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Search results 201 to 300 out of 305 for Abi1

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Type Details Score
Publication
9010225 | J:114805
First Author: Biesova Z
Year: 1997
Journal: Oncogene
Title: Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth.
Volume: 14
Issue: 2
Pages: 233-41
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Publication
7590237 | J:29673
First Author: Shi Y
Year: 1995
Journal: Genes Dev
Title: Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.
Volume: 9
Issue: 21
Pages: 2583-97
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Publication
26428302 | J:302461
 
First Author: Sekino S
Year: 2015
Journal: Cell Commun Signal
Title: The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.
Volume: 13
Pages: 41
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Publication
14765121 | J:88449
First Author: Steffen A
Year: 2004
Journal: EMBO J
Title: Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.
Volume: 23
Issue: 4
Pages: 749-59
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Publication
10995551 | J:72871
First Author: Courtney KD
Year: 2000
Journal: Mol Cell Neurosci
Title: Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.
Volume: 16
Issue: 3
Pages: 244-57
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Publication
15143189 | J:91021
First Author: Echarri A
Year: 2004
Journal: Mol Cell Biol
Title: Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.
Volume: 24
Issue: 11
Pages: 4979-93
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Publication
25297099 | J:216588
First Author: Jia JM
Year: 2014
Journal: J Neurosci
Title: The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics.
Volume: 34
Issue: 41
Pages: 13725-36
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Publication
39640588 | J:359195
First Author: Balekoglu N
Year: 2024
Journal: iScience
Title: The WAVE regulatory complex interacts with Boc and is required for Shh-mediated axon guidance.
Volume: 27
Issue: 12
Pages: 111333
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Publication
19200726 | J:146463
First Author: Millius A
Year: 2009
Journal: Curr Biol
Title: Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion.
Volume: 19
Issue: 3
Pages: 253-9
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Publication
9878254 | J:49297
First Author: Zechner U
Year: 1998
Journal: Genomics
Title: Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c-ps1 on Chr 2.
Volume: 54
Issue: 3
Pages: 505-10
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Publication
15572692 | J:95254
First Author: Grove M
Year: 2004
Journal: Mol Cell Biol
Title: ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.
Volume: 24
Issue: 24
Pages: 10905-22
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Publication
9986727 | J:53033
First Author: Xiong JW
Year: 1999
Journal: Dev Biol
Title: Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors.
Volume: 206
Issue: 2
Pages: 123-41
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Publication
20697350 | J:164892
First Author: Titz B
Year: 2010
Journal: Oncogene
Title: The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
Volume: 29
Issue: 44
Pages: 5895-910
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Publication
35108541 | J:320846
First Author: Avilés EC
Year: 2022
Journal: Cell Rep
Title: Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.
Volume: 38
Issue: 5
Pages: 110307
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Publication
35253879 | J:323057
First Author: Verdile V
Year: 2022
Journal: Nucleic Acids Res
Title: EWS splicing regulation contributes to balancing Foxp1 isoforms required for neuronal differentiation.
Volume: 50
Issue: 6
Pages: 3362-3378
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Publication
25315346 | J:315097
First Author: Leung C
Year: 2014
Journal: J Am Heart Assoc
Title: Rac1 signaling is critical to cardiomyocyte polarity and embryonic heart development.
Volume: 3
Issue: 5
Pages: e001271
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Publication
16831833 | J:119028
First Author: Rakeman AS
Year: 2006
Journal: Development
Title: Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching.
Volume: 133
Issue: 16
Pages: 3075-83
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Publication
21795692 | J:184110
First Author: Verpelli C
Year: 2011
Journal: J Biol Chem
Title: Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.
Volume: 286
Issue: 40
Pages: 34839-50
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Publication
19208628 | J:148808
First Author: Sawallisch C
Year: 2009
Journal: J Biol Chem
Title: The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.
Volume: 284
Issue: 14
Pages: 9225-36
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Publication
27565344 | J:236302
First Author: Zhang X
Year: 2016
Journal: Cell
Title: Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.
Volume: 166
Issue: 5
Pages: 1147-1162.e15
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Publication
15755804 | J:98216
First Author: García-García MJ
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Analysis of mouse embryonic patterning and morphogenesis by forward genetics.
Volume: 102
Issue: 17
Pages: 5913-9
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Publication
15102471 | J:114108
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
22993434 | J:188281
First Author: Park E
Year: 2012
Journal: J Neurosci
Title: Activity-dependent modulation of the interaction between CaMKIIα and Abi1 and its involvement in spine maturation.
Volume: 32
Issue: 38
Pages: 13177-88
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Publication
21900237 | -
First Author: Zhuang C
Year: 2011
Journal: J Biol Chem
Title: CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis.
Volume: 286
Issue: 44
Pages: 38614-26
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Publication
11477655 | -
First Author: Shibuya N
Year: 2001
Journal: Genes Chromosomes Cancer
Title: t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines.
Volume: 32
Issue: 1
Pages: 1-10
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Publication
14565974 | J:90061
First Author: Offenhäuser N
Year: 2004
Journal: Mol Biol Cell
Title: The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.
Volume: 15
Issue: 1
Pages: 91-8
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Publication
11181729 | J:182417
First Author: Vranová E
Year: 2001
Journal: J Exp Bot
Title: The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C.
Volume: 52
Issue: 354
Pages: 181-2
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Publication
23918390 | J:200669
First Author: Furness DN
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.
Volume: 110
Issue: 34
Pages: 13898-903
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Protein Domain
IPR039801 | EPS8-like
Type: Family
Description: This entry includes EPS8 and EPS8L1-3 from animals.Epidermal growth factor receptor kinase substrate 8 (EPS8) is a signalling adapter that possesses actin binding, bundling, and barbed-end capping activities []. It forms a complex with Sos-1, Abi1 and the lipid kinase phosphoinositide 3-kinase (PI3-K) to regulate Rac activation that leads to actin cytoskeletal remodeling []. It is critical for dendritic cell migration []. It is involved in the initial growth of stereocilia in both inner hair cells and outer hair cells []. It also regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF) []. It has been linked to proliferation, metastasis and prognosis of many malignant tumours [].Similarly to EPS8, EPSLs interact with Abi1 and Sos-1. However, only EPS8L1 and EPS8L2 activate the Rac-GEF activity of Sos-1, and bind to actin in vivo []. Eps8L2 null-mutant mice has been shown to exhibit a late-onset, progressive hearing loss that is directly linked to a gradual deterioration in hair bundle morphology [].
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Publication
21835647 | J:176428
First Author: Frittoli E
Year: 2011
Journal: Immunity
Title: The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration.
Volume: 35
Issue: 3
Pages: 388-99
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Publication
23628062 | -
First Author: Sun J
Year: 2013
Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi
Title: [Correlation of Eps8 with proliferation, metastasis and prognosis of malignant tumors].
Volume: 21
Issue: 2
Pages: 493-7
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Publication
24475274 | J:212708
First Author: Olt J
Year: 2014
Journal: PLoS One
Title: The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
Volume: 9
Issue: 1
Pages: e87331
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Protein Domain
IPR036993 | ABI2
Type: Family
Description: Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for cytoskeletal reorganization []. Abi1 and Abi2 play an important role in actin cytoskeleton dynamics through participation in several multiprotein complexes. They participate in the formation of the Abi/WAVE complex, which regulates Arp2/3-mediated actin filament nucleation and actin network assembly [, , ].Abi2 is a component of the WAVE1 complex. It localises to sites of actin polymerisation at the tips of lamellipodia and filopodia []. Its structure has been solved [].
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Protein Domain
IPR030222 | EPS8
Type: Family
Description: Epidermal growth factor receptor kinase substrate 8 (EPS8) is a signalling adapter that possesses actin binding, bundling, and barbed-end capping activities []. It forms a complex with Sos-1, Abi1 and the lipid kinase phosphoinositide 3-kinase (PI3-K) to regulate Rac activation that leads to actin cytoskeletal remodeling []. It is critical for dendritic cell migration []. It is involved in the initial growth of stereocilia in both inner hair cells and outer hair cells []. It also regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF) []. It has been linked to proliferation, metastasis and prognosis of many malignant tumours [].
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Publication
32728066 | J:308615
First Author: Qi Y
Year: 2020
Journal: Sci Rep
Title: PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1.
Volume: 10
Issue: 1
Pages: 12685
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Publication
20598684 | J:200509
First Author: Dubielecka PM
Year: 2010
Journal: FEBS Lett
Title: Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.
Volume: 584
Issue: 15
Pages: 3279-86
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Publication
22710157 | -
First Author: Saksela K
Year: 2012
Journal: FEBS Lett
Title: SH3 domain ligand binding: What's the consensus and where's the specificity?
Volume: 586
Issue: 17
Pages: 2609-14
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Protein Domain
IPR035462 | Eps8_SH3
Type: Domain
Description: This entry represents the SH3 domain found in Eps8 and Eps8-like proteins including Eps8-like 1-3. These proteins contain N-terminal phosphotyrosine-binding (PTB), central SH3, and C-terminal effector domains. The SH3 domains of Eps8 and similar proteins recognize peptides containing a PxxDY motif, instead of the classical PxxP motif []. Epidermal growth factor receptor kinase substrate 8 (EPS8) is a signalling adapter that possesses actin binding, bundling, and barbed-end capping activities []. It forms a complex with Sos-1, Abi1 and the lipid kinase phosphoinositide 3-kinase (PI3-K) to regulate Rac activation that leads to actin cytoskeletal remodeling []. It is critical for dendritic cell migration []. It is involved in the initial growth of stereocilia in both inner hair cells and outer hair cells []. It also regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF) []. It has been linked to proliferation, metastasis and prognosis of many malignant tumours [].
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Protein Domain
IPR035725 | Abi1_SH3
Type: Domain
Description: Abi1, also called e3B1, is a central regulator of actin cytoskeletal reorganization through interactions with many protein complexes. It is part of WAVE, a nucleation-promoting factor complex, that links Rac 1 activation to actin polymerization causing lamellipodia protrusion at the plasma membrane [, ]. Abi1 is a target of alpha4 integrin, regulating membrane protrusions at sites of integrin engagement []. Abi proteins are adaptor proteins serving as binding partners and substrates of Abl tyrosine kinases. They are involved in regulating actin cytoskeletal reorganization and play important roles in membrane-ruffling, endocytosis, cell motility, and cell migration []. Abi proteins contain a homeobox homology domain, a proline-rich region, and a SH3 domain.This entry represents the SH3 domain of Abi1.
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Protein
E9PZ95
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Protein
D3YWI5
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Publication
34369620 | J:310457
First Author: Wang Y
Year: 2021
Journal: FASEB J
Title: Acetylation of Abelson interactor 1 at K416 regulates actin cytoskeleton and smooth muscle contraction.
Volume: 35
Issue: 9
Pages: e21811
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Publication
31983435 | J:296185
First Author: Perfitt TL
Year: 2020
Journal: Biochem Biophys Res Commun
Title: CaMKIIα phosphorylation of Shank3 modulates ABI1-Shank3 interaction.
Volume: 524
Issue: 1
Pages: 262-267
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Publication
21107423 | -
First Author: Chen Z
Year: 2010
Journal: Nature
Title: Structure and control of the actin regulatory WAVE complex.
Volume: 468
Issue: 7323
Pages: 533-8
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Protein
E9PWX4
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: true
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Protein
E9PVI7
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
E9Q2P3
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Protein
A0A0G2JGZ0
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
A0A087WR90
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
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Protein
D3Z5I5
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: true
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Protein
A0A0A0MQF0
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
D3Z7F4
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
Q3UFL4
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: true
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Protein
Q3TMV3
Organism: Mus musculus/domesticus
Length: 561  
Fragment?: false
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Publication
12011975 | -
First Author: Ichigotani Y
Year: 2002
Journal: Int J Mol Med
Title: In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).
Volume: 9
Issue: 6
Pages: 591-5
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Protein
Q91WL0
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: false
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Protein
Q08509
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q3UGL1
Organism: Mus musculus/domesticus
Length: 587  
Fragment?: true
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Protein
Q3U2Z5
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
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•
•
•
Protein
Q99K30
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
•
•
•
•
•
Protein
Q8R5F8
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
•
•
•
•
•
Protein
E9Q4X5
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: false
•
•
•
•
•
Protein
A0A087WPE6
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: true
•
•
•
•
•
Protein
A0A087WNU9
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: true
•
•
•
•
•
Protein
Q3UVN6
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
•
•
•
•
•
Protein
A0A087WP64
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: true
•
•
•
•
•
Protein
P62484
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
•
•
•
•
•
Protein
A0A087WRS3
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom