| Type |
Details |
Score |
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang HJ |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds. |
| Volume: |
106 |
| Issue: |
40 |
| Pages: |
16967-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Patti JM |
| Year: |
1993 |
| Journal: |
Biochemistry |
| Title: |
Identification and biochemical characterization of the ligand binding domain of the collagen adhesin from Staphylococcus aureus. |
| Volume: |
32 |
| Issue: |
42 |
| Pages: |
11428-35 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry contains a prealbumin-like fold domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae []. It is also present in Collagen adhesin []and Trypsin-resistant surface T6 protein from Streptococci species. Some members of this family contain an isopeptide bond.This domain is also found in eukaryotic cell surface proteins including Nodal modulators. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Parisi S |
| Year: |
2003 |
| Journal: |
J Cell Biol |
| Title: |
Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. |
| Volume: |
163 |
| Issue: |
2 |
| Pages: |
303-14 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stagner EE |
| Year: |
2009 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
The polycystic kidney disease-related proteins Bicc1 and SamCystin interact. |
| Volume: |
383 |
| Issue: |
1 |
| Pages: |
16-21 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal Edil3/Edil3<+> |
| Background: |
involves: 129S/SvEv * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Acvr1c/Acvr1c<+> Gdf1/Gdf1<+> Nodal/Nodal<+> |
| Background: |
involves: 129 * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Acvr1b/Acvr1b<+> Gdf1/Gdf1<+> Nodal/Nodal<+> |
| Background: |
involves: 129/Sv * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Eomes/Eomes<+> Nodal/Nodal<+> Edil3/Edil3<+> |
| Background: |
involves: 129S/SvEv * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> Edil3/Edil3<+> Tgif1/Tgif1 Tgif2/Tgif2 |
| Background: |
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nodal/Nodal<+> Tgif1/Tgif1 Tgif2/Tgif2 Edil3/Edil3<+> |
| Background: |
involves: 129S/SvEv * C57BL/6J * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Berthet E |
| Year: |
2013 |
| Journal: |
J Orthop Res |
| Title: |
Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization. |
| Volume: |
31 |
| Issue: |
9 |
| Pages: |
1475-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mao M |
| Year: |
2022 |
| Journal: |
Matrix Biol |
| Title: |
Elevated TGFβ signaling contributes to ocular anterior segment dysgenesis in Col4a1 mutant mice. |
| Volume: |
110 |
|
| Pages: |
151-173 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Branyan K |
| Year: |
2023 |
| Journal: |
Matrix Biol |
| Title: |
Elevated TGFβ signaling contributes to cerebral small vessel disease in mouse models of Gould syndrome. |
| Volume: |
115 |
|
| Pages: |
48-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goldstein JA |
| Year: |
2014 |
| Journal: |
Hum Mol Genet |
| Title: |
Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy. |
| Volume: |
23 |
| Issue: |
25 |
| Pages: |
6722-31 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin AH |
| Year: |
2005 |
| Journal: |
J Immunol |
| Title: |
Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. |
| Volume: |
175 |
| Issue: |
1 |
| Pages: |
547-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shaterian A |
| Year: |
2012 |
| Journal: |
Neuropathology |
| Title: |
Non-invasive detection of spatio-temporal activation of SBE and NFAT5 promoters in transgenic reporter mice following stroke. |
| Volume: |
32 |
| Issue: |
2 |
| Pages: |
118-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Luo J |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration. |
| Volume: |
103 |
| Issue: |
48 |
| Pages: |
18326-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zeng HC |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts. |
| Volume: |
8 |
|
| Pages: |
15000 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Giroux M |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling. |
| Volume: |
185 |
| Issue: |
3 |
| Pages: |
1568-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grafe I |
| Year: |
2014 |
| Journal: |
Nat Med |
| Title: |
Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta. |
| Volume: |
20 |
| Issue: |
6 |
| Pages: |
670-5 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(SBE/TK-luc)7Twc/? |
| Background: |
either: (involves: FVB/N) or (involves: C57BL/6 * SJL) |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zic3/? Tg(Nodal-cre)16Hmd/? |
| Background: |
involves: C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Nodal*-cre)#Mku/? |
| Background: |
involves: 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Spiller CM |
| Year: |
2016 |
| Journal: |
Mol Oncol |
| Title: |
Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. |
| Volume: |
10 |
| Issue: |
4 |
| Pages: |
526-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakamura T |
| Year: |
2006 |
| Journal: |
Dev Cell |
| Title: |
Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system. |
| Volume: |
11 |
| Issue: |
4 |
| Pages: |
495-504 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Valentini RP |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
Post-translational processing and renal expression of mouse Indian hedgehog. |
| Volume: |
272 |
| Issue: |
13 |
| Pages: |
8466-73 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
221
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boyle ME |
| Year: |
2001 |
| Journal: |
Neuron |
| Title: |
Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve. |
| Volume: |
30 |
| Issue: |
2 |
| Pages: |
385-97 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
180
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
154
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Millay DP |
| Year: |
2016 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Structure-function analysis of myomaker domains required for myoblast fusion. |
| Volume: |
113 |
| Issue: |
8 |
| Pages: |
2116-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma J |
| Year: |
2005 |
| Journal: |
Carcinogenesis |
| Title: |
Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. |
| Volume: |
26 |
| Issue: |
2 |
| Pages: |
281-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vortkamp A |
| Year: |
1996 |
| Journal: |
Science |
| Title: |
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. |
| Volume: |
273 |
| Issue: |
5275 |
| Pages: |
613-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pathi S |
| Year: |
2001 |
| Journal: |
Mech Dev |
| Title: |
Comparative biological responses to human Sonic, Indian, and Desert hedgehog. |
| Volume: |
106 |
| Issue: |
1-2 |
| Pages: |
107-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen DH |
| Year: |
2015 |
| Journal: |
World J Gastroenterol |
| Title: |
Contactin 1: A potential therapeutic target and biomarker in gastric cancer. |
| Volume: |
21 |
| Issue: |
33 |
| Pages: |
9707-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ranscht B |
| Year: |
1988 |
| Journal: |
J Cell Biol |
| Title: |
Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system. |
| Volume: |
107 |
| Issue: |
4 |
| Pages: |
1561-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang R |
| Year: |
2015 |
| Journal: |
Biomed Pharmacother |
| Title: |
Increased sensitivity of human lung adenocarcinoma cells to cisplatin associated with downregulated contactin-1. |
| Volume: |
71 |
|
| Pages: |
172-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
De Benedictis L |
| Year: |
2006 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Activation profile of the F3/Contactin gene in the developing mouse cerebellum. |
| Volume: |
32 |
| Issue: |
4 |
| Pages: |
403-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bizzoca A |
| Year: |
2012 |
| Journal: |
Dev Biol |
| Title: |
F3/Contactin acts as a modulator of neurogenesis during cerebral cortex development. |
| Volume: |
365 |
| Issue: |
1 |
| Pages: |
133-51 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Contactins are cell adhesion molecules that belong to the immunoglobulin superfamily and are involved in neural development []. They usually consist of six N-terminal Ig domains, four fibronectin type III domains, and a C-terminal glycophosphatidylinositol (GPI)-anchor to the extracellular part of the cell membrane [].Contactin-1 (CNTN1) is expressed by a diversity of neurons and contributes to the formation and function of neuronal connections []. Contactin-1 regulates both myelin formation and organisation of nodal and paranodal domains in the central []and peripheral nervous system []. It plays a relevant role in cerebellar ontogenesis []and cerebral cortex development []. Contactin-1 contributes to the invasion and metastasis of several tumours [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Indian hedgehog protein (IHH, MEROPS identifier C46.003) is important for the development and growth of bone and cartilage in the embryo []. IHH is synthesized as a precursor and activates itself by cleavage of Gly-Cys bond, in which the thiol group of the cysteine is the nucleophile []. This results in the release of the N-terminal effector domain, and no further proteolytic activity takes place. The differentiation of chondrocytes in embryonic mouse limbs, induction of the expression of nodal in the lateral plate mesoderm of early chick embryos, and affinities for hedgehog-binding proteins have been compared for Sonic, Indian and Desert hedgehog proteins []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Proteins in this family include PGAP6 (also known as TMEM8A), NGX6 (also known as TMEM8B) and myomaker (also known as TMEM8C). TMEM8C is embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C-terminal tail. It is essential for myoblast fusion and sufficient to promote fusion of fibroblasts with muscle cells []. TMEM8A and TMEM8B has no fusogenic activity. TMEM8A is a GPI-specific phospholipase A2 involved in Nodal signaling modulation through CRIPTO shedding []. TMEM8B plays a role in cell adhesion modulation in nasopharyngeal carcinoma cells []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng SK |
| Year: |
2004 |
| Journal: |
PLoS Biol |
| Title: |
Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors. |
| Volume: |
2 |
| Issue: |
2 |
| Pages: |
E30 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gli3/Gli3<+> Nodal/Nodal<+> Tgif1/Tgif1 Tgif2/Tgif2 Edil3/Edil3<+> |
| Background: |
involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bukauskas FF |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart. |
| Volume: |
103 |
| Issue: |
25 |
| Pages: |
9726-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brott BK |
| Year: |
2005 |
| Journal: |
Differentiation |
| Title: |
Frodo proteins: modulators of Wnt signaling in vertebrate development. |
| Volume: |
73 |
| Issue: |
7 |
| Pages: |
323-9 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
E-GEOD-66029 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE43194 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen XZ |
| Year: |
2008 |
| Journal: |
FEBS J |
| Title: |
Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton. |
| Volume: |
275 |
| Issue: |
19 |
| Pages: |
4675-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mochizuki T |
| Year: |
1998 |
| Journal: |
Nature |
| Title: |
Cloning of inv, a gene that controls left/right asymmetry and kidney development. |
| Volume: |
395 |
| Issue: |
6698 |
| Pages: |
177-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Watanabe D |
| Year: |
2003 |
| Journal: |
Development |
| Title: |
The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia. |
| Volume: |
130 |
| Issue: |
9 |
| Pages: |
1725-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bamford RN |
| Year: |
2000 |
| Journal: |
Nat Genet |
| Title: |
Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. |
| Volume: |
26 |
| Issue: |
3 |
| Pages: |
365-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shukla A |
| Year: |
2008 |
| Journal: |
Mol Cancer Res |
| Title: |
Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: role in skin carcinogenesis. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
509-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bradley WG |
| Year: |
1977 |
| Journal: |
J Neuropathol Exp Neurol |
| Title: |
The nodes of Ranvier in the nerves of mice with muscular dystrophy. |
| Volume: |
36 |
| Issue: |
5 |
| Pages: |
797-806 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Piedra ME |
| Year: |
1998 |
| Journal: |
Cell |
| Title: |
Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. |
| Volume: |
94 |
| Issue: |
3 |
| Pages: |
319-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Katoh TA |
| Year: |
2023 |
| Journal: |
Science |
| Title: |
Immotile cilia mechanically sense the direction of fluid flow for left-right determination. |
| Volume: |
379 |
| Issue: |
6627 |
| Pages: |
66-71 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Nodal-cre)1Rob/? |
| Background: |
involves: 129S4/SvJaeSor * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(CAG-cat,-lacZ)11Miya/? Tg(Nodal-cre)16Hmd/? |
| Background: |
involves: C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Nodal*-cre)#Mku/? |
| Background: |
involves: 129S4/SvJaeSor |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ibrahim M |
| Year: |
2018 |
| Journal: |
J Immunol |
| Title: |
Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion. |
| Volume: |
200 |
| Issue: |
2 |
| Pages: |
847-856 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Luo J |
| Year: |
2007 |
| Journal: |
J Clin Invest |
| Title: |
Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. |
| Volume: |
117 |
| Issue: |
11 |
| Pages: |
3306-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Geraldes A |
| Year: |
2011 |
| Journal: |
Mol Ecol |
| Title: |
Higher differentiation among subspecies of the house mouse (Mus musculus) in genomic regions with low recombination. |
| Volume: |
20 |
| Issue: |
22 |
| Pages: |
4722-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baker JC |
| Year: |
1997 |
| Journal: |
Curr Opin Genet Dev |
| Title: |
From receptor to nucleus: the Smad pathway. |
| Volume: |
7 |
| Issue: |
4 |
| Pages: |
467-73 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Kingsley DM |
| Year: |
1994 |
| Journal: |
Genes Dev |
| Title: |
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. |
| Volume: |
8 |
| Issue: |
2 |
| Pages: |
133-46 |
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•
•
•
•
|
| Publication |
| First Author: |
ten Dijke P |
| Year: |
1993 |
| Journal: |
Oncogene |
| Title: |
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. |
| Volume: |
8 |
| Issue: |
10 |
| Pages: |
2879-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Massagué J |
| Year: |
1998 |
| Journal: |
Annu Rev Biochem |
| Title: |
TGF-beta signal transduction. |
| Volume: |
67 |
|
| Pages: |
753-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saffman EE |
| Year: |
1998 |
| Journal: |
Mol Cell Biol |
| Title: |
Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C. |
| Volume: |
18 |
| Issue: |
8 |
| Pages: |
4855-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park S |
| Year: |
2016 |
| Journal: |
Development |
| Title: |
A gradient of maternal Bicaudal-C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators. |
| Volume: |
143 |
| Issue: |
5 |
| Pages: |
864-71 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This is a hydrophilic cysteine-rich ligand-binding domain found in both TGF-beta receptor types (type I and II). In both types, this domain posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box [, , ].The Transforming growth factor-beta superfamily of ligands include: bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), anti-mullerian hormone (AMH), activin, nodal and TGF-beta. Signalling begins with the binding of a TGF-beta superfamily ligand to a TGF-beta type II receptors. The type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators [].The receptors for most of the members of this growth factor family are related. They are receptor-type kinases of Ser/Thr type, which have a singletransmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain [, , ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Bicaudal-C (BICC, BICC1 in vertebrates) is an RNA-binding protein with translational repression function []. It is involved in the regulation of embryonic differentiation and plays a role in the regulation of Dvl (Dishevelled) signaling, particularly in the correct cilia orientation and nodal flow generation []. In Drosophila, disruption of BICC can disturb the normal migration direction of the anterior follicle cell of oocytes []. In mammals, mutations in this gene are associated with polycystic kidney disease and it was suggested that the BICC1 protein can indirectly interact with ANKS6 protein (ANKS6 is also associated with polycystic kidney disease) through some protein and RNA intermediates [].BICC1 contains N-terminal K homology RNA-binding vigilin-like repeats and a C-terminal SAM domain. This entry represents the SAM (sterile alpha motif) domain, which is a protein-protein interaction domain []. |
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•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
241
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
241
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meno C |
| Year: |
1997 |
| Journal: |
Genes Cells |
| Title: |
Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. |
| Volume: |
2 |
| Issue: |
8 |
| Pages: |
513-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tamakoshi T |
| Year: |
2006 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice. |
| Volume: |
339 |
| Issue: |
3 |
| Pages: |
932-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McGrath J |
| Year: |
2003 |
| Journal: |
Cell |
| Title: |
Two populations of node monocilia initiate left-right asymmetry in the mouse. |
| Volume: |
114 |
| Issue: |
1 |
| Pages: |
61-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shiratori H |
| Year: |
2014 |
| Journal: |
Dev Biol |
| Title: |
Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb. |
| Volume: |
395 |
| Issue: |
2 |
| Pages: |
331-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kreuzberg MM |
| Year: |
2005 |
| Journal: |
Circ Res |
| Title: |
Functional properties of mouse connexin30.2 expressed in the conduction system of the heart. |
| Volume: |
96 |
| Issue: |
11 |
| Pages: |
1169-77 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chu J |
| Year: |
2010 |
| Journal: |
Dev Biol |
| Title: |
Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis. |
| Volume: |
342 |
| Issue: |
1 |
| Pages: |
63-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barnes RM |
| Year: |
2016 |
| Journal: |
Development |
| Title: |
MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1. |
| Volume: |
143 |
| Issue: |
5 |
| Pages: |
774-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shiratori H |
| Year: |
2006 |
| Journal: |
Development |
| Title: |
Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. |
| Volume: |
133 |
| Issue: |
15 |
| Pages: |
3015-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Clements M |
| Year: |
2011 |
| Journal: |
Curr Biol |
| Title: |
Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification. |
| Volume: |
21 |
| Issue: |
15 |
| Pages: |
1289-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schweickert A |
| Year: |
2000 |
| Journal: |
Mech Dev |
| Title: |
Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry. |
| Volume: |
90 |
| Issue: |
1 |
| Pages: |
41-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzuki K |
| Year: |
1977 |
| Journal: |
J Neurocytol |
| Title: |
Quaking mouse: an ultrastructural study of the peripheral nerves. |
| Volume: |
6 |
| Issue: |
1 |
| Pages: |
71-84 |
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•
•
•
•
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