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Search results 1901 to 2000 out of 2074 for Cx3cr1

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Hits by Strain

Type Details Score
Strain
MGI:6770638 | C57BL/6JSmoc-Cd3e<em3Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
24789099 | -
First Author: Fujita M
Year: 2014
Journal: PLoS One
Title: The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.
Volume: 9
Issue: 5
Pages: e96372
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Strain
MGI:6428504 | C57BL/6JSmoc-Cx3cr1<em2(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Cx3cr1<em1(icre)Smoc> | MGI:6724386
Name: C-X3-C motif chemokine receptor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout, Recombinase
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Allele
Cx3cr1<em3Smoc> | MGI:7289210
Name: C-X3-C motif chemokine receptor 1; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Cx3cr1<em5Smoc> | MGI:7289212
Name: C-X3-C motif chemokine receptor 1; endonuclease-mediated mutation 5, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6428505 | C57BL/6JSmoc-Cx3cr1<em1(icre)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6354716 | C57BL/6JSmoc-Cx3cr1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Cx3cr1<em4(icre)Cya> | MGI:7657239
Name: C-X3-C motif chemokine receptor 1; endonuclease-mediated mutation 4, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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Allele
Cx3cr1<tm1.1Dpa> | MGI:3842686
Name: C-X3-C motif chemokine receptor 1; targeted mutation 1.1, Dhavalkumar D Patel
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Strain
MGI:7657594 | C57BL/6J-Cx3cr1<em4(icre)Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(Cx3cr1-cre)MW126Gsat | MGI:5311737
Name: transgene insertion MW126, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Cx3cr1<tm2.1(cre/ERT2)Jung> | MGI:5467985
Name: C-X3-C motif chemokine receptor 1; targeted mutation 2.1, Steffen Jung
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Allele
Cx3cr1<em1Mbur> | MGI:6840220
Name: C-X3-C motif chemokine receptor 1; endonuclease-mediated mutation 1, Marie Burns
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout, Reporter
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Publication
38987568 | J:353050
First Author: Krishnacoumar B
Year: 2024
Journal: Bone Res
Title: Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors.
Volume: 12
Issue: 1
Pages: 40
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Strain
MGI:5313006 | STOCK Tg(Cx3cr1-cre)MW126Gsat/Mmucd
Attribute String: transgenic, mutant stock
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Strain
MGI:5562552 | B6.129P2(C)-Cx3cr1<tm2.1(cre/ERT2)Jung>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5561395 | B6.129(C)-Cx3cr1<tm2.1(cre/ERT2)Jung>/Orl
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5617704 | B6.Cg-Cx3cr1<tm2.1(cre/ERT2)Jung>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5568569 | B6.129P2(C)-Cx3cr1<tm2.1(cre/ERT2)Jung>/J
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:6840221 | C57BL/6-Cx3cr1<em1Mbur>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
33921365 | J:350015
 
First Author: Saika F
Year: 2021
Journal: Cells
Title: Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice.
Volume: 10
Issue: 4
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HT Experiment
GSE66211 | Mecp2: an unexpected regulator of macrophage gene expression and function [RNA-Seq]
Series Id: E-GEOD-66211
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
32636748 | J:308243
 
First Author: Saika F
Year: 2020
Journal: Front Pharmacol
Title: Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain.
Volume: 11
Pages: 925
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Publication
36003376 | J:349677
 
First Author: Royzman D
Year: 2022
Journal: Front Immunol
Title: The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis.
Volume: 13
Pages: 936995
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Publication
36875129 | J:335138
 
First Author: Peckert-Maier K
Year: 2023
Journal: Front Immunol
Title: CD83 expressed by macrophages is an important immune checkpoint molecule for the resolution of inflammation.
Volume: 14
Pages: 1085742
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Publication
11063828 | J:78206
First Author: Dorf ME
Year: 2000
Journal: J Neuroimmunol
Title: Astrocytes express functional chemokine receptors.
Volume: 111
Issue: 1-2
Pages: 109-21
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Publication
39769442 | J:361221
 
First Author: Yang H
Year: 2024
Journal: Int J Mol Sci
Title: Adoptive Transfer of CX3CR1-Transduced Tregs Homing to the Forebrain in Lipopolysaccharide-Induced Neuroinflammation and 3xTg Alzheimer's Disease Models.
Volume: 25
Issue: 24
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Publication
32868461 | J:298898
First Author: Zhao XF
Year: 2020
Journal: J Neurosci
Title: Microglial mTOR is Neuronal Protective and Antiepileptogenic in the Pilocarpine Model of Temporal Lobe Epilepsy.
Volume: 40
Issue: 40
Pages: 7593-7608
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Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
38025772 | J:351842
First Author: Eisa NH
Year: 2023
Journal: iScience
Title: Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer.
Volume: 26
Issue: 12
Pages: 108308
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Publication
29234059 | J:257682
First Author: Okuma A
Year: 2017
Journal: Nat Commun
Title: p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.
Volume: 8
Issue: 1
Pages: 2050
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Publication
38781024 | J:351316
 
First Author: Zhang B
Year: 2024
Journal: J Clin Invest
Title: Interruption of KLF5 acetylation promotes PTEN-deficient prostate cancer progression by reprogramming cancer-associated fibroblasts.
Volume: 134
Issue: 14
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Publication
36608690 | J:336320
First Author: de Almeida MMA
Year: 2023
Journal: Stem Cell Reports
Title: Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model.
Volume: 18
Issue: 2
Pages: 519-533
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Publication
38395613 | J:350701
 
First Author: Heir R
Year: 2024
Journal: J Neurosci
Title: Astrocytes Are the Source of TNF Mediating Homeostatic Synaptic Plasticity.
Volume: 44
Issue: 14
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Publication
33472865 | J:349851
 
First Author: Alam MM
Year: 2021
Journal: eNeuro
Title: Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures.
Volume: 8
Issue: 1
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Publication
35568187 | J:347505
 
First Author: Madalena KM
Year: 2022
Journal: Exp Neurol
Title: Genetic deletion of the glucocorticoid receptor in Cx(3)cr1(+) myeloid cells is neuroprotective and improves motor recovery after spinal cord injury.
Volume: 355
Pages: 114114
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Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
26466066 | -
First Author: Palomino DC
Year: 2015
Journal: Einstein (Sao Paulo)
Title: Chemokines and immunity.
Volume: 13
Issue: 3
Pages: 469-73
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Protein Domain
IPR039809 | Chemokine_b/g/d
Type: Family
Description: The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family), or separated by an intervening residue (the CXC family), or have only one of the first two Cys residues (C chemokines), or contain both cysteines separated by three intervening residues (CX3C chemokines).This entry includes beta-chemokines (CC chemokines), in addition to gamma (C chemokines) and delta-chemokines (CX3C chemokines). CC chemokines stimulate mainly monocytes, but also basophils, eosinophils, T-lymphocytes, and natural killer (NK) cells. C-C motif chemokine 2 (CCL2) stimulates chemotaxis of monocytes and several cellular events associated with chemotaxis. Two other chemokines structurally related to CCL2 are CCL8 (MCP-2) and CCL7 (MCP-3) [].The C chemokine subfamily is composed of two members, XC chemokine ligand 1 (XCL1), also known as lymphotactin or SCM-1 alpha, and XC chemokine ligand 2 (XCL2), also known as SCM-1 beta []. The cognate receptor for these chemokines is XCR1 []. The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. With its unique CX3CR1 receptor [], it is involved in adherence to the endothelium of the inflammatory monocyte population [].
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Publication
12810688 | -
First Author: Ancuta P
Year: 2003
Journal: J Exp Med
Title: Fractalkine preferentially mediates arrest and migration of CD16+ monocytes.
Volume: 197
Issue: 12
Pages: 1701-7
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Publication
9390561 | -
First Author: Imai T
Year: 1997
Journal: Cell
Title: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.
Volume: 91
Issue: 4
Pages: 521-30
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Publication
20101093 | J:156667
First Author: Wang Y
Year: 2010
Journal: J Clin Invest
Title: TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice.
Volume: 120
Issue: 2
Pages: 422-32
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Publication
19679829 | J:167800
First Author: Westmuckett AD
Year: 2009
Journal: Arterioscler Thromb Vasc Biol
Title: Lack of tyrosylprotein sulfotransferase activity in hematopoietic cells drastically attenuates atherosclerosis in Ldlr-/- mice.
Volume: 29
Issue: 11
Pages: 1730-6
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Publication
26826252 | J:350568
First Author: Tian Y
Year: 2016
Journal: J Immunol
Title: A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.
Volume: 196
Issue: 5
Pages: 2153-66
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Publication
29625473 | J:261172
First Author: Royer DJ
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II.
Volume: 59
Issue: 3
Pages: 1512-1522
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Publication
20070942 | J:158836
First Author: Gomez-Nicola D
Year: 2010
Journal: Exp Neurol
Title: Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice.
Volume: 222
Issue: 2
Pages: 235-42
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Publication
26932821 | J:233012
 
First Author: Hamers AA
Year: 2016
Journal: BMC Genomics
Title: Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance.
Volume: 17
Pages: 162
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Publication
36428484 | J:357648
 
First Author: Sarikidi A
Year: 2022
Journal: Biomedicines
Title: Altered Immunomodulatory Responses in the CX3CL1/CX3CR1 Axis Mediated by hMSCs in an Early In Vitro SOD1(G93A) Model of ALS.
Volume: 10
Issue: 11
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Publication
30253780 | J:267673
First Author: Bemiller SM
Year: 2018
Journal: J Neuroinflammation
Title: Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.
Volume: 15
Issue: 1
Pages: 278
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Publication
30554086 | J:276178
 
First Author: Gabbouj S
Year: 2019
Journal: Neurobiol Aging
Title: Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice.
Volume: 75
Pages: 98-108
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Publication
32125017 | J:297744
First Author: Chu KL
Year: 2020
Journal: J Leukoc Biol
Title: GITR differentially affects lung effector T cell subpopulations during influenza virus infection.
Volume: 107
Issue: 6
Pages: 953-970
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Publication
22880104 | J:189819
First Author: Sato Y
Year: 2012
Journal: PLoS One
Title: Effective elicitation of human effector CD8+ T Cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1.
Volume: 7
Issue: 8
Pages: e42776
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Publication
23691170 | J:202169
First Author: Khandelwal P
Year: 2013
Journal: PLoS One
Title: Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses.
Volume: 8
Issue: 5
Pages: e64193
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Publication
25652399 | J:220851
First Author: Yu AK
Year: 2015
Journal: Hum Mol Genet
Title: Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse.
Volume: 24
Issue: 10
Pages: 2848-60
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Publication
28096568 | J:266466
 
First Author: Cunha C
Year: 2016
Journal: Mediators Inflamm
Title: Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization.
Volume: 2016
Pages: 6986175
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Publication
23851506 | J:212577
First Author: Borsig L
Year: 2014
Journal: Oncogene
Title: Inflammatory chemokines and metastasis--tracing the accessory.
Volume: 33
Issue: 25
Pages: 3217-24
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Publication
28267793 | J:248026
First Author: Koenen A
Year: 2017
Journal: PLoS One
Title: The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion.
Volume: 12
Issue: 3
Pages: e0173486
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Publication
33325803 | J:301028
     
First Author: Godwin MS
Year: 2020
Journal: Am J Physiol Lung Cell Mol Physiol
Title: The chemokine CX3CL1/fractalkine regulates immunopathogenesis during fungal-associated allergic airway inflammation.
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Publication
31440125 | J:313078
 
First Author: Yli-Karjanmaa M
Year: 2019
Journal: Front Neurosci
Title: Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice.
Volume: 13
Pages: 781
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Publication
34896181 | J:319776
 
First Author: Barbosa-Silva MC
Year: 2022
Journal: Brain Behav Immun
Title: Mice lacking 5-lipoxygenase display motor deficits associated with cortical and hippocampal synapse abnormalities.
Volume: 100
Pages: 183-193
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Publication
36162508 | J:331082
First Author: Gayen M
Year: 2022
Journal: J Biol Chem
Title: The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling.
Volume: 298
Issue: 11
Pages: 102532
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Publication
36457161 | J:333096
 
First Author: Li Z
Year: 2023
Journal: Dis Model Mech
Title: A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models.
Volume: 16
Issue: 1
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Publication
39137048 | J:354612
 
First Author: Tripathi S
Year: 2024
Journal: J Clin Invest
Title: Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma.
Volume: 134
Issue: 19
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Publication
30765845 | J:287942
First Author: Mathur R
Year: 2019
Journal: Mucosal Immunol
Title: Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis.
Volume: 12
Issue: 3
Pages: 612-623
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Publication
36104437 | J:349118
First Author: Kemp GM
Year: 2022
Journal: Mol Psychiatry
Title: Sustained TNF signaling is required for the synaptic and anxiety-like behavioral response to acute stress.
Volume: 27
Issue: 11
Pages: 4474-4484
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Publication
27112496 | J:239474
First Author: Lewitus GM
Year: 2016
Journal: Neuron
Title: Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization.
Volume: 90
Issue: 3
Pages: 483-91
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Publication
31138885 | J:278640
First Author: Pernici CD
Year: 2019
Journal: Sci Rep
Title: Time course images of cellular injury and recovery in murine brain with high-resolution GRIN lens system.
Volume: 9
Issue: 1
Pages: 7946
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Publication
9726990 | -
First Author: Combadiere C
Year: 1998
Journal: J Biol Chem
Title: Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.
Volume: 273
Issue: 37
Pages: 23799-804
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Publication
15786508 | -
First Author: Sbrana S
Year: 2005
Journal: Cytometry B Clin Cytom
Title: Post-reperfusion changes of monocyte function in coronary blood after extracorporeal circulation.
Volume: 65
Issue: 1
Pages: 14-21
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Publication
7590284 | -
First Author: Raport CJ
Year: 1995
Journal: Gene
Title: The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues.
Volume: 163
Issue: 2
Pages: 295-9
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Publication
17479179 | -
First Author: Ludwig A
Year: 2007
Journal: Thromb Haemost
Title: Transmembrane chemokines: versatile 'special agents' in vascular inflammation.
Volume: 97
Issue: 5
Pages: 694-703
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Publication
12714508 | -
First Author: Hundhausen C
Year: 2003
Journal: Blood
Title: The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Volume: 102
Issue: 4
Pages: 1186-95
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Publication
11495925 | -
First Author: Garton KJ
Year: 2001
Journal: J Biol Chem
Title: Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).
Volume: 276
Issue: 41
Pages: 37993-8001
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Publication
12969992 | -
First Author: Umehara H
Year: 2004
Journal: Arterioscler Thromb Vasc Biol
Title: Fractalkine in vascular biology: from basic research to clinical disease.
Volume: 24
Issue: 1
Pages: 34-40
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Protein Domain
IPR005387 | Chemokine_CX3CR1
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. It is a transmembrane molecule containing a chemokine domain on an extended mucin-like stalk []. Both the adhesive and chemotactic effects of CX3CL1 are mediated through CX3C chemokine receptor type 1 (CX3CR1), also known as fractalkine receptor []. The receptor is expressed specifically on T cells, natural killer cells and monocytes [, ]. Coupling of the receptor to pertussis toxin-sensitive Gi proteins leads to calcium mobilisation and chemotaxis []. In contrast, adhesion mediated by the receptor is insensitive to pertussis toxin and does not appear to involve calcium mobilisation. CX3CR1 has also been found to act as a weak fusion cofactor for some HIV-1 strains, an interaction that can be potently and specifically blocked by CX3CL1 [].
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Protein Domain
IPR008097 | CX3CL1
Type: Family
Description: The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. With its unique CX3CR1 receptor [], it is involved in adherence to the endothelium of the inflammatory monocyte population [].CX3CL1 and CXCL16 represent two exceptions among the members of the chemokine family. In addition to their chemokine domain, they possess three other domains: a mucin-like stalk, a transmembrane (TM) domain, and a cytosolic tail [, ]. When interacting with their cognate receptors (CX3CR1 and CXCR6, respectively), these chemokines induce cell-cell adhesion []. CX3CL1 and CXCL16 can also be cleaved by metalloproteinases to yield a soluble form that is chemotactic [, ]. CX3CL1 also binds and activates integrins through its chemokine domain in a CX3CR1-dependent and independent manner, binding to the classical ligand-binding site (RGD-binding site, site 1) or to a second site (site 2) in integrins, respectively [].Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions,and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).
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Publication
25767273 | J:241334
First Author: Ebrahimian T
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE-/- Mice.
Volume: 35
Issue: 5
Pages: 1190-7
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Publication
15596719 | J:95279
First Author: Teupser D
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root.
Volume: 101
Issue: 51
Pages: 17795-800
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Publication
30816678 | J:294699
First Author: Schuett J
Year: 2019
Journal: Cell Physiol Biochem
Title: Suppressor of Cytokine Signaling 1 is Involved in Gene Regulation Which Controls the Survival of Ly6Clow Monocytes in Mice.
Volume: 52
Issue: 2
Pages: 336-353
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Publication
22575169 | J:186182
First Author: Gardner CR
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase.
Volume: 262
Issue: 2
Pages: 139-48
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Publication
30607245 | J:357806
 
First Author: Zhang J
Year: 2018
Journal: Transl Neurodegener
Title: Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model.
Volume: 7
Pages: 35
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Publication
23029290 | J:191975
First Author: Reed JR
Year: 2012
Journal: PLoS One
Title: Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent manner.
Volume: 7
Issue: 9
Pages: e45877
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Publication
26348210 | J:243007
First Author: Kim YG
Year: 2015
Journal: PLoS One
Title: Pathogenic Role of a Proliferation-Inducing Ligand (APRIL) in Murine IgA Nephropathy.
Volume: 10
Issue: 9
Pages: e0137044
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Publication
29401617 | J:274296
First Author: Song C
Year: 2018
Journal: FASEB J
Title: REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation.
Volume: 32
Issue: 6
Pages: 3215-3228
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Protein
O35188
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
Q8C9Y1
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
A0A1D5RMK8
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
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Publication
9024663 | J:42645
First Author: Bazan JF
Year: 1997
Journal: Nature
Title: A new class of membrane-bound chemokine with a CX3C motif.
Volume: 385
Issue: 6617
Pages: 640-4
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Publication
36976180 | J:349821
 
First Author: Culemann S
Year: 2023
Journal: J Exp Med
Title: Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes.
Volume: 220
Issue: 6
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Publication
24584051 | J:212017
First Author: Crotti A
Year: 2014
Journal: Nat Neurosci
Title: Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors.
Volume: 17
Issue: 4
Pages: 513-21
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Publication
30447281 | J:336190
 
First Author: Rivera PD
Year: 2019
Journal: Brain Behav Immun
Title: Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.
Volume: 76
Pages: 104-115
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Protein
O35903
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Protein
P84444
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
P86793
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
P86792
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
Q7TMS1
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: false
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