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Search results 1801 to 1900 out of 6869 for Nodal

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Type Details Score
Strain
Attribute String: coisogenic, mutant strain, transgenic
Strain
Attribute String: coisogenic, mutant strain, transgenic
Publication
First Author: Kang HJ
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds.
Volume: 106
Issue: 40
Pages: 16967-71
Publication
First Author: Patti JM
Year: 1993
Journal: Biochemistry
Title: Identification and biochemical characterization of the ligand binding domain of the collagen adhesin from Staphylococcus aureus.
Volume: 32
Issue: 42
Pages: 11428-35
Protein Domain
Type: Domain
Description: This entry contains a prealbumin-like fold domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae []. It is also present in Collagen adhesin []and Trypsin-resistant surface T6 protein from Streptococci species. Some members of this family contain an isopeptide bond.This domain is also found in eukaryotic cell surface proteins including Nodal modulators.
Publication
First Author: Parisi S
Year: 2003
Journal: J Cell Biol
Title: Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells.
Volume: 163
Issue: 2
Pages: 303-14
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Stagner EE
Year: 2009
Journal: Biochem Biophys Res Commun
Title: The polycystic kidney disease-related proteins Bicc1 and SamCystin interact.
Volume: 383
Issue: 1
Pages: 16-21
Genotype
Symbol: Nodal/Nodal Edil3/Edil3<+>
Background: involves: 129S/SvEv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Acvr1c/Acvr1c<+> Gdf1/Gdf1<+> Nodal/Nodal<+>
Background: involves: 129 * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Acvr1b/Acvr1b<+> Gdf1/Gdf1<+> Nodal/Nodal<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Eomes/Eomes<+> Nodal/Nodal<+> Edil3/Edil3<+>
Background: involves: 129S/SvEv * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nodal/Nodal<+> Edil3/Edil3<+> Tgif1/Tgif1 Tgif2/Tgif2
Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nodal/Nodal<+> Tgif1/Tgif1 Tgif2/Tgif2 Edil3/Edil3<+>
Background: involves: 129S/SvEv * C57BL/6J * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Berthet E
Year: 2013
Journal: J Orthop Res
Title: Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization.
Volume: 31
Issue: 9
Pages: 1475-83
Publication  
First Author: Mao M
Year: 2022
Journal: Matrix Biol
Title: Elevated TGFβ signaling contributes to ocular anterior segment dysgenesis in Col4a1 mutant mice.
Volume: 110
Pages: 151-173
Publication  
First Author: Branyan K
Year: 2023
Journal: Matrix Biol
Title: Elevated TGFβ signaling contributes to cerebral small vessel disease in mouse models of Gould syndrome.
Volume: 115
Pages: 48-70
Publication
First Author: Goldstein JA
Year: 2014
Journal: Hum Mol Genet
Title: Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy.
Volume: 23
Issue: 25
Pages: 6722-31
Strain
Attribute String: congenic, mutant strain, transgenic
Publication
First Author: Lin AH
Year: 2005
Journal: J Immunol
Title: Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.
Volume: 175
Issue: 1
Pages: 547-54
Publication
First Author: Shaterian A
Year: 2012
Journal: Neuropathology
Title: Non-invasive detection of spatio-temporal activation of SBE and NFAT5 promoters in transgenic reporter mice following stroke.
Volume: 32
Issue: 2
Pages: 118-23
Publication
First Author: Luo J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration.
Volume: 103
Issue: 48
Pages: 18326-31
Publication  
First Author: Zeng HC
Year: 2017
Journal: Nat Commun
Title: MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts.
Volume: 8
Pages: 15000
Publication
First Author: Giroux M
Year: 2010
Journal: J Immunol
Title: T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling.
Volume: 185
Issue: 3
Pages: 1568-76
Publication
First Author: Grafe I
Year: 2014
Journal: Nat Med
Title: Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta.
Volume: 20
Issue: 6
Pages: 670-5
Genotype
Symbol: Tg(SBE/TK-luc)7Twc/?
Background: either: (involves: FVB/N) or (involves: C57BL/6 * SJL)
Zygosity: ot
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: mutant stock, transgenic
Genotype
Symbol: Zic3/? Tg(Nodal-cre)16Hmd/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Nodal*-cre)#Mku/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Spiller CM
Year: 2016
Journal: Mol Oncol
Title: Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors.
Volume: 10
Issue: 4
Pages: 526-37
Publication
First Author: Nakamura T
Year: 2006
Journal: Dev Cell
Title: Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.
Volume: 11
Issue: 4
Pages: 495-504
Publication
First Author: Valentini RP
Year: 1997
Journal: J Biol Chem
Title: Post-translational processing and renal expression of mouse Indian hedgehog.
Volume: 272
Issue: 13
Pages: 8466-73
Protein
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
Publication
First Author: Boyle ME
Year: 2001
Journal: Neuron
Title: Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve.
Volume: 30
Issue: 2
Pages: 385-97
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
Publication
First Author: Millay DP
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Structure-function analysis of myomaker domains required for myoblast fusion.
Volume: 113
Issue: 8
Pages: 2116-21
Publication
First Author: Ma J
Year: 2005
Journal: Carcinogenesis
Title: Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells.
Volume: 26
Issue: 2
Pages: 281-91
Publication
First Author: Vortkamp A
Year: 1996
Journal: Science
Title: Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.
Volume: 273
Issue: 5275
Pages: 613-22
Publication
First Author: Pathi S
Year: 2001
Journal: Mech Dev
Title: Comparative biological responses to human Sonic, Indian, and Desert hedgehog.
Volume: 106
Issue: 1-2
Pages: 107-17
Publication
First Author: Chen DH
Year: 2015
Journal: World J Gastroenterol
Title: Contactin 1: A potential therapeutic target and biomarker in gastric cancer.
Volume: 21
Issue: 33
Pages: 9707-16
Publication
First Author: Ranscht B
Year: 1988
Journal: J Cell Biol
Title: Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system.
Volume: 107
Issue: 4
Pages: 1561-73
Publication  
First Author: Zhang R
Year: 2015
Journal: Biomed Pharmacother
Title: Increased sensitivity of human lung adenocarcinoma cells to cisplatin associated with downregulated contactin-1.
Volume: 71
Pages: 172-84
Publication
First Author: De Benedictis L
Year: 2006
Journal: Mol Cell Neurosci
Title: Activation profile of the F3/Contactin gene in the developing mouse cerebellum.
Volume: 32
Issue: 4
Pages: 403-18
Publication
First Author: Bizzoca A
Year: 2012
Journal: Dev Biol
Title: F3/Contactin acts as a modulator of neurogenesis during cerebral cortex development.
Volume: 365
Issue: 1
Pages: 133-51
Protein Domain
Type: Family
Description: Contactins are cell adhesion molecules that belong to the immunoglobulin superfamily and are involved in neural development []. They usually consist of six N-terminal Ig domains, four fibronectin type III domains, and a C-terminal glycophosphatidylinositol (GPI)-anchor to the extracellular part of the cell membrane [].Contactin-1 (CNTN1) is expressed by a diversity of neurons and contributes to the formation and function of neuronal connections []. Contactin-1 regulates both myelin formation and organisation of nodal and paranodal domains in the central []and peripheral nervous system []. It plays a relevant role in cerebellar ontogenesis []and cerebral cortex development []. Contactin-1 contributes to the invasion and metastasis of several tumours [, ].
Protein Domain
Type: Family
Description: Indian hedgehog protein (IHH, MEROPS identifier C46.003) is important for the development and growth of bone and cartilage in the embryo []. IHH is synthesized as a precursor and activates itself by cleavage of Gly-Cys bond, in which the thiol group of the cysteine is the nucleophile []. This results in the release of the N-terminal effector domain, and no further proteolytic activity takes place. The differentiation of chondrocytes in embryonic mouse limbs, induction of the expression of nodal in the lateral plate mesoderm of early chick embryos, and affinities for hedgehog-binding proteins have been compared for Sonic, Indian and Desert hedgehog proteins [].
Protein Domain
Type: Family
Description: Proteins in this family include PGAP6 (also known as TMEM8A), NGX6 (also known as TMEM8B) and myomaker (also known as TMEM8C). TMEM8C is embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C-terminal tail. It is essential for myoblast fusion and sufficient to promote fusion of fibroblasts with muscle cells []. TMEM8A and TMEM8B has no fusogenic activity. TMEM8A is a GPI-specific phospholipase A2 involved in Nodal signaling modulation through CRIPTO shedding []. TMEM8B plays a role in cell adhesion modulation in nasopharyngeal carcinoma cells [].
Publication
First Author: Cheng SK
Year: 2004
Journal: PLoS Biol
Title: Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors.
Volume: 2
Issue: 2
Pages: E30
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Genotype
Symbol: Gli3/Gli3<+> Nodal/Nodal<+> Tgif1/Tgif1 Tgif2/Tgif2 Edil3/Edil3<+>
Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Bukauskas FF
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart.
Volume: 103
Issue: 25
Pages: 9726-31
Publication
First Author: Brott BK
Year: 2005
Journal: Differentiation
Title: Frodo proteins: modulators of Wnt signaling in vertebrate development.
Volume: 73
Issue: 7
Pages: 323-9
HT Experiment
Series Id: E-GEOD-66029
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: GSE43194
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Chen XZ
Year: 2008
Journal: FEBS J
Title: Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton.
Volume: 275
Issue: 19
Pages: 4675-83
Publication
First Author: Mochizuki T
Year: 1998
Journal: Nature
Title: Cloning of inv, a gene that controls left/right asymmetry and kidney development.
Volume: 395
Issue: 6698
Pages: 177-81
Publication
First Author: Watanabe D
Year: 2003
Journal: Development
Title: The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia.
Volume: 130
Issue: 9
Pages: 1725-34
Publication
First Author: Bamford RN
Year: 2000
Journal: Nat Genet
Title: Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects.
Volume: 26
Issue: 3
Pages: 365-9
Publication
First Author: Shukla A
Year: 2008
Journal: Mol Cancer Res
Title: Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: role in skin carcinogenesis.
Volume: 6
Issue: 3
Pages: 509-16
Publication
First Author: Bradley WG
Year: 1977
Journal: J Neuropathol Exp Neurol
Title: The nodes of Ranvier in the nerves of mice with muscular dystrophy.
Volume: 36
Issue: 5
Pages: 797-806
Publication
First Author: Piedra ME
Year: 1998
Journal: Cell
Title: Pitx2 participates in the late phase of the pathway controlling left-right asymmetry.
Volume: 94
Issue: 3
Pages: 319-24
Publication
First Author: Katoh TA
Year: 2023
Journal: Science
Title: Immotile cilia mechanically sense the direction of fluid flow for left-right determination.
Volume: 379
Issue: 6627
Pages: 66-71
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Nodal-cre)1Rob/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(CAG-cat,-lacZ)11Miya/? Tg(Nodal-cre)16Hmd/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Nodal*-cre)#Mku/?
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Ibrahim M
Year: 2018
Journal: J Immunol
Title: Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion.
Volume: 200
Issue: 2
Pages: 847-856
Publication
First Author: Luo J
Year: 2007
Journal: J Clin Invest
Title: Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.
Volume: 117
Issue: 11
Pages: 3306-15
Publication
First Author: Geraldes A
Year: 2011
Journal: Mol Ecol
Title: Higher differentiation among subspecies of the house mouse (Mus musculus) in genomic regions with low recombination.
Volume: 20
Issue: 22
Pages: 4722-36
Publication
First Author: Baker JC
Year: 1997
Journal: Curr Opin Genet Dev
Title: From receptor to nucleus: the Smad pathway.
Volume: 7
Issue: 4
Pages: 467-73
Publication
First Author: Kingsley DM
Year: 1994
Journal: Genes Dev
Title: The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.
Volume: 8
Issue: 2
Pages: 133-46
Publication
First Author: ten Dijke P
Year: 1993
Journal: Oncogene
Title: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
Volume: 8
Issue: 10
Pages: 2879-87
Publication  
First Author: Massagué J
Year: 1998
Journal: Annu Rev Biochem
Title: TGF-beta signal transduction.
Volume: 67
Pages: 753-91
Publication
First Author: Saffman EE
Year: 1998
Journal: Mol Cell Biol
Title: Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C.
Volume: 18
Issue: 8
Pages: 4855-62
Publication
First Author: Park S
Year: 2016
Journal: Development
Title: A gradient of maternal Bicaudal-C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators.
Volume: 143
Issue: 5
Pages: 864-71
Protein Domain
Type: Domain
Description: This is a hydrophilic cysteine-rich ligand-binding domain found in both TGF-beta receptor types (type I and II). In both types, this domain posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box [, , ].The Transforming growth factor-beta superfamily of ligands include: bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), anti-mullerian hormone (AMH), activin, nodal and TGF-beta. Signalling begins with the binding of a TGF-beta superfamily ligand to a TGF-beta type II receptors. The type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators [].The receptors for most of the members of this growth factor family are related. They are receptor-type kinases of Ser/Thr type, which have a singletransmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain [, , ].
Protein Domain
Type: Domain
Description: Bicaudal-C (BICC, BICC1 in vertebrates) is an RNA-binding protein with translational repression function []. It is involved in the regulation of embryonic differentiation and plays a role in the regulation of Dvl (Dishevelled) signaling, particularly in the correct cilia orientation and nodal flow generation []. In Drosophila, disruption of BICC can disturb the normal migration direction of the anterior follicle cell of oocytes []. In mammals, mutations in this gene are associated with polycystic kidney disease and it was suggested that the BICC1 protein can indirectly interact with ANKS6 protein (ANKS6 is also associated with polycystic kidney disease) through some protein and RNA intermediates [].BICC1 contains N-terminal K homology RNA-binding vigilin-like repeats and a C-terminal SAM domain. This entry represents the SAM (sterile alpha motif) domain, which is a protein-protein interaction domain [].
Protein
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
GO Term
GO Term
Publication
First Author: Meno C
Year: 1997
Journal: Genes Cells
Title: Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.
Volume: 2
Issue: 8
Pages: 513-24
Publication
First Author: Tamakoshi T
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice.
Volume: 339
Issue: 3
Pages: 932-8
Publication
First Author: McGrath J
Year: 2003
Journal: Cell
Title: Two populations of node monocilia initiate left-right asymmetry in the mouse.
Volume: 114
Issue: 1
Pages: 61-73
Publication
First Author: Shiratori H
Year: 2014
Journal: Dev Biol
Title: Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb.
Volume: 395
Issue: 2
Pages: 331-41
Publication
First Author: Kreuzberg MM
Year: 2005
Journal: Circ Res
Title: Functional properties of mouse connexin30.2 expressed in the conduction system of the heart.
Volume: 96
Issue: 11
Pages: 1169-77
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Chu J
Year: 2010
Journal: Dev Biol
Title: Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis.
Volume: 342
Issue: 1
Pages: 63-73
Publication
First Author: Barnes RM
Year: 2016
Journal: Development
Title: MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1.
Volume: 143
Issue: 5
Pages: 774-9
Publication
First Author: Shiratori H
Year: 2006
Journal: Development
Title: Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs.
Volume: 133
Issue: 15
Pages: 3015-25
Publication
First Author: Clements M
Year: 2011
Journal: Curr Biol
Title: Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.
Volume: 21
Issue: 15
Pages: 1289-95
Publication
First Author: Schweickert A
Year: 2000
Journal: Mech Dev
Title: Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry.
Volume: 90
Issue: 1
Pages: 41-51
Publication
First Author: Suzuki K
Year: 1977
Journal: J Neurocytol
Title: Quaking mouse: an ultrastructural study of the peripheral nerves.
Volume: 6
Issue: 1
Pages: 71-84