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Search results 201 to 268 out of 268 for Abl2

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Type Details Score
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
33318173 | J:300389
First Author: Hoj JP
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis.
Volume: 117
Issue: 52
Pages: 33486-33495
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UniProt Feature
UniProt Feature
Begin: 2
Description: Tyrosine-protein kinase ABL2
Type: chain
End: 1182
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UniProt Feature
UniProt Feature
Begin: 34
Description: Phosphotyrosine; by ABL2
Type: modified residue
End: 34
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UniProt Feature
UniProt Feature
Begin: 34
Description: Phosphotyrosine; by ABL2
Type: modified residue
End: 34
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Allele
Abl2<tm1c(EUCOMM)Hmgu> | MGI:6111513
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready
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Protein
A0A087WQB7
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: true
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Protein
Q4JIM5
Organism: Mus musculus/domesticus
Length: 1182  
Fragment?: false
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Publication
14729179 | -
First Author: Hernández SE
Year: 2004
Journal: Trends Cell Biol
Title: How do Abl family kinases regulate cell shape and movement?
Volume: 14
Issue: 1
Pages: 36-44
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Publication
17892306 | -
First Author: Boyle SN
Year: 2007
Journal: Biochemistry
Title: Use of a chemical genetic technique to identify myosin IIb as a substrate of the Abl-related gene (Arg) tyrosine kinase.
Volume: 46
Issue: 41
Pages: 11614-20
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Publication
18182299 | -
First Author: Backert S
Year: 2008
Journal: Trends Biochem Sci
Title: Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
Volume: 33
Issue: 2
Pages: 80-90
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Protein
G3UWQ2
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
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UniProt Feature
UniProt Feature
Begin: 685
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 685
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UniProt Feature
UniProt Feature
Begin: 933
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 933
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UniProt Feature
UniProt Feature
Begin: 969
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 969
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UniProt Feature
UniProt Feature
Begin: 153
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 153
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UniProt Feature
UniProt Feature
Begin: 1105
Description: Phosphotyrosine; by ABL2 and PTK6
Type: modified residue
End: 1105
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UniProt Feature
UniProt Feature
Begin: 35
Description: Phosphotyrosine; by ABL1 and ABL2
Type: modified residue
End: 35
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Publication
16971514 | -
First Author: Bradley WD
Year: 2006
Journal: Mol Biol Cell
Title: Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.
Volume: 17
Issue: 11
Pages: 4827-36
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GXD Expression
GXD Expression
 
Probe: MGI:7282079
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3291617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7282098
Age: embryonic day 10.25
Note: Expression in neuroepithelium of dorsolateral rhombencephalon. Significant colocalization with Abl2 at apical surface of neuroepithelium.
Specimen Label: 7C Abl
Detected: true
Specimen Num: 1
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Publication
20841568 | -
First Author: Colicelli J
Year: 2010
Journal: Sci Signal
Title: ABL tyrosine kinases: evolution of function, regulation, and specificity.
Volume: 3
Issue: 139
Pages: re6
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Publication
12775773 | -
First Author: Woodring PJ
Year: 2003
Journal: J Cell Sci
Title: Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
Volume: 116
Issue: Pt 13
Pages: 2613-26
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Allele
Tg(Abl2-EGFP)HV66Gsat | MGI:4846834
Name: transgene insertion HV66, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003794 | STOCK Tg(Abl2-EGFP)HV66Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
31825826 | J:352082
First Author: Hoj JP
Year: 2019
Journal: Cell Rep
Title: A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis.
Volume: 29
Issue: 11
Pages: 3421-3434.e8
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Publication
18796434 | -
First Author: Cao X
Year: 2008
Journal: J Biol Chem
Title: Enhancement of ABL kinase catalytic efficiency by a direct binding regulator is independent of other regulatory mechanisms.
Volume: 283
Issue: 46
Pages: 31401-7
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Publication
18945674 | -
First Author: Yogalingam G
Year: 2008
Journal: J Biol Chem
Title: Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.
Volume: 283
Issue: 51
Pages: 35941-53
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Publication
6191223 | -
First Author: Groffen J
Year: 1983
Journal: Nature
Title: Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products.
Volume: 304
Issue: 5922
Pages: 167-9
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Publication
17623672 | -
First Author: Sossey-Alaoui K
Year: 2007
Journal: J Biol Chem
Title: c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.
Volume: 282
Issue: 36
Pages: 26257-65
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Publication
16943190 | -
First Author: Tanos B
Year: 2006
Journal: J Biol Chem
Title: Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
Volume: 281
Issue: 43
Pages: 32714-23
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Publication
26864341 | -
First Author: Dasgupta Y
Year: 2016
Journal: Blood
Title: Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases.
Volume: 127
Issue: 17
Pages: 2131-43
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Protein Domain
IPR033221 | ABL1
Type: Family
Description: This entry includes animal ABL1 and viral oncogene products that are homologous to ABL1 []. ABL1 plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodelling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis [, , , ]. Normal ABL1 can serve as a tumour suppressor and therapeutic target in leukemias expressing oncogenic forms of the kinase [].ABL tyrosine kinases are nonreceptor tyrosine kinases containing an SH3-SH2-TK (Src homology 3-Src homology 2-tyrosine kinase) domain cassette, which confers autoregulated kinase activity. This cassette is coupled to an actin-binding and -bundling domain, which makes ABL proteins capable of connecting phosphoregulation with actin-filament reorganization. Two vertebrate ABL tyrosine kinases have been identified, ABL1 and ABL2 [].A downstream effector of RAS, RIN1, have been found to bind to the SH3 and SH2 domains of ABL1/ABL2 to relieve autoinhibition and regulate their activity [].
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Publication
8806812 | J:34903
First Author: Hardin JD
Year: 1996
Journal: Cell Immunol
Title: Abnormal peripheral lymphocyte function in c-abl mutant mice.
Volume: 172
Issue: 1
Pages: 100-7
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Publication
12796783 | J:84071
First Author: Finn AJ
Year: 2003
Journal: Nat Neurosci
Title: Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.
Volume: 6
Issue: 7
Pages: 717-23
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Publication
16137333 | J:302576
 
First Author: Liu M
Year: 2005
Journal: Reprod Biol Endocrinol
Title: Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development.
Volume: 3
Pages: 42
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Publication
11971963 | -
First Author: Yoshida K
Year: 2002
Journal: Mol Cell Biol
Title: c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.
Volume: 22
Issue: 10
Pages: 3292-300
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Protein Domain
IPR035837 | ABL_SH2
Type: Domain
Description: ABL-family proteins are highly conserved tyrosine kinases. Each ABL protein contains an SH3-SH2-TK (Src homology 3-Src homology 2-tyrosine kinase) domain cassette, which confers autoregulated kinase activity and is common among nonreceptor tyrosine kinases. Several types of posttranslational modifications control ABL catalytic activity, subcellular localization, and stability, with consequences for both cytoplasmic and nuclear ABL functions. Binding partners provide additional regulation of ABL catalytic activity, substrate specificity, and downstream signaling. By combining this cassette with actin-binding and -bundling domains, ABL proteins are capable of connecting phosphoregulation with actin-filament reorganization []. Vertebrate paralogs, ABL1 and ABL2, have evolved to perform specialized functions. ABL1 includes nuclear localization signals and a DNA binding domain which is used to mediate DNA damage-repair functions, while ABL2 has additional binding capacity for actin and for microtubules to enhance its cytoskeletal remodeling functions. SH2 is involved in several autoinhibitory mechanism that constrain the enzymatic activity of the ABL-family kinases. In one mechanism SH2 and SH3 cradle the kinase domain while a cap sequence stabilizes the inactive conformation resulting in a locked inactive state. Another involves phosphatidylinositol 4,5-bisphosphate (PIP2) which binds the SH2 domain through residues normally required for phosphotyrosine binding in the linker segment between the SH2 and kinase domains. The SH2 domain contributes to ABL catalytic activity and target site specificity. It is thought that the ABL catalytic site and SH2 pocket have co-evolved to recognize the same sequences. Recent work now supports a hierarchical processivity model in which the substrate target site most compatible with ABL kinase domain preferences is phosphorylated with greatest efficiency. If this site is compatible with the ABL SH2 domain specificity, it will then reposition and dock in the SH2 pocket. This mechanism also explains how ABL kinases phosphorylates poor targets on the same substrate if they are properly positioned and how relatively poor substrate proteins might be recruited to ABL through a complex with strong substrates that can also dock with the SH2 pocket [].This entry includes the SH2 domain of ABL-family proteins. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , , ].
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Publication
9241420 | -
 
First Author: Kuriyan J
Year: 1997
Journal: Annu Rev Biophys Biomol Struct
Title: Modular peptide recognition domains in eukaryotic signaling.
Volume: 26
Pages: 259-88
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Publication
10398925 | -
First Author: Grucza RA
Year: 1999
Journal: Med Res Rev
Title: SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.
Volume: 19
Issue: 4
Pages: 273-93
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Publication
19273114 | -
 
First Author: Kasembeli MM
Year: 2009
Journal: Front Biosci (Landmark Ed)
Title: SH2 domain binding to phosphopeptide ligands: potential for drug targeting.
Volume: 14
Pages: 1010-22
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Protein
P00520
Organism: Mus musculus/domesticus
Length: 1123  
Fragment?: false
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Protein
Q3SYK5
Organism: Mus musculus/domesticus
Length: 1142  
Fragment?: false
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Protein
F8VQH0
Organism: Mus musculus/domesticus
Length: 1182  
Fragment?: false
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Protein
B7ZMZ2
Organism: Mus musculus/domesticus
Length: 1078  
Fragment?: false
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Protein
B2RQ57
Organism: Mus musculus/domesticus
Length: 1078  
Fragment?: false
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Publication
19926274 | -
First Author: Filippakopoulos P
Year: 2009
Journal: Curr Opin Struct Biol
Title: SH2 domains: modulators of nonreceptor tyrosine kinase activity.
Volume: 19
Issue: 6
Pages: 643-9
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Publication
19144319 | J:143718
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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