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Search results 1801 to 1900 out of 2424 for Ran

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Type Details Score
Publication
27993670 | J:250929
First Author: Fatima S
Year: 2017
Journal: Biochim Biophys Acta
Title: Interactome of the inhibitory isoform of the nuclear transporter Importin 13.
Volume: 1864
Issue: 3
Pages: 546-561
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Publication
35741036 | J:327286
 
First Author: Gajewska KA
Year: 2022
Journal: Cells
Title: Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation.
Volume: 11
Issue: 12
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Publication
33333437 | J:304045
 
First Author: Fatima S
Year: 2021
Journal: Biochem Biophys Res Commun
Title: The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation.
Volume: 534
Pages: 141-148
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Genotype
Genotype
Symbol: Ipo13/Ipo13
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Publication
39154340 | J:353585
First Author: Yan J
Year: 2024
Journal: Cell Rep
Title: Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis.
Volume: 43
Issue: 8
Pages: 114636
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Publication
39103535 | J:360117
First Author: Luo X
Year: 2024
Journal: Cell Death Differ
Title: Phospholipid peroxidation in macrophage confers tumor resistance by suppressing phagocytic capability towards ferroptotic cells.
Volume: 31
Issue: 9
Pages: 1184-1201
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Publication
34568331 | J:311200
 
First Author: Tokuhiro T
Year: 2021
Journal: Front Cell Dev Biol
Title: Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation.
Volume: 9
Pages: 718586
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Publication
36585109 | J:357810
 
First Author: Tu LF
Year: 2023
Journal: J Adv Res
Title: GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS.
Volume: 43
Pages: 205-218
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Publication
34949833 | J:325023
First Author: Wang Y
Year: 2022
Journal: Nat Immunol
Title: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis.
Volume: 23
Issue: 2
Pages: 303-317
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Genotype
Genotype
Symbol: Ranbp2/Ranbp2
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gpx4/Gpx4 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
1889746 | J:11408
First Author: Bressan A
Year: 1991
Journal: Gene
Title: Characterization of the opposite-strand genes from the mouse bidirectionally transcribed HTF9 locus.
Volume: 103
Issue: 2
Pages: 201-9
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Publication
25299344 | J:228859
First Author: Fu J
Year: 2014
Journal: PLoS Genet
Title: Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.
Volume: 10
Issue: 10
Pages: e1004579
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Publication
19033381 | J:141678
First Author: Evdokimov E
Year: 2008
Journal: J Cell Sci
Title: Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3.
Volume: 121
Issue: Pt 24
Pages: 4106-13
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Publication
34110283 | J:326734
   
First Author: He Y
Year: 2021
Journal: Elife
Title: T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.
Volume: 10
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Publication
35771867 | J:331499
First Author: Kragness S
Year: 2022
Journal: PLoS One
Title: An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.
Volume: 17
Issue: 6
Pages: e0269404
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Publication
14697343 | J:87860
First Author: Olsson M
Year: 2004
Journal: Exp Cell Res
Title: Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.
Volume: 292
Issue: 2
Pages: 359-70
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Publication
31427429 | J:283037
 
First Author: Khalaf B
Year: 2019
Journal: J Cell Sci
Title: Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.
Volume: 132
Issue: 18
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Publication
1898771 | -
First Author: Bourne HR
Year: 1991
Journal: Nature
Title: The GTPase superfamily: conserved structure and molecular mechanism.
Volume: 349
Issue: 6305
Pages: 117-27
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Publication
7616957 | J:28336
First Author: Hayashi N
Year: 1995
Journal: Mol Gen Genet
Title: RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.
Volume: 247
Issue: 6
Pages: 661-9
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Publication
23172145 | J:194221
First Author: Gkogkas CG
Year: 2013
Journal: Nature
Title: Autism-related deficits via dysregulated eIF4E-dependent translational control.
Volume: 493
Issue: 7432
Pages: 371-7
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Publication
18194653 | J:131292
First Author: Li J
Year: 2008
Journal: Dev Cell
Title: Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
Volume: 14
Issue: 1
Pages: 62-75
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Publication
9891081 | -
First Author: Bertram MJ
Year: 1999
Journal: Mol Cell Biol
Title: Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.
Volume: 19
Issue: 2
Pages: 1479-85
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Publication
26721684 | J:229478
First Author: Nelson CE
Year: 2016
Journal: Science
Title: In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.
Volume: 351
Issue: 6271
Pages: 403-7
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Publication
26721686 | J:229477
First Author: Tabebordbar M
Year: 2016
Journal: Science
Title: In vivo gene editing in dystrophic mouse muscle and muscle stem cells.
Volume: 351
Issue: 6271
Pages: 407-411
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Publication
33717842 | J:310336
First Author: Bi X
Year: 2021
Journal: Adv Sci (Weinh)
Title: Mitochondrial Damage-Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease-Associated Plaque Vulnerability.
Volume: 8
Issue: 5
Pages: 2002738
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Publication
28054918 | J:240173
   
First Author: Chen M
Year: 2017
Journal: Elife
Title: APP modulates KCC2 expression and function in hippocampal GABAergic inhibition.
Volume: 6
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Publication
32811851 | J:313543
First Author: Pharaoh G
Year: 2020
Journal: Sci Rep
Title: Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia.
Volume: 10
Issue: 1
Pages: 13968
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Publication
37932534 | J:347288
First Author: Yu J
Year: 2023
Journal: Cell Mol Immunol
Title: The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8(+) T-cell immunity.
Volume: 20
Issue: 12
Pages: 1445-1456
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Publication
34318750 | J:310423
   
First Author: Xie Z
Year: 2021
Journal: Elife
Title: Transcriptomic encoding of sensorimotor transformation in the midbrain.
Volume: 10
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Publication
38997283 | J:360352
First Author: von Roemeling CA
Year: 2024
Journal: Nat Commun
Title: Adeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade.
Volume: 15
Issue: 1
Pages: 5871
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Publication
29208777 | J:257699
First Author: Moore BD
Year: 2018
Journal: J Exp Med
Title: Short Aβ peptides attenuate Aβ42 toxicity in vivo.
Volume: 215
Issue: 1
Pages: 283-301
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Publication
37880241 | J:358730
First Author: Ding W
Year: 2023
Journal: Nat Commun
Title: The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption.
Volume: 14
Issue: 1
Pages: 6696
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Publication
29490280 | J:271104
First Author: Moore AR
Year: 2018
Journal: Cell Rep
Title: GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.
Volume: 22
Issue: 9
Pages: 2455-2468
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Publication
30111533 | J:265558
First Author: Roy S
Year: 2018
Journal: Cancer Res
Title: Macrophage-Derived Neuropilin-2 Exhibits Novel Tumor-Promoting Functions.
Volume: 78
Issue: 19
Pages: 5600-5617
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Publication
28572627 | J:274805
First Author: Kim TD
Year: 2017
Journal: Sci Rep
Title: MicroRNA-150 modulates intracellular Ca 2+ levels in naïve CD8+ T cells by targeting TMEM20.
Volume: 7
Issue: 1
Pages: 2623
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Publication
30146164 | J:267424
First Author: Ren J
Year: 2018
Journal: Cell
Title: Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems.
Volume: 175
Issue: 2
Pages: 472-487.e20
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Publication
32569093 | J:305668
First Author: Moutal A
Year: 2020
Journal: Pain
Title: Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain.
Volume: 161
Issue: 11
Pages: 2629-2651
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Publication
24207120 | J:206670
First Author: Zhang XY
Year: 2013
Journal: Am J Hum Genet
Title: Gain-of-function mutations in SCN11A cause familial episodic pain.
Volume: 93
Issue: 5
Pages: 957-66
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Publication
25964433 | J:222939
First Author: Park HJ
Year: 2015
Journal: EMBO J
Title: The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity.
Volume: 34
Issue: 12
Pages: 1674-86
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Publication
28714953 | J:258038
First Author: Shen S
Year: 2017
Journal: Nat Neurosci
Title: Gut microbiota is critical for the induction of chemotherapy-induced pain.
Volume: 20
Issue: 9
Pages: 1213-1216
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Publication
30776251 | J:292064
First Author: Peng W
Year: 2019
Journal: FASEB J
Title: Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.
Volume: 33
Issue: 5
Pages: 6327-6338
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Publication
30918291 | J:298159
First Author: Wang S
Year: 2019
Journal: Sci Rep
Title: FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer.
Volume: 9
Issue: 1
Pages: 5281
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Publication
31942069 | -
First Author: Wang L
Year: 2020
Journal: Nature
Title: Host-mediated ubiquitination of a mycobacterial protein suppresses immunity.
Volume: 577
Issue: 7792
Pages: 682-688
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Publication
37498871 | -
First Author: Gomez K
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Identification and targeting of a unique Na(V)1.7 domain driving chronic pain.
Volume: 120
Issue: 32
Pages: e2217800120
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HT Experiment
GSE142684 | RNA-seq analysis of Wildtype and Prdm16 cKO ventricular zone tissue during cortex development in mouse
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE202959 | Single-cell RNA sequencing of spinal cord CD133+ DNGR-1 traced and CD133+ non-traced cells
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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GO Term
GO:0003924 | GTPase activity
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Publication
15923632 | J:99175
First Author: Yamaguchi T
Year: 2005
Journal: Mol Cell Biol
Title: Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.
Volume: 25
Issue: 12
Pages: 5171-82
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Publication
19071120 | J:142662
First Author: Shiroshima T
Year: 2009
Journal: FEBS Lett
Title: Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1.
Volume: 583
Issue: 1
Pages: 43-8
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Publication
11804793 | J:74505
First Author: Maynard TM
Year: 2002
Journal: Mech Dev
Title: RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction.
Volume: 111
Issue: 1-2
Pages: 177-80
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Publication
21189294 | -
First Author: Tamura K
Year: 2010
Journal: Plant Cell
Title: Identification and characterization of nuclear pore complex components in Arabidopsis thaliana.
Volume: 22
Issue: 12
Pages: 4084-97
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Protein Domain
IPR045207 | RanBD_NUP50_plant
Type: Domain
Description: This entry represents the Ran-binding domain found in plant NUP50 protein. NUP50 is a nuclear pore complex component involved in nucleocytoplasmic transport via its interactions with importins and Ran [].
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Publication
34385713 | J:321322
First Author: Li P
Year: 2021
Journal: Nat Immunol
Title: Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity.
Volume: 22
Issue: 9
Pages: 1107-1117
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Publication
32541831 | J:298910
First Author: Jia M
Year: 2020
Journal: Nat Immunol
Title: Redox homeostasis maintained by GPX4 facilitates STING activation.
Volume: 21
Issue: 7
Pages: 727-735
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Publication
34279220 | J:321432
   
First Author: Ide S
Year: 2021
Journal: Elife
Title: Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair.
Volume: 10
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Publication
38233202 | J:361158
First Author: Jiang Z
Year: 2024
Journal: Adv Sci (Weinh)
Title: Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
Volume: 11
Issue: 12
Pages: e2307388
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Allele
Gt(ROSA)26Sor<tm2(CAG-NuTRAP)Evdr> | MGI:5817820
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Evan Rosen
Allele Type: Targeted
Attribute String: Conditional ready, Reporter
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Publication
36208623 | J:336854
First Author: Huang Q
Year: 2022
Journal: Cell
Title: The primordial differentiation of tumor-specific memory CD8(+) T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes.
Volume: 185
Issue: 22
Pages: 4049-4066.e25
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Publication
26885862 | J:231298
First Author: Li Y
Year: 2016
Journal: Immunity
Title: Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment.
Volume: 44
Issue: 2
Pages: 422-37
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Publication
24451987 | J:210345
First Author: Fu Z
Year: 2014
Journal: Biol Reprod
Title: Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice.
Volume: 90
Issue: 3
Pages: 52
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Publication
33045063 | J:306126
 
First Author: Fedele C
Year: 2021
Journal: J Exp Med
Title: SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.
Volume: 218
Issue: 1
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GO Term
GO:0034260 | negative regulation of GTPase activity
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Publication
12578832 | -
First Author: Braunwarth A
Year: 2003
Journal: J Biol Chem
Title: Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae.
Volume: 278
Issue: 17
Pages: 15397-405
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Protein Domain
IPR016123 | Mog1/PsbP_a/b/a-sand
Type: Homologous_superfamily
Description: This entry represents a structural domain consisting of a 3-layer α/β/α fold. The β layer is composed of seven β-sheets, and the overall order is: (β-hairpin)-β(3)-α-β(4)-α. Domains with this structure are found in the following protein families:Ran-binding protein Mog1, which interacts with Ran GTPase to stimulate guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran [, ].The photosystem II (PSII) oxygen-evolving complex protein PsbP, which is a regulator necessary for the biogenesis of optically active PSII. PsbP increases the affinity of the water oxidation site for chloride ions and provides the conditions required for high affinity binding of calcium ions [].
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Protein Domain
IPR008812 | Ran_GTP-bd-rel
Type: Family
Description: The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle and nuclear envelope formation during mitosis in higher eukaryotes. The Saccharomyces cerevisiae ORF YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p was identified. The protein competes with S. cerevisiae RanBP1 (Yrb1p) for binding to the GTP-bound form of S. cerevisiae Ran (Gsp1p) and is, like Yrb1p, able to form trimeric complexes with RanGTP and some of the karyopherins [].
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Publication
19730684 | J:152071
First Author: Ma L
Year: 2009
Journal: PLoS Genet
Title: GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline.
Volume: 5
Issue: 9
Pages: e1000635
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Publication
28254886 | J:243444
First Author: Tarabay Y
Year: 2017
Journal: J Cell Sci
Title: Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression.
Volume: 130
Issue: 8
Pages: 1463-1474
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Publication
15569683 | J:96947
First Author: Takahashi H
Year: 2005
Journal: J Biol Chem
Title: Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein.
Volume: 280
Issue: 7
Pages: 5611-21
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Publication
36351395 | J:331490
First Author: Ide S
Year: 2022
Journal: Cell Rep
Title: Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair.
Volume: 41
Issue: 6
Pages: 111610
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Publication
36652473 | J:340364
First Author: Liu D
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2.
Volume: 120
Issue: 4
Pages: e2202820120
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Publication
39287504 | J:359767
   
First Author: Yulyaningsih E
Year: 2024
Journal: Elife
Title: DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.
Volume: 12
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Strain
MGI:5817941 | B6;129S6-Gt(ROSA)26Sor<tm2(CAG-NuTRAP)Evdr>/J
Attribute String: targeted mutation, mutant stock
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HT Experiment
GSE63674 | iCD8a cells study
Series Id: E-GEOD-63674
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
17600715 | -
First Author: Xu XM
Year: 2007
Journal: Curr Biol
Title: Anchorage of plant RanGAP to the nuclear envelope involves novel nuclear-pore-associated proteins.
Volume: 17
Issue: 13
Pages: 1157-63
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Protein Domain
IPR045256 | RanBP1_RanBD
Type: Domain
Description: This entry represents the Ran-binding domain (RBD) found in RanBP1 from humans and Yrb1 from budding yeasts. RanBP1 and Yrb1 are involved in nuclear import and export. RanBP1 and Yrb1 have been shown to shuttle between the nucleus and cytoplasm and the conserved RBD is necessary and sufficient for the essential function and nucleocytoplasmic shuttling []. RanBP1/Yrb1 acts as a negative regulator of Regulator of chromosome condensation 1 (RCC1) by inhibiting RCC1-stimulated guanine nucleotide release from Ran [].
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Protein Domain
IPR007681 | Mog1
Type: Family
Description: Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP, which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran []. The human homologue of Mog1 is thought to be alternatively spliced.
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Protein Domain
IPR044696 | WIP1/2/3
Type: Family
Description: This entry represents the WPP domain-interacting protein (WIP) family which includes WIP1, 2 and 3 from Arabidopsis. These proteins are specific to plants and required for the localisation and anchorage of Ran GTPase-activating proteins (RanGAP) to the nuclear envelope (NE) mediated by WIT1 and WIT2 in undifferentiated cells of root tips [, ]. They are part of the SUN-WIP-WIT2-KAKU1 complex, in which they mediate the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes [].
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Protein
Q05D49
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Publication
9019411 | J:38226
First Author: Mahajan R
Year: 1997
Journal: Cell
Title: A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
Volume: 88
Issue: 1
Pages: 97-107
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Publication
33523882 | J:313065
 
First Author: Asamitsu S
Year: 2021
Journal: Sci Adv
Title: CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome.
Volume: 7
Issue: 3
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Publication
1398150 | J:40927
First Author: Dupree P
Year: 1992
Journal: Gene
Title: Sequence of a canine cDNA clone encoding a Ran/TC4 GTP-binding protein.
Volume: 120
Issue: 2
Pages: 325-6
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Publication
7754385 | J:25513
First Author: Weis K
Year: 1995
Journal: Science
Title: Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences.
Volume: 268
Issue: 5213
Pages: 1049-53
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Publication
19805316 | J:153232
First Author: Meechan DW
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome.
Volume: 106
Issue: 38
Pages: 16434-45
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Publication
22155005 | J:183651
First Author: Kim EY
Year: 2012
Journal: J Mol Cell Cardiol
Title: Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Volume: 52
Issue: 3
Pages: 638-49
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Publication
31673123 | J:351300
First Author: Liu S
Year: 2020
Journal: Mol Psychiatry
Title: Mutations in ASH1L confer susceptibility to Tourette syndrome.
Volume: 25
Issue: 2
Pages: 476-490
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HT Experiment
GSE152133 | Transcriptome Alterations Associated with Age-Related Decline in Physical Function
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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GO Term
GO:0043547 | positive regulation of GTPase activity
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Publication
35383160 | J:332304
First Author: von Ziegler LM
Year: 2022
Journal: Nat Commun
Title: Multiomic profiling of the acute stress response in the mouse hippocampus.
Volume: 13
Issue: 1
Pages: 1824
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Publication
36611093 | J:332603
First Author: Raus AM
Year: 2023
Journal: Commun Biol
Title: Early-life exercise primes the murine neural epigenome to facilitate gene expression and hippocampal memory consolidation.
Volume: 6
Issue: 1
Pages: 18
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Publication
33315013 | J:316377
   
First Author: Yucel N
Year: 2020
Journal: Elife
Title: Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes.
Volume: 9
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Publication
38058312 | J:359686
First Author: Kellogg CM
Year: 2023
Journal: iScience
Title: Specificity and efficiency of tamoxifen-mediated Cre induction is equivalent regardless of age.
Volume: 26
Issue: 12
Pages: 108413
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Publication
36423879 | J:334399
 
First Author: Chucair-Elliott AJ
Year: 2022
Journal: Neurobiol Dis
Title: Translatomic response of retinal Müller glia to acute and chronic stress.
Volume: 175
Pages: 105931
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Protein
A0A140LJ90
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: true
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Publication
12840024 | -
First Author: Belham C
Year: 2003
Journal: J Biol Chem
Title: A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.
Volume: 278
Issue: 37
Pages: 34897-909
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Publication
14660563 | -
First Author: Tan BC
Year: 2004
Journal: J Biol Chem
Title: Nek9, a novel FACT-associated protein, modulates interphase progression.
Volume: 279
Issue: 10
Pages: 9321-30
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Publication
16449645 | -
First Author: Kurisaki A
Year: 2006
Journal: Mol Cell Biol
Title: The mechanism of nuclear export of Smad3 involves exportin 4 and Ran.
Volume: 26
Issue: 4
Pages: 1318-32
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Protein Domain
IPR042767 | Nek9_STKc
Type: Domain
Description: STKs (serine/threonine-protein kinases) catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek9, also called Nercc1, is primarily a cytoplasmic protein but can also localize in the nucleus. It is involved in modulating chromosome alignment and splitting during mitosis. It interacts with the gamma-tubulin ring complex and the Ran GTPase, and is implicated in microtubule organization []. Nek9 associates with FACT (FAcilitates Chromatin Transcription) and modulates interphase progression []. It also interacts with Nek6, and Nek7, during mitosis, resulting in their activation. Nek9 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control [, ].
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Protein Domain
IPR044189 | XPO4/7-like
Type: Family
Description: Exportins bind cargo molecules in the nuclei and transport them through nuclear pores to the cytoplasm, a process that requires RanGTP. This entry includes Exportin 4 and 7 (also known as RanBP16), proteins that mediate the nuclear export of proteins with broad substrate specificity. They bind cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Exportin 4 transports the eukaryotic translation initiation factor 5A (eIF-5A) and Smad3, controlling protein synthesis and Smad signalling [, ].This entry also includes Ran-binding protein 17 from humans.
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Publication
10885754 | J:62506
First Author: Hemberger M
Year: 2000
Journal: Dev Biol
Title: cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion.
Volume: 222
Issue: 1
Pages: 158-69
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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