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Search results 1901 to 2000 out of 2424 for Ran

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Type Details Score
Publication
17097888 | J:116629
First Author: Meechan DW
Year: 2006
Journal: Mol Cell Neurosci
Title: Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome.
Volume: 33
Issue: 4
Pages: 412-28
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Protein Coding Gene
MGI:1913789 | Xpo5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31075303 | J:277821
First Author: Sobuz SU
Year: 2019
Journal: Biochim Biophys Acta Mol Cell Res
Title: SIRT7 regulates the nuclear export of NF-κB p65 by deacetylating Ran.
Volume: 1866
Issue: 9
Pages: 1355-1367
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Publication
16326389 | J:104945
First Author: Nacerddine K
Year: 2005
Journal: Dev Cell
Title: The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice.
Volume: 9
Issue: 6
Pages: 769-79
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Publication
19526544 | J:155590
First Author: Martínez-Solano L
Year: 2009
Journal: Proteomics
Title: Proteomics of RAW 264.7 macrophages upon interaction with heat-inactivated Candida albicans cells unravel an anti-inflammatory response.
Volume: 9
Issue: 11
Pages: 2995-3010
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Publication
7580246 | J:27376
First Author: Carter GT
Year: 1995
Journal: Neuromuscul Disord
Title: Effect of voluntary wheel-running exercise on muscles of the mdx mouse.
Volume: 5
Issue: 4
Pages: 323-32
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Publication
12458204 | J:81902
First Author: Shirasawa T
Year: 2003
Journal: J Biol Chem
Title: Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity.
Volume: 278
Issue: 7
Pages: 5035-43
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Publication
10725384 | J:61371
First Author: Hong DH
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).
Volume: 97
Issue: 7
Pages: 3649-54
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Publication
22797694 | J:187062
First Author: Bannerman DM
Year: 2012
Journal: Nat Neurosci
Title: Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.
Volume: 15
Issue: 8
Pages: 1153-9
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Publication
33621249 | J:303728
First Author: Srikanta SB
Year: 2021
Journal: PLoS One
Title: Behavioral phenotyping of mice lacking the deubiquitinase USP2.
Volume: 16
Issue: 2
Pages: e0241403
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Publication
33159114 | J:299992
First Author: Codd LN
Year: 2020
Journal: Sci Rep
Title: Exercise reverses learning deficits induced by hippocampal injury by promoting neurogenesis.
Volume: 10
Issue: 1
Pages: 19269
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Publication
21173221 | J:169017
First Author: Zu T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Non-ATG-initiated translation directed by microsatellite expansions.
Volume: 108
Issue: 1
Pages: 260-5
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Publication
26637796 | J:228731
First Author: O'Rourke JG
Year: 2015
Journal: Neuron
Title: C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.
Volume: 88
Issue: 5
Pages: 892-901
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Publication
16807353 | J:234161
First Author: Gil A
Year: 2006
Journal: Mol Biol Cell
Title: Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.
Volume: 17
Issue: 9
Pages: 4002-13
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Publication
27112499 | J:239579
First Author: Liu Y
Year: 2016
Journal: Neuron
Title: C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD.
Volume: 90
Issue: 3
Pages: 521-34
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Publication
33378537 | J:304457
First Author: Pattamatta A
Year: 2021
Journal: Hum Mol Genet
Title: Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice.
Volume: 29
Issue: 24
Pages: 3900-3918
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Publication
18708071 | J:168964
First Author: Forwood JK
Year: 2008
Journal: J Mol Biol
Title: Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics.
Volume: 383
Issue: 4
Pages: 772-82
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Publication
21964068 | J:180196
First Author: Yasuda Y
Year: 2012
Journal: EMBO J
Title: Nuclear retention of importin α coordinates cell fate through changes in gene expression.
Volume: 31
Issue: 1
Pages: 83-94
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Publication
27210745 | J:235751
First Author: Möhle L
Year: 2016
Journal: Cell Rep
Title: Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis.
Volume: 15
Issue: 9
Pages: 1945-56
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Publication
32029588 | J:285809
First Author: Yang S
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Lack of RAN-mediated toxicity in Huntington's disease knock-in mice.
Volume: 117
Issue: 8
Pages: 4411-4417
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Publication
37673856 | J:340553
First Author: Zhong J
Year: 2023
Journal: Nat Commun
Title: Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling.
Volume: 14
Issue: 1
Pages: 5451
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Publication
38677508 | J:348252
 
First Author: Kim K
Year: 2024
Journal: Mol Metab
Title: Uncoupling protein 1-driven Cre (Ucp1-Cre) is expressed in the epithelial cells of mammary glands and various non-adipose tissues.
Volume: 84
Pages: 101948
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Publication
38918066 | J:355466
 
First Author: Schwalbe DC
Year: 2024
Journal: J Neurosci
Title: Molecular Organization of Autonomic, Respiratory, and Spinally-Projecting Neurons in the Mouse Ventrolateral Medulla.
Volume: 44
Issue: 31
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Publication
33214681 | J:301491
First Author: Chucair-Elliott AJ
Year: 2020
Journal: Commun Biol
Title: Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia.
Volume: 3
Issue: 1
Pages: 693
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Publication
16787967 | J:112036
First Author: Costa Y
Year: 2006
Journal: Hum Mol Genet
Title: Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?
Volume: 15
Issue: 15
Pages: 2324-34
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Publication
12791264 | J:320054
First Author: Suntharalingam M
Year: 2003
Journal: Dev Cell
Title: Peering through the pore: nuclear pore complex structure, assembly, and function.
Volume: 4
Issue: 6
Pages: 775-89
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Protein
Q9R020
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q9D9Z2
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: false
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Protein
A2AFS9
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
A0A0G2JGA3
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
A0A0G2JGE3
Organism: Mus musculus/domesticus
Length: 38  
Fragment?: false
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Protein
B2RRT9
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
A0A1D5RLI7
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
D3Z4U0
Organism: Mus musculus/domesticus
Length: 320  
Fragment?: false
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Protein
Q3USF2
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: true
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Protein
Q3TQH3
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
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Protein
V9GX51
Organism: Mus musculus/domesticus
Length: 40  
Fragment?: false
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Protein
E9PUD0
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: false
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Publication
10318915 | -
First Author: Yaseen NR
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Two distinct classes of Ran-binding sites on the nucleoporin Nup-358.
Volume: 96
Issue: 10
Pages: 5516-21
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Publication
29748336 | -
     
First Author: Aksu M
Year: 2018
Journal: J Cell Biol
Title: Xpo7 is a broad-spectrum exportin and a nuclear import receptor.
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Protein Domain
IPR006762 | Gtr1_RagA
Type: Family
Description: GTR1 was first identified in Saccharomyces cerevisiae (Baker's yeast) as a suppressor of a mutation in RCC1. RCC1 catalyzes guanine nucleotide exchange on Ran, a well characterised nuclear Ras-like small G protein that plays an essential role in the import and export of proteins and RNAs across the nuclear membrane through the nuclear pore complex. RCC1 is located inside the nucleus, bound to chromatin. The concentration of GTP within the cell is ~30 times higher than the concentration of GDP, thus resulting in the preferential production of the GTP form of Ran by RCC1 within the nucleus.Gtr1p is located within both the cytoplasm and the nucleus and has been reported to play a role in cell growth. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1 and Rag A and Gtr1p belong to the sixth subfamily of the Ras-like small GTPase superfamily [].
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Publication
11129791 | -
First Author: Stewart M
Year: 2000
Journal: Cell Struct Funct
Title: Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2).
Volume: 25
Issue: 4
Pages: 217-25
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Protein Domain
IPR001876 | Znf_RanBP2
Type: Domain
Description: Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry representsthe zinc finger domain found in RanBP2 proteins. Ran is an evolutionary conserved member of the Ras superfamily that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Ran binding protein 2 (RanBP2) is a 358kDa nucleoporin located on the cytoplasmic side of the nuclear pore complex which plays a role in nuclear protein import []. RanBP2 contains multiple zinc fingers which mediate binding to RanGDP [].
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Protein Domain
IPR018222 | Nuclear_transport_factor_2_euk
Type: Domain
Description: Ran () is an evolutionary conserved member of the Ras superfamily of small GTPases that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Import receptors bind their cargos in the cytoplasm where the concentration of RanGTP is low and release their cargos in the nucleus where the concentration of RanGTP is high []. Export receptors respond to Ran GTP in the oppositemanner. Nuclear transport factor 2 (NTF2) is a homodimer of approximately 14kDa subunits which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. NTF2 binds to RanGDP sufficiently strongly for the complex to remain intact during transport through NPCs, but the interaction between NTF2 and FxFG nucleoporins is much more transient, which would enable NTF2 to move through the NPC by hopping from one repeat to another [, ].NTF2 folds into a cone with a deep hydrophobic cavity, the opening of which is surrounded by several negatively charged residues. RanGDP binds to NTF2 by inserting a conserved phenylalanine residue into the hydrophobic pocket of NTF2 and making electrostatic interactions with the conserved negatively charged residues that surround the cavity.This entry contains predominantly eukaryotic proteins. The following proteins contain a region similar to NTF2:Eukaryotic NXF proteins []. These are nuclear mRNA export factors. These proteins contain, in addition to a NTF2 domain, a number of leucine-rich repeats and a UBA domain.Eukaryotic NXT1/NXT2 proteins []. These proteins are stimulators of protein export for NES-containing proteins. The also play a role in mRNA nuclear export. They heterodimerize with NFX proteins. In contrast to NTF2, NXT1 and NXT2 preferentially bind RanGTP.Eukaryotic Ras-GTPase-activating protein (GAP)-binding proteins (G3BP's). These proteins contain one NTF2 domain and one RRM (see ).
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Protein Domain
IPR036443 | Znf_RanBP2_sf
Type: Homologous_superfamily
Description: Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents the zinc finger domain superfamily found in RanBP2 proteins. Ran is an evolutionary conserved member of the Ras superfamily that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Ran binding protein 2 (RanBP2) is a 358kDa nucleoporin located on the cytoplasmic side of the nuclear pore complex which plays a role in nuclear protein import []. RanBP2 contains multiple zinc fingers which mediate binding to RanGDP [].
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Publication
16837463 | J:116504
First Author: Matsui T
Year: 2006
Journal: J Biol Chem
Title: Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation.
Volume: 281
Issue: 37
Pages: 27512-25
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Publication
20668449 | J:163318
First Author: Tooley CE
Year: 2010
Journal: Nature
Title: NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
Volume: 466
Issue: 7310
Pages: 1125-8
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Publication
17276916 | J:118045
First Author: Ribbeck K
Year: 2007
Journal: Curr Biol
Title: A role for NuSAP in linking microtubules to mitotic chromosomes.
Volume: 17
Issue: 3
Pages: 230-6
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Publication
8530521 | J:68975
First Author: Jones LR
Year: 1995
Journal: J Biol Chem
Title: Purification, primary structure, and immunological characterization of the 26-kDa calsequestrin binding protein (junctin) from cardiac junctional sarcoplasmic reticulum.
Volume: 270
Issue: 51
Pages: 30787-96
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Publication
11231308 | J:68336
First Author: Aoki N
Year: 2001
Journal: J Invest Dermatol
Title: A novel type II cytokeratin, mK6irs, is expressed in the Huxley and Henle layers of the mouse inner root sheath.
Volume: 116
Issue: 3
Pages: 359-65
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Publication
17143267 | J:189990
First Author: Nakamura T
Year: 2007
Journal: Nat Cell Biol
Title: PGC7/Stella protects against DNA demethylation in early embryogenesis.
Volume: 9
Issue: 1
Pages: 64-71
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Publication
10567585 | J:66319
First Author: Black BE
Year: 1999
Journal: Mol Cell Biol
Title: Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.
Volume: 19
Issue: 12
Pages: 8616-24
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Publication
10397761 | J:289586
First Author: Nagoshi E
Year: 1999
Journal: Mol Biol Cell
Title: Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip.
Volume: 10
Issue: 7
Pages: 2221-33
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Publication
23277578 | J:193623
First Author: Monecke T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for cooperativity of CRM1 export complex formation.
Volume: 110
Issue: 3
Pages: 960-5
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Publication
18239078 | J:147321
First Author: Baltgalvis KA
Year: 2008
Journal: J Appl Physiol (1985)
Title: Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps.
Volume: 104
Issue: 4
Pages: 1137-43
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Publication
23471914 | J:196369
First Author: Kuraitis D
Year: 2013
Journal: Dis Model Mech
Title: A necrotic stimulus is required to maximize matrix-mediated myogenesis in mice.
Volume: 6
Issue: 3
Pages: 793-801
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Publication
17490632 | J:122556
First Author: Inoue T
Year: 2007
Journal: Dev Biol
Title: Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.
Volume: 306
Issue: 2
Pages: 669-84
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Publication
27006199 | J:237085
First Author: Hong YH
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Skeletal muscle glucose uptake during treadmill exercise in neuronal nitric oxide synthase-μ knockout mice.
Volume: 310
Issue: 10
Pages: E838-45
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Publication
34142210 | J:310635
First Author: Nijholt KT
Year: 2021
Journal: Pflugers Arch
Title: The erythropoietin receptor expressed in skeletal muscle is essential for mitochondrial biogenesis and physiological exercise.
Volume: 473
Issue: 8
Pages: 1301-1313
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Publication
24169546 | J:207716
First Author: Quinn LS
Year: 2014
Journal: Endocrinology
Title: IL-15 is required for postexercise induction of the pro-oxidative mediators PPARδ and SIRT1 in male mice.
Volume: 155
Issue: 1
Pages: 143-55
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Publication
21765213 | J:174502
First Author: Pistilli EE
Year: 2011
Journal: J Clin Invest
Title: Loss of IL-15 receptor α alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles.
Volume: 121
Issue: 8
Pages: 3120-32
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Publication
31724332 | J:294579
First Author: Tran PHT
Year: 2019
Journal: Physiol Rep
Title: The influence of fibrillin-1 and physical activity upon tendon tissue morphology and mechanical properties in mice.
Volume: 7
Issue: 21
Pages: e14267
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Publication
27288439 | J:236263
First Author: Li W
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Dysfunction of mitochondria and deformed gap junctions in the heart of IL-18-deficient mice.
Volume: 311
Issue: 2
Pages: H313-25
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Publication
11926297 | J:68050
First Author: Nakajima H
Year: 2001
Journal: Comp Med
Title: Anomalous (preduodenal) portal vein: autosomal recessive mutation in AKR/J mice.
Volume: 51
Issue: 1
Pages: 22-5
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Publication
30297987 | J:276015
 
First Author: Mou X
Year: 2018
Journal: Front Cell Neurosci
Title: Comparing Mouse and Rat Hippocampal Place Cell Activities and Firing Sequences in the Same Environments.
Volume: 12
Pages: 332
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Publication
11473655 | J:103972
First Author: Inokuchi S
Year: 2001
Journal: Kidney Int
Title: Hyperplastic vascular smooth muscle cells of the intrarenal arteries in angiotensin II type 1a receptor null mutant mice.
Volume: 60
Issue: 2
Pages: 722-31
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Publication
38286628 | J:354267
 
First Author: Morandell K
Year: 2024
Journal: J Neurosci
Title: Movement-Related Modulation in Mouse Auditory Cortex Is Widespread Yet Locally Diverse.
Volume: 44
Issue: 11
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Publication
32770138 | J:299278
First Author: Aguiar AS Jr
Year: 2020
Journal: Sci Rep
Title: Neuronal adenosine A2A receptors signal ergogenic effects of caffeine.
Volume: 10
Issue: 1
Pages: 13414
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Publication
12844497 | J:103037
First Author: Haubold KW
Year: 2003
Journal: J Appl Physiol (1985)
Title: Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance.
Volume: 95
Issue: 4
Pages: 1617-22
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Publication
15548643 | J:96569
First Author: Adams ME
Year: 2004
Journal: J Neurosci
Title: Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms.
Volume: 24
Issue: 46
Pages: 10302-9
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Publication
18948110 | J:149187
First Author: Lygate CA
Year: 2009
Journal: J Mol Cell Cardiol
Title: Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.
Volume: 46
Issue: 1
Pages: 93-9
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Publication
16324103 | J:104312
First Author: Li HP
Year: 2005
Journal: Eur J Neurosci
Title: Aberrant trajectory of thalamocortical axons associated with abnormal localization of neurocan immunoreactivity in the cerebral neocortex of reeler mutant mice.
Volume: 22
Issue: 11
Pages: 2689-96
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Publication
12374786 | J:80714
First Author: Bettahi I
Year: 2002
Journal: J Biol Chem
Title: Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh.
Volume: 277
Issue: 50
Pages: 48282-8
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Publication
37115627 | J:335533
First Author: Andreassen K
Year: 2023
Journal: Am J Physiol Heart Circ Physiol
Title: Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice.
Volume: 324
Issue: 6
Pages: H881-H892
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Publication
32778883 | J:320917
First Author: Rivaud MR
Year: 2020
Journal: Europace
Title: Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.
Volume: 22
Issue: 10
Pages: 1579-1589
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Publication
26563933 | J:228742
 
First Author: Moore KM
Year: 2016
Journal: Neurobiol Dis
Title: A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease.
Volume: 85
Pages: 218-224
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Publication
21689809 | J:174067
 
First Author: Ke HC
Year: 2011
Journal: Brain Res
Title: Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise.
Volume: 1403
Pages: 1-11
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Publication
19776389 | J:155917
First Author: Lustgarten MS
Year: 2009
Journal: Am J Physiol Cell Physiol
Title: Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.
Volume: 297
Issue: 6
Pages: C1520-32
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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