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Search results 1801 to 1900 out of 3113 for Rac1

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Type Details Score
Protein
Organism: Mus musculus/domesticus
Length: 728  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1379  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1499  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1224  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
Publication
First Author: Takeuchi S
Year: 2009
Journal: FEBS Lett
Title: Beta2-chimaerin binds to EphA receptors and regulates cell migration.
Volume: 583
Issue: 8
Pages: 1237-42
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Xu C
Year: 2016
Journal: Mol Biol Cell
Title: Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.
Volume: 27
Issue: 21
Pages: 3342-3356
Publication
First Author: Sasahara K
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and expression analysis of a putative nuclear protein, SR-25.
Volume: 269
Issue: 2
Pages: 444-50
Protein
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
Publication
First Author: Kukekov NV
Year: 2006
Journal: J Biol Chem
Title: Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs.
Volume: 281
Issue: 22
Pages: 15517-24
Protein
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1133  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
Publication
First Author: Suzuki T
Year: 2000
Journal: Genomics
Title: Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease.
Volume: 63
Issue: 2
Pages: 246-54
Publication
First Author: Chen B
Year: 2014
Journal: Cell
Title: The WAVE regulatory complex links diverse receptors to the actin cytoskeleton.
Volume: 156
Issue: 1-2
Pages: 195-207
Publication
First Author: Tuvia S
Year: 2007
Journal: J Cell Biol
Title: The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp.
Volume: 177
Issue: 1
Pages: 51-61
Publication
First Author: Wilhelm M
Year: 2007
Journal: J Biol Chem
Title: Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model.
Volume: 282
Issue: 2
Pages: 1288-95
Protein Domain
Type: Family
Description: Nck-associated protein 1 is part of lamellipodial complex that controls Rac-dependent actin remodeling [, ]. It associates preferentially with the first SH3 domain of Nck and is a component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. It is also a component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease [].
Protein Domain
Type: Domain
Description: The Rac1-binding domain is the C-terminal portion of YpkA from Yersinia. It is an all-helical molecule consisting of two distinct subdomains connected by a linker. The N-terminal end of this domain (residues 434-615) consists of six helices organised into two three-helix bundles packed against each other. This region is involved with binding to GTPases. The C-terminal end (residues 705-732) is a novel and elongated fold consisting of four helices clustered into two pairs, and this fold carries the helix implicated in actin activation. The Rac1-binding domain mimics host guanidine nucleotide dissociation inhibitors (GDIs) of the Rho GTPases, thereby inhibiting nucleotide exchange in Rac1 and causing cytoskeletal disruption in the host [].
Protein Domain
Type: Family
Description: SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissue types. At the N terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localisation signals strongly implies that this is a nuclear protein that may contribute to RNA splicing []. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1; also see ) signalling pathway [].
Protein Domain
Type: Domain
Description: This entry represents the SH3 domain of DBS.DBS, also called MCF2L or OST, functions as a Rho GTPase guanine nucleotide exchange factor (RhoGEF), facilitating the exchange of GDP and GTP. It was originally isolated from a cDNA screen for sequences that cause malignant growth. It plays roles in regulating clathrin-mediated endocytosis and cell migration through its activation of Rac1 and Cdc42 [, ]. Depending on cell type, DBS can also activate RhoA and RhoG [, ]. DBS contains a Sec14-like domain [], spectrin-like repeats, a RhoGEF or Dbl homology (DH) domain, a Pleckstrin homology (PH) domain [], and an SH3 domain.
Protein Domain
Type: Domain
Description: SH3RF1 (or POSH) and SH3RF3 (or POSH2) are scaffold proteins that function as E3 ubiquitin-protein ligases. They contain an N-terminal RING finger domain and four SH3 domains []. This entry represents the fourth SH3 domain, located at the C terminus of SH3RF1 and SH3RF3, and similar domains. SH3RF1 plays a role in calcium homeostasis through the control of the ubiquitin domain protein Herp []. It may also have a role in regulating death receptor mediated and JNK mediated apoptosis []. SH3RF3 interacts with p21-activated kinase 2 (PAK2) and GTP-loaded Rac1 [].
Publication
First Author: Geng J
Year: 2015
Journal: Nat Immunol
Title: Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.
Volume: 16
Issue: 11
Pages: 1142-52
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Igh-J/? Igh/? Tg(Cr2-cre)3Cgn/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Worthylake DK
Year: 2004
Journal: Structure
Title: Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Volume: 12
Issue: 6
Pages: 1078-86
Publication
First Author: Ieguchi K
Year: 2007
Journal: J Biol Chem
Title: Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1.
Volume: 282
Issue: 32
Pages: 23296-305
Protein
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: true
Publication  
First Author: Singer-Krüger B
Year: 1998
Journal: J Cell Sci
Title: Synaptojanin family members are implicated in endocytic membrane traffic in yeast.
Volume: 111 ( Pt 22)
Pages: 3347-56
Publication
First Author: Saarikangas J
Year: 2008
Journal: J Cell Sci
Title: ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension.
Volume: 121
Issue: Pt 9
Pages: 1444-54
Publication
First Author: Zhu J
Year: 2020
Journal: Mol Cell
Title: GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
Volume: 79
Issue: 5
Pages: 782-796.e6
Publication
First Author: Liu Z
Year: 2009
Journal: J Biol Chem
Title: The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration.
Volume: 284
Issue: 23
Pages: 15771-80
Publication
First Author: Kostenko EV
Year: 2005
Journal: J Biol Chem
Title: The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.
Volume: 280
Issue: 4
Pages: 2807-17
Publication
First Author: Klinger MB
Year: 2004
Journal: Eur J Immunol
Title: The RhoA- and CDC42-specific exchange factor Dbs promotes expansion of immature thymocytes and deletion of double-positive and single-positive thymocytes.
Volume: 34
Issue: 3
Pages: 806-816
Publication
First Author: Ainsua-Enrich E
Year: 2015
Journal: J Immunol
Title: The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival.
Volume: 194
Issue: 9
Pages: 4309-18
Publication
First Author: Hatani T
Year: 2008
Journal: Curr Med Chem
Title: Adaptor protein 3BP2 and cherubism.
Volume: 15
Issue: 6
Pages: 549-54
Publication
First Author: Qu X
Year: 2005
Journal: Biochemistry
Title: Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.
Volume: 44
Issue: 10
Pages: 3891-8
Publication
First Author: Bagrodia S
Year: 1999
Journal: Trends Cell Biol
Title: Pak to the future.
Volume: 9
Issue: 9
Pages: 350-5
Publication
First Author: Flanders JA
Year: 2003
Journal: FEBS Lett
Title: The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.
Volume: 550
Issue: 1-3
Pages: 119-23
Publication
First Author: Feng Q
Year: 2002
Journal: J Biol Chem
Title: Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.
Volume: 277
Issue: 7
Pages: 5644-50
Publication
First Author: Eriguchi M
Year: 2010
Journal: J Neurol Sci
Title: alpha Pix enhances mutant huntingtin aggregation.
Volume: 290
Issue: 1-2
Pages: 80-5
Protein Domain
Type: Domain
Description: There are two forms of Pix proteins: alpha Pix (also called Rho guanine nucleotide exchange factor (GEF) 6, 90Cool-2 or ARHGEF6) and beta Pix (GEF7, p85Cool-1 or ARHGEF7), which activate small GTPases by exchanging bound GDP for free GTP. betaPix contains an N-terminal SH3 domain, a RhoGEF/DH domain, a PH domain, a GIT1 binding domain (GBD), and a C-terminal coiled-coil (CC) domain []. It acts as a GEF for both Cdc42 and Rac1 [], and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion [, , , ]. alphaPix differs in that it contains a calponin homology (CH) domain, which interacts with beta-parvin, N-terminal to the SH3 domain. alphaPix is an exchange factor for Rac1 and Cdc42 and mediates Pak activation on cell adhesion to fibronectin. Mutations in alphaPix can cause X-linked mental retardation. alphaPix also interacts with Huntington's disease protein (htt), and enhances the aggregation of mutant htt (muthtt) by facilitating SDS-soluble muthtt-muthtt interactions. The DH-PH domain of a Pix was required for its binding to htt. In the majority of Rho GEF proteins, the DH-PH domain is responsible for the exchange activity [, , , , ].This entry represents the PH domain of ARHGEF6 and ARHGEF7.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Yoshizawa M
Year: 2002
Journal: Mech Dev
Title: Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain.
Volume: 113
Issue: 1
Pages: 65-8
Publication
First Author: Chu CH
Year: 2020
Journal: FASEB J
Title: TIAM2S as a novel regulator for serotonin level enhances brain plasticity and locomotion behavior.
Volume: 34
Issue: 2
Pages: 3267-3288
GXD Expression    
Probe: MGI:2667190
Assay Type: Western blot
Annotation Date: 2003-07-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:2667192
Age: embryonic day 15.0
Image: 1
Specimen Label: 5 Fetal Brain
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3783639
Age: embryonic day 7.0
Image: 4
Specimen Label: E7
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3783639
Age: embryonic day 11.0
Image: 4
Specimen Label: E11
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3783639
Age: embryonic day 15.0
Image: 4
Specimen Label: E15
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3783639
Age: embryonic day 17.0
Image: 4
Specimen Label: E17
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3783640
Age: postnatal adult
Image: 4
Specimen Label: heart
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3783640
Age: postnatal adult
Image: 4
Specimen Label: brain
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3783640
Age: postnatal adult
Image: 4
Specimen Label: spleen
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3783640
Age: postnatal adult
Image: 4
Specimen Label: lung
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3783640
Age: postnatal adult
Image: 4
Specimen Label: liver
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3783640
Age: postnatal adult
Image: 4
Specimen Label: skeletal m.
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3783640
Age: postnatal adult
Image: 4
Specimen Label: kidney
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3783637
Assay Type: Northern blot
Annotation Date: 2008-05-02
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3783640
Age: postnatal adult
Image: 4
Specimen Label: testis
Detected: true
Specimen Num: 8
GXD Expression
Probe: MGI:3783636
Assay Type: RNA in situ
Annotation Date: 2008-05-02
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3783641
Age: embryonic day 14.5
Image: 4C
Note: Expression is present at the floor of the fourth ventricle.
Specimen Label: 4C
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3783584
Assay Type: RNA in situ
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754925
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3783587
Age: embryonic day 17.0
Image: 1B
Specimen Label: 1B
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3783636
Assay Type: RNA in situ
Annotation Date: 2008-05-02
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3783641
Age: embryonic day 14.5
Image: 4C
Note: Expression is present in a part of the striatum.
Specimen Label: 4C
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7464350
Assay Type: RNA in situ
Annotation Date: 2023-04-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754923
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7464524
Age: embryonic day 15.5
Image: 6m
Specimen Label: 6m
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7464350
Assay Type: RNA in situ
Annotation Date: 2023-04-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754923
Stage: TS23
Assay Id: MGI:7464524
Age: embryonic day 15.5
Image: 6m'
Specimen Label: 6m'
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5000572
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5541132
Age: embryonic day 15.5
Image: GUDMAP:5047
Specimen Label: GUDMAP:5047
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3783584
Assay Type: RNA in situ
Annotation Date: 2008-05-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1903728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3783587
Age: postnatal adult
Image: 1F
Specimen Label: 1F
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:3783584
Assay Type: RNA in situ
Annotation Date: 2008-05-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3783587
Age: embryonic day 17.0
Image: 2B
Note: Expression is present in neurons.
Specimen Label: 2B
Detected: true
Specimen Num: 8