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Search results 201 to 300 out of 432 for Arf1

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Type Details Score
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
10788613 | -
First Author: Dontsova M
Year: 2000
Journal: FEBS Lett
Title: Translation termination factor aRF1 from the archaeon Methanococcus jannaschii is active with eukaryotic ribosomes.
Volume: 472
Issue: 2-3
Pages: 213-6
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Protein Domain
IPR020918 | Peptide_chain-rel_aRF1
Type: Family
Description: Terminating protein synthesis on the ribosome requires the presence of a class I polypeptide chain release factor (RF) to induce peptidyl-tRNA hydrolysis. Bacteria possess two class I RFs; RF1 which recognises UAG and UAA, and RF2 which recognises UGA and UAA. Mitochondrial RFs are related structurally and functionally to those of bacteria. Eukaryotes posses only a single class 1 factor, eRF1, which recognises all three termination codons. Similarly, in all archaeal species where the complete sequence of the genome is available, only a single class I factor, aRF1, has been identified so far. The aRF1 family is highly homologous to the eRF1 family, indicating a common origin and ancestor molecule. The bacterial and mitochondrial class I RFs show no significant sequence similarity with their eukaryotic and archaeal counterparts and are considered to form a separate family. For more information see [, , ].This entry represents the archaeal release factor aRF1, which seems to have functional resemblance to eukaryotic RF1 [].
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Publication
21653832 | J:178045
First Author: Nishida K
Year: 2011
Journal: J Immunol
Title: Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation.
Volume: 187
Issue: 2
Pages: 932-41
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Publication
20228810 | J:160637
First Author: Anitei M
Year: 2010
Journal: Nat Cell Biol
Title: Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.
Volume: 12
Issue: 4
Pages: 330-40
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Publication
22573888 | J:197767
First Author: Hasegawa J
Year: 2012
Journal: Mol Biol Cell
Title: ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5.
Volume: 23
Issue: 13
Pages: 2481-9
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Publication
12771146 | J:230354
First Author: Kruljac-Letunic A
Year: 2003
Journal: J Biol Chem
Title: The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1.
Volume: 278
Issue: 32
Pages: 29560-70
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Publication
38906140 | J:360201
First Author: Zhou J
Year: 2024
Journal: Cell Metab
Title: Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
Volume: 36
Issue: 9
Pages: 2054-2068.e14
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Publication
9179839 | -
First Author: Buckingham RH
Year: 1997
Journal: Mol Microbiol
Title: Polypeptide chain release factors.
Volume: 24
Issue: 3
Pages: 449-56
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Publication
10471834 | -
First Author: Karamyshev AL
Year: 1999
Journal: FEBS Lett
Title: Polypeptide release factor eRF1 from Tetrahymena thermophila: cDNA cloning, purification and complex formation with yeast eRF3.
Volume: 457
Issue: 3
Pages: 483-8
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Publication
15979507 | -
First Author: Donaldson JG
Year: 2005
Journal: Biochim Biophys Acta
Title: Multiple activities for Arf1 at the Golgi complex.
Volume: 1744
Issue: 3
Pages: 364-73
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Interaction Experiment
Zhang J (2013)
Description: Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.
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Publication
26765562 | -
   
First Author: Richardson BC
Year: 2016
Journal: Elife
Title: The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.
Volume: 5
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Protein Coding Gene
MGI:2183559 | Arfgap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
34830155 | -
 
First Author: Kolakowski D
Year: 2021
Journal: Int J Mol Sci
Title: The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus.
Volume: 22
Issue: 22
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Protein
Q9EPJ9
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q9EPJ9-2
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: false
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Publication
19669794 | -
First Author: Bui QT
Year: 2009
Journal: Mol Genet Genomics
Title: Large Arf1 guanine nucleotide exchange factors: evolution, domain structure, and roles in membrane trafficking and human disease.
Volume: 282
Issue: 4
Pages: 329-50
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Publication
8861955 | -
First Author: Rosa JL
Year: 1996
Journal: EMBO J
Title: p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.
Volume: 15
Issue: 16
Pages: 4262-73
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Publication
16115449 | -
First Author: Dubois T
Year: 2005
Journal: Med Sci (Paris)
Title: [ARHGAP10, a novel RhoGAP at the cross-road between ARF1 and Cdc42 pathways, regulates Arp2/3 complex and actin dynamics on Golgi membranes].
Volume: 21
Issue: 8-9
Pages: 692-4
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Publication
9233772 | -
First Author: Rosa JL
Year: 1997
Journal: Oncogene
Title: A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70.
Volume: 15
Issue: 1
Pages: 1-6
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Protein
Q9QWY8
Organism: Mus musculus/domesticus
Length: 1147  
Fragment?: false
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Protein
Q9QWY8-3
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
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Protein
Q9QWY8-2
Organism: Mus musculus/domesticus
Length: 1090  
Fragment?: false
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Protein
Q9QWY8-4
Organism: Mus musculus/domesticus
Length: 1132  
Fragment?: false
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Publication
16571680 | J:112531
First Author: Natsume W
Year: 2006
Journal: Mol Biol Cell
Title: SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network.
Volume: 17
Issue: 6
Pages: 2592-603
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Protein Domain
IPR031669 | Fn3_2
Type: Domain
Description: This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (), it binds to the Arf1 GTPase [].
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Protein Domain
IPR044519 | ARF_GAP_AGD6/7
Type: Family
Description: This entry represents a group of plant ADP-ribosylation factor GTPase-activating proteins (ArfGAPs), such as AGD6/7 from Arabidopsis. ArfGAPs are a family of proteins containing an ArfGAP catalytic domain that induces the hydrolysis of GTP bound to the small guanine nucleotide-binding protein Arf, a member of the Ras superfamily of GTPases. AGD7 interacts with Arf1 and stimulates Arf1 GTPase activity in a phosphatidic acid-dependent manner. It is localised to the Golgi complex and may play a critical role in protein trafficking by controlling Arf1 activity [].
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Publication
18497747 | -
First Author: Kanamori T
Year: 2008
Journal: EMBO J
Title: Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions.
Volume: 27
Issue: 12
Pages: 1647-57
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Publication
21610029 | -
First Author: Tanaka T
Year: 2011
Journal: Development
Title: Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm.
Volume: 138
Issue: 12
Pages: 2523-32
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Protein Domain
IPR026829 | Mon2-like
Type: Family
Description: Monensin-resistant homologue 2 (Mon2) is a peripheral membrane protein involved in multiple aspects of endomembrane trafficking [, ]. In Drosophila it has been described to couple endocytosis with actin remodeling []. In budding yeast, Mon2 plays a role in endocytosis and maintenance of vacuolar structure [, ]. Mon2 is distantly related to the guanine nucleotide exchange factors (GEFs) that activate Arf1 on Golgi membranes. However, Mon2 lacks the Sec7 domain that catalyses nucleotide exchange on Arf1 []. In Drosophila it has been described to couple endocytosis with actin remodeling [].
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Publication
19083995 | J:147794
 
First Author: Sanda M
Year: 2009
Journal: Brain Res
Title: The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence.
Volume: 1251
Pages: 7-15
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Protein
Q5XK24
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
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Publication
12052896 | -
First Author: Jochum A
Year: 2002
Journal: Mol Cell Biol
Title: Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1p.
Volume: 22
Issue: 13
Pages: 4914-28
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Protein Domain
IPR004403 | Peptide_chain-rel_eRF1/aRF1
Type: Family
Description: Terminating protein synthesis on the ribosome requires the presence of a class I polypeptide chain release factor (RF) to induce peptidyl-tRNA hydrolysis. Bacteria possess two class I RFs; RF1 which recognises UAG and UAA, and RF2 which recognises UGA and UAA. Mitochondrial RFs are related structurally and functionally to those of bacteria. Eukaryotes posses only a single class 1 factor, eRF1, which recognises all three termination codons. Similarly, in all archaeal species where the complete sequence of the genome is available, only a single class I factor, aRF1, has been identified so far. The aRF1 family is highly homologous to the eRF1 family, indicating a common origin and ancestor molecule. The bacterial and mitochondrial class I RFs show no significant sequence similarity with their eukaryotic and archaeal counterparts and are considered to form a separate family. For more information see [, , ].This entry represents the eRF1 and aRF1 proteins.
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Publication
17889667 | -
First Author: Lee HH
Year: 2007
Journal: Mol Cell
Title: Structural and functional insights into Dom34, a key component of no-go mRNA decay.
Volume: 27
Issue: 6
Pages: 938-50
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Protein Domain
IPR023521 | Pelota_arc
Type: Family
Description: Proteins in this entry are archaeal homologues of the eukaryotic gene pelota (DOM34 in yeast), which functions in recognising stalled ribosomes []. In eukaryotes, eRF3 and HBS1, which are homologous to the tRNA carrier GTPase EF1-alpha, respectively bind eRF1 and Pelota. In Archaea eRF1 (aRF1) and Pelota (aPelota) homologues exist, but no orthologues of eRF3 and Hbs1 have been detected. Instead, it seems that archaeal EF1-alpha (aEF1-alpha) could serve as a carrier GTPase protein for both aRF1 and aPelota onto the ribosome [].
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Publication
16698946 | -
First Author: Sieburth LE
Year: 2006
Journal: Plant Cell
Title: SCARFACE encodes an ARF-GAP that is required for normal auxin efflux and vein patterning in Arabidopsis.
Volume: 18
Issue: 6
Pages: 1396-411
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Publication
10623590 | J:59399
First Author: Takeya R
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.
Volume: 267
Issue: 1
Pages: 149-55
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Publication
28604719 | J:258924
First Author: Sasai M
Year: 2017
Journal: Nat Immunol
Title: Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Volume: 18
Issue: 8
Pages: 899-910
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Publication
37172092 | J:335681
First Author: Schlienger S
Year: 2023
Journal: Sci Adv
Title: Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control.
Volume: 9
Issue: 19
Pages: eadd5501
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Publication
23415225 | J:201285
First Author: Ren X
Year: 2013
Journal: Cell
Title: Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1.
Volume: 152
Issue: 4
Pages: 755-67
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Publication
12741954 | J:84872
First Author: Vannahme C
Year: 2003
Journal: Biochem J
Title: Characterization of SMOC-2, a modular extracellular calcium-binding protein.
Volume: 373
Issue: Pt 3
Pages: 805-14
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Publication
16774925 | -
First Author: Rocnik EF
Year: 2006
Journal: J Biol Chem
Title: The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity.
Volume: 281
Issue: 32
Pages: 22855-64
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Publication
19842175 | J:153731
First Author: Pazin DE
Year: 2009
Journal: Dev Dyn
Title: Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.
Volume: 238
Issue: 11
Pages: 2877-90
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Publication
22152679 | J:191534
First Author: Bloch-Zupan A
Year: 2011
Journal: Am J Hum Genet
Title: Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects.
Volume: 89
Issue: 6
Pages: 773-81
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Protein Domain
IPR037640 | SMOC2_EC
Type: Domain
Description: SMOC-2 is a ubiquitously expressed matricellular protein that enhances the response to angiogenic growth factors, mediate cell adhesion, keratinocyte migration, and metastasis [, ]. It is also associated with vitiligo and craniofacial and dental defects []. Moreover, SMOC-2 acts as an Arf1 GTPase-activating protein (GAP) that interacts with clathrin heavy chain (CHC) and clathrin assembly protein CALM and functions in the retrograde, early endosome/trans-Golgi network (TGN) pathway in a clathrin- and AP-1-dependent manner []. SMOC-2 contains a follistatin-like (FS) domain, two thyroglobulin-like (TY) domains and an extracellular calcium-binding (EC) domain with two EF-hand calcium-binding motifs. This entry represents the EC domain [].
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Protein Domain
IPR015403 | Mon2/Sec7/BIG1-like_HDS
Type: Domain
Description: This entry represents a HDS (homology downstream of Sec7) domain found towards the C-terminal of guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7, protein Mon2 and BIG1-like proteins [, ]. Sec7 is involved in the secretory pathway as a protein binding scaffold for the COPII-COPI protein switch for maturation of the VTC intermediate compartments for Golgi compartment biogenesis []. Sec7 has four conserved HDS1-4 domains which act to integrate the signals from several small GTPases, including Arf1 itself, to switch Sec7 from a strongly autoinhibited to a strongly auto activated form [].
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Publication
16219684 | -
First Author: Efe JA
Year: 2005
Journal: J Cell Sci
Title: Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis.
Volume: 118
Issue: Pt 20
Pages: 4751-64
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Publication
11208097 | -
First Author: Deitz SB
Year: 2000
Journal: Traffic
Title: Sec7p directs the transitions required for yeast Golgi biogenesis.
Volume: 1
Issue: 2
Pages: 172-83
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Publication
23000721 | -
First Author: Paczkowski JE
Year: 2012
Journal: EMBO J
Title: The exomer cargo adaptor structure reveals a novel GTPase-binding domain.
Volume: 31
Issue: 21
Pages: 4191-203
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Protein
Q3TTT0
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
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Protein
A0A1W2P878
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
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Publication
9819391 | J:51174
First Author: Brown MT
Year: 1998
Journal: Mol Cell Biol
Title: ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.
Volume: 18
Issue: 12
Pages: 7038-51
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Publication
11422940 | J:233589
First Author: Weissman JT
Year: 2001
Journal: Traffic
Title: The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum export.
Volume: 2
Issue: 7
Pages: 465-75
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Publication
25546260 | J:224035
First Author: Wang X
Year: 2015
Journal: Stem Cells
Title: Hematopoietic stem/progenitor cells directly contribute to arteriosclerotic progression via integrin β2.
Volume: 33
Issue: 4
Pages: 1230-40
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Publication
24719103 | J:208110
First Author: Dembla M
Year: 2014
Journal: J Neurosci
Title: ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis.
Volume: 34
Issue: 15
Pages: 5245-60
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Publication
10930456 | J:120412
First Author: Faundez VV
Year: 2000
Journal: Mol Biol Cell
Title: The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform.
Volume: 11
Issue: 8
Pages: 2591-604
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Publication
23288846 | J:197103
First Author: Hosokawa H
Year: 2013
Journal: J Biol Chem
Title: The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.
Volume: 288
Issue: 8
Pages: 5896-913
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Publication
23195223 | J:198864
First Author: Peterson TA
Year: 2013
Journal: Biochim Biophys Acta
Title: ARF1-regulated coatomer directs the steady-state localization of protein kinase C epsilon at the Golgi apparatus.
Volume: 1833
Issue: 3
Pages: 487-93
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Protein
Q80TL7
Organism: Mus musculus/domesticus
Length: 1715  
Fragment?: false
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Protein
A0JLN9
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: true
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Protein
B9EKJ3
Organism: Mus musculus/domesticus
Length: 1709  
Fragment?: false
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Publication
23386609 | -
First Author: Lowery J
Year: 2013
Journal: J Biol Chem
Title: The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
Volume: 288
Issue: 16
Pages: 11532-45
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Publication
19017632 | -
First Author: Jian X
Year: 2009
Journal: J Biol Chem
Title: Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1.
Volume: 284
Issue: 3
Pages: 1652-63
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Publication
17893324 | J:129034
First Author: Bharti S
Year: 2007
Journal: Mol Cell Biol
Title: Src-dependent phosphorylation of ASAP1 regulates podosomes.
Volume: 27
Issue: 23
Pages: 8271-83
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Publication
12522101 | -
First Author: Oda A
Year: 2003
Journal: J Biol Chem
Title: CrkL directs ASAP1 to peripheral focal adhesions.
Volume: 278
Issue: 8
Pages: 6456-60
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Publication
26291822 | -
First Author: Rennoll-Bankert KE
Year: 2015
Journal: PLoS Pathog
Title: Which Way In? The RalF Arf-GEF Orchestrates Rickettsia Host Cell Invasion.
Volume: 11
Issue: 8
Pages: e1005115
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Publication
24244168 | -
First Author: Folly-Klan M
Year: 2013
Journal: PLoS Pathog
Title: A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF.
Volume: 9
Issue: 11
Pages: e1003747
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Protein Domain
IPR038075 | RalF_C_sf
Type: Homologous_superfamily
Description: The Legionella pneumophila protein RalF is a guanine nucleotide exchange factor (GEF) of ADP-ribosylation factors (Arfs), activating and recruiting host Arf1 to the Legionella-containing vacuole []. RalF contains an N-terminal Sec7 domain and a C-terminal domain known as Sec7-capping domain (SCD). The Sec7 domain of RalF has the same overall folded structure seen in eukaryotic Sec7 domains. The eukaryotic Sec7 domain is a catalytic domain found in guanine nucleotide exchange factors (GEFs) that is sufficient to activate Arf by stimulating GDP/GTP exchange []. Structural studies showed that the C-terminal domain of RalF associates with the Sec7 domain to block access to the Arf-binding site []. This entry represents the C-terminal domain of RalF [].
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Protein Domain
IPR032691 | Mon2/Sec7/BIG1-like_HUS
Type: Domain
Description: This entry represent the HUS regulatory domain found towards the N terminus in guanine nucleotide exchange factors involved Golgi transport, such as budding yeast protein Sec7, protein Mon2 and BIG1-like proteins [, ].Sec7 and its homologues are guanine nucleotide exchange factors (GEFs) involved in the secretory pathway []. The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI []. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF [].Mon2 is distantly related to the Arf1 guanine nucleotide exchange factors (GEFs), such as Sec7. However, it lacks the Sec7 domain that catalyses nucleotide exchange on Arf1. Instead, Mon2 acts as a scaffold to recruit the Golgi-localised pool of Dop1 [].
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Protein Domain
IPR037928 | ASAP1_BAR
Type: Domain
Description: ASAP1 is an Arf GTPase activating protein (GAP) with activity towards Arf1 and Arf5 but not Arf6 However, it has been shown to bind GTP-Arf6 stably without GAP activity []. It has been implicated in cell growth, migration, and survival, as well as in tumor invasion and malignancy. It binds paxillin and cortactin, two components of invadopodia which are essential for tumor invasiveness. It also binds focal adhesion kinase (FAK) and the SH2/SH3 adaptor CrkL [, ]. ASAP1 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, ankyrin (ANK) repeats, and a C-terminal SH3 domain [].This entry represents the BAR domain of ASAP1. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of ASAP1 mediates membrane bending, is essential for function, and autoinhibits GAP activity by interacting with the PH and/or Arf GAP domains [].
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Publication
11950392 | -
First Author: Takatsu H
Year: 2002
Journal: Biochem J
Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.
Volume: 365
Issue: Pt 2
Pages: 369-78
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Publication
15728366 | -
First Author: Deretic D
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4).
Volume: 102
Issue: 9
Pages: 3301-6
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Publication
16030262 | -
First Author: Volpicelli-Daley LA
Year: 2005
Journal: Mol Biol Cell
Title: Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic.
Volume: 16
Issue: 10
Pages: 4495-508
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Publication
12446727 | -
First Author: Kim SW
Year: 2003
Journal: J Biol Chem
Title: ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation.
Volume: 278
Issue: 4
Pages: 2661-8
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Protein Domain
IPR045872 | Arf1-5-like
Type: Family
Description: Arf GTPases are involved in the formation of coated carrier vesicles by recruiting coat proteins. This entry includes Arf1, Arf2, Arf3, Arf4, Arf5, and related proteins. Each contains an N-terminal myristoylated amphipathic helix that is folded into the protein in the GDP-bound state. GDP/GTP exchange exposes the helix, which anchors to the membrane. Following GTP hydrolysis, the helix dissociates from the membrane and folds back into the protein. A general feature of Arf1-5 signaling may be the cooperation of two Arfs at the same site. Arfs1-5 are generally considered to be interchangeable in function and location, but some specific functions have been assigned []. Arf1 localizes to the early/cis-Golgi, where it is activated by GBF1 and recruits the coat protein COPI. It also localizes to the trans-Golgi network (TGN), where it is activated by BIG1/BIG2 and recruits the AP1, AP3, AP4, and GGA proteins []. Humans, but not rodents and other lower eukaryotes, lack Arf2. Human Arf3 shares 96% sequence identity with Arf1 and is believed to generally function interchangeably with Arf1. Human Arf4 in the activated (GTP-bound) state has been shown to interact with the cytoplasmic domain of epidermal growth factor receptor (EGFR) and mediate the EGF-dependent activation of phospholipase D2 (PLD2), leading to activation of the activator protein 1 (AP-1) transcription factor []. Arf4 has also been shown to recognise the C-terminal sorting signal of rhodopsin and regulate its incorporation into specialised post-Golgi rhodopsin transport carriers (RTCs) []. There is some evidence that Arf5 functions at the early-Golgi and the trans-Golgi to affect Golgi-associated alpha-adaptin homology Arf-binding proteins (GGAs) [].
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Publication
30582444 | J:293842
First Author: Abdul-Salam VB
Year: 2019
Journal: Circ Res
Title: CLIC4/Arf6 Pathway.
Volume: 124
Issue: 1
Pages: 52-65
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Publication
16301316 | -
First Author: Gillingham AK
Year: 2006
Journal: J Biol Chem
Title: Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.
Volume: 281
Issue: 4
Pages: 2273-80
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Publication
27373159 | -
First Author: Galindo A
Year: 2016
Journal: Cell Rep
Title: Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi.
Volume: 16
Issue: 3
Pages: 839-50
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Publication
3042778 | -
First Author: Achstetter T
Year: 1988
Journal: J Biol Chem
Title: SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast Golgi apparatus.
Volume: 263
Issue: 24
Pages: 11711-7
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Publication
23395181 | -
First Author: Richardson BC
Year: 2013
Journal: Structure
Title: The exomer cargo adaptor features a flexible hinge domain.
Volume: 21
Issue: 3
Pages: 486-92
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