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Search results 1801 to 1900 out of 2530 for Il6

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0.018s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:3806563 | C57BL/6-Tg(H2-L-IL6)1Kish
Attribute String: transgenic, coisogenic
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Strain
MGI:3806158 | C.B6-Tg(H2-L-IL6)1Kish/J
Attribute String: congenic, transgenic
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Publication
21807994 | J:175612
First Author: Wall JS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides.
Volume: 108
Issue: 34
Pages: E586-94
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Publication
- | J:138762
     
First Author: Kishimoto T
Year: 2008
Journal: MGI Direct Data Submission
Title: Generation of H2-L-IL6 transgenic mice
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Publication
12633573 | J:128016
First Author: Katsume A
Year: 2002
Journal: Cytokine
Title: Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice.
Volume: 20
Issue: 6
Pages: 304-11
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Strain
MGI:3806570 | C57BL/6-Tg(H2-L-IL6)46Kish
Attribute String: coisogenic, transgenic
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Strain
MGI:5301817 | C.B6-Tg(H2-L-IL6)46Kish
Attribute String: congenic, mutant strain, transgenic
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Publication
19149411 | J:177820
First Author: Wall JS
Year: 2008
Journal: Comp Med
Title: Quantitative tomography of early-onset spontaneous AA amyloidosis in interleukin 6 transgenic mice.
Volume: 58
Issue: 6
Pages: 542-50
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Publication
38578730 | J:351027
First Author: Kennel SJ
Year: 2024
Journal: PLoS One
Title: Preclinical evaluation of Tc-99m p5+14 peptide for SPECT detection of cardiac amyloidosis.
Volume: 19
Issue: 4
Pages: e0301756
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Publication
10843940 | J:127955
First Author: Kuhn C
Year: 2000
Journal: Chest
Title: Morphometry explains variation in airway responsiveness in transgenic mice overexpressing interleukin-6 and interleukin-11 in the lung.
Volume: 117
Issue: 5 Suppl 1
Pages: 260S-2S
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Publication
10233864 | J:177825
First Author: Solomon A
Year: 1999
Journal: Am J Pathol
Title: Transgenic mouse model of AA amyloidosis.
Volume: 154
Issue: 4
Pages: 1267-72
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Publication
30377267 | J:267295
First Author: Wall JS
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy.
Volume: 115
Issue: 46
Pages: E10839-E10848
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Publication
9052874 | J:328569
First Author: Peters M
Year: 1996
Journal: Immunol Lett
Title: The function of the soluble IL-6 receptor in vivo.
Volume: 54
Issue: 2-3
Pages: 177-84
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Strain
MGI:6147231 | C57BL/6NCrSlc-Tg(CAG-EGFP,-IL6,-mCherry)29Kenw/KenwRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Strain
MGI:6147232 | C57BL/6NCrSlc-Tg(CAG-EGFP,-IL6/mCherry)56Kenw/KenwRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Genotype
Genotype
Symbol: Tg(H2-L-IL6)1Kish/Tg(H2-L-IL6)1Kish
Background: C57BL/6-Tg(H2-L-IL6)1Kish
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(H2-L-IL6)46Kish/Tg(H2-L-IL6)46Kish
Background: C57BL/6-Tg(H2-L-IL6)46Kish
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(H2-L-IL6)46Kish/Tg(H2-L-IL6)46Kish
Background: involves: BALB/c * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(H2-L-IL6)46Kish/Tg(H2-L-IL6)46Kish
Background: C.B6-Tg(H2-L-IL6)46Kish
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Mt1-IL6)28Gci/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il6ra/Il6ra Tg(H2-L-IL6)40Csk/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
10441734 | J:56825
First Author: Kozak CA
Year: 1999
Journal: Mamm Genome
Title: Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.
Volume: 10
Issue: 9
Pages: 853-7
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Publication
34490261 | J:310891
 
First Author: Liu E
Year: 2021
Journal: Front Cell Dev Biol
Title: ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization.
Volume: 9
Pages: 710967
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Publication
6185626 | J:6953
First Author: Zawatzky R
Year: 1982
Journal: J Gen Virol
Title: An X-linked locus influences the amount of circulating interferon induced in the mouse by herpes simplex virus type 1.
Volume: 63
Issue: 2
Pages: 325-32
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Publication
34669463 | J:314362
First Author: Negi V
Year: 2021
Journal: Sci Adv
Title: Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension.
Volume: 7
Issue: 43
Pages: eabh3794
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Genotype
Genotype
Symbol: Il6/Il6 Tg(H2-K-IL6)2Srj/?
Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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MP Term
MP:0008597 | decreased circulating interleukin-6 level
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MP Term
MP:0008706 | decreased interleukin-6 secretion
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Protein Domain
IPR030474 | IL-6/GCSF/MGF
Type: Family
Description: Interleukin-6 (IL6), also refered to as B-cell stimulatory factor-2 (BSF-2) and interferon beta-2, is a cytokine involved in a wide variety of biological functions []. It plays an essential role in the finaldifferentiation of B-cells into IG-secreting cells, as well as inducing myeloma/plasmacytoma growth, nerve cell differentiation and, in hepatocytes, acute phase reactants [, ].A number of other cytokines may be grouped with IL6 on the basis of sequence similarity [, , ]: these include granulocyte colony-stimulating factor (GCSF) and myelomonocytic growth factor (MGF). GCSF acts in hematopoiesis by affecting the production, differentiation and function of 2 related white cell groups in the blood []. MGF also acts in hematopoiesis, stimulating proliferation and colony formation of normal and transformed avian cells of the myeloid lineage.
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Publication
3261707 | J:9311
First Author: Sutherland GR
Year: 1988
Journal: Hum Genet
Title: Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.
Volume: 79
Issue: 4
Pages: 335-7
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Publication
19322177 | J:147868
First Author: Matsushita K
Year: 2009
Journal: Nature
Title: Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.
Volume: 458
Issue: 7242
Pages: 1185-90
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Publication
26320658 | J:233655
First Author: Garg AV
Year: 2015
Journal: Immunity
Title: MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation.
Volume: 43
Issue: 3
Pages: 475-87
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Publication
34236049 | J:313003
 
First Author: Li DD
Year: 2021
Journal: JCI Insight
Title: RTEC-intrinsic IL-17-driven inflammatory circuit amplifies antibody-induced glomerulonephritis and is constrained by Regnase-1.
Volume: 6
Issue: 13
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Publication
23706741 | J:198415
First Author: Uehata T
Year: 2013
Journal: Cell
Title: Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.
Volume: 153
Issue: 5
Pages: 1036-49
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Publication
2037043 | -
First Author: Lütticken C
Year: 1991
Journal: FEBS Lett
Title: Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.
Volume: 282
Issue: 2
Pages: 265-7
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Publication
3491322 | -
First Author: Hirano T
Year: 1986
Journal: Nature
Title: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.
Volume: 324
Issue: 6092
Pages: 73-6
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Strain
MGI:7628229 | NOD.Cg-Il6<em1(IL6)Akp> Flt3<em1Akp> Prkdc<scid> Il2rg<tm1Wjl>/AkpJ
Attribute String: congenic, endonuclease-mediated mutation, targeted mutation, mutant strain, spontaneous mutation
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Publication
24292417 | J:308700
 
First Author: Duncan K
Year: 2013
Journal: Blood Cancer J
Title: (18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib.
Volume: 3
Pages: e165
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Publication
26918362 | J:308701
 
First Author: Rosean TR
Year: 2016
Journal: Blood Cancer J
Title: KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice.
Volume: 6
Pages: e398
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Publication
447069 | J:6130
First Author: Elliott RW
Year: 1979
Journal: Genetics
Title: Use of two-dimensional electrophoresis to identify and map new mouse genes.
Volume: 91
Issue: 2
Pages: 295-308
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Publication
223176 | J:6183
First Author: Slate DL
Year: 1979
Journal: Pharmacol Ther
Title: Genetics of the interferon system.
Volume: 4
Issue: 1
Pages: 221-30
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Publication
19710465 | J:152299
First Author: Enzler T
Year: 2009
Journal: J Immunol
Title: MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression.
Volume: 183
Issue: 6
Pages: 3831-8
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Publication
9347935 | J:137907
First Author: Castelnau PA
Year: 1997
Journal: Neurosci Lett
Title: Prion protein (PrP) is not involved in the pathogenesis of spongiform encephalopathy in transgenic mice expressing interleukin-6 in the brain.
Volume: 234
Issue: 1
Pages: 15-8
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Publication
1358798 | J:2176
First Author: Sieburth D
Year: 1992
Journal: Genomics
Title: Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5.
Volume: 14
Issue: 1
Pages: 59-62
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Publication
31931613 | J:302310
First Author: Omiya S
Year: 2020
Journal: Circulation
Title: Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts.
Volume: 141
Issue: 8
Pages: 667-677
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Publication
25825391 | J:229258
First Author: White K
Year: 2015
Journal: EMBO Mol Med
Title: Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
Volume: 7
Issue: 6
Pages: 695-713
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Publication
22772059 | J:193665
First Author: Bommert KS
Year: 2013
Journal: Leukemia
Title: The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival.
Volume: 27
Issue: 2
Pages: 441-50
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Publication
38974475 | J:351629
First Author: Laragione T
Year: 2024
Journal: iScience
Title: DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis.
Volume: 27
Issue: 6
Pages: 110158
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Publication
31324807 | J:279382
First Author: Fu R
Year: 2019
Journal: Nat Commun
Title: A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours.
Volume: 10
Issue: 1
Pages: 3210
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Publication
12900446 | J:84598
First Author: Molyneaux KA
Year: 2003
Journal: Development
Title: GP130, the shared receptor for the LIF/IL6 cytokine family in the mouse, is not required for early germ cell differentiation, but is required cell-autonomously in oocytes for ovulation.
Volume: 130
Issue: 18
Pages: 4287-94
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Publication
26146080 | J:265996
First Author: Wienerroither S
Year: 2015
Journal: Cell Rep
Title: Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex.
Volume: 12
Issue: 2
Pages: 300-12
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Publication
35320716 | J:324910
First Author: Stienne C
Year: 2022
Journal: Cell Rep
Title: Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.
Volume: 38
Issue: 12
Pages: 110553
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Publication
37344842 | J:341041
First Author: Mawambo G
Year: 2023
Journal: J Neuroinflammation
Title: HIF1α-dependent hypoxia response in myeloid cells requires IRE1α.
Volume: 20
Issue: 1
Pages: 145
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Publication
33876574 | J:316014
First Author: Andriessen EMMA
Year: 2021
Journal: EMBO Mol Med
Title: Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammation.
Volume: 13
Issue: 5
Pages: e11754
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Publication
37018396 | J:335300
First Author: Sun JY
Year: 2023
Journal: Sci Adv
Title: An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction.
Volume: 9
Issue: 14
Pages: eade4110
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Publication
33397952 | J:300940
First Author: Dong J
Year: 2021
Journal: Nat Commun
Title: Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.
Volume: 12
Issue: 1
Pages: 66
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Publication
34239012 | J:307608
First Author: Ng B
Year: 2021
Journal: Sci Rep
Title: Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.
Volume: 11
Issue: 1
Pages: 14088
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Publication
31292446 | J:294472
First Author: Soutto M
Year: 2019
Journal: Nat Commun
Title: Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia.
Volume: 10
Issue: 1
Pages: 3039
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Publication
28232471 | J:241520
First Author: Öhlund D
Year: 2017
Journal: J Exp Med
Title: Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.
Volume: 214
Issue: 3
Pages: 579-596
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Publication
38902237 | J:350093
First Author: Martinez S
Year: 2024
Journal: Nat Commun
Title: In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer.
Volume: 15
Issue: 1
Pages: 5266
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Publication
26441240 | J:232744
First Author: Thouverey C
Year: 2015
Journal: Endocrinology
Title: Ablation of p38α MAPK Signaling in Osteoblast Lineage Cells Protects Mice From Bone Loss Induced by Estrogen Deficiency.
Volume: 156
Issue: 12
Pages: 4377-87
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Publication
33245913 | J:304384
First Author: Hung LY
Year: 2021
Journal: Am J Pathol
Title: Myeloid-Derived IL-33 Limits the Severity of Dextran Sulfate Sodium-Induced Colitis.
Volume: 191
Issue: 2
Pages: 266-273
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Publication
28684431 | J:243810
First Author: Kim DE
Year: 2017
Journal: J Exp Med
Title: Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation.
Volume: 214
Issue: 8
Pages: 2349-2368
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Publication
36609505 | J:337511
First Author: Irazoki A
Year: 2023
Journal: Nat Commun
Title: Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation.
Volume: 14
Issue: 1
Pages: 108
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Publication
35227273 | J:329144
First Author: Chen D
Year: 2022
Journal: J Neuroinflammation
Title: Sox2 overexpression alleviates noise-induced hearing loss by inhibiting inflammation-related hair cell apoptosis.
Volume: 19
Issue: 1
Pages: 59
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Publication
25769723 | J:221119
First Author: Chen K
Year: 2015
Journal: Cancer Res
Title: The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module.
Volume: 75
Issue: 10
Pages: 1992-2004
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Publication
38714690 | J:347976
First Author: Maura F
Year: 2024
Journal: Nat Commun
Title: The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans.
Volume: 15
Issue: 1
Pages: 3844
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Publication
8697800 | J:34723
First Author: Bruch J
Year: 1996
Journal: Cytogenet Cell Genet
Title: Mapping of type I loci from human chromosome 7 reveals segments of conserved synteny on pig chromosomes 3, 9, and 18.
Volume: 73
Issue: 3
Pages: 164-7
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Publication
25607954 | J:248471
First Author: Ballon G
Year: 2015
Journal: PLoS Pathog
Title: Systemic expression of Kaposi sarcoma herpesvirus (KSHV) Vflip in endothelial cells leads to a profound proinflammatory phenotype and myeloid lineage remodeling in vivo.
Volume: 11
Issue: 1
Pages: e1004581
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Publication
29483096 | J:262294
First Author: Cai Z
Year: 2018
Journal: Cancer Res
Title: hPCL3s Promotes Hepatocellular Carcinoma Metastasis by Activating β-Catenin Signaling.
Volume: 78
Issue: 10
Pages: 2536-2549
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Publication
32511326 | J:291432
     
First Author: Sajuthi SP
Year: 2020
Journal: bioRxiv
Title: Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium.
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Publication
33436596 | J:300890
First Author: Muñoz-Rojas AR
Year: 2021
Journal: Nat Commun
Title: Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells.
Volume: 12
Issue: 1
Pages: 301
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Publication
32823063 | J:338650
First Author: Chamberlain TC
Year: 2020
Journal: iScience
Title: Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-inflammatory Effects through SHIP1/STAT3 Complexes.
Volume: 23
Issue: 8
Pages: 101433
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Publication
35961310 | J:328937
First Author: Plana-Carmona M
Year: 2022
Journal: Stem Cell Reports
Title: The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling.
Volume: 17
Issue: 9
Pages: 1991-2004
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Publication
37852176 | J:350461
First Author: Liang M
Year: 2023
Journal: Cell Rep Med
Title: Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis.
Volume: 4
Issue: 10
Pages: 101228
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Protein
P08505
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
P09920
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
Q0PMN1
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
Q3U8J8
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
Q3UM22
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
A0A0G2JFG1
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
A0A0G2JGF4
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
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Protein
A0A0G2JFT1
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
A2RTD1
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
Q0VB73
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Publication
2472117 | -
First Author: Clogston CL
Year: 1989
Journal: Arch Biochem Biophys
Title: Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor.
Volume: 272
Issue: 1
Pages: 144-51
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Publication
20018915 | J:157726
First Author: Rutsch S
Year: 2010
Journal: Blood
Title: IL-6 and MYC collaborate in plasma cell tumor formation in mice.
Volume: 115
Issue: 9
Pages: 1746-54
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Protein Coding Gene
MGI:88229 | C4bp
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0014554 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGI:2684869 | Trim38
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0018340 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGI:1918414 | Zdhhc11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0018712 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016436 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0020368 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_129S1SvImJ_G0020755 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0020317 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0020711 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0016384 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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