Type |
Details |
Score |
Author |
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Author |
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Author |
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Author |
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Author |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
484
 |
Fragment?: |
false |
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Publication |
First Author: |
Ryu DK |
Year: |
2021 |
Journal: |
bioRxiv |
Title: |
Therapeutic efficacy of CT-P59 against P.1 variant of SARS-CoV-2. |
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Author |
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Author |
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Allele |
Name: |
liver metabolism QTL 11; BTBR |
Allele Type: |
QTL |
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Allele |
Name: |
liver metabolism QTL 11; C57BL/6J |
Allele Type: |
QTL |
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Publication |
First Author: |
Cheung SKK |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models. |
Volume: |
13 |
Issue: |
1 |
Pages: |
6763 |
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•
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•
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Publication |
First Author: |
Björkegren JL |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. |
Volume: |
10 |
Issue: |
2 |
Pages: |
e1004201 |
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•
•
•
•
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Publication |
First Author: |
Rossignoli A |
Year: |
2017 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration. |
Volume: |
37 |
Issue: |
3 |
Pages: |
534-542 |
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•
•
•
•
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Publication |
First Author: |
Hradilkova K |
Year: |
2019 |
Journal: |
Arthritis Rheumatol |
Title: |
Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation. |
Volume: |
71 |
Issue: |
10 |
Pages: |
1756-1765 |
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•
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•
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Publication |
First Author: |
Zhu M |
Year: |
2024 |
Journal: |
Cell Metab |
Title: |
PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer. |
Volume: |
36 |
Issue: |
8 |
Pages: |
1711-1725.e8 |
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•
•
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•
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Publication |
First Author: |
Tian Y |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. |
Volume: |
10 |
Issue: |
1 |
Pages: |
3391 |
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•
•
•
•
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Publication |
First Author: |
Wang Y |
Year: |
2022 |
Journal: |
Theranostics |
Title: |
MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. |
Volume: |
12 |
Issue: |
15 |
Pages: |
6509-6526 |
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•
•
•
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•
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Publication |
First Author: |
Wong LJ |
Year: |
1995 |
Journal: |
Genomics |
Title: |
Characterization of the cDNA and the gene encoding murine adenylosuccinate lyase. |
Volume: |
28 |
Issue: |
2 |
Pages: |
341-3 |
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•
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Protein Domain |
Type: |
Domain |
Description: |
This domain is found at the C terminus of adenylosuccinate lyase (ASL; PurB in Escherichia coli). It has been identified in bacteria, eukaryotes and archaea and is found together with the lyase domain . ASL catalyses the cleavage of succinylaminoimidazole carboxamide ribotide to aminoimidazole carboxamide ribotide and fumarate and the cleavage of adenylosuccinate to adenylate and fumarate []. |
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Publication |
First Author: |
Shang MM |
Year: |
2014 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis. |
Volume: |
34 |
Issue: |
9 |
Pages: |
2068-77 |
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•
•
•
•
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Publication |
First Author: |
Pasterkamp G |
Year: |
2016 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype. |
Volume: |
36 |
Issue: |
6 |
Pages: |
1240-6 |
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•
•
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Publication |
First Author: |
Sun H |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. |
Volume: |
9 |
Issue: |
1 |
Pages: |
5214 |
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Publication |
First Author: |
Zhang Q |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. |
Volume: |
9 |
Issue: |
44 |
Pages: |
eadi4777 |
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Protein Domain |
Type: |
Family |
Description: |
Argininosuccinate lyase (ASL or ASAL, ) participates in arginine synthesis in all organisms catalysing the reversible breakdown of argininosuccinate to arginine and fumarate. The reaction is also part of the urea cycle []. The crystal structures of ASLs from several species have been studied, in particular the duck delta1 and delta2 eye lens crystallins, which are inactive and active homologues of ASL, respectively []. ASL is a member of the Lyase class I family, these proteins are active as tetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. In humans, mutations in ASAL result in the autosomal recessive disorder argininosuccinic aciduria [].This entry represents argininosuccinate lyase and includes avian delta crystallins whose biological role is to provide the optically clear cellular protein of the eye lens. |
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Publication |
First Author: |
Cowley EA |
Year: |
2000 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Airway surface liquid composition in mice. |
Volume: |
278 |
Issue: |
6 |
Pages: |
L1213-20 |
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•
•
•
•
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Publication |
First Author: |
Stone RL |
Year: |
1992 |
Journal: |
Nat Genet |
Title: |
A mutation in adenylosuccinate lyase associated with mental retardation and autistic features. |
Volume: |
1 |
Issue: |
1 |
Pages: |
59-63 |
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Publication |
First Author: |
Ferrara CT |
Year: |
2008 |
Journal: |
PLoS Genet |
Title: |
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. |
Volume: |
4 |
Issue: |
3 |
Pages: |
e1000034 |
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Publication |
First Author: |
Sampaleanu LM |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Mutational analysis of duck delta 2 crystallin and the structure of an inactive mutant with bound substrate provide insight into the enzymatic mechanism of argininosuccinate lyase. |
Volume: |
277 |
Issue: |
6 |
Pages: |
4166-75 |
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•
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Publication |
First Author: |
Bhaumik P |
Year: |
2004 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
Structure determination and refinement at 2.44 A resolution of argininosuccinate lyase from Escherichia coli. |
Volume: |
60 |
Issue: |
Pt 11 |
Pages: |
1964-70 |
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Publication |
First Author: |
Mall MA |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. |
Volume: |
285 |
Issue: |
35 |
Pages: |
26945-55 |
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•
•
•
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•
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Publication |
First Author: |
Grubb BR |
Year: |
2012 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Transgenic hCFTR expression fails to correct β-ENaC mouse lung disease. |
Volume: |
302 |
Issue: |
2 |
Pages: |
L238-47 |
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•
•
•
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•
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Publication |
First Author: |
Garth J |
Year: |
2019 |
Journal: |
Front Med (Lausanne) |
Title: |
The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance. |
Volume: |
6 |
|
Pages: |
339 |
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•
•
•
•
•
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Publication |
First Author: |
Nakagami Y |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model. |
Volume: |
181 |
Issue: |
3 |
Pages: |
2203-10 |
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•
•
•
•
•
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Publication |
First Author: |
Shen Z |
Year: |
2018 |
Journal: |
Brain Res |
Title: |
Multifaceted assessment of the APP/PS1 mouse model for Alzheimer's disease: Applying MRS, DTI, and ASL. |
Volume: |
1698 |
|
Pages: |
114-120 |
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•
•
•
•
•
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Publication |
First Author: |
Amery L |
Year: |
2000 |
Journal: |
J Lipid Res |
Title: |
Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans. |
Volume: |
41 |
Issue: |
11 |
Pages: |
1752-9 |
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•
•
•
•
•
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Publication |
First Author: |
Boivin-Angèle S |
Year: |
2000 |
Journal: |
Int J Cancer |
Title: |
Ras gene mutations in vinyl chloride-induced liver tumours are carcinogen-specific but vary with cell type and species. |
Volume: |
85 |
Issue: |
2 |
Pages: |
223-7 |
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•
•
•
•
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Publication |
First Author: |
Haggie PM |
Year: |
2016 |
Journal: |
FASEB J |
Title: |
Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. |
Volume: |
30 |
Issue: |
6 |
Pages: |
2187-97 |
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•
•
•
•
•
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Publication |
First Author: |
Song Y |
Year: |
2001 |
Journal: |
J Gen Physiol |
Title: |
Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. |
Volume: |
117 |
Issue: |
6 |
Pages: |
573-82 |
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•
•
•
•
•
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Publication |
First Author: |
Davis BW |
Year: |
2015 |
Journal: |
Biophys J |
Title: |
Colocalization and Sequential Enzyme Activity in Aqueous Biphasic Systems: Experiments and Modeling. |
Volume: |
109 |
Issue: |
10 |
Pages: |
2182-94 |
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•
•
•
•
•
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Publication |
First Author: |
Ariyananda Lde Z |
Year: |
2009 |
Journal: |
Biochemistry |
Title: |
Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants. |
Volume: |
48 |
Issue: |
23 |
Pages: |
5291-302 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
74
 |
Fragment?: |
true |
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•
•
•
•
•
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Publication |
First Author: |
Womack JE |
Year: |
1989 |
Journal: |
Cytogenet Cell Genet |
Title: |
Syntenic mapping of 37 loci in cattle. Chromosomal conservation with mouse and man. |
Volume: |
51 |
|
Pages: |
1109 (Abstr.) |
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•
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•
•
•
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Publication |
First Author: |
Lalley PA |
Year: |
1981 |
Journal: |
Mouse News Lett |
Title: |
Mouse gene mapping in somatic cell hybrids |
Volume: |
64 |
|
Pages: |
79-81 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
262
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
464
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
464
 |
Fragment?: |
false |
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•
•
•
•
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