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Search results 1901 to 2000 out of 2051 for Gsk3b

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:5784738
Assay Type: Western blot
Annotation Date: 2016-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:5785042
Age: embryonic day 18.5
Image: 5
Specimen Label: kidney +/+
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:5784738
Assay Type: Western blot
Annotation Date: 2016-07-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:5785042
Age: embryonic day 18.5
Image: 5
Specimen Label: kidney -/-
Detected: false
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:5784738
Assay Type: Western blot
Annotation Date: 2016-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:5785042
Age: embryonic day 18.5
Image: 5
Specimen Label: liver +/+
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:5784738
Assay Type: Western blot
Annotation Date: 2016-07-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:5785042
Age: embryonic day 18.5
Image: 5
Specimen Label: liver -/-
Detected: false
Specimen Num: 9
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Pathway
R-MMU-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
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Allele
Gskip<Gt(E223H07)Wrst> | MGI:3910083
 
Name: GSK3B interacting protein; gene trap E223H07, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Gskip<Gt(OST57674)Lex> | MGI:4165647
 
Name: GSK3B interacting protein; gene trap OST57674, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Gskip<Gt(OST245201)Lex> | MGI:4248782
 
Name: GSK3B interacting protein; gene trap OST245201, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Gskip<Gt(OST419814)Lex> | MGI:4311366
 
Name: GSK3B interacting protein; gene trap OST419814, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Gskip<Gt(OST430414)Lex> | MGI:4314465
 
Name: GSK3B interacting protein; gene trap OST430414, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Gskip<Gt(OST369153)Lex> | MGI:4296529
 
Name: GSK3B interacting protein; gene trap OST369153, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Gskip<Gt(OST401845)Lex> | MGI:4306025
 
Name: GSK3B interacting protein; gene trap OST401845, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Gskip<Gt(EUCE0190b09)Hmgu> | MGI:4395574
 
Name: GSK3B interacting protein; gene trap EUCE0190b09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Gskip<tm1.1Ekn> | MGI:5784740
Name: GSK3B interacting protein; targeted mutation 1.1, Enno Klussmann
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Gskip<tm1.2Ekn> | MGI:5784741
Name: GSK3B interacting protein; targeted mutation 1.2, Enno Klussmann
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Gskip<em1Gpt> | MGI:7299955
Name: GSK3B interacting protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Gskip<em2Gpt> | MGI:7299956
Name: GSK3B interacting protein; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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UniProt Feature
UniProt Feature
Begin: 130
Description: Required for GSK3B interaction; contributes to a protective effect against H(2)O(2)-induced apoptosis
Type: site
End: 130
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Allele
Gskip<Gt(IST10876G6)Tigm> | MGI:3971444
 
Name: GSK3B interacting protein; gene trap IST10876G6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Gskip<tm1(KOMP)Mbp> | MGI:4867934
Name: GSK3B interacting protein; targeted mutation 1, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Gskip<Gt(98A12)Cmhd> | MGI:4958278
 
Name: GSK3B interacting protein; gene trap 98A12, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Gskip<Gt(IST13874G5)Tigm> | MGI:5200920
 
Name: GSK3B interacting protein; gene trap IST13874G5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Gskip<Gt(IST14802F11)Tigm> | MGI:5263687
 
Name: GSK3B interacting protein; gene trap IST14802F11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:5784862 | B6.129P2(Cg)-Gskip<tm1.1Ekn>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5784864 | B6.129P2(Cg)-Gskip<tm1.2Ekn>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:8358679 | C57BL/6JGpt-Gskip<em1Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:8356506 | C57BL/6JGpt-Gskip<em2Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Gskip/Gskip
Background: B6.129P2(Cg)-Gskip
Zygosity: hm
Has Mutant Allele: true
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Allele
Gsk3b<em2Smoc> | MGI:7645431
Name: glycogen synthase kinase 3 beta; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Gskip/Gskip<+>
Background: B6.129P2(Cg)-Gskip
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:6770799 | C57BL/6JSmoc-Gsk3b<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
27484798 | -
First Author: Dema A
Year: 2016
Journal: J Biol Chem
Title: The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3? Interaction Protein (GSKIP) Regulates ?-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3?.
Volume: 291
Issue: 37
Pages: 19618-30
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Protein Domain
IPR037395 | GSKIP
Type: Family
Description: A-kinase anchoring protein GSKIP is a cytosolic scaffolding protein that binds GSK3B (glycogen synthase kinase 3-beta) and PKA (protein kinase A). Both interactions with GSK3B and PKA are required for the regulation of beta-catenin, and thus Wnt signaling [].
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Publication
30018153 | J:265192
 
First Author: Hikita T
Year: 2018
Journal: EMBO Rep
Title: PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow.
Volume: 19
Issue: 9
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Publication
34748402 | J:320198
First Author: Sakai SS
Year: 2022
Journal: Mol Cell Biol
Title: Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size.
Volume: 42
Issue: 1
Pages: e0002421
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Allele
Gsk3b<em1Smoc> | MGI:7290034
Name: glycogen synthase kinase 3 beta; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Gt(ROSA)26Sor<tm1(CAG-Gsk3b)Ddb> | MGI:8394334
Name: gene trap ROSA 26, Philippe Soriano; argeted mutation 1, Daniel D Billadeau
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Allele
Tg(GSK3B*S9A)1Vln | MGI:3722095
Name: transgene insertion 1, Fred Fan Leuven
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6475439 | C57BL/6JSmoc-Gsk3b<tm1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Coding Gene
MGI:108420 | Nfe2l2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q60795
Organism: Mus musculus/domesticus
Length: 597  
Fragment?: false
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Publication
12182887 | J:129808
First Author: Spittaels K
Year: 2002
Journal: Neuroscience
Title: Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice.
Volume: 113
Issue: 4
Pages: 797-808
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Allele
Tg(Myh6/tetO-Gsk3b*S9A)1Rbns | MGI:3757954
Name: transgene insertion 1, Jeffrey Robbins
Allele Type: Transgenic
Attribute String: Constitutively active, Inducible, Inserted expressed sequence
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Allele
Tg(tetO-lacZ,-Gsk3b)G6Avil | MGI:8209198
Name: transgene insertion G6, J Avila
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence, Reporter
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Protein
Q8BGR8
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: false
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Protein
Q3TBR1
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Protein
A0A1Y7VNZ5
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Allele
Gt(ROSA)26Sor<tm4(RNAi:Gsk3a,Gsk3b)Rkuhn> | MGI:3785819
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Ralf Kuhn
Allele Type: Targeted
Attribute String: Knockdown, RMCE-ready
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Allele
Gt(ROSA)26Sor<tm7(RNAi:Gsk3b)Rkuhn> | MGI:3785845
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 7, Ralf Kuhn
Allele Type: Targeted
Attribute String: Conditional ready, Knockdown, RMCE-ready
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Genotype
Genotype
Symbol: Tg(GSK3B*S9A)1Vln/? Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln
Background: involves: FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(GSK3B*S9A)1Vln/? Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
Background: involves: FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: ht
Has Mutant Allele: true
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Publication
26572622 | J:230742
First Author: Wakatsuki S
Year: 2015
Journal: J Cell Biol
Title: Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration.
Volume: 211
Issue: 4
Pages: 881-96
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Publication
17241269 | J:118621
First Author: Hooper C
Year: 2007
Journal: Eur J Neurosci
Title: Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.
Volume: 25
Issue: 1
Pages: 81-6
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Publication
22647378 | -
First Author: Genovese G
Year: 2012
Journal: Cell Cycle
Title: The tumor suppressor HINT1 regulates MITF and ??-catenin transcriptional activity in melanoma cells.
Volume: 11
Issue: 11
Pages: 2206-15
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Publication
18086858 | -
First Author: Bahmanyar S
Year: 2008
Journal: Genes Dev
Title: beta-Catenin is a Nek2 substrate involved in centrosome separation.
Volume: 22
Issue: 1
Pages: 91-105
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Publication
18957423 | -
First Author: Li H
Year: 2009
Journal: J Biol Chem
Title: Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells.
Volume: 284
Issue: 4
Pages: 2012-22
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Publication
21262353 | -
First Author: Fiset A
Year: 2011
Journal: Cell Signal
Title: Compartmentalized CDK2 is connected with SHP-1 and ??-catenin and regulates insulin internalization.
Volume: 23
Issue: 5
Pages: 911-9
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Publication
22155184 | -
First Author: Satow R
Year: 2012
Journal: Gastroenterology
Title: ??-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.
Volume: 142
Issue: 3
Pages: 572-81
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Protein Domain
IPR064738 | CTNNAbd_CTNNB1
Type: Domain
Description: This entry corresponds to a small region at the C terminus of CTNNB1, which is responsible for alpha-catenin binding. CTNNB1, also called beta-catenin, is a key downstream component of the canonical Wnt signalling pathway. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of a Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt-responsive genes. CTNNB1 is involved in the regulation of cell adhesion as a component of an E-cadherin:catenin adhesion complex. It acts as a negative regulator of centrosome cohesion. It is involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalisation. It blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. It disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML [, , , , ].
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Publication
35806020 | J:326854
 
First Author: Lacerda JT
Year: 2022
Journal: Int J Mol Sci
Title: Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes.
Volume: 23
Issue: 13
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Publication
37115627 | J:335533
First Author: Andreassen K
Year: 2023
Journal: Am J Physiol Heart Circ Physiol
Title: Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice.
Volume: 324
Issue: 6
Pages: H881-H892
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Publication
25568307 | J:221688
First Author: Bhattacharjee R
Year: 2015
Journal: Biol Reprod
Title: Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility.
Volume: 92
Issue: 3
Pages: 65
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Publication
26743080 | J:246654
First Author: Vattulainen-Collanus S
Year: 2016
Journal: J Cell Sci
Title: Loss of PPAR? in endothelial cells leads to impaired angiogenesis.
Volume: 129
Issue: 4
Pages: 693-705
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Publication
19754464 | J:156556
First Author: Agam G
Year: 2009
Journal: Biochem Soc Trans
Title: Knockout mice in understanding the mechanism of action of lithium.
Volume: 37
Issue: Pt 5
Pages: 1121-5
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Publication
22423052 | J:346833
First Author: Nagamatsu G
Year: 2012
Journal: Biol Reprod
Title: Tracing the conversion process from primordial germ cells to pluripotent stem cells in mice.
Volume: 86
Issue: 6
Pages: 182
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Publication
27083516 | J:233697
First Author: Haxaire C
Year: 2016
Journal: Am J Pathol
Title: Runx2 Controls Bone Resorption through the?Down-Regulation of the Wnt Pathway in?Osteoblasts.
Volume: 186
Issue: 6
Pages: 1598-609
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Genotype
Genotype
Symbol: Tg(Myh6-tTA)55Rbns/? Tg(Myh6/tetO-Gsk3b*S9A)1Rbns/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
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Protein
D3YUH4
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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HT Experiment
E-GEOD-32321 | A Wnt-Bmp feedback circuit controls inter-tissue signaling dynamics in tooth organogenesis
Series Id: GSE32321
Experiment Type: transcription profiling by array
Study Type: Baseline and WT vs. Mutant
Source: ArrayExpress
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Publication
23349361 | J:194982
First Author: Ahmed MM
Year: 2013
Journal: Hum Mol Genet
Title: Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.
Volume: 22
Issue: 9
Pages: 1709-24
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Protein Coding Gene
MGI:103575 | Skp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891829 | Rbx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349658 | Cul1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62878
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
Q9WTX5
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Protein
Q9WTX6
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
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Protein
Q02248
Organism: Mus musculus/domesticus
Length: 781  
Fragment?: false
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Protein
E9Q6A9
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
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Protein
Q3UZT7
Organism: Mus musculus/domesticus
Length: 781  
Fragment?: false
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Protein Coding Gene
MGI:1917497 | Psmd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104880 | Psmb6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916327 | Psmd11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347014 | Psmb3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98858 | Psmd3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105047 | Psmc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914247 | Psmd12
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347006 | Psma6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104883 | Psma3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106054 | Psmc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104885 | Psma2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913663 | Psmd6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914339 | Psmc6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1194513 | Psmb5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1096584 | Psmd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104884 | Psmb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107637 | Psmb7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913284 | Psmd14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098754 | Psmc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347070 | Psma7
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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