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Search results 19101 to 19200 out of 2418182 for a

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Type Details Score
Publication
21093315 | J:167007
First Author: Bao X
Year: 2010
Journal: Immunity
Title: Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes.
Volume: 33
Issue: 5
Pages: 817-29
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Publication
37995189 | J:344294
First Author: Belilos A
Year: 2023
Journal: Cell Rep
Title: Nucleus accumbens local circuit for cue-dependent aversive learning.
Volume: 42
Issue: 12
Pages: 113488
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Publication
11225990 | J:67755
First Author: Van Pel A
Year: 2001
Journal: Cancer Immunol Immunother
Title: Induction of cytolytic T lymphocytes by immunization of mice with an adenovirus containing a mouse homolog of the human MAGE-A genes.
Volume: 49
Issue: 11
Pages: 593-602
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Genotype
Genotype
Symbol: Mfsd12/Mfsd12
Background: involves: A * STOCK fz
Zygosity: hm
Has Mutant Allele: true
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Publication
21420414 | J:173798
First Author: Kirabo A
Year: 2011
Journal: J Mol Cell Cardiol
Title: Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.
Volume: 50
Issue: 6
Pages: 1026-34
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Publication
26496923 | J:340169
First Author: Kamijo A
Year: 2016
Journal: Histochem Cell Biol
Title: Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine.
Volume: 145
Issue: 1
Pages: 81-92
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Publication
35316840 | J:328304
First Author: Lee K
Year: 2022
Journal: Diabetologia
Title: XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice.
Volume: 65
Issue: 6
Pages: 984-996
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Publication
30510213 | J:267823
First Author: Bahat A
Year: 2018
Journal: Nat Commun
Title: MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells.
Volume: 9
Issue: 1
Pages: 5132
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Publication
15165831 | J:97175
First Author: Cope DW
Year: 2004
Journal: Neuropharmacology
Title: Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit.
Volume: 47
Issue: 1
Pages: 17-34
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Publication
15169892 | J:91025
First Author: Parlakian A
Year: 2004
Journal: Mol Cell Biol
Title: Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality.
Volume: 24
Issue: 12
Pages: 5281-9
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Publication
26118640 | J:226937
First Author: Tsutiya A
Year: 2015
Journal: Eur J Neurosci
Title: Mouse pups lacking collapsin response mediator protein 4 manifest impaired olfactory function and hyperactivity in the olfactory bulb.
Volume: 42
Issue: 6
Pages: 2335-45
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Protein Domain
IPR021151 | GINS_A
Type: Domain
Description: DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the pre-replication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origin recognition complex (ORC), Cdc6 and Cdt1 proteins, and the MCM complex. Activation of the pre-RC into the initiation complex (IC) is achieved via the action of S-phase kinases, eventually leading to the loading of the replication machinery.Recently, a novel replication complex, GINS (for Go, Ichi, Nii, and San; five, one, two, and three in Japanese), has been identified [, ]. The precise function of GINS is not known. However, genetic and two-hybrid interactions indicate that it mediates the loading of the enzymatic replication machinery at a step after the action of the S-phase kinases []. Furthermore, GINS may be a part of the replication machinery itself, since it is found associated with replicating DNA [, ]. Electron microscopy of GINS shows that it forms a ring-like structure [], reminiscent of the structure of PCNA [], the DNA polymerase delta replication clamp. This observation, coupled with the observed interactions for GINS, indicates that the complex may represent the replication clamp for DNA polymerase epsilon [].The GINS complex is essential for initiation of DNA replication in Xenopus egg extracts []. This 100kDa stable complex includes Sld5, Psf1, Psf2, and Psf3. Homologues of these components are found also in other eukaryotes []. The archaeal GINS complex contains two subunits (SSO0772/gins23 and SO1049/gins15 in Sulfolobus) that are poorly conserved homologues of the eukaryotic GINS subunits []. Only Gins23 is included in this entry.The eukaryotic GINS subunits are homologous. The four subunits of the complex consist of two domains each, termed the α-helical (A) and β-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3 [].
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Publication
38509075 | J:346456
First Author: Lozovska A
Year: 2024
Journal: Nat Commun
Title: Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape.
Volume: 15
Issue: 1
Pages: 2509
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Publication
28334862 | J:242243
First Author: Nathan A
Year: 2017
Journal: Hum Mol Genet
Title: The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis.
Volume: 26
Issue: 9
Pages: 1694-1705
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Publication
22323546 | J:181852
First Author: Calcinotto A
Year: 2012
Journal: J Immunol
Title: Targeting TNF-α to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy.
Volume: 188
Issue: 6
Pages: 2687-94
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Publication
38444862 | J:345892
 
First Author: Amarnani A
Year: 2024
Journal: Front Immunol
Title: Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance.
Volume: 15
Pages: 1339325
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Publication
8710854 | J:34830
First Author: Rothe M
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.
Volume: 93
Issue: 16
Pages: 8241-6
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Publication
17921248 | J:125992
First Author: Kim S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A mouse model of conditional lipodystrophy.
Volume: 104
Issue: 42
Pages: 16627-32
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Protein Coding Gene
MGI:1338944 | Acvr1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21858071 | J:176367
First Author: Seoane M
Year: 2011
Journal: PLoS One
Title: The mitochondrial genome is a "genetic sanctuary" during the oncogenic process.
Volume: 6
Issue: 8
Pages: e23327
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Publication
9087426 | J:72124
First Author: Lundgren K
Year: 1997
Journal: Genes Dev
Title: Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
Volume: 11
Issue: 6
Pages: 714-25
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Publication
26427439 | J:319160
 
First Author: Reagan A
Year: 2016
Journal: Adv Exp Med Biol
Title: Retinal Caveolin-1 Modulates Neuroprotective Signaling.
Volume: 854
Pages: 411-8
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Publication
14621990 | -
First Author: Dubin G
Year: 2003
Journal: Biochemistry
Title: A novel class of cysteine protease inhibitors: solution structure of staphostatin A from Staphylococcus aureus.
Volume: 42
Issue: 46
Pages: 13449-56
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Publication
33514739 | J:302139
First Author: Ramirez-Martinez A
Year: 2021
Journal: Nat Commun
Title: The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization.
Volume: 12
Issue: 1
Pages: 690
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Publication
9653191 | J:48731
First Author: Mohand-Said S
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse.
Volume: 95
Issue: 14
Pages: 8357-62
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Publication
16908864 | J:112917
First Author: Rossi F
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor.
Volume: 103
Issue: 34
Pages: 12843-8
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Publication
15755806 | J:97039
First Author: Vacík T
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes.
Volume: 102
Issue: 12
Pages: 4500-5
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Publication
26586761 | J:227045
First Author: Jaworski A
Year: 2015
Journal: Science
Title: Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.
Volume: 350
Issue: 6263
Pages: 961-5
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Publication
17566405 | J:125330
First Author: Reis JL
Year: 2007
Journal: J Neurosurg
Title: In utero topographic analysis of astrocytes and neuronal cells in the spinal cord of mutant mice with myelomeningocele.
Volume: 106
Issue: 6 Suppl
Pages: 472-9
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Publication
21828128 | J:178408
First Author: Li HS
Year: 2011
Journal: Blood
Title: Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response.
Volume: 118
Issue: 14
Pages: 3879-89
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Publication
36045289 | J:339916
First Author: Doron A
Year: 2022
Journal: Nature
Title: Hippocampal astrocytes encode reward location.
Volume: 609
Issue: 7928
Pages: 772-778
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Protein Coding Gene
MGI:1349389 | Gcat
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11687625 | J:72574
First Author: Murai M
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Early postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne syndrome Group B DNA repair genes.
Volume: 98
Issue: 23
Pages: 13379-84
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Publication
16360036 | -
First Author: Moumen A
Year: 2005
Journal: Cell
Title: hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.
Volume: 123
Issue: 6
Pages: 1065-78
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Publication
1826006 | -
First Author: Carattoli A
Year: 1991
Journal: J Biol Chem
Title: The Neurospora crassa carotenoid biosynthetic gene (albino 3) reveals highly conserved regions among prenyltransferases.
Volume: 266
Issue: 9
Pages: 5854-9
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Publication
9261355 | -
First Author: Webster A
Year: 1997
Journal: J Virol
Title: Role of preterminal protein processing in adenovirus replication.
Volume: 71
Issue: 9
Pages: 6381-9
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Publication
11707262 | -
First Author: Urbani A
Year: 2001
Journal: FEBS Lett
Title: Properties of the detergent solubilised cytochrome c oxidase (cytochrome cbb(3)) purified from Pseudomonas stutzeri.
Volume: 508
Issue: 1
Pages: 29-35
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Publication
11118617 | -
First Author: Caricasole A
Year: 2000
Journal: Biochim Biophys Acta
Title: Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).
Volume: 1517
Issue: 1
Pages: 63-72
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Publication
11882720 | -
First Author: Pikis A
Year: 2002
Journal: Microbiology
Title: Metabolism of sucrose and its five isomers by Fusobacterium mortiferum.
Volume: 148
Issue: Pt 3
Pages: 843-52
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Publication
12168951 | -
First Author: Kamei A
Year: 2002
Journal: DNA Res
Title: Biochemical examination of the potential eukaryotic-type protein kinase genes in the complete genome of the unicellular Cyanobacterium synechocystis sp. PCC 6803.
Volume: 9
Issue: 3
Pages: 71-8
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Publication
8947311 | -
First Author: Cahill A
Year: 1996
Journal: Alcohol Clin Exp Res
Title: Differential effects of chronic ethanol consumption on hepatic mitochondrial and cytoplasmic ribosomes.
Volume: 20
Issue: 8
Pages: 1362-7
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Publication
22820328 | -
First Author: Markkula A
Year: 2012
Journal: Appl Environ Microbiol
Title: Roles of four putative DEAD-box RNA helicase genes in growth of Listeria monocytogenes EGD-e under heat, pH, osmotic, ethanol, and oxidative stress conditions.
Volume: 78
Issue: 19
Pages: 6875-82
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Publication
22564273 | -
First Author: Markkula A
Year: 2012
Journal: Environ Microbiol
Title: Genes encoding putative DEAD-box RNA helicases in Listeria monocytogenes EGD-e are needed for growth and motility at 3°C.
Volume: 14
Issue: 8
Pages: 2223-32
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Publication
25404173 | -
First Author: Vit A
Year: 2015
Journal: Chembiochem
Title: Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis.
Volume: 16
Issue: 1
Pages: 119-25
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Publication
26079795 | -
First Author: Vit A
Year: 2015
Journal: Chembiochem
Title: Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC.
Volume: 16
Issue: 10
Pages: 1490-6
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Publication
23088497 | -
First Author: Gaugel A
Year: 2012
Journal: J Mol Signal
Title: Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 β-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition.
Volume: 7
Issue: 1
Pages: 16
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Publication
12503088 | -
First Author: Zamorano A
Year: 2003
Journal: J Neurosci Res
Title: Transcriptionally mediated gene targeting of gas1 to glioma cells elicits growth arrest and apoptosis.
Volume: 71
Issue: 2
Pages: 256-63
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Publication
15777640 | -
First Author: Geisinger A
Year: 2005
Journal: Biochim Biophys Acta
Title: The mammalian gene pecanex 1 is differentially expressed during spermatogenesis.
Volume: 1728
Issue: 1-2
Pages: 34-43
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Publication
12065837 | -
First Author: Baxter-Burrell A
Year: 2002
Journal: Science
Title: RopGAP4-dependent Rop GTPase rheostat control of Arabidopsis oxygen deprivation tolerance.
Volume: 296
Issue: 5575
Pages: 2026-8
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Publication
32928960 | -
First Author: Söderholm A
Year: 2020
Journal: J Biol Chem
Title: Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation.
Volume: 295
Issue: 47
Pages: 15948-15956
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Publication
23022483 | J:196224
First Author: Vera E
Year: 2012
Journal: Cell Rep
Title: The rate of increase of short telomeres predicts longevity in mammals.
Volume: 2
Issue: 4
Pages: 732-7
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Publication
22863752 | J:187587
First Author: Marcoe JP
Year: 2012
Journal: Nat Immunol
Title: TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy.
Volume: 13
Issue: 9
Pages: 843-50
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Publication
21762674 | J:176320
First Author: Alikhan MA
Year: 2011
Journal: Am J Pathol
Title: Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses.
Volume: 179
Issue: 3
Pages: 1243-56
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Publication
18940593 | J:149871
First Author: Drenan RM
Year: 2008
Journal: Neuron
Title: In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors.
Volume: 60
Issue: 1
Pages: 123-36
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Publication
15852008 | J:98953
First Author: Laouar Y
Year: 2005
Journal: Nat Immunol
Title: Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.
Volume: 6
Issue: 6
Pages: 600-7
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Publication
26392529 | J:227079
First Author: Schneeberger K
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.
Volume: 112
Issue: 40
Pages: 12408-13
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Publication
22203995 | J:179973
First Author: Delhase M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Volume: 109
Issue: 4
Pages: E177-86
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Publication
34434198 | J:345753
 
First Author: Logeswaran A
Year: 2021
Journal: Front Immunol
Title: Conjunctival Goblet Cell Responses to TLR5 Engagement Promote Activation of Local Antigen-Presenting Cells.
Volume: 12
Pages: 716939
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Publication
8189541 | J:18556
First Author: Azoulay A
Year: 1994
Journal: J Virol
Title: FVB mice transgenic for the H-2Db gene become resistant to persistent infection by Theiler's virus.
Volume: 68
Issue: 6
Pages: 4049-52
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Publication
20385802 | J:159377
First Author: Ruiz de Azua I
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo.
Volume: 107
Issue: 17
Pages: 7999-8004
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Protein
Q8C6V3
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
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Protein
E9PZI3
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
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Protein
G5E851
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
Q9DA92
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein
A0A494BAN6
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
Q9D9Y7
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: false
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Protein
Q6P8I0
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: false
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Publication
29263889 | -
 
First Author: Sutton TC
Year: 2017
Journal: NPJ Vaccines
Title: Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines.
Volume: 2
Pages: 35
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Publication
24582528 | -
First Author: Wu Y
Year: 2014
Journal: Trends Microbiol
Title: Bat-derived influenza-like viruses H17N10 and H18N11.
Volume: 22
Issue: 4
Pages: 183-91
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Publication
24981432 | -
First Author: Ma J
Year: 2015
Journal: Mol Neurobiol
Title: MS4A Cluster in Alzheimer's Disease.
Volume: 51
Issue: 3
Pages: 1240-8
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Publication
8706733 | -
First Author: Vanhooren JC
Year: 1996
Journal: Eur J Biochem
Title: Rat pristanoyl-CoA oxidase. cDNA cloning and recognition of its C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor.
Volume: 239
Issue: 2
Pages: 302-9
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Publication
8947475 | -
 
First Author: Baumgart E
Year: 1996
Journal: Biochem J
Title: Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase.
Volume: 320 ( Pt 1)
Pages: 115-21
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Protein Domain
IPR000149 | Hemagglutn_influenz_A
Type: Family
Description: Haemagglutinin (HA) is one of two main surface fusion glycoproteins embedded in the envelope of influenza viruses, the other being neuraminidase (NA). There are sixteen known HA subtypes (H1-H16) and nine NA subtypes (N1-N9), which together are used to classify influenza viruses (e.g. H5N1). The antigenic variations in HA and NA enable the virus to evade host antibodies made to previous influenza strains, accounting for recurrent influenza epidemics []. The HA glycoprotein is present in the viral membrane as a single polypeptide (HA0), which must be cleaved by the host's trypsin-like proteases to produce two peptides (HA1 and HA2) in order for the virus to be infectious. Once HA0 is cleaved, the newly exposed N-terminal of the HA2 peptide then acts to fuse the viral envelope to the cellular membrane of the host cell, which allows the viral negative-stranded RNA to infect the host cell. The type of host protease can influence the infectivity and pathogenicity of the virus.The haemagglutinin glycoprotein is a trimer containing three structurally distinct regions: a globular head consisting of anti-parallel β-sheets that form a β-sandwich with a jelly-roll fold (contains the receptor binding site and the HA1/HA2 cleavage site); a triple-stranded, coiled-coil, α-helical stalk; and a globular foot composed of anti-parallel β-sheets [, ]. Each monomer consists of an intact HA0 polypeptide with the HA1 and HA2 regions linked by disulphide bonds. The N terminus of HA1 provides the central strand in the 5-stranded globular foot, while the rest of the HA1 chain makes its way to the 8-stranded globular head. HA2 provides two alpha helices, which form part of the triple-stranded coiled-coil that stabilises the trimer, its C terminus providing the remaining strands of the 5-stranded globular foot.This entry represents haemagglutinin from influenza virus A. The influenza A HAs can be divided into group 1 encompassing H1, H2, H5, H6, H8, H9, H11, H12, H13, H16, H17, and H18, and group 2 including H3, H4, H7, H10, H14, and H15 subtypes []. This entry also includes HA from Bat-derived influenza-like viruses H17N10 () [].
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Protein Domain
IPR036094 | NadA_sf
Type: Homologous_superfamily
Description: Quinolinate synthetase catalyses the second step of the de novobiosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid []. This synthesis requires two enzymes, an FAD-containing "B protein"and an "A protein". B protein converts L-aspartate to iminoaspartate. The A protein, NadA, converts iminoaspartate to quinolate. NadA harbours a [4Fe-4S]cluster []. The structure of NadA is composed of three similar domains related by pseudo threefold symmetry. Each domain has three layers (alpha/beta/alpha) with parallel beta sheet.
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Protein Domain
IPR034171 | ACO
Type: Family
Description: Peroxisomal acyl-CoA oxidases (ACO) catalyze the first set in the peroxisomal fatty acid beta-oxidation, the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. In a second oxidative half-reaction, the reduced FAD is reoxidized by molecular oxygen. ACO is generally a homodimer. There are several subtypes of AXO's, based on substrate specificity. Palmitoyl-CoA oxidase (ACOX1) acts on straight-chain fatty acids and prostanoids [, ]; whereas, the closely related Trihydroxycoprostanoly-CoA oxidase (ACOX2) has the greatest activity for 2-methyl branched side chains of bile precursors []. Pristanoyl-CoA oxidase (ACOX3), acts on 2-methyl branched fatty acids [, ].
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Protein Domain
IPR000596 | Cholcy_rcpt_A
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Cholecystokinins (CCKs) and gastrins are naturally-occurring peptides that share a common C-terminal sequence, GWMDF; full biological activity resides in this region. In the periphery, the principal physiological actions of CCK include gall bladder contraction, pancreatic enzyme secretion and regulation of secretion/absorption in the gastrointestinal tract. In the CNS, CCK induces analgesia, satiety and a decrease in exploratory behaviour. In mesolimbic andmesocortical neurons, CCK coexists with dopamine. It is found throughout the digestive tract, with high concentrations in the duodenum and jejunum. It is also found in peripheral nerves to other smooth muscles and to secretory glands, and is one of the most abundant peptides in the brain. The highest levels of the CCKA receptor are found in peripheral tissues, notably the pancreas, stomach, intestine and gall bladder. It has only a limited distribution in the brain. The receptor has been implicated in the pathogenesis of schizophrenia, Parkinson's disease, drug addiction and feeding disorders.
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Protein Domain
IPR030417 | MS4A
Type: Family
Description: Membrane-spanning four-domains subfamily A (MS4A) includes B-cell-specific antigen CD20 (MS4A1), high affinity immunoglobulin epsilon receptor beta chain (MS4A2), hematopoietic-cell-specific protein HTm4 (MS4A3), and related proteins. These proteins share a similar structure with four transmembrane domains and have amino acid identities of 25-40% []. They are predominantly expressed in hematopoietic cells, but some can be found in other tissues including testis and brain [, ].MS4A1 (B-lymphocyte antigen CD20) [], MS4A2 (high affinity IgE receptor subunit beta) [, ], and MS4A4B []have been shown to have an important role in immunity.Several variants within the MS4A gene cluster have been implicated in Alzheimer's disease [].
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Publication
35884958 | J:330621
 
First Author: Ramshekar A
Year: 2022
Journal: Biomedicines
Title: Role of Erythropoietin Receptor Signaling in Macrophages or Choroidal Endothelial Cells in Choroidal Neovascularization.
Volume: 10
Issue: 7
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Publication
20303521 | J:161976
First Author: Hains DS
Year: 2010
Journal: J Urol
Title: High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma.
Volume: 183
Issue: 5
Pages: 2077-84
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Publication
10455180 | J:57063
First Author: Miyake A
Year: 1999
Journal: J Biol Chem
Title: New ether-à-go-go K(+) channel family members localized in human telencephalon.
Volume: 274
Issue: 35
Pages: 25018-25
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Publication
26139524 | J:223798
First Author: Golden EJ
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.
Volume: 112
Issue: 29
Pages: E3864-73
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Protein Coding Gene
MGI:3606565 | Fam167a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2140983 | Fam185a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2447768 | Fam193a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
28856392 | J:317886
First Author: Bengsch F
Year: 2017
Journal: Cancer Immunol Immunother
Title: CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer.
Volume: 66
Issue: 12
Pages: 1609-1617
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Publication
25130304 | J:329036
First Author: Kawakami Y
Year: 2015
Journal: J Bone Miner Res
Title: SDF-1/CXCR4 axis in Tie2-lineage cells including endothelial progenitor cells contributes to bone fracture healing.
Volume: 30
Issue: 1
Pages: 95-105
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Publication
37556373 | J:341748
 
First Author: Gabdulkhakova A
Year: 2023
Journal: Hepatol Commun
Title: Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury.
Volume: 7
Issue: 9
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Publication
17893233 | J:133299
First Author: Matoso A
Year: 2008
Journal: Carcinogenesis
Title: Cell lineage-specific interactions between Men1 and Rb in neuroendocrine neoplasia.
Volume: 29
Issue: 3
Pages: 620-8
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Publication
8788029 | J:133842
First Author: Li M
Year: 1996
Journal: Cell Growth Differ
Title: Apoptosis and remodeling of mammary gland tissue during involution proceeds through p53-independent pathways.
Volume: 7
Issue: 1
Pages: 13-20
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Publication
23294106 | -
First Author: Aspatwar A
Year: 2013
Journal: J Enzyme Inhib Med Chem
Title: An update on carbonic anhydrase-related proteins VIII, X and XI.
Volume: 28
Issue: 6
Pages: 1129-42
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Publication
8670887 | J:34979
First Author: Strasser A
Year: 1996
Journal: EMBO J
Title: Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival.
Volume: 15
Issue: 15
Pages: 3823-34
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Publication
2250704 | J:69571
First Author: Strasser A
Year: 1990
Journal: Nature
Title: Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.
Volume: 348
Issue: 6299
Pages: 331-3
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Publication
24966386 | J:212541
First Author: Rudchenko A
Year: 2014
Journal: J Neurosci
Title: Synapses on sympathetic neurons and parasympathetic neurons differ in their vulnerability to diabetes.
Volume: 34
Issue: 26
Pages: 8865-74
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Publication
2405398 | J:10282
First Author: Harada N
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding.
Volume: 87
Issue: 3
Pages: 857-61
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Publication
12732657 | J:133242
First Author: Drayton DL
Year: 2003
Journal: J Exp Med
Title: Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase.
Volume: 197
Issue: 9
Pages: 1153-63
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Publication
25088202 | J:222532
First Author: Vassilopoulos A
Year: 2015
Journal: Oncogene
Title: WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis.
Volume: 34
Issue: 23
Pages: 3023-35
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Publication
20237291 | J:159871
First Author: Suzuki A
Year: 2010
Journal: J Immunol
Title: Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung.
Volume: 184
Issue: 8
Pages: 4510-20
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Publication
29735270 | -
First Author: Keßler M
Year: 2018
Journal: Neuromuscul Disord
Title: A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations.
Volume: 28
Issue: 6
Pages: 521-531
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Publication
31027317 | J:303280
 
First Author: Lesaffer B
Year: 2019
Journal: Cells
Title: Comparison of the Opn-CreER and Ck19-CreER Drivers in Bile Ducts of Normal and Injured Mouse Livers.
Volume: 8
Issue: 4
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Publication
19556245 | -
First Author: Patel A
Year: 2009
Journal: J Biol Chem
Title: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Volume: 284
Issue: 36
Pages: 24242-56
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