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Search results 1801 to 1900 out of 2287 for Mx1

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Type Details Score
Publication
First Author: Ribezzo F
Year: 2019
Journal: Leukemia
Title: Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome.
Volume: 33
Issue: 7
Pages: 1759-1772
Publication
First Author: Fu W
Year: 2012
Journal: Nat Immunol
Title: A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Volume: 13
Issue: 10
Pages: 972-80
Publication
First Author: Coury F
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts.
Volume: 110
Issue: 6
Pages: 2163-8
Publication
First Author: Wang Z
Year: 2009
Journal: Blood
Title: Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement.
Volume: 113
Issue: 20
Pages: 4856-65
Publication
First Author: Hara T
Year: 2006
Journal: Nature
Title: Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice.
Volume: 441
Issue: 7095
Pages: 885-9
Publication
First Author: Kalim KW
Year: 2017
Journal: PLoS One
Title: mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.
Volume: 12
Issue: 8
Pages: e0183266
Publication
First Author: Guo H
Year: 2018
Journal: J Immunol
Title: Progression from the Common Lymphoid Progenitor to B/Myeloid PreproB and ProB Precursors during B Lymphopoiesis Requires C/EBPα.
Volume: 201
Issue: 6
Pages: 1692-1704
Publication
First Author: Canli Ö
Year: 2016
Journal: Blood
Title: Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
Volume: 127
Issue: 1
Pages: 139-48
Publication
First Author: Jiang Y
Year: 2019
Journal: Blood
Title: AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia.
Volume: 134
Issue: 24
Pages: 2183-2194
Publication  
First Author: Lei H
Year: 2021
Journal: J Biol Chem
Title: Dysregulation of intercellular signaling by MOF deletion leads to liver injury.
Volume: 296
Pages: 100235
Publication  
First Author: Maurice NJ
Year: 2021
Journal: JCI Insight
Title: Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8+ T cells.
Volume: 6
Issue: 13
Publication
First Author: Menzl I
Year: 2019
Journal: Nat Commun
Title: A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.
Volume: 10
Issue: 1
Pages: 4741
Publication
First Author: Saez B
Year: 2014
Journal: Blood
Title: Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Volume: 124
Issue: 19
Pages: 2937-47
Publication
First Author: Khandanpour C
Year: 2010
Journal: Blood
Title: Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells.
Volume: 116
Issue: 24
Pages: 5149-61
Publication
First Author: Starck J
Year: 2010
Journal: Blood
Title: Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.
Volume: 116
Issue: 23
Pages: 4795-805
Publication
First Author: Philips ST
Year: 2014
Journal: Oncogene
Title: Toward a therapeutic reduction of imatinib refractory myeloproliferative neoplasm-initiating cells.
Volume: 33
Issue: 46
Pages: 5379-90
Publication
First Author: Loizou JI
Year: 2009
Journal: J Immunol
Title: Histone acetyltransferase cofactor Trrap is essential for maintaining the hematopoietic stem/progenitor cell pool.
Volume: 183
Issue: 10
Pages: 6422-31
Publication
First Author: Bailly AL
Year: 2020
Journal: J Immunol
Title: GRASP55 Is Dispensable for Normal Hematopoiesis but Necessary for Myc-Dependent Leukemic Growth.
Volume: 204
Issue: 10
Pages: 2685-2696
Publication
First Author: Wu Y
Year: 2016
Journal: J Cell Sci
Title: Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.
Volume: 129
Issue: 19
Pages: 3675-3684
Publication
First Author: Song R
Year: 2008
Journal: J Exp Med
Title: Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development.
Volume: 205
Issue: 11
Pages: 2525-36
Publication
First Author: Kalaszczynska I
Year: 2009
Journal: Cell
Title: Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
Volume: 138
Issue: 2
Pages: 352-65
Publication
First Author: Hui L
Year: 2007
Journal: Nat Genet
Title: p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway.
Volume: 39
Issue: 6
Pages: 741-9
Publication
First Author: Mupo A
Year: 2013
Journal: Leukemia
Title: A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice.
Volume: 27
Issue: 9
Pages: 1917-20
Publication
First Author: Hur KY
Year: 2012
Journal: J Exp Med
Title: IRE1α activation protects mice against acetaminophen-induced hepatotoxicity.
Volume: 209
Issue: 2
Pages: 307-18
Publication
First Author: Sasca D
Year: 2014
Journal: Blood
Title: SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia.
Volume: 124
Issue: 1
Pages: 121-33
Publication
First Author: Liu F
Year: 2020
Journal: Nucleic Acids Res
Title: PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2.
Volume: 48
Issue: 6
Pages: 2956-2968
Publication
First Author: Kahlfuss S
Year: 2020
Journal: EMBO Mol Med
Title: STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.
Volume: 12
Issue: 8
Pages: e11592
Publication
First Author: Roebroek AJ
Year: 2004
Journal: J Biol Chem
Title: Limited redundancy of the proprotein convertase furin in mouse liver.
Volume: 279
Issue: 51
Pages: 53442-50
Publication
First Author: Malik N
Year: 2019
Journal: Sci Rep
Title: mTORC1 activity is essential for erythropoiesis and B cell lineage commitment.
Volume: 9
Issue: 1
Pages: 16917
Publication
First Author: Byrnes JR
Year: 2015
Journal: Blood
Title: Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking.
Volume: 126
Issue: 16
Pages: 1940-8
Publication
First Author: Forand A
Year: 2013
Journal: Blood
Title: EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro.
Volume: 121
Issue: 4
Pages: 666-78
Publication
First Author: Kudo T
Year: 2013
Journal: Blood
Title: C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes.
Volume: 122
Issue: 9
Pages: 1649-57
Publication  
First Author: Bluemn T
Year: 2021
Journal: Exp Hematol
Title: Arid2 regulates hematopoietic stem cell differentiation in normal hematopoiesis.
Volume: 94
Pages: 37-46
Publication
First Author: Xu L
Year: 2020
Journal: Nat Cell Biol
Title: Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions.
Volume: 22
Issue: 10
Pages: 1162-1169
Publication
First Author: Dakic A
Year: 2005
Journal: J Exp Med
Title: PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.
Volume: 201
Issue: 9
Pages: 1487-502
Publication
First Author: Welner RS
Year: 2013
Journal: Blood
Title: C/EBPα is required for development of dendritic cell progenitors.
Volume: 121
Issue: 20
Pages: 4073-81
Publication
First Author: Wirth KG
Year: 2004
Journal: Genes Dev
Title: Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation.
Volume: 18
Issue: 1
Pages: 88-98
Publication
First Author: Tesio M
Year: 2015
Journal: J Exp Med
Title: Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.
Volume: 212
Issue: 4
Pages: 525-38
Publication
First Author: Nayak RC
Year: 2019
Journal: Nat Commun
Title: The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.
Volume: 10
Issue: 1
Pages: 46
Publication
First Author: Pelanda R
Year: 2002
Journal: Genesis
Title: Cre recombinase-controlled expression of the mb-1 allele.
Volume: 32
Issue: 2
Pages: 154-7
Publication
First Author: Huebener P
Year: 2015
Journal: J Clin Invest
Title: The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis.
Volume: 125
Issue: 2
Pages: 539-50
Publication  
First Author: Ge G
Year: 2024
Journal: J Clin Invest
Title: Targeting lysine demethylase 6B ameliorates ASXL1 truncation-mediated myeloid malignancies in preclinical models.
Volume: 134
Issue: 1
Publication
First Author: Kunimoto H
Year: 2018
Journal: Cancer Cell
Title: Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.
Volume: 33
Issue: 1
Pages: 44-59.e8
Publication
First Author: Meyer SE
Year: 2016
Journal: Cancer Discov
Title: DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.
Volume: 6
Issue: 5
Pages: 501-15
Publication
First Author: Onoyama I
Year: 2011
Journal: J Clin Invest
Title: Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.
Volume: 121
Issue: 1
Pages: 342-54
Publication
First Author: Kong G
Year: 2016
Journal: Leukemia
Title: Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis.
Volume: 30
Issue: 7
Pages: 1542-51
Publication
First Author: Geng Y
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Kinase-independent function of E-type cyclins in liver cancer.
Volume: 115
Issue: 5
Pages: 1015-1020
Publication
First Author: Booth CAG
Year: 2018
Journal: Cancer Cell
Title: Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Volume: 33
Issue: 2
Pages: 274-291.e8
Publication
First Author: Mallaney C
Year: 2019
Journal: Leukemia
Title: Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis.
Volume: 33
Issue: 10
Pages: 2506-2521
Publication
First Author: Kleppe M
Year: 2017
Journal: Cell Stem Cell
Title: Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.
Volume: 21
Issue: 4
Pages: 489-501.e7
Publication      
First Author: Loberg MA
Year: 2019
Journal: Leukemia
Title: Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis.
Publication
First Author: Bluemn T
Year: 2022
Journal: Leukemia
Title: Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in MLL-AF9 leukemogenesis.
Volume: 36
Issue: 4
Pages: 946-955
Publication
First Author: Gough DJ
Year: 2014
Journal: Blood
Title: STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.
Volume: 124
Issue: 14
Pages: 2252-61
Publication
First Author: Liu L
Year: 2013
Journal: Genesis
Title: Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2.
Volume: 51
Issue: 8
Pages: 587-95
Publication
First Author: Mancini E
Year: 2012
Journal: EMBO J
Title: FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.
Volume: 31
Issue: 2
Pages: 351-65
Publication
First Author: Lotinun S
Year: 2013
Journal: J Clin Invest
Title: Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation.
Volume: 123
Issue: 2
Pages: 666-81
Publication
First Author: Nakano Y
Year: 2022
Journal: Commun Biol
Title: Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice.
Volume: 5
Issue: 1
Pages: 85
Publication
First Author: Aranda-Orgilles B
Year: 2016
Journal: Cell Stem Cell
Title: MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.
Volume: 19
Issue: 6
Pages: 784-799
Publication
First Author: Pajerowski AG
Year: 2010
Journal: Blood
Title: Adult hematopoietic stem cells require NKAP for maintenance and survival.
Volume: 116
Issue: 15
Pages: 2684-93
Publication
First Author: Bär C
Year: 2016
Journal: Blood
Title: Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia.
Volume: 127
Issue: 14
Pages: 1770-9
Publication
First Author: Fang J
Year: 2018
Journal: Cell Rep
Title: TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis.
Volume: 22
Issue: 5
Pages: 1250-1262
Publication
First Author: Cai X
Year: 2011
Journal: PLoS One
Title: Runx1 loss minimally impacts long-term hematopoietic stem cells.
Volume: 6
Issue: 12
Pages: e28430
Publication
First Author: Chatterjee A
Year: 2014
Journal: Cell Rep
Title: Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.
Volume: 9
Issue: 4
Pages: 1333-48
Publication
First Author: Nagamachi A
Year: 2014
Journal: PLoS One
Title: Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function.
Volume: 9
Issue: 1
Pages: e87425
Publication
First Author: Chen S
Year: 2022
Journal: Cancer Discov
Title: Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.
Volume: 12
Issue: 10
Pages: 2434-2453
Publication
First Author: Obeng EA
Year: 2016
Journal: Cancer Cell
Title: Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.
Volume: 30
Issue: 3
Pages: 404-417
Publication
First Author: Zhang H
Year: 2013
Journal: Cancer Cell
Title: Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.
Volume: 24
Issue: 5
Pages: 575-88
Publication
First Author: Viny AD
Year: 2015
Journal: J Exp Med
Title: Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.
Volume: 212
Issue: 11
Pages: 1819-32
Publication
First Author: Zhao J
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes.
Volume: 114
Issue: 2
Pages: E142-E151
Publication
First Author: Kubovcakova L
Year: 2013
Journal: Blood
Title: Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.
Volume: 121
Issue: 7
Pages: 1188-99
Publication
First Author: Hosoya T
Year: 2009
Journal: J Exp Med
Title: GATA-3 is required for early T lineage progenitor development.
Volume: 206
Issue: 13
Pages: 2987-3000
Publication
First Author: Chang YI
Year: 2015
Journal: Leukemia
Title: Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.
Volume: 29
Issue: 9
Pages: 1847-56
Publication
First Author: Bereshchenko O
Year: 2012
Journal: Haematologica
Title: Pontin is essential for murine hematopoietic stem cell survival.
Volume: 97
Issue: 9
Pages: 1291-4
Publication
First Author: Akada H
Year: 2012
Journal: Haematologica
Title: Erythroid lineage-restricted expression of Jak2V617F is sufficient to induce a myeloproliferative disease in mice.
Volume: 97
Issue: 9
Pages: 1389-93
Publication
First Author: Kalaitzidis D
Year: 2017
Journal: J Clin Invest
Title: Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.
Volume: 127
Issue: 4
Pages: 1405-1413
Publication
First Author: Flick MJ
Year: 2013
Journal: Blood
Title: Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia.
Volume: 121
Issue: 10
Pages: 1783-94
Publication  
First Author: Wong JC
Year: 2020
Journal: JCI Insight
Title: KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.
Volume: 5
Issue: 21
Publication
First Author: Goodwin CB
Year: 2014
Journal: Blood
Title: PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.
Volume: 123
Issue: 18
Pages: 2838-42
Publication
First Author: Muto T
Year: 2022
Journal: Cell Stem Cell
Title: TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.
Volume: 29
Issue: 2
Pages: 298-314.e9
Publication
First Author: Chua BA
Year: 2023
Journal: Cell Stem Cell
Title: Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis.
Volume: 30
Issue: 4
Pages: 460-472.e6
Publication
First Author: Poulos MG
Year: 2013
Journal: Cell Rep
Title: Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis.
Volume: 4
Issue: 5
Pages: 1022-34
Publication
First Author: Chan IT
Year: 2006
Journal: Blood
Title: Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.
Volume: 108
Issue: 5
Pages: 1708-15
Publication
First Author: Ames K
Year: 2023
Journal: Sci Adv
Title: PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells.
Volume: 9
Issue: 8
Pages: eade8222
Publication  
First Author: Murakami S
Year: 2017
Journal: Mol Cell Biol
Title: NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells.
Volume: 37
Issue: 19
Publication
First Author: Sankaran VG
Year: 2009
Journal: Nature
Title: Developmental and species-divergent globin switching are driven by BCL11A.
Volume: 460
Issue: 7259
Pages: 1093-7
Publication
First Author: Izzo F
Year: 2020
Journal: Nat Genet
Title: DNA methylation disruption reshapes the hematopoietic differentiation landscape.
Volume: 52
Issue: 4
Pages: 378-387
Publication
First Author: Tanaka A
Year: 2022
Journal: Blood
Title: Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.
Volume: 140
Issue: 8
Pages: 875-888
Publication  
First Author: Bai Q
Year: 2023
Journal: Endocrinology
Title: Hepatic but not Intestinal FBP1 Is Required for Fructose Metabolism and Tolerance.
Volume: 164
Issue: 6
Publication
First Author: Wein MN
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Control of bone resorption in mice by Schnurri-3.
Volume: 109
Issue: 21
Pages: 8173-8
Publication
First Author: Richter LE
Year: 2019
Journal: Mol Cancer Res
Title: HDAC1 Is a Required Cofactor of CBFβ-SMMHC and a Potential Therapeutic Target in Inversion 16 Acute Myeloid Leukemia.
Volume: 17
Issue: 6
Pages: 1241-1252
Publication
First Author: Takei H
Year: 2022
Journal: Cancer Sci
Title: Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms.
Volume: 113
Issue: 2
Pages: 597-608
Publication
First Author: Araya R
Year: 2005
Journal: J Cell Sci
Title: Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43.
Volume: 118
Issue: Pt 1
Pages: 27-37
Publication
First Author: Endoh M
Year: 2020
Journal: Cell Rep
Title: A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity.
Volume: 30
Issue: 6
Pages: 1823-1834.e5
Publication
First Author: Gorjestani S
Year: 2011
Journal: J Biol Chem
Title: Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses.
Volume: 286
Issue: 51
Pages: 43651-9
Publication
First Author: Anderson NR
Year: 2023
Journal: Leukemia
Title: Microenvironmental CXCL12 deletion enhances Flt3-ITD acute myeloid leukemia stem cell response to therapy by reducing p38 MAPK signaling.
Volume: 37
Issue: 3
Pages: 560-570
Publication
First Author: Dovey OM
Year: 2017
Journal: Blood
Title: Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.
Volume: 130
Issue: 17
Pages: 1911-1922
Publication
First Author: Li L
Year: 2011
Journal: Nat Immunol
Title: Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.
Volume: 12
Issue: 2
Pages: 129-36
Publication
First Author: Kim E
Year: 2015
Journal: Cancer Cell
Title: SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.
Volume: 27
Issue: 5
Pages: 617-30
Publication
First Author: Mupo A
Year: 2017
Journal: Leukemia
Title: Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.
Volume: 31
Issue: 3
Pages: 720-727
Publication
First Author: Giotopoulos G
Year: 2015
Journal: J Exp Med
Title: A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.
Volume: 212
Issue: 10
Pages: 1551-69