terminal domain of GREB1 and similar proteins, whose function is not yet known. Structure predictions suggest that it may have an α/β fold. |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Vicki L Davis |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blyth K |
| Year: |
2000 |
| Journal: |
Oncogene |
| Title: |
Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice. |
| Volume: |
19 |
| Issue: |
6 |
| Pages: |
773-82 |
|
•
•
•
•
•
|
| Allele |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Thomas Ludwig |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
pancreas specific transcription factor, 1a; targeted mutation 2, Christopher VE Wright |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
forkhead box A2; targeted mutation 2, Anna M Moon |
| Allele Type: |
Targeted |
| Attribute String: |
Hypomorph, Inducible, Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
WT1 transcription factor; targeted mutation 2, William T Pu |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Castet A |
| Year: |
2004 |
| Journal: |
Nucleic Acids Res |
| Title: |
Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. |
| Volume: |
32 |
| Issue: |
6 |
| Pages: |
1957-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Christian M |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. |
| Volume: |
279 |
| Issue: |
15 |
| Pages: |
15645-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Poliandri AH |
| Year: |
2011 |
| Journal: |
J Biol Rhythms |
| Title: |
Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140). |
| Volume: |
26 |
| Issue: |
3 |
| Pages: |
187-99 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
758
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
991
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
121
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
151
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
123
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
250
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
129
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the fourth (C-terminal) repression domain of nuclear receptor-interacting protein 1 [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the third repression domain of nuclear receptor-interacting protein 1 [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the second repression domain of nuclear receptor-interacting protein 1 [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the first (N-terminal) repression domain of nuclear receptor-interacting protein 1 [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Histone-lysine N-methyltransferase 2D (KMT2D, also known as MLL2; ) is a catalytic component of the MLL2/3 complex (also named ASCOM complex) []and methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D is recruited by ESR1 and acts as a coactivator of the oestrogen receptor alpha []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1161
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cavaillès V |
| Year: |
1995 |
| Journal: |
EMBO J |
| Title: |
Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. |
| Volume: |
14 |
| Issue: |
15 |
| Pages: |
3741-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Subramaniam N |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids. |
| Volume: |
274 |
| Issue: |
25 |
| Pages: |
18121-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Couse JF |
| Year: |
1997 |
| Journal: |
Mol Carcinog |
| Title: |
Accelerated onset of uterine tumors in transgenic mice with aberrant expression of the estrogen receptor after neonatal exposure to diethylstilbestrol. |
| Volume: |
19 |
| Issue: |
4 |
| Pages: |
236-42 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Ueli Suter |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Niessen K |
| Year: |
2010 |
| Journal: |
Blood |
| Title: |
ALK1 signaling regulates early postnatal lymphatic vessel development. |
| Volume: |
115 |
| Issue: |
8 |
| Pages: |
1654-61 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suffee N |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Atrial natriuretic peptide regulates adipose tissue accumulation in adult atria. |
| Volume: |
114 |
| Issue: |
5 |
| Pages: |
E771-E780 |
|
•
•
•
•
•
|
| Allele |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Gerard Evan |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Humanized sequence, Inducible, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transcription factor 3; targeted mutation 6, Yuan Zhuang |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible |
|
•
•
•
•
•
|
| Allele |
| Name: |
TEK receptor tyrosine kinase; targeted mutation 1.1, Hans-Reimer Rodewald |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Null/knockout, Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
estrogen receptor 1 (alpha); targeted mutation 1.1, CheMyong Ko |
| Allele Type: |
Targeted |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
estrogen receptor 1 (alpha); endonuclease-mediated mutation 1, Kenneth S Korach |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
estrogen receptor 1 (alpha); endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
estrogen receptor 1 (alpha); endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Gerard Evan |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Inducible, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
achaete-scute family bHLH transcription factor 3; targeted mutation 2.1, Catherine E Ovitt |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Iannis Talianidis |
| Allele Type: |
Transgenic |
| Attribute String: |
Epitope tag, Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Foxa2/Foxa2 |
| Background: |
Not Specified |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Wt1/Wt1<+> |
| Background: |
involves: 129S4/SvJae * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee YS |
| Year: |
2002 |
| Journal: |
Biol Reprod |
| Title: |
Activating signal cointegrator 1 is highly expressed in murine testicular Leydig cells and enhances the ligand-dependent transactivation of androgen receptor. |
| Volume: |
67 |
| Issue: |
5 |
| Pages: |
1580-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsuo Y |
| Year: |
2020 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. |
| Volume: |
27 |
| Issue: |
4 |
| Pages: |
323-332 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Activating signal cointegrator 1 (TRIP4) is a transcription coactivator that interacts with nuclear receptors, including thyroid hormone receptor [], the androgen receptor []and ESR1 [], provided ligand is bound to the receptor. This interaction facilitates nuclear receptor-mediated transcription. TRIP4 contains a C4-type zinc finger. It is polyufmylated by the UFM1-conjugating system and deufmylated by the protease UFSP2; ufmylation promotes the recruitment of additional transcriptional coactivators []. This entry also includes the uncharacterized proteins C1A6.01c from the fission yeast and Rqt4 from baker's yeast. Rqt4 is part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation []. |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion F, Vicki L Davis |
| Allele Type: |
Transgenic |
| Attribute String: |
Dominant negative, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Robert Feil |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgelin; targeted mutation 1, Robert Feil |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grove M |
| Year: |
2024 |
| Journal: |
Elife |
| Title: |
TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves. |
| Volume: |
13 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dumas L |
| Year: |
2015 |
| Journal: |
Glia |
| Title: |
Multicolor analysis of oligodendrocyte morphology, interactions, and development with Brainbow. |
| Volume: |
63 |
| Issue: |
4 |
| Pages: |
699-717 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 2, Ueli Suter |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Badea TC |
| Year: |
2003 |
| Journal: |
J Neurosci |
| Title: |
A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse. |
| Volume: |
23 |
| Issue: |
6 |
| Pages: |
2314-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Holmes JB |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication. |
| Volume: |
112 |
| Issue: |
30 |
| Pages: |
9334-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wolf G |
| Year: |
2020 |
| Journal: |
Elife |
| Title: |
KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage. |
| Volume: |
9 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo K |
| Year: |
2007 |
| Journal: |
Endocrinology |
| Title: |
Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. |
| Volume: |
148 |
| Issue: |
8 |
| Pages: |
3987-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lord CA |
| Year: |
2009 |
| Journal: |
J Immunol |
| Title: |
Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. |
| Volume: |
182 |
| Issue: |
5 |
| Pages: |
2948-58 |
|
•
•
•
•
•
|