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Search results 201 to 242 out of 242 for Arf3

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Type Details Score
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Atf3<em1(cre/ERT2)Wlf> | MGI:7450981
Name: activating transcription factor 3; endonuclease-mediated mutation 1, Clifford J Woolf
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Publication
18397879 | -
First Author: Tsai PC
Year: 2008
Journal: J Biol Chem
Title: Afi1p functions as an Arf3p polarization-specific docking factor for development of polarity.
Volume: 283
Issue: 24
Pages: 16915-27
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Protein Domain
IPR012860 | Afi1_N
Type: Domain
Description: This domain occurs at the N terminus of Afi1 (Arf3-interacting protein 1), a protein necessary for vesicle trafficking in yeast. This domain is the interacting region of the protein which binds to Arf3. Afi1 is distributed asymmetrically at the plasma membrane and is required for polarized distribution of Arf3 but not of an Arf3 guanine nucleotide-exchange factor, Yel1p. However, Afi1 is not required for targeting of Arf3 or Yel1p to the plasma membrane. Afi1 functions as an Arf3 polarization-specific adapter and participates in development of polarity []. Although Arf3 is the homologue of human Arf6 it does not function in the same way, not being necessary for endocytosis or for mating factor receptor internalisation. In the S phase, however, it is concentrated at the plasma membrane of the emerging bud. Because of its polarized localisation and its critical function in the normal budding pattern of yeast, Arf3 is probably a regulator of vesicle trafficking, which is important for polarized growth.
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Protein Domain
IPR045007 | LSB5
Type: Family
Description: Lsb5 plays important roles in membrane-trafficking events through association with the actin regulators, the yeast Wiskott-Aldrich syndrome protein (WASP) homologue Las17 and the cortical protein Sla1, the yeast Arf3 (orthologous with mammalian Arf6), and ubiquitin. Lsb5 contains an N-terminal VHS (Vps27p/Hrs/STAM)-domain and a GAT (GGA and TOM1) domain. In contrast to GGA proteins, Lsb5 harbours a C-terminal NPF (Asn-Pro-Phe) motif, but does not have either a GAE (gamma-adaptin ear homology) domain or a clathrin-binding motif [, , ].
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Genotype
Genotype
Symbol: Atf3/Atf3 Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR044103 | GAT_LSB5
Type: Domain
Description: Lsb5 plays important roles in membrane-trafficking events through association with the actin regulators, the yeast Wiskott-Aldrich syndrome protein (WASP) homologue Las17 and the cortical protein Sla1, the yeast Arf3 (orthologous with mammalian Arf6), and ubiquitin. Lsb5 contains an N-terminal VHS (Vps27p/Hrs/STAM)-domain and a GAT (GGA and TOM1) domain. In contrast to GGA proteins, Lsb5 harbours a C-terminal NPF (Asn-Pro-Phe) motif, but does not have either a GAE (gamma-adaptin ear homology) domain or a clathrin-binding motif [, , ].This entry represents the GAT domain found in Lsb5.
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Publication
32415087 | J:322486
First Author: Liu L
Year: 2020
Journal: Cell Death Dis
Title: BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis.
Volume: 11
Issue: 5
Pages: 374
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Publication
15651983 | -
First Author: Costa R
Year: 2005
Journal: Biochem J
Title: Lsb5p interacts with actin regulators Sla1p and Las17p, ubiquitin and Arf3p to couple actin dynamics to membrane trafficking processes.
Volume: 387
Issue: Pt 3
Pages: 649-58
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Publication
12388763 | -
First Author: Dewar H
Year: 2002
Journal: Mol Biol Cell
Title: Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae.
Volume: 13
Issue: 10
Pages: 3646-61
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Publication
16246096 | -
First Author: Costa R
Year: 2005
Journal: Biochem Soc Trans
Title: Interactions between Sla1p, Lsb5p and Arf3p in yeast endocytosis.
Volume: 33
Issue: Pt 6
Pages: 1273-5
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Publication
32810432 | J:329557
First Author: Renthal W
Year: 2020
Journal: Neuron
Title: Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury.
Volume: 108
Issue: 1
Pages: 128-144.e9
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Publication
26198097 | -
 
First Author: Hsu JW
Year: 2015
Journal: Nat Commun
Title: Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain.
Volume: 6
Pages: 7840
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Publication
12912991 | -
First Author: Donaldson JG
Year: 2003
Journal: J Biol Chem
Title: Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane.
Volume: 278
Issue: 43
Pages: 41573-6
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Publication
15210957 | -
First Author: Tague SE
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway.
Volume: 101
Issue: 26
Pages: 9671-6
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Publication
15087504 | -
First Author: Hashimoto S
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Requirement for Arf6 in breast cancer invasive activities.
Volume: 101
Issue: 17
Pages: 6647-52
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Publication
15897187 | -
First Author: Balañá ME
Year: 2005
Journal: J Cell Sci
Title: ARF6 GTPase controls bacterial invasion by actin remodelling.
Volume: 118
Issue: Pt 10
Pages: 2201-10
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Protein Domain
IPR041838 | Arf6
Type: Family
Description: Arf6 (ADP ribosylation factor 6) proteins localize to the plasma membrane, where they perform a wide variety of functions. In its active, GTP-bound form, Arf6 is involved in cell spreading, Rac-induced formation of plasma membrane ruffles, cell migration, wound healing, and Fc-mediated phagocytosis. Arf6 appears to change the actin structure at the plasma membrane by activating Rac, a Rho family protein involved in membrane ruffling. Arf6 is required for and enhances Rac formation of ruffles. Arf6 can regulate dendritic branching in hippocampal neurons, and in yeast it localizes to the growing bud, where it plays a role in polarized growth and bud site selection. In leukocytes, Arf6 is required for chemokine-stimulated migration across endothelial cells. Arf6 also plays a role in down-regulation of beta2-adrenergic receptors and luteinizing hormone receptors by facilitating the release of sequestered arrestin to allow endocytosis. Arf6 is believed to function at multiple sites on the plasma membrane through interaction with a specific set of GEFs, GAPs, and effectors []. Arf6 has been implicated in breast cancer and melanoma cell invasion [, ], and in actin remodelling at the invasion site of Chlamydia infection [].It's worth noting that the Arf6 homologue in Saccharomyces cerevisiae is known as Arf3 [].
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Publication
11950392 | -
First Author: Takatsu H
Year: 2002
Journal: Biochem J
Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.
Volume: 365
Issue: Pt 2
Pages: 369-78
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Publication
15979507 | -
First Author: Donaldson JG
Year: 2005
Journal: Biochim Biophys Acta
Title: Multiple activities for Arf1 at the Golgi complex.
Volume: 1744
Issue: 3
Pages: 364-73
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Publication
15728366 | -
First Author: Deretic D
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4).
Volume: 102
Issue: 9
Pages: 3301-6
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Publication
16030262 | -
First Author: Volpicelli-Daley LA
Year: 2005
Journal: Mol Biol Cell
Title: Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic.
Volume: 16
Issue: 10
Pages: 4495-508
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Publication
12446727 | -
First Author: Kim SW
Year: 2003
Journal: J Biol Chem
Title: ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation.
Volume: 278
Issue: 4
Pages: 2661-8
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Protein Domain
IPR045872 | Arf1-5-like
Type: Family
Description: Arf GTPases are involved in the formation of coated carrier vesicles by recruiting coat proteins. This entry includes Arf1, Arf2, Arf3, Arf4, Arf5, and related proteins. Each contains an N-terminal myristoylated amphipathic helix that is folded into the protein in the GDP-bound state. GDP/GTP exchange exposes the helix, which anchors to the membrane. Following GTP hydrolysis, the helix dissociates from the membrane and folds back into the protein. A general feature of Arf1-5 signaling may be the cooperation of two Arfs at the same site. Arfs1-5 are generally considered to be interchangeable in function and location, but some specific functions have been assigned []. Arf1 localizes to the early/cis-Golgi, where it is activated by GBF1 and recruits the coat protein COPI. It also localizes to the trans-Golgi network (TGN), where it is activated by BIG1/BIG2 and recruits the AP1, AP3, AP4, and GGA proteins []. Humans, but not rodents and other lower eukaryotes, lack Arf2. Human Arf3 shares 96% sequence identity with Arf1 and is believed to generally function interchangeably with Arf1. Human Arf4 in the activated (GTP-bound) state has been shown to interact with the cytoplasmic domain of epidermal growth factor receptor (EGFR) and mediate the EGF-dependent activation of phospholipase D2 (PLD2), leading to activation of the activator protein 1 (AP-1) transcription factor []. Arf4 has also been shown to recognise the C-terminal sorting signal of rhodopsin and regulate its incorporation into specialised post-Golgi rhodopsin transport carriers (RTCs) []. There is some evidence that Arf5 functions at the early-Golgi and the trans-Golgi to affect Golgi-associated alpha-adaptin homology Arf-binding proteins (GGAs) [].
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Protein
P62331
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
Q3U0D7
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
P61750
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
P84084
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
Q8BSL7
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
P61205
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
P84078
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
Q9DD04
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
Q3U344
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
Q14BR4
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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