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Search results 1801 to 1900 out of 2155 for Maf

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Type Details Score
Publication
23927931 | J:210724
First Author: ZeRuth GT
Year: 2013
Journal: Mol Endocrinol
Title: The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription.
Volume: 27
Issue: 10
Pages: 1692-705
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Protein Domain
IPR033531 | MafF
Type: Family
Description: Maf transcription factors form a distinct subfamily of the basic leucine zipper (bZip) transcription factors []. Maf genes have been identified in a wide range of higher eukaryotes, including both vertebrate and invertebrate species. These proteins are unique among the bZip factors in that they contain a highly conserved extended homology region (EHR), or ancillary DNA binding region, in addition to a typical basic region, and both regions are involved in target DNA sequence recognition. Maf transcription factors regulate tissue-specific gene expression and cell-differentiation in a wide variety of tissues and are also involved in human diseases and oncogenic transformation. Tissue-specific expression invloves Maf binding to Maf-recognition elements (MAREs) in the regulatory regions of target genes, and interacting with other transcription factors.This entry represents MafF, a small Maf protein (sMaf) that lacks the transcriptional activation domain. It forms homodimers that act as transcriptional repressors. sMafs can also form heterodimers with cap 'n' collar (CNC) proteins (p45 NF-E2, Nrf1, Nrf2, and Nrf3) and also with Bach proteins (Bach1 and Bach2) [].
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Genotype
Genotype
Symbol: Maf/Maf Isl1/Isl1<+>
Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mafb/Mafb Foxg1/Foxg1<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Arhgap29/Arhgap29<+> Mafb/Mafb<+>
Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Maf/Maf Egr2/Egr2<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
25658941 | -
First Author: Jin J
Year: 2015
Journal: PLoS One
Title: Insights into the cellular function of YhdE, a nucleotide pyrophosphatase from Escherichia coli.
Volume: 10
Issue: 2
Pages: e0117823
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Publication
28811554 | -
First Author: Shen Q
Year: 2017
Journal: Sci Rep
Title: A new method to investigate the catalytic mechanism of YhdE pyrophosphatase by using a pyrophosphate fluorescence probe.
Volume: 7
Issue: 1
Pages: 8169
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Publication
4210219 | -
First Author: Medarde Agustín A
Year: 1973
Journal: Rev Sanid Hig Publica (Madr)
Title: [Valve of the detection of Australia antigen in blood donors].
Volume: 47
Issue: 6
Pages: 529-36
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Protein Domain
IPR003697 | Maf-like
Type: Family
Description: The Maf protein of Bacillus subtilis shares substantial amino acid sequence identity with Escherichia coli YhdE (previously known as OrfE) []. Maf-like proteins are conserved in bacteria, archaea, and eukaryotes. Maf proteins have been implicated in cell division arrest []. It has also been proposed that they belong to a family of house-cleaning nucleotide hydrolyzing enzymes which prevent the incorporation of noncanonical nucleotides into cellular DNA []. Maf proteins exhibit nucleotide pyrophosphatase activity against canonical and modified nucleotides, which might represent a molecular mechanism for this dual role in cell division arrest and in house-cleaning []. This entry includes pyrophosphatases, such as YhdE and YceF from E. coli. YhdE is a nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP [, , ]. YceF is a nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m7GTP) [].
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Publication
9171106 | -
First Author: Bean TL
Year: 1997
Journal: Nucleic Acids Res
Title: Multiple regions of p45 NF-E2 are required for beta-globin gene expression in erythroid cells.
Volume: 25
Issue: 12
Pages: 2509-15
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Publication
16287851 | -
First Author: Shyu YC
Year: 2005
Journal: Mol Cell Biol
Title: Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.
Volume: 25
Issue: 23
Pages: 10365-78
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Protein
D3Z706
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
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Protein
D3YUM3
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
D3Z6L9
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
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Protein
D3Z0J1
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Protein
D3Z4E8
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Publication
11154691 | -
First Author: Hung HL
Year: 2001
Journal: J Biol Chem
Title: Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.
Volume: 276
Issue: 14
Pages: 10715-21
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Protein Domain
IPR029853 | NF-E2_p45
Type: Family
Description: Transcription factor NF-E2 45kDa subunit (p45/NF-E2) belongs to the CNC (Cap'n'Collar) transcription factor family. It is a subunit of the NF-E2 transcription activator, which regulates a number of erythroid- and megakaryocytic lineage-specific genes []. NF-E2 is a heterodimer consisting of p45 and a small Maf protein []. p45 and a small Maf protein dimerise through their leucine zipper domains to generate a DNA binding domain. The N-terminal domain of p45 contains an activation domain that is important for the biological activity of p45 [].
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Genotype
Genotype
Symbol: Icos/Icos Tg(Cd4-Maf)6666Glm/?
Background: involves: 129S1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
7939715 | -
First Author: Blackwell TK
Year: 1994
Journal: Science
Title: Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements.
Volume: 266
Issue: 5185
Pages: 621-8
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Protein Domain
IPR004826 | bZIP_Maf
Type: Domain
Description: Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property []. This entry also includes the DNA binding domain of Skn-1 (); this domain lacks the leucine zipper found in other bZip domains, and binds DNA as a monomer [, ].
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HT Experiment
E-GEOD-75388 | Gene expression profile of E18.5 epidermis from WT and MafB KO mice
Series Id: GSE75388
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-65500 | Compound mouse mutants of bZIP transcription factors MafG and MafK reveal a regulatory network of non-crystallin genes linked to cataract
Series Id: GSE65500
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
11493525 | J:69856
First Author: Wendling O
Year: 2001
Journal: Development
Title: Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning.
Volume: 128
Issue: 11
Pages: 2031-8
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Publication
11528388 | J:71547
First Author: Pasqualetti M
Year: 2001
Journal: Nat Genet
Title: Retinoic acid rescues inner ear defects in Hoxa1 deficient mice.
Volume: 29
Issue: 1
Pages: 34-9
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Publication
14623822 | J:87221
First Author: Alvarez Y
Year: 2003
Journal: Development
Title: Requirements for FGF3 and FGF10 during inner ear formation.
Volume: 130
Issue: 25
Pages: 6329-38
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Publication
18294628 | J:135698
First Author: Burlison JS
Year: 2008
Journal: Dev Biol
Title: Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells.
Volume: 316
Issue: 1
Pages: 74-86
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Publication
23578930 | J:311850
First Author: Kayam G
Year: 2013
Journal: Development
Title: A novel role for Pax6 in the segmental organization of the hindbrain.
Volume: 140
Issue: 10
Pages: 2190-202
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Publication
25556170 | J:316553
First Author: Dong L
Year: 2015
Journal: J Am Soc Nephrol
Title: Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance.
Volume: 26
Issue: 9
Pages: 2118-28
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Publication
32375022 | J:296539
First Author: Helman A
Year: 2020
Journal: Cell Metab
Title: A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion.
Volume: 31
Issue: 5
Pages: 1004-1016.e5
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Publication
35038200 | J:326361
First Author: Li S
Year: 2022
Journal: Dev Dyn
Title: Fate-mapping analysis of cochlear cells expressing Atoh1 mRNA via a new Atoh13*HA-P2A-Cre knockin mouse strain.
Volume: 251
Issue: 7
Pages: 1156-1174
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Publication
16354937 | J:163657
First Author: Mar L
Year: 2005
Journal: J Neurosci
Title: A genetic screen for mutations that affect cranial nerve development in the mouse.
Volume: 25
Issue: 50
Pages: 11787-95
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Publication
28118374 | J:246292
First Author: Nishimura K
Year: 2017
Journal: PLoS One
Title: Dynamic Expression of Sox2, Gata3, and Prox1 during Primary Auditory Neuron Development in the Mammalian Cochlea.
Volume: 12
Issue: 1
Pages: e0170568
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Publication
26495868 | J:234058
First Author: Galloway JR
Year: 2015
Journal: Mol Endocrinol
Title: SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.
Volume: 29
Issue: 12
Pages: 1774-86
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Publication
35444273 | J:330324
First Author: Masuda T
Year: 2022
Journal: Nature
Title: Specification of CNS macrophage subsets occurs postnatally in defined niches.
Volume: 604
Issue: 7907
Pages: 740-748
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Publication
19168627 | -
First Author: Schembri F
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium.
Volume: 106
Issue: 7
Pages: 2319-24
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Protein Domain
IPR028574 | MafK
Type: Family
Description: Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs and small Mafs (MafF, MafK []and MafG []). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. Small Mafs can act as negative regulators of transcription by recruiting transcriptional repressors or by forming homodimers that can then displace active dimers. Small Mafs lack a transactivator domain, but they can also serve as transcriptional activators by dimerising with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites.The small Mafs (MafF, MafG and MafK) appear to be crucial regulators of mammalian gene expression. Small Mafs are also involved in regulating stress response and detoxification pathways [].
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Protein Domain
IPR028551 | MafG
Type: Family
Description: Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors []. The Maf family is divided into two subclasses, large Mafs and small Mafs (MafF, MafK []and MafG []). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. Small Mafs can act as negative regulators of transcription by recruiting transcriptional repressors or by forming homodimers that can then displace active dimers. Small Mafs lack a transactivator domain, but they can also serve as transcriptional activators by dimerising with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. This entry represents MafG. The p45/MafG heterodimer plays a role in the regulation of erythropoiesis []and may be involved in signal transduction of extracellular H+ []. MAFG is up-regulated in smokers [].
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Mafb/Mafb<+> Tg(Neurog1-cre)1Jejo/?
Background: involves: 129S * C57BL/6J * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Publication
9166829 | -
First Author: Blank V
Year: 1997
Journal: Blood
Title: Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression.
Volume: 89
Issue: 11
Pages: 3925-35
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Protein
Q9D927
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Publication
10693804 | J:60593
First Author: Millonig JH
Year: 2000
Journal: Nature
Title: The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS.
Volume: 403
Issue: 6771
Pages: 764-9
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Publication
17977745 | J:132603
First Author: Saul SM
Year: 2008
Journal: Mol Cell Neurosci
Title: Math5 expression and function in the central auditory system.
Volume: 37
Issue: 1
Pages: 153-69
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Publication
16627579 | J:129652
First Author: Vuguin PM
Year: 2006
Journal: Endocrinology
Title: Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.
Volume: 147
Issue: 9
Pages: 3995-4006
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Publication
32668405 | J:345638
First Author: Scoville DW
Year: 2020
Journal: J Mol Endocrinol
Title: Identification of a novel lncRNA (G3R1) regulated by GLIS3 in pancreatic β-cells.
Volume: 65
Issue: 3
Pages: 59-67
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Publication
24574009 | J:208408
First Author: Prin F
Year: 2014
Journal: Development
Title: Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation.
Volume: 141
Issue: 7
Pages: 1492-502
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Publication
11044623 | J:65646
First Author: Tomotsune D
Year: 2000
Journal: Mech Dev
Title: Regulation of Hoxb3 expression in the hindbrain and pharyngeal arches by rae28, a member of the mammalian Polycomb group of genes.
Volume: 98
Issue: 1-2
Pages: 165-9
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Publication
15790971 | J:98385
First Author: Li JY
Year: 2005
Journal: Development
Title: New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression.
Volume: 132
Issue: 8
Pages: 1971-81
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Publication
21497760 | J:171613
First Author: Vitobello A
Year: 2011
Journal: Dev Cell
Title: Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.
Volume: 20
Issue: 4
Pages: 469-82
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Publication
10529420 | J:41540
First Author: Rossel M
Year: 1999
Journal: Development
Title: Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development.
Volume: 126
Issue: 22
Pages: 5027-40
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Publication
12563036 | J:81969
First Author: Vermot J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice.
Volume: 100
Issue: 4
Pages: 1763-8
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Publication
9463359 | J:46972
First Author: Gavalas A
Year: 1998
Journal: Development
Title: Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch.
Volume: 125
Issue: 6
Pages: 1123-36
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Publication
18599523 | J:141886
First Author: Jiang Y
Year: 2008
Journal: Diabetes
Title: Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin.
Volume: 57
Issue: 10
Pages: 2718-27
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Publication
26887806 | J:250031
 
First Author: Kodama S
Year: 2016
Journal: Sci Rep
Title: Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice.
Volume: 6
Pages: 21211
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Publication
29272356 | J:257425
First Author: Kim DS
Year: 2018
Journal: Endocrinology
Title: GRP94 Is an Essential Regulator of Pancreatic β-Cell Development, Mass, and Function in Male Mice.
Volume: 159
Issue: 2
Pages: 1062-1073
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Publication
23863477 | J:199303
First Author: Diaferia GR
Year: 2013
Journal: Development
Title: β1 integrin is a crucial regulator of pancreatic β-cell expansion.
Volume: 140
Issue: 16
Pages: 3360-72
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Publication
15741321 | J:96329
First Author: Ladher RK
Year: 2005
Journal: Genes Dev
Title: FGF8 initiates inner ear induction in chick and mouse.
Volume: 19
Issue: 5
Pages: 603-13
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Publication
8967950 | J:37450
First Author: Studer M
Year: 1996
Journal: Nature
Title: Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1.
Volume: 384
Issue: 6610
Pages: 630-4
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Publication
15367676 | J:93020
First Author: Remacle S
Year: 2004
Journal: Mol Cell Biol
Title: Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo.
Volume: 24
Issue: 19
Pages: 8567-75
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Publication
17141632 | J:144661
First Author: Zhang W
Year: 2006
Journal: Cell Metab
Title: PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
Volume: 4
Issue: 6
Pages: 491-7
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Publication
30886905 | J:278104
 
First Author: Acebedo AR
Year: 2019
Journal: Commun Biol
Title: Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice.
Volume: 2
Pages: 95
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Publication
20025861 | J:157959
First Author: Wang S
Year: 2010
Journal: Dev Biol
Title: Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas.
Volume: 339
Issue: 1
Pages: 26-37
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Publication
16964608 | J:113424
First Author: Dichmann DS
Year: 2006
Journal: Dev Dyn
Title: Analysis of pancreatic endocrine development in GDF11-deficient mice.
Volume: 235
Issue: 11
Pages: 3016-25
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Publication
37536498 | J:339475
 
First Author: Toren E
Year: 2023
Journal: Mol Metab
Title: The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity.
Volume: 76
Pages: 101785
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Publication
16766712 | J:154438
 
First Author: Cobos I
Year: 2006
Journal: Cereb Cortex
Title: Cellular patterns of transcription factor expression in developing cortical interneurons.
Volume: 16 Suppl 1
Pages: i82-8
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Publication
27398620 | J:236317
First Author: Bader E
Year: 2016
Journal: Nature
Title: Identification of proliferative and mature β-cells in the islets of Langerhans.
Volume: 535
Issue: 7612
Pages: 430-4
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Publication
39379383 | J:355262
First Author: Kadhim AZ
Year: 2024
Journal: Nat Commun
Title: Transcriptional coactivator MED15 is required for beta cell maturation.
Volume: 15
Issue: 1
Pages: 8711
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Publication
34255394 | J:313969
First Author: Alcantara MC
Year: 2021
Journal: Congenit Anom (Kyoto)
Title: Stage-dependent function of Wnt5a during male external genitalia development.
Volume: 61
Issue: 6
Pages: 212-219
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Publication
33852861 | J:308553
First Author: Akerman I
Year: 2021
Journal: Cell Rep
Title: Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene.
Volume: 35
Issue: 2
Pages: 108981
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Publication
10354604 | J:56607
First Author: Fekete DM
Year: 1999
Journal: Trends Neurosci
Title: Development of the vertebrate ear: insights from knockouts and mutants.
Volume: 22
Issue: 6
Pages: 263-9
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Publication
11880356 | J:74910
First Author: Theil T
Year: 2002
Journal: Development
Title: Requirement for downregulation of kreisler during late patterning of the hindbrain.
Volume: 129
Issue: 6
Pages: 1477-85
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Publication
14517998 | J:85919
First Author: Wright TJ
Year: 2003
Journal: Dev Dyn
Title: Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development.
Volume: 228
Issue: 2
Pages: 267-72
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Publication
39627229 | J:359191
First Author: Lin HH
Year: 2024
Journal: Nat Commun
Title: Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFA.
Volume: 15
Issue: 1
Pages: 10537
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Publication
28580283 | J:301635
First Author: Bastidas-Ponce A
Year: 2017
Journal: Mol Metab
Title: Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells.
Volume: 6
Issue: 6
Pages: 524-534
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Publication
38958700 | J:355694
First Author: Davidson RK
Year: 2024
Journal: Diabetologia
Title: The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo.
Volume: 67
Issue: 10
Pages: 2275-2288
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Publication
9628487 | -
First Author: Rupert PB
Year: 1998
Journal: Nat Struct Biol
Title: A new DNA-binding motif in the Skn-1 binding domain-DNA complex.
Volume: 5
Issue: 6
Pages: 484-91
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Publication
11477108 | J:71808
First Author: Swain PK
Year: 2001
Journal: J Biol Chem
Title: Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors.
Volume: 276
Issue: 39
Pages: 36824-30
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Protein
Q07279
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
D3Z224
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
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Protein
A0A0R4J0Y5
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Publication
19476513 | J:155649
First Author: Peng S
Year: 2009
Journal: Immunology
Title: c-Maf increases apoptosis in peripheral CD8 cells by transactivating Caspase 6.
Volume: 127
Issue: 2
Pages: 267-78
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Publication
18929642 | J:143576
First Author: Cheng G
Year: 2008
Journal: Free Radic Biol Med
Title: Identification and characterization of VPO1, a new animal heme-containing peroxidase.
Volume: 45
Issue: 12
Pages: 1682-94
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