Type |
Details |
Score |
Publication |
First Author: |
Middleton MK |
Year: |
2009 |
Journal: |
Infect Immun |
Title: |
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis. |
Volume: |
77 |
Issue: |
12 |
Pages: |
5690-700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu S |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Smooth muscle-specific expression of calcium-independent phospholipase A2β (iPLA2β) participates in the initiation and early progression of vascular inflammation and neointima formation. |
Volume: |
287 |
Issue: |
29 |
Pages: |
24739-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Funk CD |
Year: |
1996 |
Journal: |
Biochim Biophys Acta |
Title: |
The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice. |
Volume: |
1304 |
Issue: |
1 |
Pages: |
65-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krieg P |
Year: |
1998 |
Journal: |
Biochim Biophys Acta |
Title: |
cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. |
Volume: |
1391 |
Issue: |
1 |
Pages: |
7-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zarbock A |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). |
Volume: |
183 |
Issue: |
7 |
Pages: |
4715-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rong S |
Year: |
2012 |
Journal: |
J Lipid Res |
Title: |
Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis. |
Volume: |
53 |
Issue: |
4 |
Pages: |
686-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wen Y |
Year: |
2008 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages. |
Volume: |
294 |
Issue: |
4 |
Pages: |
H1933-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Allen-Redpath K |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. |
Volume: |
116 |
Issue: |
16 |
Pages: |
8038-8047 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gregus AM |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. |
Volume: |
109 |
Issue: |
17 |
Pages: |
6721-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han YH |
Year: |
2019 |
Journal: |
J Clin Invest |
Title: |
A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis. |
Volume: |
129 |
Issue: |
4 |
Pages: |
1684-1698 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li SL |
Year: |
2005 |
Journal: |
J Lipid Res |
Title: |
Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs. |
Volume: |
46 |
Issue: |
2 |
Pages: |
220-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rudhard Y |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening. |
Volume: |
35 |
Issue: |
7 |
Pages: |
2927-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pernet E |
Year: |
2023 |
Journal: |
Nature |
Title: |
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. |
Volume: |
614 |
Issue: |
7948 |
Pages: |
530-538 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poeckel D |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice. |
Volume: |
284 |
Issue: |
31 |
Pages: |
21077-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yeung J |
Year: |
2014 |
Journal: |
Blood |
Title: |
Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation. |
Volume: |
124 |
Issue: |
14 |
Pages: |
2271-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao L |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia. |
Volume: |
277 |
Issue: |
38 |
Pages: |
35350-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brütsch SH |
Year: |
2015 |
Journal: |
Antioxid Redox Signal |
Title: |
Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice. |
Volume: |
22 |
Issue: |
4 |
Pages: |
281-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stumpo DJ |
Year: |
2009 |
Journal: |
Blood |
Title: |
Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. |
Volume: |
114 |
Issue: |
12 |
Pages: |
2401-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sapieha P |
Year: |
2011 |
Journal: |
Sci Transl Med |
Title: |
5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids. |
Volume: |
3 |
Issue: |
69 |
Pages: |
69ra12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deliri H |
Year: |
2011 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Increased 12/15-lipoxygenase enhances cell growth, fibronectin deposition, and neointimal formation in response to carotid injury. |
Volume: |
31 |
Issue: |
1 |
Pages: |
110-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagelin MH |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways. |
Volume: |
284 |
Issue: |
45 |
Pages: |
31303-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leiria LO |
Year: |
2019 |
Journal: |
Cell Metab |
Title: |
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. |
Volume: |
30 |
Issue: |
4 |
Pages: |
768-783.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Srivastava AK |
Year: |
2006 |
Journal: |
J Lipid Res |
Title: |
Identification of quantitative trait loci that regulate obesity and serum lipid levels in MRL/MpJ x SJL/J inbred mice. |
Volume: |
47 |
Issue: |
1 |
Pages: |
123-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nikolic DM |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation. |
Volume: |
282 |
Issue: |
46 |
Pages: |
33405-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee GS |
Year: |
2005 |
Journal: |
Genetics |
Title: |
A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11. |
Volume: |
170 |
Issue: |
1 |
Pages: |
345-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chandrasekaran P |
Year: |
2022 |
Journal: |
Development |
Title: |
CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth. |
Volume: |
149 |
Issue: |
21 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto K |
Year: |
2015 |
Journal: |
J Exp Med |
Title: |
The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. |
Volume: |
212 |
Issue: |
11 |
Pages: |
1901-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lahbib-Mansais Y |
Year: |
2000 |
Journal: |
Mamm Genome |
Title: |
Comparative mapping between humans and pigs: localization of 58 anchorage markers (TOASTs) by use of porcine somatic cell and radiation hybrid panels. |
Volume: |
11 |
Issue: |
12 |
Pages: |
1098-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lemon WJ |
Year: |
2002 |
Journal: |
J Med Genet |
Title: |
Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. |
Volume: |
39 |
Issue: |
9 |
Pages: |
644-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Y |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
Volume: |
12 |
Issue: |
9 |
Pages: |
e1006355 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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|
•
•
•
•
•
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
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•
•
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•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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•
•
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•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
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•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
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•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Polyunsaturated fatty acid lipoxygenase ALOX12 |
Type: |
chain |
End: |
663 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tak J |
Year: |
2022 |
Journal: |
Theranostics |
Title: |
Gα12 overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation. |
Volume: |
12 |
Issue: |
4 |
Pages: |
1570-1588 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hagmann W |
Year: |
1995 |
Journal: |
Prostaglandins |
Title: |
12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes. |
Volume: |
49 |
Issue: |
1 |
Pages: |
49-62 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
663
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
390
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
arachidonate 12-lipoxygenase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 2, Arthur H M Burghes |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, transgenic, mutant stock |
|
•
•
•
•
•
|
Publication |
First Author: |
Kutzner L |
Year: |
2017 |
Journal: |
Biochim Biophys Acta |
Title: |
Mammalian ALOX15 orthologs exhibit pronounced dual positional specificity with docosahexaenoic acid. |
Volume: |
1862 |
Issue: |
7 |
Pages: |
666-675 |
|
•
•
•
•
•
|
Publication |
First Author: |
Iyer CC |
Year: |
2018 |
Journal: |
Hum Mol Genet |
Title: |
Mild SMN missense alleles are only functional in the presence of SMN2 in mammals. |
Volume: |
27 |
Issue: |
19 |
Pages: |
3404-3416 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gupta D |
Year: |
2013 |
Journal: |
Exp Eye Res |
Title: |
Regulation of mouse lens maturation and gene expression by Krüppel-like factor 4. |
Volume: |
116 |
|
Pages: |
205-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGovern VL |
Year: |
2021 |
Journal: |
Hum Mol Genet |
Title: |
Intragenic complementation of amino and carboxy terminal SMN missense mutations can rescue Smn null mice. |
Volume: |
29 |
Issue: |
21 |
Pages: |
3493-3503 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
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Genome Res |
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
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Cell |
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PLoS Biol |
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