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Search results 201 to 269 out of 269 for Arsa

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Type Details Score
Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
20981284 | -
 
First Author: Castillo R
Year: 2010
Journal: Int J Microbiol
Title: Functional Promiscuity of Homologues of the Bacterial ArsA ATPases.
Volume: 2010
Pages: 187373
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Publication
10970874 | -
First Author: Zhou T
Year: 2000
Journal: EMBO J
Title: Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump.
Volume: 19
Issue: 17
Pages: 4838-45
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Allele
Arsa<em1Smoc> | MGI:7288351
Name: arylsulfatase A; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
1688427 | -
First Author: Tisa LS
Year: 1990
Journal: J Biol Chem
Title: Molecular characterization of an anion pump. The ArsB protein is the membrane anchor for the ArsA protein.
Volume: 265
Issue: 1
Pages: 190-4
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Protein
O54984
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Strain
MGI:6474801 | C57BL/6JSmoc-Arsa<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Coding Gene
MGI:1928379 | Get3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
7721697 | -
First Author: Diorio C
Year: 1995
Journal: J Bacteriol
Title: An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteria.
Volume: 177
Issue: 8
Pages: 2050-6
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Protein Domain
IPR000802 | Arsenical_pump_ArsB
Type: Family
Description: Arsenic is a toxic metalloid whose trivalent and pentavalent ions inhibita variety of biochemical processes. Operons that encode arsenic resistancehave been found in multicopy plasmids from both Gram-positive andGram-negative bacteria []. The resistance mechanism is encoded from a singleoperon, which houses an anion pump. The pump has two polypeptide components:a catalytic subunit (the ArsA protein), which functions as anoxyanion-stimulated ATPase; and an arsenite export component (the ArsB protein),which is associated with the inner membrane []. The ArsA and ArsB proteinsare thought to form a membrane complex that functions as ananion-translocating ATPase.The ArsB protein is distinguished by its overall hydrophobic character,in keeping with its role as a membrane-associated channel. Sequenceanalysis reveals the presence of 13 putative transmembrane (TM) regions.
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Publication
16797549 | J:110338
First Author: Mukhopadhyay R
Year: 2006
Journal: FEBS Lett
Title: Targeted disruption of the mouse Asna1 gene results in embryonic lethality.
Volume: 580
Issue: 16
Pages: 3889-94
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Publication
17419726 | -
First Author: Tseng YY
Year: 2007
Journal: FEBS J
Title: Caenorhabditis elegans expresses a functional ArsA.
Volume: 274
Issue: 10
Pages: 2566-72
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Publication
12680698 | -
First Author: Shen J
Year: 2003
Journal: Biometals
Title: The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance.
Volume: 16
Issue: 3
Pages: 369-78
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Publication
17289575 | -
First Author: Kao G
Year: 2007
Journal: Cell
Title: ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.
Volume: 128
Issue: 3
Pages: 577-87
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Publication
18724936 | -
First Author: Schuldiner M
Year: 2008
Journal: Cell
Title: The GET complex mediates insertion of tail-anchored proteins into the ER membrane.
Volume: 134
Issue: 4
Pages: 634-45
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Publication
21658170 | -
First Author: Sherrill J
Year: 2011
Journal: Traffic
Title: A conserved archaeal pathway for tail-anchored membrane protein insertion.
Volume: 12
Issue: 9
Pages: 1119-23
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Publication
20406421 | -
First Author: Borgese N
Year: 2010
Journal: Traffic
Title: Remote origins of tail-anchored proteins.
Volume: 11
Issue: 7
Pages: 877-85
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Protein Domain
IPR016300 | ATPase_ArsA/GET3
Type: Family
Description: Active extrusion is a common mechanism for the detoxification of heavy metals, drugs and antibiotics in bacteria, protozoa and mammals. This is particularly important for arsenic extrusion because of its prevalence in the environment and its potential to cause health and environmental problems. In prokaryotes, arsenic detoxification is accomplished by chromosomal and plasmid-borne operon-encoded efflux systems. ArsA from Escherichia coli is the catalytic subunit of the ArsAB extrusion pump, providing resistance to arsenite and antimonite. This pump consists of a soluble ATPase (ArsA) and a membrane channel (ArsB). Maintenance of a low intracellular concentration of oxidation produces resistance to the toxic agents. A third protein, ArsC, expands the substrate specificity to allow for arsenate resistance. ArsC reduces arsenate to arsenite, which is subsequently pumped out of the cell []. ArsA contains two nucleotide-binding sites (NBSs) and a binding site for arsenic or antimony. Binding of metalloids to the pump stimulates the ATPase activity [].Homologues of the bacterial ArsA ATPase are found in eukaryotes, where theyhave several recognised functions unrelated to arsenic resistance []. Caenorhabditis elegans homologue Asna-1 is required for defence against arsenite and antimonite toxicity [], and may be also involved in insulin signaling []. The homologue in yeast, GET3/Arr4, is part of the GET complex and not only is involved in stress tolerance to metals and heat [], but also specifically recognises transmenbrane domains of tail-anchored (TA) proteins destined for the secretory pathway []. Archaeal GET3 homologues have also been discovered, suggesting that that archaea may possess a TA protein targeting pathway similar to that in eukaryotes [, ].
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Protein Domain
IPR027542 | ATPase_ArsA/GET3_euk
Type: Family
Description: Active extrusion is a common mechanism for the detoxification of heavy metals, drugs and antibiotics in bacteria, protozoa and mammals. This is particularly important for arsenic extrusion because of its prevalence in the environment and its potential to cause health and environmental problems. In prokaryotes, arsenic detoxification is accomplished by chromosomal and plasmid-borne operon-encoded efflux systems. ArsA from Escherichia coli is the catalytic subunit of the ArsAB extrusion pump, providing resistance to arsenite and antimonite. This pump consists of a soluble ATPase (ArsA) and a membrane channel (ArsB). Maintenance of a low intracellular concentration of oxidation produces resistance to the toxic agents. A third protein, ArsC, expands the substrate specificity to allow for arsenate resistance. ArsC reduces arsenate to arsenite, which is subsequently pumped out of the cell []. ArsA contains two nucleotide-binding sites (NBSs) and a binding site for arsenic or antimony. Binding of metalloids to the pump stimulates the ATPase activity [].Homologues of the bacterial ArsA ATPase are found in eukaryotes, where theyhave several recognised functions unrelated to arsenic resistance []. Caenorhabditis elegans homologue Asna-1 is required for defence against arsenite and antimonite toxicity [], and may be also involved in insulin signaling []. The homologue in yeast, GET3/Arr4, is part of the GET complex and not only is involved in stress tolerance to metals and heat [], but also specifically recognises transmenbrane domains of tail-anchored (TA) proteins destined for the secretory pathway []. Archaeal GET3 homologues have also been discovered, suggesting that that archaea may possess a TA protein targeting pathway similar to that in eukaryotes [, ].This entry represents the eukaryotic branch of the ArsA/GET3 family.
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Publication
1704144 | -
First Author: Rosen BP
Year: 1990
Journal: Res Microbiol
Title: The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase.
Volume: 141
Issue: 3
Pages: 336-41
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Publication
12877744 | -
 
First Author: Jackson CR
Year: 2003
Journal: BMC Evol Biol
Title: Phylogenetic analysis of bacterial and archaeal arsC gene sequences suggests an ancient, common origin for arsenate reductase.
Volume: 3
Pages: 18
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Publication
12426124 | -
 
First Author: Mukhopadhyay R
Year: 2002
Journal: Environ Health Perspect
Title: Arsenate reductases in prokaryotes and eukaryotes.
Volume: 110 Suppl 5
Pages: 745-8
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Protein Domain
IPR006659 | Arsenate_reductase
Type: Family
Description: This entry describes a distinct clade, including ArsC itself, of the broader family of ArsC and related proteins. This clade is almost completely restricted to the proteobacteria. An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773 []. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. The pump is composed of two polypeptides, the products of the arsA and arsB genes. The pump alone produces resistance to arsenite and antimonite. This protein, ArsC, catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate. ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate []. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases [, ].
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Publication
19536613 | J:215968
First Author: Mitsunaga-Nakatsubo K
Year: 2009
Journal: Med Mol Morphol
Title: Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers.
Volume: 42
Issue: 2
Pages: 63-9
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Publication
11470536 | J:71368
First Author: Bhattacharjee H
Year: 2001
Journal: Gene
Title: Genomic organization and chromosomal localization of the Asna1 gene, a mouse homologue of a bacterial arsenic-translocating ATPase gene.
Volume: 272
Issue: 1-2
Pages: 291-9
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Publication
30657900 | J:276098
First Author: Simonis H
Year: 2019
Journal: Hum Mol Genet
Title: Evolutionary redesign of the lysosomal enzyme arylsulfatase A increases efficacy of enzyme replacement therapy for metachromatic leukodystrophy.
Volume: 28
Issue: 11
Pages: 1810-1821
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Publication
- | J:4570
 
First Author: Hameister H
Year: 1989
Journal: Cytogenet Cell Genet
Title: Physical and genetic linkage map of murine Chromosome 15.
Volume: 51
Pages: 1010 (Abstr. 2606)
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Protein
Q8VEI6
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q8C1Q1
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
A0A1B0GRE1
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Publication
7860609 | -
First Author: Carlin A
Year: 1995
Journal: J Bacteriol
Title: The ars operon of Escherichia coli confers arsenical and antimonial resistance.
Volume: 177
Issue: 4
Pages: 981-6
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Publication
9261111 | -
First Author: Liu J
Year: 1997
Journal: J Biol Chem
Title: Ligand interactions of the ArsC arsenate reductase.
Volume: 272
Issue: 34
Pages: 21084-9
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Publication
15028674 | -
First Author: Zuber P
Year: 2004
Journal: J Bacteriol
Title: Spx-RNA polymerase interaction and global transcriptional control during oxidative stress.
Volume: 186
Issue: 7
Pages: 1911-8
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Protein Domain
IPR006660 | Arsenate_reductase-like
Type: Family
Description: Several bacterial taxon have a chromosomal resistance system, encoded by the ars operon, for the detoxification of arsenate, arsenite, and antimonite []. This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite before it is extruded. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance. ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. ArsC forms an active quaternary complex with GSH, arsenate, and glutaredoxin 1 (Grx1). The three ligands must be present simultaneously for reduction to occur [].The arsC family also comprises the Spx proteins which are GRAM-positive bacterial transcription factors that regulate the transcription of multiple genes in response to disulphide stress [, ].The arsC protein structure has been solved []. It belongs to the thioredoxin superfamily fold which is defined by a β-sheet core surrounded by α-helices. The active cysteine residue of ArsC is located in the loop between the first β-strand and the first helix, which is also conserved in the Spx protein and its homologues.
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Publication
11709171 | -
First Author: Martin P
Year: 2001
Journal: Structure
Title: Insights into the structure, solvation, and mechanism of ArsC arsenate reductase, a novel arsenic detoxification enzyme.
Volume: 9
Issue: 11
Pages: 1071-81
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Publication
29271514 | -
First Author: Rojas-Tapias DF
Year: 2018
Journal: Mol Microbiol
Title: Induction of the Spx regulon by cell wall stress reveals novel regulatory mechanisms in Bacillus subtilis.
Volume: 107
Issue: 5
Pages: 659-674
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