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Search results 1901 to 2000 out of 2795 for Egfr

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
Q8R550
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
Q62420
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Protein
O88811
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
P70297
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Publication
24917243 | J:223994
 
First Author: Zangrando J
Year: 2014
Journal: BMC Genomics
Title: Identification of candidate long non-coding RNAs in response to myocardial infarction.
Volume: 15
Pages: 460
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Protein Coding Gene
MGI:95290 | Egf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107508 | Ereg
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
36525973 | J:336850
First Author: Pan Y
Year: 2023
Journal: Cancer Cell
Title: KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition.
Volume: 41
Issue: 1
Pages: 88-105.e8
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Allele
Tg(tetO-EGFR*L858R)57Hev | MGI:3690075
Name: transgene insertion 57, Harold E Varmus
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Strain
MGI:7545203 | C57BL/6-Gt(ROSA)26Sor<tm2(CAG-Egfr*L860R)Rnem>/J
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Egfr/Egfr<+>
Background: involves: BALB/cAnN * C3H/HeN
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egfr/Egfr
Background: involves: BALB/cAnN * C3H/HeN
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egfr/Egfr
Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egfr/Egfr<+>
Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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GO Term
GO:1901185 | negative regulation of ERBB signaling pathway
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GO Term
GO:1901186 | positive regulation of ERBB signaling pathway
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GO Term
GO:1905282 | regulation of epidermal growth factor receptor signaling pathway involved in heart process
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Publication
27702896 | J:238629
First Author: McFadden DG
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.
Volume: 113
Issue: 42
Pages: E6409-E6417
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Publication
25767874 | J:232975
First Author: Cai Y
Year: 2015
Journal: PLoS One
Title: CCAAT/enhancer binding protein β is dispensable for development of lung adenocarcinoma.
Volume: 10
Issue: 3
Pages: e0120647
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Publication
25596284 | J:219801
First Author: Song X
Year: 2015
Journal: Cancer Res
Title: ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas.
Volume: 75
Issue: 6
Pages: 1035-45
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Protein Domain
IPR028539 | Fer
Type: Family
Description: Fer () is a tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis [, ]. In non-small cell lung cancer cells, Fer kinase expression has been linked to cell invasion and tumour metastasis []. It also acts downstream of EGFR (EGF receptor) to promote activation of NF-kappa-B and cell proliferation [].
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Protein Domain
IPR028654 | SNX5
Type: Family
Description: Sorting nexin-5 (SNX5) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. SNX5 also contains a BAR domain that is C terminus to the PX domain. Besides being involved in several stages of intracellular trafficking, SNX5 also plays a role in macropinocytosis and in the internalisation of EGFR after EGF stimulation [, ].
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Publication
20007486 | J:157671
First Author: Politi K
Year: 2010
Journal: Dis Model Mech
Title: Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma.
Volume: 3
Issue: 1-2
Pages: 111-9
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Protein Coding Gene
MGI:97615 | Plcg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1860493 | Arhgef7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88537 | Csk
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P31955
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Protein
Q9ES28
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
P41241
Organism: Mus musculus/domesticus
Length: 450  
Fragment?: false
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Protein
P48030
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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HT Experiment
E-GEOD-6672 | Differential gene expression in brain of the Cin85-/- mutant mouse line
Series Id: GSE6672
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE68270 | Lysophosphatidic acid receptor expression identifies a pure population of adult hippocampal stem cells with an immune cell-related transcriptional profile
Series Id: E-GEOD-68270
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
26404003 | J:226773
First Author: Biktasova AK
Year: 2015
Journal: Cancer Res
Title: Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted Therapy.
Volume: 75
Issue: 22
Pages: 4728-41
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Strain
MGI:6144463 | B6;CBA-Tg(tetO-EGFR*L858R)56Hev/Nci
Attribute String: mutant stock, transgenic
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Publication
36612121 | J:332504
 
First Author: Hong SH
Year: 2022
Journal: Cancers (Basel)
Title: EGFR-Tyrosine Kinase Inhibitors Induced Activation of the Autocrine CXCL10/CXCR3 Pathway through Crosstalk between the Tumor and the Microenvironment in EGFR-Mutant Lung Cancer.
Volume: 15
Issue: 1
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Allele
Egfr<m2Btlr> | MGI:5775041
 
Name: epidermal growth factor receptor; mutation 2, Bruce Beutler
Allele Type: Chemically induced (ENU)
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Genotype
Genotype
Symbol: Egfr/Egfr
Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egfr/Egfr<+> Tgfa/Tgfa
Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apc/Apc<+> Egfr/Egfr<+>
Background: involves: BALB/cAnN * C3H/HeN * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Protein
Q3UZ39
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
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Protein
Q91WK0
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
G5E8E1
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q8C062
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: true
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Protein
A0A087WNU6
Organism: Mus musculus/domesticus
Length: 575  
Fragment?: true
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Protein
Q8BLM1
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: true
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Protein
E9Q9T1
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
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Protein
A0A0G2JEF6
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
A0A1L1SQW1
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Protein
A0A668KLE1
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
A0A087WPT0
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
A0A0G2JEP4
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
A0A0G2JGZ1
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Protein
F6WPJ5
Organism: Mus musculus/domesticus
Length: 62  
Fragment?: true
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Protein
E9QN52
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
A0A1L1SSC0
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
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Protein
A0A087WPK3
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Protein
A0A0G2JDR6
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Protein
A0A1L1SVG1
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
Q8BLV4
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: true
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Protein
A0A0R4J169
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
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Protein
A0A087WSF5
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: true
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Protein
A0A0G2JFV5
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
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Protein
A6H5U5
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Publication
16199883 | -
First Author: Suriano AR
Year: 2005
Journal: Mol Cell Biol
Title: GCF2/LRRFIP1 represses tumor necrosis factor alpha expression.
Volume: 25
Issue: 20
Pages: 9073-81
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Publication
19265123 | J:145929
First Author: Dai P
Year: 2009
Journal: J Immunol
Title: Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.
Volume: 182
Issue: 6
Pages: 3450-60
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Publication
15677333 | -
First Author: Liu J
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
Volume: 102
Issue: 6
Pages: 1927-32
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Publication
27411854 | -
 
First Author: Guan F
Year: 2016
Journal: Sci Rep
Title: Two-stage association study to identify the genetic susceptibility of a novel common variant of rs2075290 in ZPR1 to type 2 diabetes.
Volume: 6
Pages: 29586
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Protein Domain
IPR040141 | ZPR1
Type: Family
Description: This family consist of zinc finger protein ZPR1 and ZPR1-like proteins. The function of ZPR1 is not clear. ZPR1 is present in both the cytoplasm and nucleoplasma and its subcellular distribution changes during proliferation []. ZPR1 binds to the cytoplasmic tyrosine kinase domain of the epidermal growth factor receptor (EGFR) []and is a component of downstream signaling of both EGFR and FGFR signaling []. It has been associated with susceptibility to type 2 diabetes []and is downregulated in patients with spinal muscular atrophy [].
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Protein Domain
IPR019139 | LRRFIP1/2
Type: Family
Description: Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA []. It may control smooth muscle cell proliferation following artery injury through PDGFA repression and may also bind double-stranded RNA. It interacts with the leucine-rich repeat domain of human flightless-I (FliI) protein [].Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) may function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin []. It positively regulates Toll-like receptor (TLR) signalling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding [].
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Protein Domain
IPR037452 | Fer_F-BAR
Type: Domain
Description: Fer () is a tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis [, ]. In non-small cell lung cancer cells, Fer kinase expression has been linked to cell invasion and tumour metastasis []. It also acts downstream of EGFR (EGF receptor) to promote activation of NF-kappa-B and cell proliferation [].This entry represents the F-BAR domain of Fer. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization [, ].
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Publication
22975369 | J:192909
First Author: Perera RM
Year: 2012
Journal: Cancer Cell
Title: Ready, set, go: the EGF receptor at the pancreatic cancer starting line.
Volume: 22
Issue: 3
Pages: 281-2
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Publication
25941338 | J:225617
First Author: Izumchenko E
Year: 2015
Journal: Cancer Discov
Title: Understanding the MIG6-EGFR Signaling Axis in Lung Tumorigenesis.
Volume: 5
Issue: 5
Pages: 472-4
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Publication
29321659 | J:261026
First Author: An Z
Year: 2018
Journal: Oncogene
Title: Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
Volume: 37
Issue: 12
Pages: 1561-1575
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Publication
17606629 | J:125059
First Author: Sangrar W
Year: 2007
Journal: Mol Cell Biol
Title: Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion.
Volume: 27
Issue: 17
Pages: 6140-52
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Publication
19738202 | -
First Author: Itoh T
Year: 2009
Journal: Sci Signal
Title: The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.
Volume: 2
Issue: 87
Pages: ra52
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Publication
23699534 | -
First Author: Ahn J
Year: 2013
Journal: Mol Cancer Res
Title: Fer protein-tyrosine kinase promotes lung adenocarcinoma cell invasion and tumor metastasis.
Volume: 11
Issue: 8
Pages: 952-63
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Publication
16705038 | J:109092
First Author: Politi K
Year: 2006
Journal: Genes Dev
Title: Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.
Volume: 20
Issue: 11
Pages: 1496-510
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Protein Coding Gene
MGI:88279 | Cbl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q05928
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
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Protein
P22682
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
P01132
Organism: Mus musculus/domesticus
Length: 1217  
Fragment?: false
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Protein
Q06186
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
Q61521
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Protein
Q9QYY0
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein Coding Gene
MGI:98354 | Sos1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99511 | Ptpn11
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23143308 | J:193977
First Author: Maeda Y
Year: 2012
Journal: J Clin Invest
Title: Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung.
Volume: 122
Issue: 12
Pages: 4388-400
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Publication
32286289 | J:336880
First Author: Morales Torres C
Year: 2020
Journal: Nat Commun
Title: Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis.
Volume: 11
Issue: 1
Pages: 1792
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Publication
26759237 | J:231326
First Author: Dubois F
Year: 2016
Journal: Cancer Res
Title: RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway.
Volume: 76
Issue: 6
Pages: 1627-40
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Publication
36439884 | J:331704
First Author: Zhang Y
Year: 2022
Journal: Int J Biol Sci
Title: Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer.
Volume: 18
Issue: 16
Pages: 6114-6128
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Publication
35990740 | J:348819
First Author: Park JH
Year: 2022
Journal: STAR Protoc
Title: Protocol to analyze antitumor immunity of orthotopic injection and spontaneous murine high-grade glioma models using flow cytometry and single-cell RNA sequencing.
Volume: 3
Issue: 3
Pages: 101607
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Strain
MGI:5775055 | C57BL/6J-Egfr<m2Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Genotype
Genotype
Symbol: Egfr/Egfr
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egfr/Egfr
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA)1Jaw/? Tg(tetO-EGFR*L858R)56Hev/?
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA)1Jaw/? Tg(tetO-EGFR*L858R)57Hev/?
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA)1Jaw/? Tg(tetO-EGFR*delta19)11Hev/?
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a Col1a1/Col1a1 Pten/Pten
Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a Col1a1/Col1a1 Pten/Pten
Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Sftpc-rtTA,Nudt18-tetO-cre)1Ptch/? Tg(tetO-EGFR*L858R)56Hev/?
Background: involves: C57BL/6 * CBA * CD-1
Zygosity: cx
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom