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Search results 201 to 212 out of 212 for Apoa4

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0.018s

Type

Details

Score

Protein Domain

IPR000074 | ApoA_E

Type:

Family

Description:

Exchangeable apolipoproteins (apoA, apoC and apoE) have the same genomic structure and are members of a multi-gene family that probably evolved from a common ancestral gene. This entry includes the ApoA1, ApoA4, Apo5 and ApoE proteins. ApoA1, ApoA4 and Apo5 are part of the APOA1/C3/A4/A5 gene cluster on chromosome 11 []. Apolipoproteins function in lipid transport as structural components of lipoprotein particles, cofactors for enzymes and ligands for cell-surface receptors. In particular, apoA1 is the major protein component of high-density lipoproteins; apoA4 is thought to act primarily in intestinal lipid absorption; and apoE is a blood plasma protein that mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor. Recent findings with apoA1 and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related []. The three-dimensional structure of the LDL receptor-binding domain of apoE indicates that the protein forms an unusually elongated four-helix bundle that may be stabilised by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix [].

•

Publication

23542898 | J:213303

First Author:	Graham MJ
Year:	2013
Journal:	Circ Res
Title:	Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans.
Volume:	112
Issue:	11
Pages:	1479-90

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Publication

11557675 | J:103233

First Author:	Sentman ML
Year:	2001
Journal:	Arterioscler Thromb Vasc Biol
Title:	Extracellular superoxide dismutase deficiency and atherosclerosis in mice.
Volume:	21
Issue:	9
Pages:	1477-82

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Publication

11551841 | J:72104

First Author:	Hirano T
Year:	2001
Journal:	Am J Physiol Endocrinol Metab
Title:	Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E.
Volume:	281
Issue:	4
Pages:	E665-9

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Publication

26160324 | J:258766

First Author:	Li H
Year:	2015
Journal:	Cardiovasc Res
Title:	Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII.
Volume:	107
Issue:	4
Pages:	579-89

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Publication

28825717 | J:254382

First Author:	Khetarpal SA
Year:	2017
Journal:	Nat Med
Title:	A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.
Volume:	23
Issue:	9
Pages:	1086-1094

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Publication

10069372 | J:82359

First Author:	Baralle M
Year:	1999
Journal:	FEBS Lett
Title:	Regulation of the human apolipoprotein AIV gene expression in transgenic mice.
Volume:	445
Issue:	1
Pages:	45-52

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Publication

30333155 | J:269329

First Author:	Saadane A
Year:	2018
Journal:	J Lipid Res
Title:	Mechanisms that minimize retinal impact of apolipoprotein E absence.
Volume:	59
Issue:	12
Pages:	2368-2382

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Publication

38796472 | J:348980

First Author:	Smith DM
Year:	2024
Journal:	Nat Commun
Title:	Rab30 facilitates lipid homeostasis during fasting.
Volume:	15
Issue:	1
Pages:	4469

•

Publication

16478678 | J:110564

First Author:	van der Hoogt CC
Year:	2006
Journal:	Biochim Biophys Acta
Title:	Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice.
Volume:	1761
Issue:	2
Pages:	213-20

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Publication

29449313 | J:260518

First Author:	Larsson M
Year:	2018
Journal:	J Lipid Res
Title:	Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure.
Volume:	59
Issue:	4
Pages:	706-713

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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