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Type Details Score
Publication
27477282 | J:238979
First Author: Prudova A
Year: 2016
Journal: Cell Rep
Title: TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.
Volume: 16
Issue: 6
Pages: 1762-1773
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Publication
24625929 | J:209599
First Author: Mortha A
Year: 2014
Journal: Science
Title: Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.
Volume: 343
Issue: 6178
Pages: 1249288
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Publication
14522873 | J:86049
First Author: Gavalas A
Year: 2003
Journal: Development
Title: Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes.
Volume: 130
Issue: 23
Pages: 5663-79
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Publication
30925931 | -
First Author: Abu Irqeba A
Year: 2019
Journal: BMC Res Notes
Title: Novel binding partners for Prenylated Rab Acceptor 1 identified by a split-ubiquitin yeast two-hybrid screen.
Volume: 12
Issue: 1
Pages: 188
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Publication
18344281 | J:134065
First Author: Zhang A
Year: 2008
Journal: Am J Physiol Cell Physiol
Title: Serum response factor neutralizes Pur alpha- and Pur beta-mediated repression of the fetal vascular smooth muscle alpha-actin gene in stressed adult cardiomyocytes.
Volume: 294
Issue: 3
Pages: C702-14
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Publication
25787061 | J:225759
 
First Author: Milano A
Year: 2015
Journal: J Mol Cell Cardiol
Title: TNNI3K in cardiovascular disease and prospects for therapy.
Volume: 82
Pages: 167-73
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Publication
22451941 | J:183539
First Author: Voutilainen M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB.
Volume: 109
Issue: 15
Pages: 5744-9
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Publication
11688994 | J:72614
First Author: Nakada K
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Correlation of functional and ultrastructural abnormalities of mitochondria in mouse heart carrying a pathogenic mutant mtDNA with a 4696-bp deletion.
Volume: 288
Issue: 4
Pages: 901-7
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Publication
10564497 | -
First Author: Buchet A
Year: 1999
Journal: Mol Microbiol
Title: Positive co-regulation of the Escherichia coli carnitine pathway cai and fix operons by CRP and the CaiF activator.
Volume: 34
Issue: 3
Pages: 562-75
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Publication
756334 | -
 
First Author: Neetens A
Year: 1978
Journal: Bull Soc Belge Ophtalmol
Title: Sectorial ischemic discopathy.
Volume: 182
Pages: 90-103
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Publication
21742882 | -
First Author: Ostrowski A
Year: 2011
Journal: J Bacteriol
Title: YuaB functions synergistically with the exopolysaccharide and TasA amyloid fibers to allow biofilm formation by Bacillus subtilis.
Volume: 193
Issue: 18
Pages: 4821-31
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Publication
28009253 | -
   
First Author: Bebel A
Year: 2016
Journal: Elife
Title: Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending.
Volume: 5
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Publication
20473270 | J:160524
First Author: Cuadrado A
Year: 2010
Journal: EMBO J
Title: Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.
Volume: 29
Issue: 12
Pages: 2014-25
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Publication
12398221 | J:113961
First Author: Honda A
Year: 2002
Journal: Hum Reprod Update
Title: Role of acrosomal matrix proteases in sperm-zona pellucida interactions.
Volume: 8
Issue: 5
Pages: 405-12
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Publication
32180899 | J:287714
First Author: Kale A
Year: 2020
Journal: Oncotarget
Title: Calcitonin receptor is required for T-antigen-induced prostate carcinogenesis.
Volume: 11
Issue: 9
Pages: 858-874
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Publication
24890125 | J:213496
First Author: Quintás-Cardama A
Year: 2014
Journal: J Pathol
Title: Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.
Volume: 234
Issue: 1
Pages: 108-19
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Publication
31354981 | J:277622
First Author: Koerner MV
Year: 2019
Journal: Epigenomes
Title: An Orphan CpG Island Drives Expression of a let-7 miRNA Precursor with an Important Role in Mouse Development.
Volume: 3
Issue: 1
Pages: 7
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Publication
23980137 | J:201055
First Author: Goldlust IS
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Mouse model implicates GNB3 duplication in a childhood obesity syndrome.
Volume: 110
Issue: 37
Pages: 14990-4
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Publication
22558422 | J:187272
First Author: Végh A
Year: 2012
Journal: PLoS One
Title: FcRn overexpression in transgenic mice results in augmented APC activity and robust immune response with increased diversity of induced antibodies.
Volume: 7
Issue: 4
Pages: e36286
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Publication
20930145 | J:182928
First Author: Nagarajan P
Year: 2010
Journal: J Cell Sci
Title: Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.
Volume: 123
Issue: Pt 20
Pages: 3566-75
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Publication
14630831 | J:88562
First Author: Turhan A
Year: 2004
Journal: Blood
Title: Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes.
Volume: 103
Issue: 6
Pages: 2397-400
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Publication
33679392 | J:314053
 
First Author: Martire A
Year: 2020
Journal: Front Pharmacol
Title: P2X7 Receptor Agonist 2'(3')-O-(4-Benzoylbenzoyl)ATP Differently Modulates Cell Viability and Corticostriatal Synaptic Transmission in Experimental Models of Huntington's Disease.
Volume: 11
Pages: 633861
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Publication
25416063 | J:217384
First Author: Suzuki A
Year: 2014
Journal: Biol Open
Title: Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells.
Volume: 3
Issue: 12
Pages: 1207-16
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Publication
17267394 | J:121155
First Author: Ban N
Year: 2007
Journal: J Biol Chem
Title: ABCA3 as a lipid transporter in pulmonary surfactant biogenesis.
Volume: 282
Issue: 13
Pages: 9628-34
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Protein Coding Gene
MGI:1913544 | Fam3a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12162805 | J:77910
First Author: Cowan DA
Year: 2002
Journal: DNA Cell Biol
Title: Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development.
Volume: 21
Issue: 7
Pages: 505-17
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Publication
27586459 | J:242106
 
First Author: Vikram A
Year: 2016
Journal: Nat Commun
Title: Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1.
Volume: 7
Pages: 12565
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Publication
24264229 | J:208082
First Author: Stoddart A
Year: 2014
Journal: Blood
Title: Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc.
Volume: 123
Issue: 2
Pages: 228-38
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Publication
32978288 | J:302728
First Author: Rozov A
Year: 2020
Journal: J Neurosci
Title: Processing of Hippocampal Network Activity in the Receiver Network of the Medial Entorhinal Cortex Layer V.
Volume: 40
Issue: 44
Pages: 8413-8425
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Publication
23785280 | J:213390
First Author: McBride A
Year: 2013
Journal: PLoS Pathog
Title: Host defense and recruitment of Foxp3⁺ T regulatory cells to the lungs in chronic Mycobacterium tuberculosis infection requires toll-like receptor 2.
Volume: 9
Issue: 6
Pages: e1003397
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Allele
Sha | MGI:1856629
 
Name: shaven
Allele Type: Spontaneous
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Publication
34938194 | J:351884
 
First Author: Murao A
Year: 2021
Journal: Front Pharmacol
Title: Exosome-Mediated eCIRP Release From Macrophages to Induce Inflammation in Sepsis.
Volume: 12
Pages: 791648
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Publication
30532187 | J:269453
First Author: Kalvisa A
Year: 2018
Journal: PLoS Biol
Title: Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.
Volume: 16
Issue: 12
Pages: e2006249
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Publication
21363966 | J:174640
First Author: Sehic A
Year: 2011
Journal: Physiol Genomics
Title: Effects of in vivo transfection with anti-miR-214 on gene expression in murine molar tooth germ.
Volume: 43
Issue: 9
Pages: 488-98
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Publication
20615958 | J:162312
First Author: Osborn SL
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis.
Volume: 107
Issue: 29
Pages: 13034-9
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Publication
10087302 | J:54005
First Author: Lee CG
Year: 1999
Journal: Mamm Genome
Title: Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.
Volume: 10
Issue: 4
Pages: 402-4
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Publication
25989451 | J:241468
 
First Author: Yamagata A
Year: 2015
Journal: Sci Rep
Title: Structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.
Volume: 5
Pages: 9686
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Protein
P09470
Organism: Mus musculus/domesticus
Length: 1312  
Fragment?: false
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Protein
D0G895
Organism: Mus musculus/domesticus
Length: 737  
Fragment?: false
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Protein
Q3U3Q7
Organism: Mus musculus/domesticus
Length: 1312  
Fragment?: false
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Protein
F6QCP8
Organism: Mus musculus/domesticus
Length: 1016  
Fragment?: true
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Protein
Q7TSV8
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: true
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Protein
Q8K233
Organism: Mus musculus/domesticus
Length: 1015  
Fragment?: true
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Protein
Q5XK22
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: true
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Protein
Q61265
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein
Q3TU20
Organism: Mus musculus/domesticus
Length: 1312  
Fragment?: false
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Publication
1851160 | -
First Author: Wei L
Year: 1991
Journal: J Biol Chem
Title: The two homologous domains of human angiotensin I-converting enzyme are both catalytically active.
Volume: 266
Issue: 14
Pages: 9002-8
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Publication
12633854 | -
First Author: Kim HM
Year: 2003
Journal: FEBS Lett
Title: Crystal structure of Drosophila angiotensin I-converting enzyme bound to captopril and lisinopril.
Volume: 538
Issue: 1-3
Pages: 65-70
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Publication
17439247 | -
First Author: Corradi HR
Year: 2007
Journal: Biochemistry
Title: The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380.
Volume: 46
Issue: 18
Pages: 5473-8
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Publication
18457420 | -
First Author: Watermeyer JM
Year: 2008
Journal: Biochemistry
Title: Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme.
Volume: 47
Issue: 22
Pages: 5942-50
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Publication
17464936 | -
First Author: Hamming I
Year: 2007
Journal: J Pathol
Title: The emerging role of ACE2 in physiology and disease.
Volume: 212
Issue: 1
Pages: 1-11
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Protein Domain
IPR001548 | Peptidase_M2
Type: Family
Description: This group of metallopeptidases belong to the MEROPS peptidase family M2 (clan MA(E)). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA. The catalytic residues and zinc ligands have been identified, the zinc ion being ligated to two His residues within the motif HEXXH, showing that the enzyme belongs to the glu-zincin sub-group of metalloproteases [].Peptidyl-dipeptidase A (angiotensin-converting enzyme or ACE, ) is a mammalian enzyme responsible for cleavage of dipeptides from the C-termini of proteins, notably converting decapeptide angiotensin I to the octapeptide angiotensin II []. The enzyme exists in two differentially transcribed forms, the most common of which is from lung endothelium; this contains two homologous domains that have arisen by gene duplication []. The testis-specific form contains only the C-terminal domain, arising from a duplicated promoter region present in intron 12 of the gene []. Both enzymatic forms are membrane proteins that are anchored by means of a C-terminal transmembrane domain. Both domains of the endothelial enzyme are active, but have differing kinetic constants [, ]. ACE is well-known as a key part of the renin-angiotensin system that regulates blood pressure and ACE inhibitors are important for the treatment of hypertension [, ].An ACE homologue, ACE2 (MEROPS identifier M02.006), has been identified in humans that differs from ACE; it preferentially removes carboxy-terminal hydrophobic or basic amino acids and appears to be important in cardiac function [, ]. ACE3 is a non-peptidase homologue included in this entry which lacks Glu378 in the HEXXH motif.A number of insect enzymes have been shown to be similar to peptidyl-dipeptidase A, these containing a single catalytic domain [, ].
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Publication
22171010 | J:181974
First Author: Seo S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.
Volume: 109
Issue: 6
Pages: 2015-20
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Publication
1676894 | J:11316
First Author: Westaway D
Year: 1991
Journal: Neuron
Title: Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice.
Volume: 7
Issue: 1
Pages: 59-68
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Publication
11085929 | J:66748
 
First Author: Kiss A
Year: 2000
Journal: Biochem J
Title: Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain.
Volume: 352 Pt 2
Pages: 363-72
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Publication
10426284 | J:55875
First Author: Wong A
Year: 1999
Journal: Biochem Cell Biol
Title: Myoid cell density in the thymus is reduced during mdx dystrophy and after muscle crush.
Volume: 77
Issue: 1
Pages: 33-40
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Publication
25188282 | J:223424
First Author: Hill A
Year: 2014
Journal: PLoS One
Title: Lubricin protects the temporomandibular joint surfaces from degeneration.
Volume: 9
Issue: 9
Pages: e106497
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Publication
22553324 | J:186188
First Author: Garidou L
Year: 2012
Journal: J Virol
Title: Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.
Volume: 86
Issue: 13
Pages: 7060-71
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Publication
32793592 | J:359537
 
First Author: Hahn A
Year: 2020
Journal: Front Cell Dev Biol
Title: DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.
Volume: 8
Pages: 639
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Publication
22530652 | -
 
First Author: Kasaras A
Year: 2012
Journal: BMC Plant Biol
Title: Arabidopsis senescence-associated protein DMP1 is involved in membrane remodeling of the ER and tonoplast.
Volume: 12
Pages: 54
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Publication
17336467 | -
First Author: Montesanti A
Year: 2007
Journal: Gene
Title: Cloning and characterization of Xenopus laevis Smac/DIABLO.
Volume: 392
Issue: 1-2
Pages: 187-95
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Publication
18202662 | -
First Author: Deana A
Year: 2008
Journal: Nature
Title: The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal.
Volume: 451
Issue: 7176
Pages: 355-8
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Publication
7969155 | -
First Author: Jenny A
Year: 1994
Journal: Mol Cell Biol
Title: Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit.
Volume: 14
Issue: 12
Pages: 8183-90
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Publication
18034856 | -
First Author: Okumura A
Year: 2008
Journal: FEBS J
Title: Interaction of alpha1-syntrophin with multiple isoforms of heterotrimeric G protein alpha subunits.
Volume: 275
Issue: 1
Pages: 22-33
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Publication
12887062 | -
First Author: Farkas A
Year: 2003
Journal: Biol Chem
Title: Revisiting ubiquity and tissue specificity of human calpains.
Volume: 384
Issue: 6
Pages: 945-9
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Publication
17681937 | -
First Author: Singh A
Year: 2007
Journal: J Biol Chem
Title: The metalloreductase Fre6p in Fe-efflux from the yeast vacuole.
Volume: 282
Issue: 39
Pages: 28619-26
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Publication
25155057 | -
First Author: Murshid A
Year: 2014
Journal: Immunobiology
Title: Hsp90-peptide complexes stimulate antigen presentation through the class II pathway after binding scavenger receptor SREC-I.
Volume: 219
Issue: 12
Pages: 924-31
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Publication
22981770 | -
First Author: Hinas A
Year: 2012
Journal: Curr Biol
Title: SID-5 is an endosome-associated protein required for efficient systemic RNAi in C. elegans.
Volume: 22
Issue: 20
Pages: 1938-43
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Publication
15037311 | -
First Author: Nayal A
Year: 2004
Journal: Curr Opin Cell Biol
Title: Talin: an emerging focal point of adhesion dynamics.
Volume: 16
Issue: 1
Pages: 94-8
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Publication
3881388 | -
First Author: Rodríguez-Tébar A
Year: 1985
Journal: J Bacteriol
Title: Location of some proteins involved in peptidoglycan synthesis and cell division in the inner and outer membranes of Escherichia coli.
Volume: 161
Issue: 1
Pages: 243-8
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Publication
29758043 | -
First Author: Berrun A
Year: 2018
Journal: PLoS One
Title: Isthmin 1 (ism1) is required for normal hematopoiesis in developing zebrafish.
Volume: 13
Issue: 5
Pages: e0196872
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Publication
25090086 | -
 
First Author: Sadhukhan A
Year: 2014
Journal: Plant Physiol Biochem
Title: The cowpea RING ubiquitin ligase VuDRIP interacts with transcription factor VuDREB2A for regulating abiotic stress responses.
Volume: 83
Pages: 51-6
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Publication
19383092 | -
First Author: Bravo-Garcia A
Year: 2009
Journal: New Phytol
Title: Specialization of the Golden2-like regulatory pathway during land plant evolution.
Volume: 183
Issue: 1
Pages: 133-141
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Publication
37000005 | J:338879
First Author: Hernández-García A
Year: 2023
Journal: Hum Mol Genet
Title: SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2.
Volume: 32
Issue: 13
Pages: 2152-2161
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Publication
7875225 | J:23271
First Author: Kaushik A
Year: 1995
Journal: Eur J Immunol
Title: The nude mutation results in impaired primary antibody repertoire.
Volume: 25
Issue: 2
Pages: 631-4
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Publication
10508182 | J:110493
First Author: Wilson A
Year: 1999
Journal: Int Immunol
Title: Unexpectedly late expression of intracellular CD3epsilon and TCR gammadelta proteins during adult thymus development.
Volume: 11
Issue: 10
Pages: 1641-50
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Publication
14978084 | J:88234
First Author: Khanolkar A
Year: 2004
Journal: J Immunol
Title: CD4 T cell-dependent CD8 T cell maturation.
Volume: 172
Issue: 5
Pages: 2834-44
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Publication
25574039 | J:230914
First Author: Waddell A
Year: 2015
Journal: Int Immunol
Title: NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis in mice.
Volume: 27
Issue: 5
Pages: 237-44
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Publication
9317154 | J:43086
First Author: Shiraishi A
Year: 1997
Journal: J Immunol
Title: The role of IFN regulatory factor-1 in synovitis and nitric oxide production.
Volume: 159
Issue: 7
Pages: 3549-54
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Publication
10557086 | J:58363
First Author: Diévart A
Year: 1999
Journal: Oncogene
Title: Involvement of Notch1 in the development of mouse mammary tumors.
Volume: 18
Issue: 44
Pages: 5973-81
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Publication
18368112 | J:134169
First Author: Losonczy A
Year: 2008
Journal: Nature
Title: Compartmentalized dendritic plasticity and input feature storage in neurons.
Volume: 452
Issue: 7186
Pages: 436-41
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Publication
20801198 | J:166780
First Author: Lockridge A
Year: 2010
Journal: Neuroscience
Title: Abnormal 5-HT modulation of stress behaviors in the Kv4.2 knockout mouse.
Volume: 170
Issue: 4
Pages: 1086-97
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Publication
37759786 | J:342508
 
First Author: Almotiri A
Year: 2023
Journal: Biomolecules
Title: Zeb1 Regulates the Function of Lympho-Myeloid Primed Progenitors after Transplantation.
Volume: 13
Issue: 9
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Publication
27208894 | J:310270
First Author: Hascup KN
Year: 2017
Journal: J Gerontol A Biol Sci Med Sci
Title: Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging.
Volume: 72
Issue: 3
Pages: 329-337
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Publication
36880575 | J:335733
First Author: Teghanemt A
Year: 2023
Journal: EMBO Rep
Title: DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.
Volume: 24
Issue: 5
Pages: e55543
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Publication
15579462 | -
First Author: Putrenko I
Year: 2005
Journal: J Biol Chem
Title: A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans.
Volume: 280
Issue: 8
Pages: 6392-8
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Publication
31735332 | J:292590
First Author: Shen A
Year: 2020
Journal: Biochem Biophys Res Commun
Title: MicroRNA-24-3p alleviates hepatic ischemia and reperfusion injury in mice through the repression of STING signaling.
Volume: 522
Issue: 1
Pages: 47-52
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Publication
22846424 | J:187997
First Author: Chamberlain CM
Year: 2012
Journal: Hum Mol Genet
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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