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Search results 201 to 283 out of 283 for Ash2l

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Type Details Score
Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE120986 | COMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Interaction Experiment
Stoller JZ (2010)
Description: Ash2l interacts with Tbx1 and is required during early embryogenesis.
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GXD Expression
GXD Expression
Probe: MGI:7565524
Assay Type: Immunohistochemistry
Annotation Date: 2023-12-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7565550
Age: embryonic day 14.5
Image: 1B cKO
Note: Authors state that expression decreased concurrently with Ash2l and Dpy30 expression.
Specimen Label: 1B cKO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6887682
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6887756
Age: postnatal
Image: 4E
Note: Co-expression of Smyd1 and Ash2l was noted in the nuclei and cytoplasm of cardiomyocytes.
Specimen Label: 4E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6887682
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6887756
Age: postnatal
Image: 4E
Note: Co-expression of Smyd1 and Ash2l was noted in the nuclei and cytoplasm of cardiomyocytes.
Specimen Label: 4E
Detected: true
Specimen Num: 1
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Protein
D6RI55
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
D6RET1
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Publication
21527717 | -
First Author: Xiao Y
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.
Volume: 108
Issue: 20
Pages: 8305-10
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Publication
28160335 | -
First Author: Vedadi M
Year: 2017
Journal: Protein Sci
Title: Targeting human SET1/MLL family of proteins.
Volume: 26
Issue: 4
Pages: 662-676
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Publication
20118203 | -
First Author: Aquea F
Year: 2010
Journal: J Exp Bot
Title: TRAUCO, a Trithorax-group gene homologue, is required for early embryogenesis in Arabidopsis thaliana.
Volume: 61
Issue: 4
Pages: 1215-24
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Protein Domain
IPR037353 | ASH2
Type: Family
Description: The trithorax-group (trxG) protein Ash2 from C. elegans (or ASH2L in mammals) is a component of the Set1/Ash2 histone methyltransferase (HMT) complex that methylates 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation [, ]. Mammals posses several SET1 family proteins (MLL1-4, SET1A, and SET1B). ASH2L is a core component of all the resulting mammalian histone H3K4 methyltransferase complexes, including mixed lineage leukemia (MLL) complexes [].S. cerevisiae Bre2 is homologous to Ash2 []. TRAUCO (TRO) is the homologue from Arabidopsis, which is required for early embryogenesis [].
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Publication
27239938 | J:238163
First Author: Jung Y
Year: 2016
Journal: Nat Neurosci
Title: An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior.
Volume: 19
Issue: 7
Pages: 905-14
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Publication
16990798 | -
First Author: Allen MD
Year: 2006
Journal: EMBO J
Title: Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase.
Volume: 25
Issue: 19
Pages: 4503-12
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Publication
12453419 | -
First Author: Nakamura T
Year: 2002
Journal: Mol Cell
Title: ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
Volume: 10
Issue: 5
Pages: 1119-28
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Publication
26886794 | -
First Author: Li Y
Year: 2016
Journal: Nature
Title: Structural basis for activity regulation of MLL family methyltransferases.
Volume: 530
Issue: 7591
Pages: 447-52
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Protein Domain
IPR041958 | KMT2A_ePHD
Type: Domain
Description: The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This entry represents the ePHD finger of Histone-lysine N-methyltransferase 2A (KMT2A), which is a histone methyltransferase that belongs to the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2). It regulates chromatin-mediated transcription through the catalysis of methylation of histone 3 lysine 4 (H3K4), and is frequently rearranged in acute leukemia []. KMT2A functions as the catalytic subunit in the MLL1 complex, which also contains WDR5, RbBP5, ASH2L and DPY30 as integral core subunits required for the efficient methylation activity of the complex [, ]. The MLL1 complex is highly active and specific for H3K4 methylation. KMT2A contains a CxxC (x for any residue) zinc finger domain, three PHD fingers, a Bromodomain domain, this extended PHD finger, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain [].
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Publication
35915089 | J:339243
First Author: Wang J
Year: 2022
Journal: Cell Discov
Title: A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors.
Volume: 8
Issue: 1
Pages: 74
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Publication
26691508 | J:281188
First Author: Yang Z
Year: 2015
Journal: PLoS One
Title: Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.
Volume: 10
Issue: 12
Pages: e0145336
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Publication
11742990 | -
First Author: Roguev A
Year: 2001
Journal: EMBO J
Title: The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4.
Volume: 20
Issue: 24
Pages: 7137-48
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Publication
10637508 | -
First Author: Huntsman DG
Year: 1999
Journal: Oncogene
Title: MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.
Volume: 18
Issue: 56
Pages: 7975-84
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Publication
23426673 | J:194254
First Author: Kerimoglu C
Year: 2013
Journal: J Neurosci
Title: Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice.
Volume: 33
Issue: 8
Pages: 3452-64
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Publication
23358417 | J:203327
First Author: Ladopoulos V
Year: 2013
Journal: Mol Cell Biol
Title: The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.
Volume: 33
Issue: 7
Pages: 1383-93
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Publication
10409430 | -
First Author: FitzGerald KT
Year: 1999
Journal: Genomics
Title: MLL2: A new mammalian member of the trx/MLL family of genes.
Volume: 59
Issue: 2
Pages: 187-92
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Publication
29323282 | J:308602
First Author: Hanna CW
Year: 2018
Journal: Nat Struct Mol Biol
Title: MLL2 conveys transcription-independent H3K4 trimethylation in oocytes.
Volume: 25
Issue: 1
Pages: 73-82
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Publication
16540515 | J:107403
First Author: Glaser S
Year: 2006
Journal: Development
Title: Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.
Volume: 133
Issue: 8
Pages: 1423-32
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Protein Domain
IPR041959 | KMT2B_ePHD
Type: Domain
Description: The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This entry represents the ePHD finger of Histone-lysine N-methyltransferase 2B (KMT2B), also known as MLL2. KMT2B is a second human homologue of Drosophila trithorax, located on chromosome 19 [, ]. It belongs to the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2) and is vital for normal mammalian embryonic development []. KMT2B functions as the catalytic subunit in the MLL2 complex, which contains WDR5, RbBP5, ASH2L and DPY30 as integral core subunits required for the efficient methylation activity of the complex. The MLL2 complex is highly active and specific for histone 3 lysine 4 (H3K4) methylation, which stimulates chromatin transcription in a SAM- and H3K4-dependent manner []. Moreover, KMT2B plays a critical role in memory formation by mediating hippocampal H3K4 di- and trimethylation []. It is also required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter []. KMT2B contains a CxxC (x for any residue) zinc finger domain, three PHD fingers, this ePHD finger, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain.
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Publication
32358019 | J:292161
First Author: Zhang Z
Year: 2020
Journal: J Immunol
Title: Suppression of Mll1-Complex by Stat3/Cebpβ-Induced miR-21a/21b/181b Maintains the Accumulation, Homeostasis, and Immunosuppressive Function of Polymorphonuclear Myeloid-Derived Suppressor Cells.
Volume: 204
Issue: 12
Pages: 3400-3415
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Publication
12670868 | -
First Author: Wysocka J
Year: 2003
Journal: Genes Dev
Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.
Volume: 17
Issue: 7
Pages: 896-911
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Publication
19556245 | -
First Author: Patel A
Year: 2009
Journal: J Biol Chem
Title: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Volume: 284
Issue: 36
Pages: 24242-56
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Protein
Q91X20
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: false
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Protein
E9PU93
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
Q3UKZ9
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: true
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Protein
Q3UJ62
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: true
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Protein
D3YYA0
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
Q3UJY9
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: true
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Protein
Q8CHH1
Organism: Mus musculus/domesticus
Length: 1744  
Fragment?: true
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Protein
P55200
Organism: Mus musculus/domesticus
Length: 3966  
Fragment?: false
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Protein
O08550
Organism: Mus musculus/domesticus
Length: 2713  
Fragment?: false
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Protein
F8WJ40
Organism: Mus musculus/domesticus
Length: 2721  
Fragment?: false
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Protein
Q6PHU4
Organism: Mus musculus/domesticus
Length: 2013  
Fragment?: true
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Protein
F6W623
Organism: Mus musculus/domesticus
Length: 2014  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom