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Search results 201 to 300 out of 1211 for Aim2

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Type Details Score
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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GO Term
GO:0097169 | AIM2 inflammasome complex
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UniProt Feature
UniProt Feature
Begin: 1
Description: Interferon-inducible protein AIM2
Type: chain
End: 354
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Pathway
R-MMU-844615 | The AIM2 inflammasome
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GO Term
GO:0140973 | positive regulation of AIM2 inflammasome complex assembly
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GO Term
GO:0140971 | regulation of AIM2 inflammasome complex assembly
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GO Term
GO:0140972 | negative regulation of AIM2 inflammasome complex assembly
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Protein
D3Z341
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
G3UZ36
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Publication
29855523 | J:323710
First Author: Rodrigue-Gervais IG
Year: 2018
Journal: Sci Rep
Title: The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes.
Volume: 8
Issue: 1
Pages: 8446
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Publication
24270411 | J:229062
First Author: Wu YH
Year: 2014
Journal: Cell Death Differ
Title: Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation.
Volume: 21
Issue: 3
Pages: 451-61
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Publication
31822523 | J:315641
First Author: Cho SJ
Year: 2020
Journal: Thorax
Title: GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation.
Volume: 75
Issue: 3
Pages: 227-236
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Interaction Experiment
Liu T (2016)
Description: TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy.
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Publication
38594840 | J:349090
First Author: Alanazi M
Year: 2024
Journal: Cancer Sci
Title: Cytosolic DNA sensor AIM2 promotes KRAS-driven lung cancer independent of inflammasomes.
Volume: 115
Issue: 6
Pages: 1834-1850
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Publication
24798340 | J:216031
First Author: Zhao C
Year: 2014
Journal: J Biol Chem
Title: Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.
Volume: 289
Issue: 24
Pages: 17020-9
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Publication
31914678 | J:299487
First Author: Zhang MJ
Year: 2020
Journal: FASEB J
Title: The HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by downregulating the AIM2 inflammasome.
Volume: 34
Issue: 1
Pages: 648-662
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Publication
34861878 | J:324799
First Author: Cao LL
Year: 2021
Journal: J Neuroinflammation
Title: Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice.
Volume: 18
Issue: 1
Pages: 281
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Publication
32001670 | J:297765
First Author: Yuan B
Year: 2020
Journal: Cell Death Dis
Title: Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage.
Volume: 11
Issue: 1
Pages: 76
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Publication
37769964 | J:356795
 
First Author: Yang M
Year: 2023
Journal: Ocul Surf
Title: Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells.
Volume: 30
Pages: 263-275
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Allele
Aim2<em2Smoc> | MGI:7288204
Name: absent in melanoma 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
15896773 | -
First Author: Ludlow LE
Year: 2005
Journal: Exp Cell Res
Title: The HIN-200 family: more than interferon-inducible genes?
Volume: 308
Issue: 1
Pages: 1-17
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Protein Coding Gene
MGI:1347080 | Ifi202a
Type: protein_coding_gene
Organism: mouse, laboratory
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Strain
MGI:6474749 | C57BL/6JSmoc-Aim2<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Aim2<em1Smoc> | MGI:7288203
Name: absent in melanoma 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
25327779 | -
First Author: Kim HY
Year: 2015
Journal: FEBS J
Title: Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion.
Volume: 282
Issue: 2
Pages: 259-70
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Publication
22483801 | -
First Author: Jin T
Year: 2012
Journal: Immunity
Title: Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Volume: 36
Issue: 4
Pages: 561-71
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Pseudogene
MGI:3649299 | Gm12250
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2137355 | Trim11
Type: protein_coding_gene
Organism: mouse, laboratory
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Pseudogene
MGI:3840117 | Ifi203-ps
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96544 | Casp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3646410 | Ifi206
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2442822 | Ifi208
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3695276 | Ifi213
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2138243 | Ifi209
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3584522 | Ifi214
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2138302 | Ifi207
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3780953 | Mndal
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96428 | Ifi203
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2429943 | Gbp5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102772 | Gbp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Del(1Aim2-Ifi205)1Stsn | MGI:5789602
Name: deletion, Chr 1, Daniel Stetson 1
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
22258606 | J:320140
First Author: Strowig T
Year: 2012
Journal: Nature
Title: Inflammasomes in health and disease.
Volume: 481
Issue: 7381
Pages: 278-86
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Publication
26140588 | J:224532
First Author: Rommereim LM
Year: 2015
Journal: Cell
Title: AIMing 2 Curtail Cancer.
Volume: 162
Issue: 1
Pages: 18-20
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Publication
24492532 | J:244194
 
First Author: Van Opdenbosch N
Year: 2014
Journal: Nat Commun
Title: Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
Volume: 5
Pages: 3209
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Strain
MGI:5789962 | B6(129S4)-Del(1Aim2-Ifi205)1Stsn
Attribute String: chromosome aberration, deletion, mutant strain, targeted mutation
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Strain
MGI:5789626 | B6(129S4)-Del(1Aim2-Ifi205)1Stsn/J
Attribute String: deletion, mutant strain
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Genotype
Genotype
Symbol: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
Background: B6(129S4)-Del(1Aim2-Ifi205)1Stsn
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Publication
28345580 | J:263294
 
First Author: Man SM
Year: 2017
Journal: Sci Rep
Title: Differential roles of caspase-1 and caspase-11 in infection and inflammation.
Volume: 7
Pages: 45126
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Publication
27800616 | J:247253
First Author: Silveira TN
Year: 2017
Journal: Eur J Immunol
Title: NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus.
Volume: 47
Issue: 1
Pages: 51-59
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Publication
24407287 | J:219619
First Author: Dowling JK
Year: 2014
Journal: J Biol Chem
Title: Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.
Volume: 289
Issue: 10
Pages: 6429-37
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Publication
21957143 | J:179435
First Author: Fang R
Year: 2011
Journal: J Immunol
Title: Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.
Volume: 187
Issue: 9
Pages: 4890-9
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Protein Coding Gene
MGI:1931465 | Pycard
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1347080 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11567633 | J:123266
First Author: Rozzo SJ
Year: 2001
Journal: Immunity
Title: Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus.
Volume: 15
Issue: 3
Pages: 435-43
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Publication
1382418 | J:2375
First Author: Lembo D
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Regulation of the 202 gene expression by interferons in L929 cells.
Volume: 187
Issue: 2
Pages: 628-34
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Publication
8454910 | J:17917
First Author: Choubey D
Year: 1993
Journal: J Interferon Res
Title: Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kD protein that is encoded by the Ifi 200 gene from the gene 200 cluster.
Volume: 13
Issue: 1
Pages: 43-52
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Publication
8524315 | J:31083
First Author: Min W
Year: 1996
Journal: Mol Cell Biol
Title: The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities.
Volume: 16
Issue: 1
Pages: 359-68
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Publication
36070769 | J:329937
First Author: Maltbaek JH
Year: 2022
Journal: Immunity
Title: ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.
Volume: 55
Issue: 10
Pages: 1799-1812.e4
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Genotype
Genotype
Symbol: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn Trex1/Trex1
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(1Aim2-Ifi205)1Stsn/+ Trex1/Trex1
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
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Publication
30930743 | J:310545
 
First Author: Pronin A
Year: 2019
Journal: Front Mol Neurosci
Title: Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury.
Volume: 12
Pages: 36
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Publication
25043000 | J:217119
First Author: Walle LV
Year: 2014
Journal: Nature
Title: Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.
Volume: 512
Issue: 7512
Pages: 69-73
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Publication
26814970 | J:229240
First Author: He Y
Year: 2016
Journal: Nature
Title: NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
Volume: 530
Issue: 7590
Pages: 354-7
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Publication
28397782 | J:250403
 
First Author: Zhong Z
Year: 2017
Journal: Nat Commun
Title: Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice.
Volume: 8
Pages: 15004
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Publication
27035940 | J:232121
First Author: Monteith AJ
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus.
Volume: 113
Issue: 15
Pages: E2142-51
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Publication
20890285 | J:166541
First Author: Unterholzner L
Year: 2010
Journal: Nat Immunol
Title: IFI16 is an innate immune sensor for intracellular DNA.
Volume: 11
Issue: 11
Pages: 997-1004
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Publication
23100513 | J:190677
First Author: Hernandez-Cuellar E
Year: 2012
Journal: J Immunol
Title: Cutting edge: nitric oxide inhibits the NLRP3 inflammasome.
Volume: 189
Issue: 11
Pages: 5113-7
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Publication
29531021 | J:262083
 
First Author: Huang Y
Year: 2018
Journal: EMBO Mol Med
Title: Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.
Volume: 10
Issue: 4
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Publication
27270400 | J:244991
First Author: Akula MK
Year: 2016
Journal: Nat Immunol
Title: Control of the innate immune response by the mevalonate pathway.
Volume: 17
Issue: 8
Pages: 922-9
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Publication
36103544 | J:331763
First Author: de Almeida L
Year: 2022
Journal: Sci Adv
Title: Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection.
Volume: 8
Issue: 37
Pages: eabo5400
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Publication
32791101 | J:295186
First Author: Hooftman A
Year: 2020
Journal: Cell Metab
Title: The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.
Volume: 32
Issue: 3
Pages: 468-478.e7
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Publication
34010627 | J:328725
First Author: Avgustinova A
Year: 2021
Journal: Cell Stem Cell
Title: Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development.
Volume: 28
Issue: 10
Pages: 1790-1804.e8
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Publication
30777924 | J:273125
First Author: Murakami T
Year: 2019
Journal: J Immunol
Title: Cutting Edge: G Protein Subunit β 1 Negatively Regulates NLRP3 Inflammasome Activation.
Volume: 202
Issue: 7
Pages: 1942-1947
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Publication
22105559 | J:187797
First Author: Luheshi NM
Year: 2012
Journal: Eur J Immunol
Title: Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.
Volume: 42
Issue: 3
Pages: 716-25
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Publication
36844454 | J:334452
First Author: Traughber CA
Year: 2023
Journal: iScience
Title: Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.
Volume: 26
Issue: 2
Pages: 106076
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Publication
30940803 | J:276765
First Author: Zhang P
Year: 2019
Journal: Nat Commun
Title: The lncRNA Neat1 promotes activation of inflammasomes in macrophages.
Volume: 10
Issue: 1
Pages: 1495
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Publication
31597705 | J:282055
First Author: Chen Y
Year: 2019
Journal: J Immunol
Title: Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist.
Volume: 203
Issue: 10
Pages: 2712-2723
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Publication
31914640 | J:299490
First Author: Shi Y
Year: 2020
Journal: FASEB J
Title: Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly.
Volume: 34
Issue: 1
Pages: 208-221
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Publication
24419611 | J:333978
First Author: Li H
Year: 2014
Journal: Acta Crystallogr F Struct Biol Commun
Title: Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling.
Volume: 70
Issue: Pt 1
Pages: 21-9
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Publication
10493828 | J:57929
First Author: Wang H
Year: 1999
Journal: Genomics
Title: Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster.
Volume: 60
Issue: 3
Pages: 281-94
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Publication
16670293 | J:131681
First Author: Xin H
Year: 2006
Journal: J Immunol
Title: Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis.
Volume: 176
Issue: 10
Pages: 5863-70
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Publication
2457983 | J:9335
First Author: Engel DA
Year: 1988
Journal: Virology
Title: Interferons as gene activators: close linkage of two interferon-activatable murine genes.
Volume: 166
Issue: 1
Pages: 24-9
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Publication
17702989 | J:124676
First Author: Yamauchi M
Year: 2007
Journal: Int Immunol
Title: Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells.
Volume: 19
Issue: 8
Pages: 935-42
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Publication
31836654 | J:289587
First Author: Bhatta A
Year: 2020
Journal: J Immunol
Title: A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome.
Volume: 204
Issue: 2
Pages: 428-437
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Publication
28935571 | J:252318
First Author: Durga Devi T
Year: 2017
Journal: Am J Pathol
Title: Aggravated Postinfarct Heart Failure in Type 2 Diabetes Is Associated with Impaired Mitophagy and Exaggerated Inflammasome Activation.
Volume: 187
Issue: 12
Pages: 2659-2673
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Publication
22156592 | J:180799
First Author: Koppe U
Year: 2012
Journal: J Immunol
Title: Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.
Volume: 188
Issue: 2
Pages: 811-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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