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Search results 1801 to 1900 out of 2672 for Mapt

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Type Details Score
Publication
38513667 | J:347663
     
First Author: Zhang D
Year: 2024
Journal: Neuron
Title: P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy.
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Publication
36907286 | J:351751
 
First Author: Lee HJ
Year: 2023
Journal: Pharmacol Res
Title: Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
Volume: 190
Pages: 106725
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Publication
32380752 | J:291917
 
First Author: Maron R
Year: 2020
Journal: Int J Mol Sci
Title: Peptide Interference with APP and Tau Association: Relevance to Alzheimer's Disease Amelioration.
Volume: 21
Issue: 9
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Publication
33709472 | J:304378
First Author: Lee HJ
Year: 2021
Journal: Aging Cell
Title: Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease.
Volume: 20
Issue: 3
Pages: e13332
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Publication
35944999 | J:355382
First Author: Guo T
Year: 2022
Journal: J Neurosci
Title: Downregulating PTBP1 Fails to Convert Astrocytes into Hippocampal Neurons and to Alleviate Symptoms in Alzheimer's Mouse Models.
Volume: 42
Issue: 38
Pages: 7309-7317
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Publication
38489190 | J:355489
First Author: Zhong P
Year: 2024
Journal: J Alzheimers Dis
Title: Distinct and Convergent Alterations of Entorhinal Cortical Circuits in Two Mouse Models for Alzheimer's Disease and Related Disorders.
Volume: 98
Issue: 3
Pages: 1121-1131
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Publication
28345579 | J:355618
 
First Author: Zhang Z
Year: 2017
Journal: Nat Commun
Title: Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Volume: 8
Pages: 14740
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Publication
31929163 | J:355624
First Author: Ano Y
Year: 2020
Journal: J Alzheimers Dis
Title: β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline.
Volume: 73
Issue: 4
Pages: 1331-1342
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Publication
38884283 | J:360714
First Author: Yao Y
Year: 2024
Journal: Alzheimers Dement
Title: A small-molecule microtubule-stabilizing agent safely reduces Aβ plaque and tau pathology in transgenic mouse models of Alzheimer's disease.
Volume: 20
Issue: 7
Pages: 4540-4558
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Publication
39434878 | J:359173
 
First Author: Lee HJ
Year: 2024
Journal: Front Immunol
Title: Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of AD.
Volume: 15
Pages: 1421455
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Publication
39326823 | J:355386
 
First Author: Chongtham A
Year: 2024
Journal: Exp Neurol
Title: Common and divergent pathways in early stages of glutamate and tau-mediated toxicities in neurodegeneration.
Volume: 382
Pages: 114967
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Publication
30487735 | J:351264
 
First Author: Romero-Molina C
Year: 2018
Journal: Front Cell Neurosci
Title: Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Volume: 12
Pages: 421
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Publication
34019997 | J:311276
 
First Author: Vautheny A
Year: 2021
Journal: Neurobiol Dis
Title: THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency.
Volume: 155
Pages: 105398
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Publication
21807097 | J:178562
First Author: Chong SA
Year: 2011
Journal: Neurobiol Dis
Title: Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study.
Volume: 44
Issue: 3
Pages: 284-91
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Publication
31866856 | J:288913
 
First Author: Samaey C
Year: 2019
Journal: Front Aging Neurosci
Title: Early Cognitive and Behavioral Deficits in Mouse Models for Tauopathy and Alzheimer's Disease.
Volume: 11
Pages: 335
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Publication
32653674 | J:297600
 
First Author: Detrez JR
Year: 2020
Journal: Neurobiol Dis
Title: Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice.
Volume: 143
Pages: 105011
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Publication
24704314 | J:212120
 
First Author: Crespo-Biel N
Year: 2014
Journal: Neurobiol Dis
Title: Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L×GSK3β mice by delaying brainstem tauopathy.
Volume: 67
Pages: 119-32
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Publication
36198316 | J:330567
First Author: Yan Y
Year: 2022
Journal: Cell
Title: X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.
Volume: 185
Issue: 21
Pages: 3913-3930.e19
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Publication
34069029 | J:311295
 
First Author: Zampar S
Year: 2021
Journal: Int J Mol Sci
Title: Characterization of a Mouse Model of Alzheimer's Disease Expressing Aβ4-42 and Human Mutant Tau.
Volume: 22
Issue: 10
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Publication
29059326 | J:285786
First Author: Woerman AL
Year: 2017
Journal: JAMA Neurol
Title: Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.
Volume: 74
Issue: 12
Pages: 1464-1472
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Publication
38657612 | J:355381
First Author: Li Y
Year: 2024
Journal: Cell Metab
Title: Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.
Volume: 36
Issue: 6
Pages: 1351-1370.e8
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Publication
29088368 | J:256289
First Author: Nguyen APT
Year: 2018
Journal: Hum Mol Genet
Title: G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.
Volume: 27
Issue: 1
Pages: 120-134
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Publication
28912154 | J:253019
First Author: Seo J
Year: 2017
Journal: J Neurosci
Title: Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.
Volume: 37
Issue: 41
Pages: 9917-9924
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Publication
39241778 | J:354801
     
First Author: McGregor JN
Year: 2024
Journal: Neuron
Title: Failure in a population: Tauopathy disrupts homeostatic set-points in emergent dynamics despite stability in the constituent neurons.
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Publication
36634180 | J:343013
First Author: Seo DO
Year: 2023
Journal: Science
Title: ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy.
Volume: 379
Issue: 6628
Pages: eadd1236
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Publication
25471585 | J:218742
First Author: Warmus BA
Year: 2014
Journal: J Neurosci
Title: Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.
Volume: 34
Issue: 49
Pages: 16482-95
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Publication
31925534 | J:310496
First Author: Ando K
Year: 2020
Journal: Acta Neuropathol
Title: Picalm reduction exacerbates tau pathology in a murine tauopathy model.
Volume: 139
Issue: 4
Pages: 773-789
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Strain
MGI:6369613 | B6(SJL)-Apoe<em2(APOE*)Adiuj> Tc(HSA17)1Mdk App<em1Adiuj>/AdiujJ
Attribute String: endonuclease-mediated mutation, mutant strain
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Publication
27297240 | J:263643
First Author: Bondulich MK
Year: 2016
Journal: Brain
Title: Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate.
Volume: 139
Issue: Pt 8
Pages: 2290-306
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Publication
28917666 | J:258060
 
First Author: Tamagnini F
Year: 2017
Journal: Neurobiol Aging
Title: Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein.
Volume: 60
Pages: 44-56
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Genotype
Genotype
Symbol: Mapt/Mapt<+> Mecp2/Mecp2<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/? Tg(Thy1-MAPT)183Gotz/?
Background: B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mapt/Mapt Tg(Thy1-MAPT*)30Schd/?
Background: involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pitx2/Pitx2 Tg(Nes-cre)1Kln/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPV717F)109Ili/? Tg(Prnp-MAPT*P301S)PS19Vle/?
Background: involves: C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-MAPT*K280,-luc)#Eman/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? Tg(Prnp-MAPT*P301S)PS19Vle/?
Background: B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Prnp-MAPT*P301S)PS19Vle
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-MAPT*A152T)L1Lms/?
Background: B6.Cg-Tg(Camk2a-tTA)1Mmay Tg(tetO-MAPT*A152T)L1Lms
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hprt1/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Mapt/Mapt Prnp/Prnp
Background: B6.Cg-Prnp Mapt App
Zygosity: cx
Has Mutant Allele: true
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Publication
28978354 | J:274036
First Author: Eskandari-Sedighi G
Year: 2017
Journal: Mol Neurodegener
Title: The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.
Volume: 12
Issue: 1
Pages: 72
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Publication
30659012 | J:276927
First Author: Goodwin LO
Year: 2019
Journal: Genome Res
Title: Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.
Volume: 29
Issue: 3
Pages: 494-505
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Publication
27896923 | J:239960
First Author: Li JG
Year: 2017
Journal: Aging Cell
Title: Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.
Volume: 16
Issue: 2
Pages: 273-280
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Publication
21898763 | J:181058
First Author: Skidmore JM
Year: 2012
Journal: Genesis
Title: A novel TaulacZ allele reveals a requirement for Pitx2 in formation of the mammillothalamic tract.
Volume: 50
Issue: 1
Pages: 67-73
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Publication
25930235 | J:224493
First Author: Shibuya Y
Year: 2015
Journal: Neurobiol Aging
Title: Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
Volume: 36
Issue: 7
Pages: 2248-2259
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Publication
16845469 | J:110604
First Author: Ohtoshi A
Year: 2006
Journal: Mamm Genome
Title: Generation and maintenance of Dmbx1 gene-targeted mutant alleles.
Volume: 17
Issue: 7
Pages: 744-50
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Publication
30135302 | J:315628
 
First Author: Wang ZH
Year: 2018
Journal: JCI Insight
Title: BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.
Volume: 3
Issue: 16
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Publication
21107132 | J:357505
First Author: Philips T
Year: 2010
Journal: J Neuropathol Exp Neurol
Title: Microglial upregulation of progranulin as a marker of motor neuron degeneration.
Volume: 69
Issue: 12
Pages: 1191-200
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Publication
32795415 | J:328941
First Author: Ndoja A
Year: 2020
Journal: Cell
Title: Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Volume: 182
Issue: 5
Pages: 1156-1169.e12
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Publication
22623685 | J:184975
First Author: Hurtado DE
Year: 2012
Journal: J Neurosci
Title: Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.
Volume: 32
Issue: 21
Pages: 7392-402
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Publication
37337279 | J:348690
First Author: Williams T
Year: 2023
Journal: Acta Neuropathol Commun
Title: Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Volume: 11
Issue: 1
Pages: 99
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Publication
35440098 | J:338335
First Author: Williams T
Year: 2022
Journal: Acta Neuropathol Commun
Title: Impact of APOE genotype on prion-type propagation of tauopathy.
Volume: 10
Issue: 1
Pages: 57
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Publication
37863057 | J:342239
First Author: Koutsodendris N
Year: 2023
Journal: Cell Rep
Title: APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release.
Volume: 42
Issue: 10
Pages: 113252
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Publication
37118426 | J:338450
First Author: Koutsodendris N
Year: 2023
Journal: Nat Aging
Title: Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits.
Volume: 3
Issue: 3
Pages: 275-296
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Publication
35987206 | J:329976
First Author: Adaikkan C
Year: 2022
Journal: Neuron
Title: Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration.
Volume: 110
Issue: 19
Pages: 3091-3105.e9
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Publication
18199773 | J:131379
First Author: Mocanu MM
Year: 2008
Journal: J Neurosci
Title: The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.
Volume: 28
Issue: 3
Pages: 737-48
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Publication
30559478 | J:271514
First Author: Klein HU
Year: 2019
Journal: Nat Neurosci
Title: Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.
Volume: 22
Issue: 1
Pages: 37-46
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Publication
21325519 | J:169532
First Author: Sydow A
Year: 2011
Journal: J Neurosci
Title: Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
Volume: 31
Issue: 7
Pages: 2511-25
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Publication
32778793 | J:298251
First Author: Park L
Year: 2020
Journal: Nat Neurosci
Title: Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration.
Volume: 23
Issue: 9
Pages: 1079-1089
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Publication
37774679 | J:355379
First Author: Dileep V
Year: 2023
Journal: Cell
Title: Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration.
Volume: 186
Issue: 20
Pages: 4404-4421.e20
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Publication
34670118 | J:355478
 
First Author: Ramirez P
Year: 2022
Journal: Prog Neurobiol
Title: Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system.
Volume: 208
Pages: 102181
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Publication
33125873 | J:300552
First Author: Tagai K
Year: 2021
Journal: Neuron
Title: High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies.
Volume: 109
Issue: 1
Pages: 42-58.e8
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Publication
11487626 | J:70838
First Author: Ishihara T
Year: 2001
Journal: J Neurosci
Title: Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments.
Volume: 21
Issue: 16
Pages: 6026-35
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Publication
37640701 | J:340856
First Author: Nutma E
Year: 2023
Journal: Nat Commun
Title: Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Volume: 14
Issue: 1
Pages: 5247
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Publication
16854430 | J:114872
First Author: Duce JA
Year: 2006
Journal: J Mol Biol
Title: Linker histone H1 binds to disease associated amyloid-like fibrils.
Volume: 361
Issue: 3
Pages: 493-505
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Publication
17764962 | J:134804
First Author: Parachikova A
Year: 2007
Journal: Neurobiol Dis
Title: Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease.
Volume: 28
Issue: 2
Pages: 143-53
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Publication
18378358 | J:155158
First Author: Weissman L
Year: 2009
Journal: Neurobiol Aging
Title: DNA base excision repair activities in mouse models of Alzheimer's disease.
Volume: 30
Issue: 12
Pages: 2080-1
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Publication
25073087 | J:218336
 
First Author: Köhler C
Year: 2014
Journal: Neurobiol Dis
Title: Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis.
Volume: 71
Pages: 169-79
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Publication
23294633 | J:203370
First Author: Köhler C
Year: 2013
Journal: Neurobiol Aging
Title: Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Volume: 34
Issue: 5
Pages: 1369-79
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Publication
28704727 | J:326004
 
First Author: Rojo AI
Year: 2017
Journal: Redox Biol
Title: NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.
Volume: 13
Pages: 444-451
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Publication
26468204 | J:226690
First Author: Caccamo A
Year: 2015
Journal: J Neurosci
Title: Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.
Volume: 35
Issue: 41
Pages: 14042-56
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Publication
35649351 | J:337819
First Author: Dhandapani R
Year: 2022
Journal: Cell Rep
Title: Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease.
Volume: 39
Issue: 9
Pages: 110883
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Publication
37952157 | J:343258
First Author: Matthews I
Year: 2023
Journal: Cell Rep
Title: Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease.
Volume: 42
Issue: 11
Pages: 113436
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Publication
34593029 | J:311553
First Author: Soto-Faguás CM
Year: 2021
Journal: Acta Neuropathol Commun
Title: Loss of presenilin function enhances tau phosphorylation and aggregation in mice.
Volume: 9
Issue: 1
Pages: 162
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Publication
36688823 | J:338758
First Author: Schnöder L
Year: 2023
Journal: FASEB J
Title: Deficiency of IKKβ in neurons ameliorates Alzheimer's disease pathology in APP- and tau-transgenic mice.
Volume: 37
Issue: 2
Pages: e22778
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Publication
34118085 | J:310781
First Author: Schnöder L
Year: 2021
Journal: FASEB J
Title: P38α-MAPK phosphorylates Snapin and reduces Snapin-mediated BACE1 transportation in APP-transgenic mice.
Volume: 35
Issue: 7
Pages: e21691
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Publication
32475008 | J:303141
First Author: Schnöder L
Year: 2020
Journal: FASEB J
Title: Neuronal deficiency of p38α-MAPK ameliorates symptoms and pathology of APP or Tau-transgenic Alzheimer's mouse models.
Volume: 34
Issue: 7
Pages: 9628-9649
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Publication
34851693 | J:321548
First Author: Sayed FA
Year: 2021
Journal: Sci Transl Med
Title: AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Volume: 13
Issue: 622
Pages: eabe3947
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Publication
33762004 | J:311727
First Author: Xia F
Year: 2021
Journal: Acta Neuropathol Commun
Title: Early alterations of neurovascular unit in the retina in mouse models of tauopathy.
Volume: 9
Issue: 1
Pages: 51
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Publication
28285415 | J:264962
First Author: Olszewski RT
Year: 2017
Journal: Neurochem Res
Title: NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.
Volume: 42
Issue: 9
Pages: 2646-2657
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Publication
25763777 | J:303695
First Author: van Eersel J
Year: 2015
Journal: Neuropathol Appl Neurobiol
Title: Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration.
Volume: 41
Issue: 7
Pages: 906-25
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Publication
20869593 | J:167861
First Author: Min SW
Year: 2010
Journal: Neuron
Title: Acetylation of tau inhibits its degradation and contributes to tauopathy.
Volume: 67
Issue: 6
Pages: 953-66
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Publication
35910789 | J:327114
First Author: Parekh P
Year: 2022
Journal: Theranostics
Title: A surrogate marker for very early-stage tau pathology is detectable by molecular magnetic resonance imaging.
Volume: 12
Issue: 12
Pages: 5504-5521
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Publication
34972522 | J:348533
First Author: Ou W
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